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Repressor in Medical News

Synthetic gene circuit allows precise dosing of gene expression

...rts with a promoter that launches the tetracycline repressor gene, which then blocks yEGFP via a promoter for ...culture in measured doses stifles the tetracycline repressor and permits expression of yEGFP. When ATc was a...lifier The team then made the promoter for the repressor identical to that used for yEGFP. This, in effect...

A new relationship between brain derived neurotrophic factor and inflammatory signaling

...lpha 1 gene regulation is dependent upon the induction of a transcriptional repressor called inducible cAMP early repressor (ICER) that binds to the alpha 1 gene in coordination with the cAMP regulat...

NYU Langone Medical Center's tip sheet to the 44th annual meeting of ASCO

...tract # 5065 Androgen receptor (AR) overexpression and sensitivity to hormones reversed by epigenetic therapy that restores Pura to a transcriptional repressor complex (RC) of AR deregulated in hormone refractory prostate cancer (HRPC). NYU Cancer Institutes Anna Ferrari, M.D., associate professor of medicin...

Novel mechanism found that may boost impaired function of leukemia protein

...en researching the AML1-ETO protein at MSKCC since 1993. He and his colleagues first demonstrated in 1995 that AML1-ETO functions as a transcriptional repressor and dominantly inhibits AML1 function. ...

JCI online early table of contents: Jan. 2, 2008

...e authors therefore concluded from these data that AHRR is a tumor suppressor gene present in various tissues. TITLE: The aryl hydrocarbon receptor repressor is a putative tumor suppressor gene in multiple human cancers AUTHOR CONTACT: Enrique Zudaire National Cancer Institute, Bethesda, Maryland, US...

JCI table of contents: Nov. 15, 2007

...er, these data led the authors to conclude that FOXP3 is a suppressor of tumor development induced by SKP2. TITLE: FOXP3 is a novel transcriptional repressor for the breast cancer oncogene SKP2 AUTHOR CONTACT: Yang Liu University of Michigan, Ann Arbor, Michigan, USA. Phone: (734) 615-3158; Fax: (734)...

Insights into Acute Promyelocytic Leukemia

... protein called a fusion protein. In APL, the fusion protein, always involving the transcription factor RARA, acts as a potent transcriptional repressor that interferes with gene expression and prevents normal differentiation of white blood cells. Previous work of these two groups suggested that PML/RA...

New Target for Muscular Dystrophy Drug Therapy Discovered

...or dystrophin as a possible therapy for DMD. Experiments on mice have now shown that utrophin silencing is applied by a protein called Ets-2 repressor factor (ERF) sitting on a small piece of the utrophin gene called the N-box. "We demonstrated that ERF significantly reduces or represses the ...

Molecular ‘On/Off Switch’ Controls Immune Defenses Against Viruss

...ng is normally regulated, however, hadn’t been known. In the current study, UT Southwestern researchers found that RIG-I and LGP2 each contain a repressor domain, a sort of docking site that controls the actions of each protein. The domain is the key site that regulates the ability of RIG-I to bind to it...

Hormone Transforming Caterpillars to Moths Identified

...vance and another hormone that represses metamorphosis, but have never really asked what starts metamorphosis. When we did we found a new role for the repressor hormone and in the process identified a hormone never before known that starts metamorphosis.’ Researchers foresee wide the implications of their ...
Repressor in Biological News

Xie Lab uncovers molecular machinery related to stem cell fate

...rs participate in stem cell misregulation and the development of tumors." "Our studies have established the role of BAM as a protein translational repressor using biochemical and genetic tests," said Ting Xie, Ph.D., Investigator and senior author on the paper. "Translational control is very important in r...

The evolution of gene regulation

... manner, on the other hand, are kept inactive by a repressor that is removed only when the gene is needed. Whic...e key fits the lock to this protein, to detach the repressor from the lactase gene: a lactose molecule, as a si...ve genetic codes that are only released from their repressor when needed." The "use-it-or-lose-it" principle wa...

6 young ASU faculty earn NSF Career awards

...hich is involved in embryonic development, angiogenesis and cancer), which partially unfolds upon binding and bends the DNA by 26 degrees; and the lac repressor headpiece (part of a much larger bacterial protein), which folds upon binding and bends the DNA by 36 degrees. Computer simulations will give insi...

