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Refractory in Medical News

Neovasc Inc. Postpones Plans for U.S. Listing to Focus Funds on Commercializing Its Reducer Device for Refractory Angina

- Company files to deregister Common Stock with the SEC - - Canadian public listing on TSX Venture Exchange unaffected by postponement of plans for U.S. listing - TSX Venture Exchange: NVC VANCOUVER, June 25 /PRNewswire-FirstCall/ - Neovasc Inc. (TSX...

Telik Presents Results at ASCO From ASSIST-5 Trial of TELCYTA in Platinum Refractory and Resistant Ovarian Cancer

PALO ALTO, Calif., May 31 /PRNewswire-FirstCall/ -- Telik, Inc. (Nasdaq: TELK ) today announced presentation at the 45th Annual Meeting of the American Society of Clinical Oncology (ASCO) in Orlando, Florida, of results from the ASSIST-5 Phase 3 randomized, multinational study of TELCYTA(...

A potential new target for treatment of hormone refractory prostate cancer

A new study identifies a protein that modifies the androgen receptor (AR) and influences its ability to regulate target genes linked with the progression of prostate cancer. The research, published by Cell Press in the April 7th issue of the journal Cancer Cell , may also drive creation of new st...

Dosing Begins in Phase 1 Clinical Study Evaluating NKTR-105 in Cancer Patients With Refractory Solid Tumors

SAN CARLOS, Calif., Feb. 17 /PRNewswire-FirstCall/ -- Nektar Therapeutics (Nasdaq: NKTR ) announced today that the first patients have been dosed in a Phase 1 dose-escalation study of NKTR-105, a novel PEGylated form of docetaxel. The Phase 1 study will assess the safety, pharmacokinetics and a...

Three Italian Multicenter Studies Report High (>70%) Rates of Complete Remission (CR) Utilizing Zevalin Radio-Immunotherapy (RIT) in Treatment of Newly Diagnosed or Relapsed or Refractory Non-Hodgkin's Lymphoma

SEATTLE, Dec. 9 /PRNewswire-FirstCall/ -- Cell Therapeutics, Inc. (Nasdaq and MTA: CTIC) announced today that the results of three Italian multicenter studies utilizing Zevalin(R) ([90Y]-ibritumomab tiuxetan) were presented at the American Society of Hematology (ASH) 50th Annual Meeting in San Fra...

30 percent RA patients refractory to anti-TNFs achieve disease remission with tocilizumab plus metho

Paris, France, Friday 13 June 2008: Tocilizumab plus methotrexate showed significant clinical improvements in efficacy and safety in patients with moderate to severe rheumatoid arthritis (RA), who had not adequately responded to anti-tumour necrosis factor (anti-TNF) therapy, according to a new st...

Adalimumab therapy effective in AS, RA and PsA patients refractory to other anti-TNF therapies

Paris, France, Thursday, 12 June 2008: Adalimumab therapy is effective and well-tolerated in ankylosing spondylitis (AS), rheumatoid arthritis (RA) and psoriatic arthritis (PsA) patients with a previously inadequate response to anti-tumour necrosis factor (anti-TNF) therapies etanercept and inflix...

Hormone refractory prostate cancers more likely to spread to other organs

Prostate cancers that are resistant to androgen deprivation therapy are more invasive and more likely to spread to other organs than androgen dependent prostate cancers, UCLA cancer researchers have found. Virtually all prostate cancers are androgen dependent at first, but they progress and be...

Bioniche Provides Update on Refractory Bladder Cancer Trial with Urocidin(TM)

- Data Safety Monitoring Committee holds third meeting - BELLEVILLE, ON, Feb. 13 /PRNewswire-FirstCall/ - Bioniche Life Sciences Inc. (TSX: BNC), a research-based, technology-driven Canadian biopharmaceutical company, is pleased to provide an update on the progress of its North America...

1-year results of bronchial thermoplasty in refractory asthma

Sunnyvale, CA, February 11, 2008 Asthmatx, Inc., a medical device company that has developed a catheter-based procedure under investigation for the treatment of asthma, announced today the publication of data from the Research in Severe Asthma (RISA) Trial of bronchial thermoplasty in the America...
Refractory in Medical Technology

Pharmacyclics Initiates Phase 1 Clinical Trial of Novel Oral Btk Inhibitor for Refractory B-cell Non-Hodgkin's Lymphoma

SUNNYVALE, Calif., April 13 /PRNewswire-FirstCall/ -- Pharmacyclics, Inc. (Nasdaq: PCYC ) today announced that it has begun treating patients in a Phase 1 dose-escalation study to evaluate the safety and tolerability of PCI-32765, an orally available, selective inhibitor of Bruton's tyrosine ...

