Renin

Why African-Americans are at greater risk of hypertension and kidney disease

...t mechanisms of TGF-B1 require further study, the authors believe that in black patients, higher levels of the growth factor are correlated with lower renin activity -- an enzyme that constricts blood vessels and raises blood pressure. High blood pressure is the leading risk factor for end-stage kidney dis...

Center receives grant renewal for hypertension and vascular disease studies

...and those that lower it. Specifically, researchers at the School of Medicine plan to use the money to continue studying the mechanisms by which the renin angiotensin system, which regulates blood pressure, contributes to hypertension, cardiac hypertrophy (a thickening of the heart muscle that results in...

Are angiotensins involved in the hemodynamic changes of cirrhosis patients?

... Liver cirrhosis has been recently studied in the light of the new view of the renin angiotensin system (RAS). While the angiotensin converting enzyme (ACE)-Ang 2-AT1 receptor arm contributes to liver tissue injury and fibrosis and the...

New Survey Finds Majority of Adults Don't Understand a Key Source of High Blood Pressure

...ssure are not at all familiar with the role of the renin system(1) -- a key regulator of blood pressure in ... materials about an important enzyme called renin. renin plays a role in blood pressure rising and falling ...dy that narrows blood vessels. In some people, the renin system is too active and that can lead to high blo...

New target for maintaining healthy blood pressure discovered

...anism unique among the prostaglandins," says FitzGerald. "Besides the case of thromboxane, two other types of prostaglandins, PGI2 and PGE2, stimulate renin secretion, which is part of the RAAS pathway." Assuming these findings can be translated to humans, targeting the PG F2-alpha pathway could represe...

Single-Pill Combinations Diovan HCT and Exforge Approved in US as First-Line Treatments for High Blood Pressure

...e treatment of high blood pressure. These include Diovan, the world's most-prescribed ARB, Tekturna(R) (aliskiren), the first and only approved direct renin inhibitor, and Exforge, a single pill combining two leading high blood pressure medicines. Novartis is dedicated to helping physicians and patients im...

JCI online early table of contents: June 5, 2008

...f glucose triggered cells in the kidney to release renin and this was associated with accumulation of a mol...rotein GPR91, which recognizes succinate, had less renin in their kidney that did diabetic mice expressing ...ides a direct link between high glucose levels and renin release in murine and rabbit kidney AUTHOR CONT...

MultiVu Video Feed: Study in the New England Journal of Medicine Shows High Blood Pressure Drug Tekturna(R) Reduces Key Marker of Kidney Disease

... US diagnosed with diabetes and high blood pressure. Data published in this week's New England Journal of Medicine demonstrate that the first direct renin inhibitor Tekturna (aliskiren), when added to the maximum dose of the angiotensin-receptor-blocker (ARB) losartan, reduced proteinuria, a key indicato...

Two-Drug Combo Reduces Diabetic Kidney Damage

...ge in diabetes, he said. "What this study seems to indicate is that using a renin inhibitor is another way of blocking the pathway that is associated with th... "Based on the results of this study, I am much more likely to use a direct renin inhibitor in addition to an angiotensin blocker in patients with Type 2 dia...

SAGE acquires 2 new medical journals

... of the Renin-Angiotensin-Aldosterone System is the official journal of the renin Academy, dedicated to highlighting the importance of the renin Angiotensin Aldosterone System (RAAS) in circulatory control and hypertensi...

Renin in Medical Technology

FDA Approves Tekturna HCT(R) as Initial Treatment in Patients Unlikely to Achieve Their Blood Pressure Goals With a Single Agent

...)) (aliskiren), the first and only approved direct renin inhibitor, and the diuretic hydrochlorothiazide (H...d drug, Tekturna, that works by directly targeting renin and decreasing the activity of the renin angiotensin aldosterone system (RAAS) and, HCTZ, a...

