Relapses

AUDIO from Medialink and Genzyme: Study in New England Journal of Medicine Shows Investigational Compound Reduced Relapses and Disability in Patients With MS

NEW YORK, Oct. 23 /PRNewswire/ -- Phase II clinical trial data appearing in today's issue of the New England Journal of Medicine shows that an investigational compound reduced the effect of multiple sclerosis in comparison to a comparator product, and allowed patients to regain some lost funct...

Pill Reduces Relapses in MS Patients

First oral drug could benefit many with the autoimmune disease, researchers say TUESDAY, April 15 (HealthDay News) -- The first pill designed to reduce the number of attacks in people with multiple sclerosis appears to be effective in early tests, Italian researchers report. The pil...

Bipolar disorder relapses halved by Melbourne researchers

Melbourne mental health researchers have succeeded in halving the number of relapses experienced by people with bipolar disorder which strikes two in 100 Australians, accounts for 12 per cent of suicides each year and costs the country at least $1.5 billion annually(1). With funding from the MB...

ALL Relapses in Most Children After Treatment

A recent study finds that approximately 20% of children with Acute Lymphoblastic Leukemia (ALL) will experience a relapse of their disease following treatment//. Of these, most will never be cured. "We have previously shown that these relapses were due to small numbers of cells which survived...

Alcoholism Drug Fails To Prevent Drinking Relapses

The Food and Drug Administration approved naltrexone for the treatment of alcoholism in 1994. At that time, the only other drug therapy available was disulfiram, or Antabuse, which provokes a sickening reaction to alcohol.// A new study casts sobering doubts on earlier claims that an alcoholism dru...

Jackson Tragedy May Serve to Educate Public on Addiction, Says American Society of Addiction Medicine

...Research and experience have shown that addiction is a chronic disease that may run the course of a lifetime, and those with addictions may experience relapses and remissions. A disease of the brain, addiction is also influenced by genetic, psychosocial, and environmental factors. Addiction is characterized ...

Research identifies successful new treatment for Hodgkin's lymphoma, reduces long-term risks

...igh risk HL patients. The five-year event-free survival for intermediate risk HL patients was 84 percent and 85 percent for high risk HL patients. Few relapses occurred beyond three years after enrollment. Schwartz concludes, "We have successfully achieved five-year event free survival in 84 percent of th...

Independence Blue Cross Expands Its Preventive Health Efforts With Focus on Heart Disease and Diabetes

... treatable. We must encourage our members to receive proper treatment, and remain consistent with their medications in order to avoid complications or relapses of their condition. We strive to help our members get on the path to healthier lifestyles now, in the hopes that they will lessen their chance of deve...

Ready for relapse: Molecule helps breast cancer cells to survive in the bone marrow

...d from the initial site of origin to other parts of the body, occurs frequently in breast cancer. Although it is clear that the majority of late-onset relapses after breast cancer arise in the bone, the mechanisms that contribute to cancer cell survival in the bone marrow environment are unknown. "We soug...

Subclinical markers predict relapse in juvenile idiopathic arthritis post methotrexate withdrawal

...the point of remission does not affect the risk of relapses after withdrawal of therapy. Clinical (disease sub...ssion in those patients who subsequently developed relapses (715140 ng/ml) compared to patients with stable re...s of MRP8/14 were especially high in patients with relapses occurring within 6 months, compared to 12 months. ...

Relapses in Medical Technology

Trius Announces Positive Results From Phase 2 Clinical Trial of Torezolid in Patients With Complicated Skin and Skin Structure Infections

...ients (133, 71%), clinical cure was achieved in 100%, 93% and 96% of patients receiving 200, 300 or 400 mg doses, respectively. There were no clinical relapses at the late follow-up visit 21-28 days post treatment. Highlighting the growing problem of drug resistance in the community, MRSA was the primary path...