Ascenta Therapeutics Announces Positive Preliminary Results with AT-101 in Docetaxel Refractory Prostate Cancer

- Data presented today at American Society of Clinical Oncology (ASCO) Genitourinary Cancers Symposium - MALVERN, Pa., Feb. 27 /PRNewswire/ -- Ascenta Therapeutics announced today positive preliminary results from its Phase II study of AT-101 in combination with docetaxel and prednisone (D/P)...

Arzerra(TM) (ofatumumab) Demonstrates High Response Rates in Patients With Fludarabine Refractory Chronic Lymphocytic Leukemia (CLL)

Data from a pivotal trial suggests that ofatumumab has activity in heavily pre-treated patients who have failed standard treatments PHILADELPHIA, Dec. 8 /PRNewswire-USNewswire/ -- GlaxoSmithKline (GSK) and Genmab A/S (OMX: GEN) announced today positive results from a pivotal trial pr...

Poniard Announces Positive First-Line Efficacy and Safety Data From Ongoing Phase 2 Trial of Picoplatin in Patients with Metastatic Hormone Refractory Prostate Cancer

- Poster Presented at ASCO Annual Meeting - SOUTH SAN FRANCISCO, Calif. and CHICAGO, May 31 /PRNewswire-FirstCall/ -- Poniard Pharmaceuticals, Inc. (Nasdaq: PARD ), a biopharmaceutical company focused on oncology, today presented preliminary safety and efficacy data from its ong...

Significant Anti-Tumor Activity of NKTR-102 in Patients With Refractory Solid Tumors; Interim Data Published in ASCO 2008 Proceedings

Nektar's Technology Enables First-Ever PEGylation of a Small Molecule with Demonstrated Therapeutic Activity SAN CARLOS, Calif., May 16 /PRNewswire-FirstCall/ -- Nektar Therapeutics (Nasdaq: NKTR ) announced initial results today from a Phase 1 study of NKTR- 102, PEGylated i...

Oral Talactoferrin Alfa Improves Overall Survival in Patients With Refractory Non-Small Cell Lung Cancer: Final Phase 2 Study Results Presented at the 8th Annual Targeted Therapies for the Treatment Of Lung Cancer Meeting

Company Also Announces Receipt of Fast Track Designation from FDA, Favorable Scientific Advice from EMEA and Phase 3 Plans for the Non-Small Cell Lung Cancer Monotherapy Indication SANTA MONICA, Calif., Feb. 26 /PRNewswire/ -- Dr. Giuseppe Giaccone, Chief of the Medical Onco...

Pharmion and MethylGene Start Phase 2 Combination Clinical Trial With MGCD0103 and Vidaza(R) in Patients With Relapsed or Refractory Hodgkin Lymphoma or Non-Hodgkin Lymphoma

BOULDER, Colo. and MONTREAL, Jan. 9 /PRNewswire-FirstCall/ -- Pharmion Corporation (Nasdaq: PHRM ) and MethylGene Inc. (TSX: MYG) today announced the enrollment of the first patient in a Phase 2 clinical trial (Trial CL002) evaluating MGCD0103, the Companies' isotype-selective histone deacety...

Medivation's MDV3100 Demonstrates Substantial PSA Reductions in First Patient Groups Treated in Phase 1-2 Hormone Refractory Prostate Cancer Trial

- Early study data from the two lowest dose groups show dose-dependent PSA declines to date in all patients - - Conference call to be held today at 8:30 A.M. Eastern time - SAN FRANCISCO, Nov. 5 /PRNewswire-FirstCall/ -- Medivation, Inc. (Nasdaq: MDVN ) today announced th...

Nektar Therapeutics Reports Second Quarter 2009 Financial Results

... in Phase 2 clinical studies in ovarian, breast and colorectal cancer. NKTR-105, PEGylated docetaxel, is currently in a Phase 1 study in patients with refractory solid tumors. Nektar technology is used in nine approved partnered products in the U.S. or Europe today, including UCB's Cimzia(R), Roche's PE...