Evolution of fruit size in tomato

...and sequencing of this locus reveals that the wild type protein codes for a repressor of cell division. When the control sequence is mutated, the repressor protein is not expressed or only very little, leading to higher cell divisi...

A study reveals how cells communicate to activate the cell division machinery

...s elucidated the relationship between Notch and Wnt/Wingless in the control of proliferation and the development of the fly wing. In fact, Notch has a repressor function, that is to say, when it is activated the cell division machinery is arrested. Only when Wnt/Wingless starts to work is Notch silenced, there...

New technique yields more detailed picture of chromatin structure

...o the chromosomes. A bacterial protein, the Lac repressor, recognizes and binds to the Lac operator in living cells. The researchers combined a Lac repressor protein with another protein that fluoresces green under blue light. This engineered protein adhered to the chromosomes in regions containing the Lac ...

Root or shoot? EAR calls the shots

...g plant to have its genome unlocked and is loved by plant biologists for its short generation time. She discovered that BODENLOS, a transcriptional repressor that silences auxin-responsive genes, relies on its EAR domain to recruit the co-repressor TOPLESS to help with the job. While auxins are found throug...

3 Columbia University Medical Center faculty elected to Institute of Medicine

...ratory work focuses primarily on transcriptional regulation of lymphocyte development. A major focus of her current work is an unusual transcriptional repressor called Blimp-1 (B lymphocyte induced maturation protein). Her studies on Blimp-1 are revealing important aspects of regulation in both B and T cells. ...

Genome sequencing reveals key to viable ethanol production

...ymes break down some of that wood. A product of that tiny reaction is a sugar called laminaribiose that diffuses into the cell. There it deactivates a repressor for two genes, which wake up and start pumping out the two triggers the full production of wood-degrading enzymes CelC and LicA. Wu’s paper shows ...

Researchers identify a key regulator for skin stem cells

...y to differentiate into multiple types of tissues, one challenge they face is maintaining the stem cells in their immature state. The newly identified repressor switch could provide part of the answer. Led by Howard Hughes Medical Institute investigator Elaine Fuchs, the researchers published discovery of...
Repressor in Biological Technology

JCI table of contents: April 22, 2008

...ized by a reliance on either cyclin D1 or cyclin D2, such as many individuals with multiple myeloma. TITLE: Identification of kinetin riboside as a repressor of CCND1 and CCND2 with preclinical antimyeloma activity AUTHOR CONTACT: A. Keith Stewart Mayo Clinic, Scottsdale, Arizona, USA. Phone: (480) 30...

Sequence-Validated and Expression-Tested Human cDNA in a Dual Expression Vector

...contain features designed for inducible high-level protein expression in bacterial cells. The vector contains the hybrid T7/lac O promoter and lac repressor gene (lac I) to regulate protein expression. Therefore, expression is inducible using isopropyl-1-thio-b-D-galatopyranoside (IPTG) in BL21(DE3) ...

Mammalian and Bacterial Expression in One Vector

...n cells. Expression of heterologous genes in bacteria is regulated by a hybrid T7/ lacO promoter. The pDual vector was engineered to carry the lac repressor gene (lacI). Expression is therefore inducible using IPTG in bacteria that contain the T7 RNA polymerase. ## In both bacterial and mammalian c...

pFB-ERV: Retroviral Delivery of the Ecdysone Receptor Proteins

...ightly repressed until ligand binding, at which time high-level transcriptional activation occurs (i.e., the heterodimer is converted from a tight repressor to a trans-activator). Using the Complete Control plasmid-based system, induction ratios of greater than 1,000-fold have been achieved in both tra...

Expression and Purification of Recombinant Proteins That Have Native Amino Acid Sequence

...s released by Stratagene. 1 It is derived from the pET-11 vector series and contains the lacI q gene for expression of the Lac repressor protein and the hybrid T7 promoter for controlled expression of the inserted protein coding sequence. 7,8 The vector is transfo...

High-Level Protein Expression, One-Column Purification, and FLAG Epitope Tagging in E. coli

...ors released by Stratagene. It is derived from the pET-11 vector series and contains the lacI q gene for expression of the Lac repressor protein and the hybrid T7 promoter for controlled expression of the inserted protein coding sequence. 8 The vector is transfo...