RISPERDAL(R) CONSTA(R) (Risperidone) Long-Acting Treatment Delayed the Time to Relapse in Patients with Bipolar I Disorder

...earch & Development, L.L.C. (J&JPRD). "These findings are important because the clinical course of Bipolar Disorder is often unpredictable and relapses can be very debilitating." The study was presented and sponsored by Janssen, a Division of Ortho-McNeil-Janssen Pharmaceuticals, Inc and J&J...

Two-Year Phase III Data Presented at AAN 61st Annual Meeting Show Positive Outcome of Cladribine Tablets in Patients With Multiple Sclerosis

... The results from both Cladribine Tablets treatment groups in the study demonstrated a statistically significant reduction in the annualized rate of relapses compared to placebo (primary endpoint). Patients treated with the low-dose regimen of Cladribine Tablets experienced a 58% relative reduction in annua...

Agendia's MammaPrint(R) Predicts Response to Neoadjuvant Chemotherapy in Breast Cancer

...signature group achieved a pCR, whereas none of the patients with a good prognosis signature achieved a pCR. After a median follow-up of 25 months, 19 relapses were seen in the poor signature and none in the good signature group. These findings suggest tumors with a poor prognosis MammaPrint signature are sen...

Diplomat Specialty Pharmacy Tapped by Teva Neuroscience for Therapy Optimization Study for Multiple Sclerosis (TOP MS)

...ric model. When we focus on adherence and tolerance, and offer patients a personalized medication program, we can reduce the frequency and severity of relapses and ultimately improve the quality of life." "Diplomat Specialty Pharmacy was selected to participate in this study because they have shown a commit...

Merck Serono Announces Initiation of the ORACLE MS Trial to Evaluate Cladribine Tablets in Patients at Risk of Developing Multiple Sclerosis

...period. These maintenance and long-term follow-up periods of the study are intended to assess the effect of early treatment with Cladribine tablets on relapses and subsequent treatment response to disease-modifying therapy for relapsing-remitting MS and to evaluate the sustained effect of Cladribine tablets i...

Merck Serono Completes Enrollment in the REFLEX Trial of Rebif(R) in Patients at Risk of Developing Multiple Sclerosis

...iteria. Further endpoints include time to conversion to clinically definite MS (the main secondary endpoint), assessments of MRI brain scans, clinical relapses and disability progression. Rebif(R) is currently approved for the treatment of relapsing forms of MS. It has been proven effective in all three key...

Vermillion and the Ohio State University Report That Novel Diagnostic Test May Help Predict Risk for Relapse of TTP, A Serious Blood Disorder

...urpura (TTP) diagnostic test could be used to help estimate the risk of TTP relapses during clinical remission. OSU currently offers the TTP test as a laborator...y low levels of ADAMTS13 activity are associated with increased risk of TTP relapses during remission. A key characteristic of the assay is that it is more sens...

FTY720, a novel oral therapy in development for MS, shows sustained benefits for the majority of patients after three years of treatment

... began the study on FTY720 5 mg remained free from relapses after three years, and 68% of those who began the ...helping the majority of patients to remain free of relapses as the study progresses." FTY720 has the potenti... active therapy in the extension, 51% were free of relapses at three years. The figure at two years was 57%. ...

Cutanea Announces Promising Phase II Results in Rosacea with Omiganan

...ears of age and is more prevalent in women than men. Clearing up the initial outbreak is only the beginning, as rosacea is characterized by periods of relapses and remissions. Relapse episodes can be spurred by sun exposure, stress, hot or cold weather, alcohol, spicy foods, exercise, and certain skin care pr...

Relapses in Medical Dictionary

Clostridium

...ic bacteria of the genus Clostridium , such as the Explains how Clostridium difficile bacteria cause colitis and why patients may suffer relapses of the condition. Read about botulism causes ( Clostridium botulinum toxin), symptoms (muscle paralysis, dry mouth, constipation), history, tr...

