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Replicon in Medical News

ImQuest BioSciences and Arisyn Therapeutics Introduce Novel New HCV Therapeutic Agent at Hepatitis Conference

...ined its potential mechanism of antiviral action through the selection of a replicon resistant to the antiviral effects of the compound. Resistant HCV replicon sequences were selected in cell culture and resulted in mutations in the vi...

Study Showing Improved Virologic Response with Nitazoxanide in Chronic Hepatitis C Published in Gastroenterology

...development as a treatment of chronic hepatitis C. Nitazoxanide is a potent inhibitor of hepatitis C virus (HCV) replication in HCV genotype 1-derived replicon cell lines, and in vitro studies have shown that it does not induce mutations in the virus that confer resistance. Phase II clinical trials are ongo...

Tibotec presents interim findings for TMC435, an investigational genotype 1 hepatitis C treatment

...ratory parameters, ECGs, or vital signs. Steady-state plasma trough levels of TMC435 25 mg and 75 mg represented ~10 and >30-fold excess above the HCV replicon EC50 value, respectively. Mean reductions of HCV RNA from baseline to day seven with TMC435 alone and in triple therapy were 2.63 and 3.47 log10 IU...

Link Between Hepatitis C And Liver Cancer Unraveled By Scientists

...er cancer. Reduced quantities of the protein product of the retinoblastoma gene have been found in cells that harbor the Hepatitis C ‘replicon’. A replicon is nothing but a part of the genetic material of the hepatitis C virus that has the intrinsic property of self-replication and protein production. Exp...

Morphine Withdrawal Complicates Hepatitis C Infection in Drug Abusers

...the events that occur in liver cells. Although the replicon does not produce the infectious virus, the HCV replicon system represents the best available system for ex...nd that there was an increase in the number of HCV replicon in both the withdrawal scenario. Furthermore, ther...
Replicon in Medical Technology

AlphaVax Announces Promising Results in Melanoma Studies

...ists Annual Meeting in Seattle, Washington. Results from pre-clinical studies conducted at MSKCC demonstrate the ability of AlphaVax's virus-like replicon vector particles (VRP) encoding melanoma-specific tumor antigens to reduce melanoma tumor burden in a state-of-the-art murine melanoma model. Jed...

Tibotec Presents Interim Findings for TMC435, an Investigational Genotype 1 Hepatitis C Treatment, at the AASLD Liver Meeting 2008

...ratory parameters, ECGs, or vital signs. Steady-state plasma trough levels of TMC435 25 mg and 75 mg represented ~10 and >30-fold excess above the HCV replicon EC50 value, respectively. Mean reductions of HCV RNA from baseline to day seven with TMC435 alone and in triple therapy were 2.63 and 3.47 log10 IU/...

Idenix Pharmaceuticals Advances HCV Discovery Program to Clinic

...d that IDX375 targets the palm non-nucleoside pocket of HCV polymerase. IDX375 has exhibited single nanomolar in vitro potency against HCV genotype 1b replicon (EC50 = 2 nM) and against HCV genotype 1a and 1b polymerases. Additionally, cellular cytotoxicity testing in Huh-7 cells demonstrated that IDX375 is n...

Idenix Pharmaceuticals Reports First Quarter 2008 Financial Results

...itive preclinical data from its HCV protease inhibitor program, with internally discovered compounds exhibiting potency in the HCV replicon system and good pharmacokinetic profiles in several animal species. "We have made significant progress in the last six months in the discov...

Idenix Pharmaceuticals Presents Positive Preclinical Data on HCV Programs at The Annual Meeting of The European Association for the Study of the Liver (EASL)

...ntiviral activity of the drug and limiting systemic side effects. In an HCV replicon model, IDX184 exhibited 10 times greater potency than the first-generation ...olgus monkeys. IDX184 demonstrated additive antiviral activity in the HCV replicon in combination with HCV protease inhibitors and interferon and synergistic ...

