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Regression in Medical News

Positive Results for Ophthotech's Novel Therapy for Wet AMD - Study of Anti-PDGF and Anti-VEGF Therapy Shows Significant Neovascular Regression and Enhanced Visual Outcome

59% of patients showed 3-line gain (significant visual gain) and 100% neovascular regression FORT LAUDERDALE, Fla., May 4 /PRNewswire/ -- Ophthotech Corp. today announced positive results of a phase 1 clinical study evaluating E10030, its novel anti-platelet derived growth factor (anti-PDGF...

New Antibody for EGFR Causes Lung Cancer Regression

Mutant forms of the protein EGFR are important for the development of lung cancer in a substantial proportion of individuals with this disease. However, not all individuals// express the same mutant EGFR, for example, some have a mutation that affects the intracellular part of EGFR and some have a ...

Bionovo Presents Positive Results from Phase 1B Trial of Bezielle for Metastatic Breast Cancer

...nt radiology review. Four patients discontinued from the study with stable disease, and of these four patients, one patient had objective tumor regression during 449 days of Bezielle treatment and continues to be stable off of study medication for a total of 600 days. A second patient who discontinued Be...

Pancreatic cancer risk decreased by one anti-diabetic therapy, increased by others

...adenocarcinoma (including 259 diabetics) and 863 controls (including 109 diabetics). Pancreatic cancer risk was estimated using unconditional logistic regression analysis. "Further study is needed in other study populations to confirm or refute a possible role of antidiabetic therapy in pancreatic cancer. Si...

Study: Bariatric surgery patients have 67 percent lower chance of complications at top hospitals

...ns of clinical outcomes at different hospitals with different patient characteristics, HealthGrades risk adjusted the data using multivariate logistic regression to account for age, gender and underlying medical conditions that could increase the patient's risk of mortality or complication. The full study and i...

GIE: Gastrointestinal Endoscopy June issue study highlights

...ients with any-sized polyp, any-sized adenoma, an adenoma one cm or larger in maximum diameter, and multiple (more than one) adenomas. Multiple linear regression analysis (a technique for determining the linear relationship between one dependent variable and two or more independent variables) identified factors...

Carnegie Mellon algorithm charts evolution of genetic networks during fruit fly life cycle

...Tesla algorithm was used to determine the links between the genes in those networks at the time of the snapshot. Using a novel extension of the sparse regression technique popular in statistical inference, Tesla was able to reverse engineer the rewiring of those links, figuring out exactly how one network relat...

Inoperable Colon Cancer Responds to New Treatment

...he arrest of their cancers' growth and spread in as few as eight weeks of treatment. In many cases, such as this one, patients have experienced active regression of tumors. The medicines used have the advantage of being safe and well tolerated. Fatigue is the most notable side effect of NeoPlas Innovation's...

Anxiety and depression lower quality of life in majority of systemic lupus erythematosus patients

... of the European League Against Rheumatism in Copenhagen, Denmark. Logistic regression analysis revealed that depression was the most significant factor shown to ...a were analysed through the Spearman correlation coefficient and a logistic regression analysis. SLICC-DI was correlated with the physical activity (PA) subscal...

Study finds segregation decreases access to surgical care for minorities

...x, a measure of the probability that a member of one minority group will come into contact with members of the same racial group. Multivariable linear regression analysis was performed to examine the association between access to surgical services and proportion of minority population with varying levels of seg...
Regression in Medical Technology

SuperGen's PIM Kinase Inhibitor, SGI-1776, Causes Tumor Regression in AML Xenograft Models

DUBLIN, Calif., June 13 /PRNewswire-FirstCall/ -- SuperGen Inc. (Nasdaq: SUPG ), a pharmaceutical company dedicated to the discovery, rapid development and commercialization of therapies for solid tumors and hematological malignancies, today announced at the 13th Congress of the European Hema...

SuperGen Identifies Lead PIM Kinase Inhibitor, SGI-1776, That Causes Tumor Regression in AML Xenograft Models

DUBLIN, Calif., April 16 /PRNewswire-FirstCall/ -- SuperGen Inc. (Nasdaq: SUPG ), a pharmaceutical company dedicated to the discovery, rapid development and commercialization of therapies for solid tumors and hematological malignancies, today announced as part of a series of presentations at ...

EntreMed's Aurora Kinase Inhibitor Induces Tumor Regression in Preclinical Models

ROCKVILLE, Md., June 01, 2007 /PRNewswire-FirstCall/ -- EntreMed, Inc. , a clinical-stage pharmaceutical company developing therapeutics for the treatment of cancer and inflammatory diseases, announced the presentation of preclinical results for its Aurora kinase - angiogenesis inhibitor, ENMD-981...