British Woman Celebrates a Year of Living Cancer-Free

...uding Ms. Scott, had failed all prior therapies before admission to the study. "The results so far are very encouraging, as three patients with refractory disease enjoy long-term remission," Dr. Kottaridis said. "However, this is a Phase I study that has been designed to assess toxicity as the main end p...

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Refractory in Medical Products

VNS Therapy System

Description:...use as an adjunctive therapy in reducing the frequency of seizures in adults and adolescents over 12 years of age with partial onset seizures that are refractory to antiepileptic medications. This indication is based on outcomes from 5 controlled, clinical trials. Efficacy, measured as median seizure reduction,...
Company:Cyberonics, Inc.

SD9 SQUARE PULSE STIMULATOR

Description:...ories. The built-in isolation circuit enhances subject safety and minimizes stimulus artifacts. The twin pulse circuit makes this stimulator ideal for refractory measurements. Built-in Signal Marker For those investigators requiring a signal mark for each stimulus in a volly, a signal marker circuit is included...
Company:Grass Technologies

EECP

Description:...reat coronary artery disease, and provides non-interventional cardiologists with a means of participating in the treatment of patients who have become refractory to drugs. Vasomedical's EECP therapy provides a noninvasive, atraumatic treatment for coronary artery disease, and offers new hope to patients who are...
Company:Vasomedical
Refractory in Medical Dictionary

Ulcer disease

...peptic ulcer disease . ... Peptic ulcer — Comprehensive overview covers symptoms, causes, treatment and self-care of this ... Treatment of refractory or recurrent peptic ulcer disease . ... What are the symptoms of peptic ulcer disease ? Can I prevent peptic ulcers? ... Have active ...

Gastroesophageal reflux disease

...geal reflux and laryngeal disease . ... GASTROESOPHAGEAL REFLUX OVERVIEW Gastroesophageal reflux , also known as acid ... Approach to refractory gastroesophageal reflux disease in adults ... When symptoms of heartburn or acid indigestion are frequent or can't be attributed to sp...

Acute lymphoblastic

... Lymphoblastic Leukemia ... ACUTE LYMPHOBLASTIC LEUKEMIA OVERVIEW Acute lymphoblastic leukemia (ALL) is a ... Treatment of relapsed or refractory acute lymphoblastic leukemia in adults ... Review Article from The New England Journal of Medicine -- Acute Lymphoblastic Leukemia ... A...
Refractory in Biological News

Antibiotics take toll on beneficial microbes in gut

...t of eating the feces of their cage mates and therefore picked up normal gut microbes quickly. Not a lesson applicable to humans? In patients with refractory antibiotic-associated diarrhea due to C. difficile , there have been limited trials of treatments using "fecal transplants" to replace lost gut micro...

ORNL nanotechnologies big winners in DOE call

...roved mechanical, electrical and thermal properties compared to traditional refractory materials that are subject to corrosion and mechanical degradation. refractory materials are those that are chemically and physically stable at high tempe...

NARSAD announces 2008 Prizes for Outstanding Achievement in Research on Mental Health Disorders

...onconvulsive physiological interventions --rTMS (repeated transcranial magnetic stimulation) and VNS (vagus nerve stimulation) -- for the treatment of refractory unipolar and bipolar depression. He has also studied their mechanisms using novel brain imaging techniques and is now applying these technologies to t...

Eribulin mesylate demonstrated anti-tumor activity in patients with advanced breast cancer

...patients with locally advanced or metastatic breast cancer who had received an anthracycline, a taxane and capecitabine as prior therapy, and who were refractory to their last chemotherapy regimen, as documented by progression on or within six months of that therapy. Of 299 patients enrolled in the study, ...

Cell Therapy for Cardiovascular Diseases

...ients with critical limb ischemia, presented by both Drs. Berthold Amann and Brian Annex Transplantation of bone marrow stem cells for persistent, refractory angina, presented and discussed by Drs. Douglas Losordo and Jorge Tuma CausMic: A randomized, controlled study of myoblasts in patients with heart...

Top scientists meet for global conference on stem cell therapy for cardiovascular diseases

...itical limb ischemia, presented by both Drs. Berthold Amann and Brian Annex Transplantation of bone marrow stem cells for persistent, refractory angina, presented and discussed by Drs. Douglas Losordo and Jorge Tuma CausMic: A randomized, controlled study of myoblasts in patien...