Romark Announces Presentation of New Data for Nitazoxanide in Chronic Hepatitis C at EASL 2008

...ifferent genotypes, predominately genotype 4. replicon studies and an early clinical experience (unpublis...o Nitazoxanide or Tizoxanide in HCV-Containing replicon Cell Lines," also demonstrated that treatment of HCV replicon cells with tizoxanide potentiates the antivira...

Anadys Pharmaceuticals Presents Data on ANA598, a Non-Nucleoside Inhibitor of the HCV Polymerase, at the 21st International Conference on Antiviral Research

... ANA598 retained full activity against a number of replicon mutations known to confer resistance to other anti...excess of the protein-binding adjusted genotype 1a replicon EC95, suggesting the potential for twice-daily or ...5b inhibitor, cellular activity in the hepatitis C replicon assay, oral bioavailability and early indicators o...

AlphaVax Announces Initial Analysis of Data From CMV Phase 1 Clinical Trial

...phavirus. One replicon vector expresses the pp65 and IE1 genes of CMV and the second the CMV gB glycoprotein gene. Virus-like particles containing the replicon vectors were produced in cell culture, harvested and administered to the volunteers at two dosage levels. A key design and safety feature of this sing...

Idenix Pharmaceuticals Provides Update on Hepatitis C Pipeline at JP Morgan Healthcare Conference

...f nucleoside triphosphate in the liver, potentially maximizing drug efficacy and limiting systemic side effects. In preclinical studies using an HCV replicon assay, IDX184 exhibited 10 times greater potency than nucleosides currently in clinical development. In a 7-day preclinical toxicology study of IDX184...

Anadys Pharmaceuticals Announces Positive Results for ANA598 in Animal Model of Chronic Hepatitis C Virus Infection

... including intrinsic potency as an NS5B inhibitor, cellular activity in the replicon assay, oral bioavailability and early indicators of safety and tolerability...lasma concentrations of ANA598 exceeded the EC95 for HCV genotype 1a and 1b replicon inhibition. The EC95 is the concentration required in vitro to suppress hep...
Replicon in Biological News

Evolutionary origin of bacterial chromosomes revealed

...ars I and III, Agrobacteria gene movements have produced second chromosomes derived from plasmids, while in the biovar II strain K84 the plasmid-based replicon has yet to reach second chromosome status." Derek Wood, associate professor at Seattle Pacific University, remarked: "The findings in this work pro...

Cyclosporine inhibits hepatitis C virus in vitro

...ffect on hepatitis C in vitro. For the in vitro study, the researchers, led by Roberto J. Firpi, M.D. of the University of Florida, treated the HCV replicon line, GSB1, with varying doses of Cyclosporine for 48 hours and examined the results. They found that Cyclosporine reduced HCV replication by 20 perce...

Texas scientists discover how a hepatitis C protein promotes liver cancer

...of hepatitis C genetic material that is able to reproduce itself in cultured cells and also able to produce proteins made by hepatitis C viruses. "The replicon experiments enabled us to identify a protein known as NS5B that attaches to the retinoblastoma protein, a critical tumor suppressor, and accelerates i...

Hepatitis C complicated by morphine withdrawal

...rphine withdrawal enhances hepatitis C virus (HCV) replicon expression, appears in the November issue of The A...To measure HCV replication, they used a virus-like replicon that mimics the events that occur in liver cells a...iral RNA and proteins that HCV uses. Although the replicon does not produce the infectious virus, the HCV...

A comprehensive response to HIV could prevent 10 million AIDS deaths in Africa by 2020

...udy, the researchers inserted the gene for the HER2/neu protein in place of the deleted viral genes and then packaged the virus vector into virus-like replicon particles, referred to as “VRP-neu.?When these non-propagating particles are injected into an animal, the vector directs the animal’s cells to make th...