Keryx Biopharmaceuticals, Inc. Commences Phase 1 Study of KRX-0401 (Perifosine) in Recurrent Pediatric Solid Tumors at Memorial Sloan-Kettering Cancer Center

... vivo data presented at AACR 2009 by investigators from the National Cancer Institute demonstrated that single agent perifosine not only induced tumor regression and delayed tumor growth, but that perifosine also improved the survival of mice bearing neuroblastoma tumors. Moreover, in a Phase 2 study conducted ...

Proteolix, Inc. Drug Candidate, PR-957, Prevents Disease Progression in Rheumatoid Arthritis Models by Selective Inhibition of the Immunoproteasome

...matory effect induced by PR-957 was rapid and long-lasting, lowering expression of multiple inflammatory mediators, including TNF-a and IL-6. Disease regression was evident 24 hours after dosing and a complete amelioration of disease was achieved with a single dose. When compared to anti-TNF-a therapy (etaner...

Access Pharmaceuticals Announces Publication of Thiarabine Combination Data

...nt, Research and Development. "But, in the combination of these two agents, efficacy was dramatically superior to the use of either agent alone. Tumor regression and cures were observed in several models including colorectal cancer and leukemia. The combination of agents proved to be effective even when used at...

Neurobiological Technologies' Partner, Celtic Pharma, Announces Results of XERECEPT(R) Phase 3 Clinical Program

...udies were conducted using both pediatric and adult human brain tumor xenografts. The mouse tumor models demonstrated statistically significant tumor regression and prolongation of survival following treatment with XERECEPT(R). XERECEPT(R) also demonstrated significant dose-related angiogenesis inhibition, co...

Encouraging First Data on New Targeted Treatment for Patients With Melanoma - the Deadliest Form of Skin Cancer

... mutation-positive melanoma patients and minor responses in four mutation-positive melanoma patients have been observed - regression of metastatic lesions in every site to which melanoma commonly spreads, including to the liver, lung and bone - Disease control las...

Results and Additional Analyses From Study Show That Corthera's Relaxin for Acute Heart Failure is the Strongest Predictor of Improved Longer-Term Outcomes Following Hospital Discharge When Compared to Other Variables

...scharge when compared to other variables. The new analyses of predictors of 60-day and 180-day outcomes, which included univariate and multivariate regression analyses, were presented today by Marco Metra, M.D., professor of cardiology at the University of Brescia, Italy, and co-principal investigator of the...

Medarex Announces Preclinical Data from Multiple Research Programs Demonstrating Anti-Tumor Activity in Cancer

...s, single dose treatment with conjugates using the cleavable linker demonstrated selective and antigen-dependent killing of tumor cells leading to the regression of established tumors. Antibody-drug conjugates comprising a non-cleavable linker had greatly reduced specificity and efficacy. In addition to demonst...
Regression in Medical Products

MIS/AMH ELISA Test

Description:... ovarian granulosa cells in the female. During embryonic development in males, secretion of MIS/AMH from testicular Sertoli cells is essential for the regression of the Mullerian ducts, and thus the normal development of the male reproductive tract (5). The Mullerian ducts are the primordium for the uterus, Fal...
Company:Diagnostic Systems Laboratories, Inc.

Corneo-Gage Plus

Description:...ion Sonogage pachometers can be used intra-operatively to monitor flap thicknesses in LASIK and to measure epithelium thickness for refractive surgery regression and for the fitting of CRT/ORTHO-K lenses for corneal reshaping....
Company:Sonogage, Inc.

QCNet

Features:...ochek Hemoglobin A1C Linearity Set. A comparison using peer group values is a unique feature of this software. Useful graphics are provided for linear regression and percent bias. eLearning Courses for Continuing Education Units (CEU) are provided on QCNet for laboratory professionals to conveni...
Company:Bio-Rad Laboratories

CODA Automated EIA Analyzer

Features:...ssays with the ability to customize test steps New protocols are easily created with the user friendly interface Flexible software provides multiple regression options for data calculation with the ability to recalculate results on stored data using a different regression Complete automation of EIA plate pro...
Company:Bio-Rad Laboratories
Regression in Medical Definition

Réseau Sentinelles

...h The data provided by the Sentinelles Network had provided research in the following domains: Models of detection and alert systems (Serfling regression methods, Costagliola D. and coll ., Am. J. Public Health, on 1991 ) Prediction models of epidemics involving different geographical levels (“Meth...
Regression in Biological News

Metastatic bone disease patients can walk in Lazarus' footsteps

...restore function for them to do daily activities and help them to stay ambulatory," said Anselmetti. He noted that osteoplasty provided effective pain regression for individuals with both painful bone metastases and benign lytic lesions that didn't respond to conventional analgesic treatment. Bones are the t...

