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Redox in Medical News

Engineering chimeric polypeptides to illuminate cellular redox states

UIUC interdisciplinary team reports the design of chimeric polypeptides leading to development of noninvasive biosensors for potential application in biomedical research. Reduction/oxidation (redox) systems research is reaching a stage where domains that traditionally belonged to the physical s...

Lactate test made easy

...nic Circuits and Systems IMS in Duisburg. An electrochemical method is used to measure the lactate value. In a chemical reaction, an enzyme triggers a redox flow from the lactate which can be measured using electrodes. The measurement system, which could be installed for example in an ear clip, consists of...

Cordex Pharma to Collaborate with BG Medicine in a Clinical Study of Heart Failure Biomarkers

...out CDP-1050 CDP-1050 is an investigational drug candidate for the treatment of heart failure. The drug is designed to correct the nitric oxide and redox imbalance in the failing heart and the cardiovascular system. CDP-1050 has a dual mechanism of action; it inhibits the production of excessive reactiv...

N30 Pharma Forms Scientific Advisory Board

... to assist the company in the design and execution of its discovery and development programs across cardiopulmonary medicine and Nitric Oxide (NO) and redox biology. Dr. Joseph Loscalzo, Chairman of the Department of Medicine at Brigham and Women's Hospital and Hersey Professor of the Theory and Practice ...

Targeting oxidized cysteine through diet could reduce inflammation and lower disease risk

...k between the oxidative stress biomarker (cysteine redox potential) and pro-inflammatory cytokines, which h... and others have already established that cysteine redox potential is oxidized with aging and with a number...tors. This suggests that one could target cysteine redox potential as a means to decrease chronic proinflam...

New study shows how spikes in nitrite can have

...d persisting changes in the heart's oxidation status together with lasting alterations to numerous proteins involved in the heart's energy metabolism, redox regulation, and signaling," said David H. Perlman, a post-doctoral research associate in the Cardiovascular Proteomics Center at Boston University Sch...

5 Brown faculty elected to world's largest scientific body

...aphic fabrication and sciences of quantum-arrays made from metals, superconducting, molecules and semiconductors; DNA conductivity; and the physics of redox processes in proteins and cells. ...

Pine bark reduces inflammatory marker CRP in osteoarthritis

... of the French maritime pine tree, has been shown to reduce osteoarthritis in multiple studies. A study published in the current issue of the journal redox Report , reveals Pycnogenol's anti-inflammatory potency further to improving OA symptoms and pain was able to significantly lower plasma levels of C-r...

EPA scientists recognized with prestigious honor

.... Elucidating Basic Controls on Transformations of Aquatic N(org), Essential Knowledge for Addressing Eutrophication: Groundwater N Speciation and redox Control of Organic N Mineralization by O 2 Reduction to H 2 O 2 Geochimica Et Cosmochimica Acta (GCA), 70:3533-3548 (2006). John W. Washington; R...

Metametrix Introduces the New Neopterin/Biopterin Profile

...in Profile. This latest testing profile measures the oxidative products of tetrahydrobiopterin (BH4). Neopterin and biopterin are by-products of the redox reactions involving tetrahydrobiopterin (BH4). Restricted BH4 availability has been suggested as an etiologic factor in neurological diseases such as ...
Redox in Medical Technology

Edison Pharma Hits Milestone as A0001 Enters Phase 1 Clinical Development

...upon CoQ10's biological activity by optimizing its redox properties. A0001 is the first redox-optimized CoQ...lopment pipeline. Edison's technical focus is on redox drugs targeting metabolic control and energy metab...in mitochondrial disease and aging, as well as its redox activity, Edison's initial investigations are focu...

Duska Therapeutics Licenses Portfolio of Heart Failure Drugs From Duke and Johns Hopkins

...merly associated with Johns Hopkins University. The Phase II candidate and all other drugs in the portfolio are designed to correct nitric oxide and redox disequilibrium in the failing heart and cardiovascular system. All have a dual mechanism of action of inhibiting the creation of reactive oxygen radic...

Reata's Synthetic Triterpenoids Profiled in Nature Reviews Cancer

...iew of the discovery and activity of these agents. The authors note that Reata's Synthetic Triterpenoids have profound effects on inflammation and the redox state of cells and tissues, as well as being potent anti-proliferative and pro-apoptotic agents. Because of their unique pharmacology, these agents ar...
Redox in Biological News

Mitochondrial dysfunction and redox signaling in atrial tachyarrhythmia

Researchers at the University Hospital of Magdeburg (Germany) have discovered that atrial tachycardia is associated with mitochondrial dysfunction and oxidative stress followed by the activation of the NF-kB signalling pathway with induction of NF-kB target gene expression in atrial tissue. Their ...