NCI renewal grant to develop new cancer therapies

... in combination with flavopiridol, a cell cycle inhibitor, in patients with refractory acute leukemia or myelodysplastic syndrome. Additionally, the team has ...rial of vorinostat and bortezomib, a proteasome inhibitor, in patients with refractory diffuse lymphocytic B-cell lymphoma or mantle cell lymphoma. ...

Fourth Annual International Conference on Cell Therapy for Cardiovascular Diseases

...derived stem cells for patients with chronic limb ischemia, presented by Dr. Brian Annex Transplantation of bone marrow stem cells for persistent, refractory angina, presented and discussed by Drs. Douglas Losordo and Jorge Tuma CausMic: A randomized, controlled study of myoblasts in patients with hear...

Clinical studies show REMICADE reduces incidence of bowel surgeries in ulcerative colitis patients

...olectomy surgery. "These data illustrate that treatment with REMICADE significantly reduces the need for life-altering colectomy in patients with refractory ulcerative colitis," said Paul Rutgeerts, M.D., Ph.D., University Hospital Gasthuisberg, University of Leuven; Leuven, Belgium. "REMICADE may offer p...

Cancer stem cells similar to normal stem cells can thwart anti-cancer agents

...n and do relapse after apparently successful therapy indicates the survival of a drug-resistant, tumor-initiating population of cells in many types of refractory cancers. “Because of the similarities between the way that normal stem cells and cancer stem cells protect themselves, cancer therapies have to be des...
Refractory in Biological Technology

FDA Appointed Arthritis Advisory Committee Recommends U.S. Food and Drug Administration Approval for KRYSTEXXA(TM) for Refractory Chronic Gout

Savient to Host Conference Call and Webcast on Wednesday, June 17 at 8:30 a.m. Eastern Time EAST BRUNSWICK, N.J., June 16 /PRNewswire-FirstCall/ -- Savient Pharmaceuticals, Inc. (Nasdaq: SVNT ) announced today that the Arthritis Advisory Committee appointed by the U.S. Food and Drug Admini...

Pixantrone Significantly Increases Complete Remissions, Overall Response Rates, Frequency of Durable Remissions and Progression Free Survival in Patients with Relapsed and Refractory Aggressive Non-Hodgkin's Lymphoma

First Randomized Trial to Demonstrate Superior Clinical Benefit in Relapsed/Refractory Aggressive NHL ORLANDO, Fla., June 1 /PRNewswire-FirstCall/ -- Intent to treat Analysis results per FDA agreed upon Statistical Analysis Plan Significant Increase in Complete Rem...

Telik Announces Top-Line Results From Assist-5 Trial of Telcyta(R) in Combination With Pegylated Liposomal Doxorubicin in Platinum Refractory and Resistant Ovarian Cancer

PALO ALTO, Calif., Oct. 29 /PRNewswire-FirstCall/ -- Telik, Inc. (Nasdaq: TELK ) today announced top-line results from an interrupted Phase 3 randomized study of Telcyta (canfosfamide HCL) in combination with pegylated liposomal doxorubicin (PLD) versus PLD alone in second-line therapy in pla...

UCB Announces New Data Showing Investigational Drug Lacosamide Significantly Reduced Seizures in Refractory Epilepsy Patients

ATLANTA, Dec. 3 /PRNewswire/ -- UCB today announced new data demonstrating that the investigational drug lacosamide, with the proposed brand name Vimpat(TM), administered as oral, adjunctive therapy, significantly reduced the frequency of seizures and was generally well-tolerated in patients w...

Cell Therapeutics Second Quarter Net Loss Decreases 54%; Pixantrone NDA Submitted to the FDA for Approval

...ue to advance pixantrone to market." Recent Highlights Completed the submission of the pixantrone NDA to the FDA to treat relapsed or refractory aggressive non-Hodgkin's lymphoma (NHL). CTI requested priority review of the pixantrone NDA which, if granted, could lead to an approval decision fro...

DOR BioPharma Receives FDA Orphan Drug Designation for orBec(R) for the Treatment of Chronic Gastrointestinal GVHD

...om profound chronic immune suppression leading to recurrent or life-threatening infections. Treatment of cGVHD is a challenge because it can be refractory to frontline immunosuppression. High-dose systemic corticosteroids are used with some success but carry significant toxicity. The risks of prolonged ...