Wildflower declines in Thoreau's Concord woods are due to climate changes

...wering times have shifted to be earlier in the years over the long-term have also fared significantly better under recent warming trends. Based on our regression estimates, change in abundance over the last 100 years is greatest when assessed against species' ability to track short-term seasonal temperature ver...

Researchers identify Achilles heel of common childhood tumor

...ng why they regress," he said. "Knowing that and being able to induce that regression in the rapidly growing tumors, or induce regression of the blood vessels in malignant tumors, would be very effective." ...

The Rett Syndrome Research Trust launches operations

...toms typically begin to appear in little girls between infancy and two years of age. Onset may be heralded by hypotonia and delayed development, or by regression and loss of acquired skills, including speech and functional hand use. As the disorder progresses, symptoms may include disordered breathing, sleep di...

Gene is likely cause of stroke-inducing vascular malformations

...brain that causes stroke. The UCSF studies were done in mice, and the new findings are the first to provide information on both the progression and regression of this particular brain disorder, known as BAVM, and to provide molecular clues into the disease, which is not well-understood and chiefly affects yo...

Senescence in liver cells is found by CSHL scientists to help limit acute tissue damage

...team. When they activated p53 in mice with HCC, tumors receded -- and this regression was associated directly with activation of the immune system, whose killer ...e system. Thus, just as senescent liver cells can play a role in tumor regression by stimulating an immune reaction, so can senescent HSCs in damaged liver t...

Commercialization aim of grant supporting technology that destroys cancer cells

... colleagues published the first experiments on using IRE on tumors in the November 2007 issue of PLoS ONE. Their optimal parameters achieved complete regression in 92 percent of the treated tumors in vivo in preclinical mouse models. These results were achieved with a single treatment that lasted less than fiv...

Sociological research shows combined impact of genetics, social factors on delinquency

...systematically examines layers of social context simultaneously (i.e., family dynamics, peer relations, and school-related variables). The study uses regression analysis to reveal non-intuitive and complex relations among the researched variables. "While genetics appear to influence delinquency, social infl...

New type of drug shrinks primary breast cancer tumors significantly in just 6 weeks

...n important role in many types of cancer can bring about significant tumour regression in breast cancer after only six weeks of use, a scientist told the 6th Euro...s from the tumours were obtained and analyzed. We saw significant tumour regression after six weeks of single agent lapatinib, said Dr. Rodriguez. Bi-dimensio...

Conservation of freshwater fish biodiversity: a challenge for the countries of the South

...ientists as none-native, have the power to upset an ecosystem. The 2002 Convention on Biodiversity recognized that the species introductions can cause regression of biological diversity, following destruction of natural habitats. Although it has long seemed likely that human activity plays a major role in such ...
Regression in Biological Technology

EntreMed's ENMD-2076 Demonstrates Tumor Regression in Human Colon Cancer Model

ROCKVILLE, Md., Oct. 23 /PRNewswire-FirstCall/ -- EntreMed, Inc. (Nasdaq: ENMD ), a clinical-stage pharmaceutical company developing therapeutics for the treatment of cancer and inflammatory diseases, today announced the presentation of preclinical data for its Aurora A/angiogenesis kinase in...

SuperGen's MP-470 Demonstrates Clinical Tumor Regression When Combined with Standard of Care Chemotherapy

DUBLIN, Calif., Oct. 23 /PRNewswire-FirstCall/ -- SuperGen, Inc. (Nasdaq: SUPG ), a pharmaceutical company dedicated to the discovery and development of novel cancer therapies, today presented data on MP-470, its lead product candidate, and four additional posters, at the 20th EORTC-NCI-AACR ...

Lixte Biotechnology Holdings' Lead Compound, LB-1.2, Enhances the Effectiveness of Standard Cancer Chemotherapy in Animal Models

...e models, LB-1.2 plus Temozolomide caused complete regression without recurrence in 50 % of animals bearing tumo...aggressive brain tumor of adults, and also, marked regression of neuroblastoma, the most common cancer of childr...e treatment of patients with GBM, by itself caused regression but with recurrence of all tumors." Dr. Kovac...

New statistical technique improves precision of nanotechnology data

...uture industrial applications. Known as sequential profile adjustment by regression (SPAR), the technique could also reduce the amount of experimental data req...that uses the data itself to filter out the mismatch step-by-step using the regression technique." Ideally, researchers would search out and correct the experi...