Pharmacopeia Announces Upcoming Late-Breaker Presentation of Phase 2a Results for Its First-in-Class Investigational DARA Compound, PS433540

...rriott, Acadia Ballroom, 3rd Floor Poster presentation: -- "PS433540 a Novel Dual Acting Receptor Antagonist Dose Dependently Increases Plasma renin Activity in Healthy Volunteers" -- Abstract # P-14 -- Wednesday, May 14, 2008, Posters on Display: 3:00 - 7:00 p.m. CDT (4:00 - 8:00 p....

New Data Highlights Potential of SPP100 (Tekturna) as Gold Standard Therapy in Treatment of Hypertension

...dvantages of this first-in-class once daily direct renin inhibitor for the treatment of hypertension. Te...ive therapy which lowers blood pressure and plasma renin activity, irrespective of the amount of renin circulating in the bloodstream." Speedel also we...

Hypertension Vaccine CYT006-AngQb Achieves Strong Blood Pressure Reduction During Important Early Morning Period When Most Adverse Cardiovascular Events Occur

...se in plasma renin concentration (PRC) from a mean renin concentration of 5.1 pg/ml at baseline to 6.3 pg/m...s is known to induce a reactive rise of the plasma renin concentration, which is a counter-reaction of the...unt for the minor reactive rise observed in plasma renin concentration, and to the potent effect of the vac...

Speedel Reports Successful SPP635 Phase IIa Trial in Hypertension

... Next Generation renin Inhibitor to Continue Phase II Profiling in Diabet...cant milestone in the development of its family of renin inhibitors with the successful completion of a Pha...This compound is the first of a next generation of renin inhibitors following Speedel's lead product SPP100...

Renin in Medical Products

Plasma Renin Activity

Description: ARUP Laboratories is a national reference laboratory and a worldwide leader in innovative laboratory research and development. ARUP offers an extensive test menu of highly complex and unique medical tests in clinical and anatomic pathology. Owned by the University of Utah, ARUP Laboratories' client...
Company:ARUP Laboratories

Aldosterone RIA Test

Description:...a sodium chloride concentrations lead to increased renin secretion and activation of angiotensin, with angi...e observed in primary hyperaldosteronism, in which renin levels are low, blood pressure is elevated and pot...condary hyperaldosteronism as a result of elevated renin secretion [3,6]. Abnormally low aldosterone secret...
Company:Diagnostic Systems Laboratories, Inc.

Renin IRMA Test

Description:...ols water and electrolyte retention by the kidney. renin is secreted in response to several factors includi...ecreased plasma sodium and chloride concentration. renin acts by converting the renin-substrate (angiotensi...ncomitant secretion of potassium and hydrogen [1]. renin plasma levels are useful in the diagnosis of hyper...
Company:Diagnostic Systems Laboratories, Inc.

Lyphochek Hypertension Markers Control

Description:... Lyphochek Hypertension Markers Control is a trilevel control designed to monitor the performance of testing procedures for renin and other analytes associated with hypertension disorders....
Company:Bio-Rad Laboratories

Renin in Medical Dictionary

Renin

Renin , also known as Angiotensinogenase, is a circulating enzyme that participates in the body's renin -angiotensin system (RAS) that mediates extracellular volume, and arterial vasoconstriction. Thus it regulates the body's mean arterial blood pressure. The renin -angiotensin s...

Vasodilation

...ediators. ... ... function in human subjects as indexed by flow-mediated arterial vasodilation . ... Key Words: aldosterone • hypertension • renin • ultrasonics • vasodilation ... BK promotes vasodilation ,1 exerts antiproliferative effects,2 inhibits thrombin ... Although BK is known to ...

Calcium channel blockers

...el blockers . Chloride (Cl-) channel blockers . Potassium (K+) ... Diuretics • Vasodilators • Beta blockers • Calcium channel blockers • renin ... ...

Aldosterone

...pe of hormone that is essential ... Describes when aldosterone and renin tests are ordered, how these tests are used, and what the results of aldosterone and renin tests might mean Aldosterone Information from Drugs.com ... Aldoste...