Functional Cloning Using ViraPort Retroviral cDNA Expression Libraries

... 2.2 Transcriptional repressor of known cell-cycle regulatory protein (to be discussed in a futur...termini. 13. Onco-1 contained a gene encoding a transcriptional repressor of a known cell cycle regulatory protein. It is not surprising, ...
Repressor in Biological Products

NovaBlue Glycerol Stock from Novagen

Description:...n high yields of excellent quality plasmid DNA. The DE3 lysogen of NovaBlue is potentially useful as a stringent host due to the presence of the lacIq repressor encoded by the F episome....
Company:Novagen
Repressor in Biological Definition

Lac repressor

The lac repressor is an enzyme which stops the metabolism of lactose in bacteria as long as glucose is available. When glucose is scarce and lactose is plentiful the lac repressor becomes inactive to permit the conversion of lactose to glucose. Human DNA encodes recipes for maki...

Lambda phage

...e phage DNA is now part of the host's genome. repressor In the following, the convention that genes are ...esulting protein encoded by that gene. The lambda repressor gene system consists of (from left to right on the...gene OR3 OR2 OR1 cro gene The lambda repressor is a dimer also known as the cI protein. It regula...

Operon

...ed a repressor. In summary: The "operator" is a DNA binding site for a repressor; transcription of the structural genes takes place unless a repressor is bound to the operator. See also gene regulatory network Lac operon ...

Tumor

... can also eventually lead to cancer. A mutation in one oncogen or one tumor repressor gen is usually not enough for a tumor to occur. A combination of a number o...cessary. DNA microarrays can be used to determine if oncogens or tumor repressor gens have been mutated. Possibly in the future tumors can be treated better...
Repressor in Biological Dictionary

Repressor

A repressor is a DNA-binding protein that regulates the expression of one or more genes by decreasing the rate of transcription. This blocking of expression is called repression. The lac repressor is a DNA-binding protein which inhibits the expression of genes coding for proteins ...

Lac repressor

The lac repressor is a DNA-binding protein which inhibits the expression of genes coding for proteins involved in the metabolism of lactose in bacteria. It is active in the absence of lactose, ensuring that the bacterium only... The lac operon is an operon required for the transp...

Zinc finger

... Finding Zinc Fingers that Bind ... Zinc fingers are a common protein motif ... A particular six zinc finger combination fused with a repressor should silence ... ...

Pachytene

...re perinuclear, and pachytene B, when SCs are uniformly distributed ... We find that the pachytene checkpoint requires Sum1, a transcriptional repressor ... NDT80 is required for exit from pachytene (Xu et al., 1995) ... Staging of pachytene nuclei based on the morphology of the XY pair with ...

Operon

... including an ... The operon may also contain regulatory genes such as a repressor gene which ... s, are not necessarily coded for by that operon . ... The operon may also contain regulatory genes such as a repressor. repressor ... Operon gene regulation ... Molecular Cell Biology concentrates o...

Lambda phage

...ge is a virus particle consisting of a head, containing double ... The repressor found in the phage lambda is a notable example of the level of ......age is a virus particle consisting of a head, containing double ... The repressor found in the phage lambda is a notable example of the level of ... ...

Helix-turn-helix

...pean Bioinformatics Institute ... Helix - turn - helix biotin operon repressor region. Example proteins. Open in usermanual ... Notably there is a he...x motif consists of two a helices and a short extended amino ... Each l repressor contains a helix - turn - helix motif. ... What does HTH stand for? D...

G1 phase

...oInfoBank Library :: G1 Phase :: A fine-structure map of spontaneous mitotic ... Exit from G1 and S phase of the cell cycle is regulated by repressor complexes ... G1 phase • In the cell cycle, the gap between the end of mitosis and the onset of the S phase . ... the multicellular hapl...

Exon

...mouse orthologous genes that undergo exon skipping. ... For example, mutations in exon 18 of the breast cancer BRCA1 gene cause ... PTB: A repressor OF EXON DEFINITION. MECHANISMS OF PTB REPRESSION ... The recognition of intron- exon boundaries, the splice sites, however, requires ... ...

AP endonuclease

... AP endonuclease (Ape1 or ref-1) DNA base excision repair (BER) enzyme ... Human AP - endonuclease 1 and hnRNP-L interact with a nCaRE-like repressor element ... environmental health issues ... AP endonucleases from other species can replace Apn1 ... Robust class II AP endonuclease w...
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