Crystal Research Associates, LLC Issues Executive Informational Overview(R) (EIO(R)) on GenSpera, Inc.

...ad prodrug candidate, G-202, is designed to attack existing tumor vasculature, potentially debilitating the tumor's nutrient supply and causing cancer regression without affecting normal tissues within the body. In preclinical evaluation, G-202 demonstrated anti-tumor effects on the growth of breast, renal, bla...

New Discoveries on a Fingertip Test for Screening Silent Heart Disease Promising Results of Recent Clinical Studies to be Presented during the 2009 American College of Cardiology Conference, March 29th - April 1st in Orlando

...s, much like blood pressure. Furthermore, unlike coronary calcium or carotid IMT, it is a dynamic marker and changes quickly with the progression and regression of the disease." Every year, over 1.4 million heart attacks occur in the United States and many more worldwide. About half of these heart att...

OLIGOMERIX Awarded NIH Grant to Develop Novel Biomarkers for Alzheimer's Disease

...omplished after death, through brain autopsy. There are no validated biomarkers from patient samples such as CSF or plasma that predict progression or regression of AD. OLIGOMERIX plans to evaluate novel AD biomarkers based on the paradigm of protein-protein interactions. This strategy may enable more specific ...

Genetic information personalizes warfarin prescribing

...nd that two modelsan older technique called linear regression and a newer one called support vector regressionwe...y. In the end, the researchers chose the linear regression model, with eight variables, as the best. "Cli...sier to understand and use than the support vector regression model," says Page, noting that the program is easi...

Gene Signal Enters Phase III Clinical Tests for the Prevention of Corneal Graft Rejection

...e successfully completed the phase II study. The results show a significant regression of corneal neovascularization, whereas the placebo group all showed an incr...arisation over the 3-month period, the optimal treatment group achieved 86% regression and progression in only 14%", he added. Prof. Cursiefen will take advanta...

EntreMed's MKC-1 Meets Primary Efficacy Endpoint in Non-Small Cell Lung Cancer Clinical Trial

... multi-drug resistant cell lines. Data from previous studies with MKC-1 demonstrate broad-acting antitumor effects, showing tumor growth inhibition or regression in multiple preclinical models, including paclitaxel-resistant models. MKC-1 has been shown to inhibit mitotic spindle formation, prevent chromosome...
Regression in Biological Products

Luminex 100 IS System from Upstate

Description:...loped by Luminex. The user can design specific templates for commercial or home-made multiplex kits. The system has fully integrated graphing and data regression capabilities; the internal trouble shooting and self diagnostic capabilities allows the user to quickly identify problems....
Company:Upstate

Luminex® 200 xPONENT System from Upstate

Description:...loped by Luminex. The user can design specific templates for commercial or home-made multiplex kits. The system has fully integrated graphing and data regression capabilities; the internal trouble shooting and self diagnostic capabilities allows the user to quickly identify problems....
Company:Upstate

Luminex® 200 IS System from Upstate

Description:...loped by Luminex. The user can design specific templates for commercial or home-made multiplex kits. The system has fully integrated graphing and data regression capabilities; the internal trouble shooting and self diagnostic capabilities allows the user to quickly identify problems. Applications: &nbnsp; ...
Company:Upstate
Regression in Biological Definition

Chi-square test

...square test Some likelihood-ratio tests are approximately chi-square tests when the sample-size is large. They are widely used in logistic regression . Other likelihood-ratio tests cannot be regarded as even approximately chi-square tests; e.g., F -tests in the analysis of variance and t -tests ar...

Francis Galton

...cs , Galton was the first to describe and explain the common phenomenon of regression toward the mean in the 1870s and 1880s . After examining forearm and he...rror and the normal distribution . He also invented the questionnaire , regression analysis , composite photography (layering images upon one another to cre...
Regression in Biological Dictionary

Wolffian duct

...including humans during embryogenesis ... In males, the Wolffian ducts develop into epididymis, vas deferens, and seminal ... Wolffian duct regression may be an example of apoptosis, a kind of cell death ... Definition of Wolffian duct at Dictionary.com with free online dictionary, ... Main ...

Heritability

... in unexpected ways. ... Heritability is a fundamental concept in genetics. ... Figure 1: Narrow sense heritability can be estimated from the regression of ... Facebook is a social utility that connects people with friends and others who ... A small heritability means that the average genetic var...

Gene interaction

...raction · Heritability · Quantitative genetics ... Penalized Logistic regression for Detecting Gene . Interactions . Mee Young Park. Trevor Hastie ... in modeling gene - gene interactions , logistic regression is ... GENE INTERACTIONS ... Dominant and Recessive Interaction - ...
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