Bipolar disorder

...mptoms, and treatment. (Redirected from Bipolar II Disorder ) Jump to: navigation, search ... There is no cure for Bipolar II disorder , and relapses can occur even with ... Articles, treatment information, links. Bipolar Disorder . Alchohol Abuse. Eating Disorders. Sleep Disorders ... ...

Relapses in Biological News

'Erasing' drug-associated memories may stop drug addiction relapses

'Erasing' drug-associated memories may prevent recovering drug abusers from relapsing, researchers at the University of Cambridge have discovered. The team, led by Professor Barry Everitt, was able to reduce drug-seeking behaviours in rats by blocking a brain chemical receptor important to learn...

Source of drug-tolerant tuberculosis possibly behind TB relapses, intensity of treatment

...findings suggest a possible reason why human tuberculosis (TB) requires months of intensive antibiotic treatment and indicate a potential cause of the relapses that can nonetheless occur. The researchers are the first to show that Mycobacterium tuberculosis can grow in surface-level bacteria clusters known...

Tumor-targeting viral therapy slows neuroblastoma, malignant peripheral nerve sheath tumors

...tatic disease, neuroblastoma is a much harder to fight. Tumor cells are often able to survive ordinary doses of chemotherapy and radiation, leading to relapses that are difficult to cure. During the last three decades, Cincinnati Childrens has been a leader in developing high-dose chemotherapy used in combina...

Further breakthroughs for breast cancer patients

...n treating breast cancer, for a significant proportion of sufferers the drugs either fail to work, or after an initial successful response the patient relapses as the cancer acquires or possesses resistance to the drug. However the researchers have discovered that inhibiting the activity of a certain prote...

Parasite infection may benefit MS patients

...verage of 4.6 years. During the study period, there were three clinical relapses of MS in the infected group and 56 relapses in the uninfected group. Only two infected patients showed minimal Expanded...

Anti-inflammatory drug's potentially deadly side effect found to be rare

...he brain and the central nervous system. Prior to the studies that were halted last year, earlier studies showed a 66 percent reduction in the rate of relapses in MS patients treated with the natalizumab, which has to be injected on a monthly basis. Clifford predicts that his group's report and the other s...

Relapses in Biological Technology

Biovista Inc. Announces Positive Efficacy Results in a Pre-Clinical Trial of its BVA-101 Repositioned Drug for Multiple Sclerosis

...l, BVA-101 was compared to dexamethasone, a potent anti-inflammatory and immunosuppressive drug that is efficient in accelerating the recovery from MS relapses but too toxic for chronic use. BVA-101 induced a statistically significant reduction of EAE severity, the magnitude of which was statistically similar...

Agendia Publishes Direct Evidence That MammaPrint Predicts Benefit of Chemotherapy in Breast Cancer

...ts in the high risk group achieved a pCR, whereas none of the patients in the low risk group achieved a pCR. After a median follow-up of 25 months, 17 relapses were seen in the high risk group and none in the low risk group. These findings demonstrate that tumors with a high risk MammaPrint(R) signature are s...

Telik Announces Top-Line Results From Assist-5 Trial of Telcyta(R) in Combination With Pegylated Liposomal Doxorubicin in Platinum Refractory and Resistant Ovarian Cancer

...m-resistance is defined as those patients whose disease fails to respond or relapses within 6 months of completion of initial platinum-based treatment. Secondary platinum resistance is defined as those patients whose disease relapses after 6 months of completion of therapy and fails a reinduction platinum-ba...

SGX Pharmaceuticals Submits Investigational New Drug Application for SGX393

... effective front-line therapy for CML, there are patients who relapse while on Gleevec or who are intolerant to the therapy. In the majority of cases, relapses have been linked to the emergence of a number of drug-resistant mutant forms of the tyrosine kinase BCR-ABL. The single mutant that has been the most ...

Vermillion Announces First Quarter 2008 Financial Results and Business Progress

...n commercially launched as a laboratory developed test by the institution, also could be used to help estimate the risk of TTP relapses during clinical remission. The data -- published in the online edition of the British Journal of Haematology -- indicate that use of t...