Renin in Biological Technology

Recombinant Human Renin - Crystallographic Grade

ST. LOUIS, Sept. 21 /PRNewswire/ -- Lee Biosolutions, Inc (http://www.leebio.com ) announces the availability of crystallographic grade recombinant human renin and native human renin from human kidney. Human Renin is an important enzyme in the regulation of blood pressure and electrolyte hom...

Video and Photo: Tekturna HCT(R), a Single-tablet Combination of Tekturna(R)* and a Diuretic, Receives US Approval for Treatment of High Blood Pressure

... - Tekturna HCT combines first approved direct renin inhibitor with the diuretic hydrochlorothi...ons and convenience, by combining the first direct renin inhibitor and a diuretic in one tablet." High bl... Tekturna is the only drug that works by targeting renin and decreasing the activity of the...

Bystolic(TM), a Novel Beta Blocker, is Now Approved by the FDA for the Treatment of Hypertension

...cidence of traditional beta blocker side effects. Like other beta blockers, Bystolic decreases heart rate and myocardial contractility, and suppresses renin activity. Bystolic is a selective beta 1 blocker at doses less than or equal to 10 mg per day and has the added pharmacological properties of producin...

Presentation of Phase IIa Results for Cytos Biotechnology's Hypertension Vaccine at the American Heart Association Scientific Sessions 2007

...ensive drugs on the market: inhibitors of the angiotensin-converting enzyme (ACEI), blockers of the angiotensin II subtype I receptor (ARB) and direct renin inhibitors (DRI). Like other antihypertensive drugs these also come with the need for daily dosing and often fail to provide a good solution for impro...

Medical College receives $11 million grant to study high blood pressure

...ale rats. In the third and final project, the research team will attempt to identify and characterize the mutation that regulates the "renin gene." renin is an enzyme released by special cells in the kidney in response to salt, and its release can lead to an increase in blood pressure. Eight Medical...

Gq-coupled Receptor Assays Using FLEXstation

...eptor. Immunol. Cell. Biol. 78: 369374. 7. van der Weyden, L., D. J. Adams, and B. J. Morris. 2000. Capacity for purinergic control of renin promoter via P2Y(11) receptor and cAMP pathways. Hypertension 36: 10931098. 8. Communi, D., R. Janssens, B. Robaye, N. Zeelis, and J. ...

Renin in Biological Definition

Hormone

...mone (LH) melanocyte stimulating hormone (MSH or α-MSH) neuropeptide Y oxytocin parathyroid hormone (PTH) prolactin (PRL) renin secretin somatostatin thrombopoietin thyroid-stimulating hormone (TSH) thyrotropin-releasing hormone (TRH) Steroid hormo...

Kidney

...a densa and juxtaglomerular cells . Juxtaglomerular cells are the site of renin synthesis and secretion. Fluids become more concentrated along the tubu...the bloodstream, secretion of hormones - particularly erythropoietin and renin and maintaining serum electrolyte, acid-base levels and osmolality. For ...

Renin in Biological Dictionary

Osmoregulation

...smoregulation n. Maintenance of an optimal, constant osmotic pressure in the body of a living organism ... Blood sugar · Osmoregulation · Pressure: renin ... Osmoregulation is usually achieved by excretory organs that serve also for the ... Thus, urination is a mechanism of both waste excretion a...

Kidney

...of treatment for kidney cancer? ... Offers emergency financial assistance to transplant or dialysis patients. The kidney makes hormones. ... renin is made by the kidney if there is low blood ... Kidney stones – this is when a solid substance forms in the urine. ... The kidneys perform se...

Glomerulus

...aving the glomerulus passes into a second capillary network (not shown ... only 50% of the urea filtered at the glomerulus is reclaimed ... renin Release by Kidney Glomerulus ,Afferent arteries from the glomerulus release renin, an enzyme that acts on circulating angiotensinogen to form ...