AEterna Zentaris Partner, Keryx, Announces Agreement with FDA on a Special Protocol Assessment for Phase 3 Trial with Perifosine (KRX-0401) for the Treatment of Multiple Myeloma

...ltiple myeloma. Despite this progress, patients continue to relapse, become refractory to prior treatments and eventually die from their disease. Thus, new therap...perifosine in combination with bortezomib +/- dexamethasone in relapsed and refractory myeloma. About Special Protocol Assessments The Special Protocol ...

Nektar Therapeutics to Present at the BMO Capital Markets 9th Annual Focus on Healthcare Conference in New York City

... in Phase 2 clinical studies in ovarian, breast and colorectal cancer. NKTR-105, PEGylated docetaxel, is currently in a Phase 1 study in patients with refractory solid tumors. Nektar technology is used in nine approved partnered products in the U.S. or Europe today, including UCB's Cimzia(R), Roche's PE...

Nektar to Announce Financial Results for the Second Quarter of 2009 on Tuesday, August 4, 2009, After Close of U.S.-Based Financial Markets

... in Phase 2 clinical studies in ovarian, breast and colorectal cancer. NKTR-105, PEGylated docetaxel, is currently in a Phase 1 study in patients with refractory solid tumors. Nektar technology is used in nine approved partnered products in the U.S. or Europe today, including UCB's Cimzia(R), Roche's PEGASYS...

Cephalon Appoints Craig C. Phillips as Vice President and General Manager of Oncology Business Unit

...th rituximab or a rituximab-containing regimen and TRISENOX((R)) (arsenic trioxide) injection, approved for the treatment of patients with relapsed or refractory acute promyelocytic leukemia. In Europe, Cephalon markets three additional oncology products in 19 countries. About Cephalon, Inc. ...
Refractory in Biological Definition

Biomechanics

...pe. These involuntarily contracted cells are located in the heart wall and operate in concert to develop synchronized beats. This is attributable to a refractory period between twitches. Smooth Muscle (smooth - lacking striations) The stomach, vasculature, and most of the digestive tract are largely compo...
Refractory in Biological Dictionary

Hyperpolarization

...a depolarization. 4.3 Hyperpolarization ("undershoot") 4.4 refractory period. 5 Propagation ... and the balancing outward potassium current (repo...rd rush of ... The duration of the hyperpolarization determines a nerve's refractory period ... Scientists discover the important role that voltage changes a...

Action potential

...ant Features of the Neuronal Action Potential . refractory Periods. Na+ and K+ Concentrations Do Not Change during an Action Potential ... refractory period the period immediately after an action p...ials . Myelinated Neurons. Multiple sclerosis. The refractory period ... action potential ... this way, the ...
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Breaking Medicine News(10 mins):Health News:ISI Telemanagement Solutions, Inc. has been Awarded the 2014 Microsoft Lync Pioneer Award 2Health News:Medical Suction & Vacuum Products Procurement Category Market Research Report from IBISWorld has Been Updated 2Health News:Medical Suction & Vacuum Products Procurement Category Market Research Report from IBISWorld has Been Updated 3Health News:Medical Suction & Vacuum Products Procurement Category Market Research Report from IBISWorld has Been Updated 4Health News:Louisiana Back Institute Welcomes Dr. K. Samer Shamieh into Medical Provider Network 2Health News:Royal Blue Bridesmaid Dresses Now Are Available for Christmas at BellasDress.com 2Health News:Teens Given Anxiety, Sleep Meds May Be at Risk for Drug Abuse 2
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Breaking Biology News(10 mins):Fast food marketing for children disproportionately affects certain communities 2Fast food marketing for children disproportionately affects certain communities 3Neurotechnology Places Second in Ongoing MINEX Ranking for Fingerprint Matching Algorithms 2Neurotechnology Places Second in Ongoing MINEX Ranking for Fingerprint Matching Algorithms 3NeuroSigma Receives Notice of Allowance from the Mexican Institute of Industrial Property Covering Subcutaneous Trigeminal Nerve Stimulation (sTNS) 2NeuroSigma Receives Notice of Allowance from the Mexican Institute of Industrial Property Covering Subcutaneous Trigeminal Nerve Stimulation (sTNS) 3
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