Gene Vaccine Protects Mice Against Development Of Her2/neu Breast Cancer

...udy, the researchers inserted the gene for the HER2/neu protein in place of the deleted viral genes and then packaged the virus vector into virus-like replicon particles, referred to as “VRP-neu.?When these non-propagating particles are injected into an animal, the vector directs the animal’s cells to make th...
Replicon in Biological Technology

InterMune to Present Abstracts on HCV Protease Inhibitor ITMN-191 and HCV Development Program at the EASL Meeting

...as follows: Combination of the NS3/4A Protease Inhibitor ITMN-191 with the Allosteric NS5B Polymerase Inhibitor ITMN-8020 Enhances replicon Clearance and Reduces the Emergence of Drug Resistant Variants . Discovery of Potent, Bioavailable HCV NS3/4A Inhibitors that Display Unimp...

Romark and Chugai Pharmaceutical Enter Into Exclusive Licensing Agreement for Nitazoxanide in Japan

...evelopment as a treatment of chronic hepatitis C. Nitazoxanide is a potent inhibitor of hepatitis C virus (HCV) replication in HCV genotype 1-derived replicon cell lines, and in vitro studies have shown that it does not induce mutations in the virus that confer resistance. In phase II clinical trials, the a...

Romark Announces Presentation of New Data for Controlled Release Nitazoxanide in Chronic Hepatitis C

...evelopment as a treatment of chronic hepatitis C. Nitazoxanide is a potent inhibitor of hepatitis C virus (HCV) replication in HCV genotype 1-derived replicon cell lines, and in vitro studies have shown that it does not induce mutations in the virus that confer resistance. In phase II clinical trials, the a...

InterMune Reports Third Quarter 2008 Financial Results and Business Highlights

...e moiety of polymerase inhibitor R7128 (Roche/Pharmasset) in a 14-day replicon clearance assay and in a 3-week colony formation assay resulted in clearance of the HCV replicon and reduced or suppressed the emergence of drug-resistant viral varia...

GenOdyssee Receives Broad Product Applications Protection in EU for Founding Natural Evolution Technology

...anti-HCV efficacy using the industry gold standard replicon assay without significantly increased toxicity as ...tivity in vitro in the HCV genotype 1b subgenomic replicon assay (BM4-5 cells) as compared to IFN alpha 2. G...FN alpha 2. - Viral clearance of HCV genotype 1b replicon subgenome was obtained in BM4-5 cells after long-...

InterMune to Present Four Abstracts on HCV Protease Inhibitor ITMN-191 at the AASLD Meeting

... assays. One assay modeled HCV replication (14-day replicon clearance assay) and the other assay modeled viral...ted in significantly enhanced clearance of the HCV replicon and reduced or suppressed the emergence of drug-re...ety of the NS5B Inhibitors R1626 or R7128 Enhances replicon Clearance and Reduces the Emergence of Drug Resist...

Anadys Pharmaceuticals Reports First Quarter 2008 Financial Results and Highlights

... interferon-alpha and non-antagonistic with ribavirin in cell-based assays. ANA598 was also shown to retain full activity against a number of replicon mutations known to confer resistance to other anti-HCV agents currently in clinical development, including protease inhibitors and nucleoside ...

XTL Biopharmaceuticals Signs $108 Million Deal for the Licensing of its Pre- Clinical Program in Hepatitis C to Presidio Pharmaceuticals

...l production. NS5A is distinct from the protease and polymerase. The Program's lead compounds are highly potent inhibitors of viral replication in the replicon assay, which is known to have good correlation with clinical efficacy and is currently the leading method for preclinical testing of inhibitors of the...

Your Data: Silencing Hepatitis C Virus Replication With In Vitro Transcribed siRNAs

... multiple siRNAs targeting various regions of the HCV subgenomic replicon sequence. These siRNAs were transfected into an Huh-7 cell line that stably expressed the HCV RNA replicon and screened for their gene silencing activities by real-time RT...
Replicon in Biological Dictionary

Replicon

A replicon is a DNA molecule or RNA molecule, or a region of DNA or RNA, that replicates from a single origin of replication. A Replicon in genetics is a region of DNA or RNA, that replicates from a single ... Replicon is a software company providing timesheet and expense managem...
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