August 2009 Geology and GSA Today media highlights

...ut probably rose prior to the major diversification of animals in Early Cambrian time. Pore-fluid Fe isotopes reflect the extent of benthic Fe redox recycling: Evidence from continental shelf and deep-sea sediments W.B. Homoky et al., National Oceanography Centre, University of Southampton, South...

Impact of floods on soils

...n aggregate stability reached approximately 20% during a 14-day ponding period, which is quite significant in terms of soil disaggregation. Changes in redox sensitive elements, alkaline metals, and dissolved organic carbon under reducing conditions contributed to the decrease in aggregate stability. Ove...

Impact of floods on soils

...n aggregate stability reached approximately 20% during a 14-day ponding period, which is quite significant in terms of soil disaggregation. Changes in redox sensitive elements, alkaline metals, and dissolved organic carbon under reducing conditions contributed to the decrease in aggregate stability. Ove...

January-February GSA Bulletin media highlights

...rete intervals in the Precambrian, and are, in some fashion, related to the redox state of the oceans and atmosphere. Previous interest in BIFs largely conce...ion that demonstrates mechanistically how an active Late Archean biological redox cycle of iron can explain the environmental, textural, mineralogical, geoch...

From sheet metal elements to host cells: DFG launches 10 new collaborative research centers

...bniz University of Hannover, Technical University of Dortmund) So-called redox research was previously involved primarily with the occurrence and affects ... Consequences", comes in. The objective is to better understand the role of redox signals in physiological processes and in the transition to pathophysiologi...

Understanding how oxidative stress impairs endothelial progenitor cell function

...Research at the Indiana University School of Medicine and Riley Hospital for Children report in the November 2008 issue of the journal Antioxidants & redox Signaling that a review of the scientific literature reveals that how EPCs respond to oxidantive stress appears to be a critical determinant in maint...

Illuminating biology: An evolutionary perspective

... the evolution of life on Earth. The development of the ability of some photosynthetic organisms to oxidize water to form molecular oxygen changed the redox balance of the Earth and provided the energetic basis for more advanced life to develop. This talk will discuss the complex nonlinear evolutionary pat...

October 2008 GEOLOGY and GSA TODAY media highlights

...stitut fur Geologie, Balzerstrasse 3, 3012 Bern, Switzerland. Pages 775-778. NSF funding received. Molybdenum is a trace metal that is sensitive to redox (reduction/oxidation reaction) changes in the water column. It is used by biogeochemists who study changes within the ocean system to track the rise o...

MIT: Preventing forest fires with tree power

... - many of them exotic. That meant a slew of experiments that showed, among other things, that the electricity was not due to a simple electrochemical redox reaction (the type that powers the 'potato batteries' common in high school science labs, http://en.wikipedia.org/wiki/Lemon_battery ). The team also...
Redox in Biological Technology

Successful Field-Trial Remediation of 1,2-DCA and VC Contaminated Groundwater in Northern Italy

...ection points using direct-push technology. Groundwater monitoring from four proximal observation wells showed a widespread and sustained reduction in redox (Eh -150 mV to -450 mV) and, most significantly, within ca. 9 months the groundwater concentrations of both 1,2-DCA and VC were reduced from ca. 800,...

Oncothyreon announces clinical data from three product candidates presented at American Society of Clinical Oncology (ASCO) Annual Meeting

... About PX-12 PX-12 is a small molecule irreversible inhibitor of the redox protein thioredoxin. Thioredoxin is involved in the first unique step in DN...ion factors affecting cell proliferation and death through the mechanism of redox regulation. An initial Phase 1 trial involving 38 patients with advanced ...

Joseph Loscalzo, M.D., PhD. to Join N30 Pharma Board and Chair Scientific Advisory Board

...al Board of Harrison's Principles of Internal Medicine. Dr. Loscalzo has longstanding research interests in cardiovascular medicine, nitric oxide and redox biology with over 500 scientific publications and authoring or editing of 24 books. "I am pleased to join the Board of N30 at an exciting time f...

Cordex Pharma Forms Heart Failure Medical Advisory Board

...rt on a multi-center clinical trial with oxypurinol, a modifier of cellular redox potential, in patients with symptomatic heart failure. He served as the pr...ent of heart failure. The drug is designed to correct the nitric oxide and redox imbalance in the failing heart and the cardiovascular system. CDP-1050 has...

New uses for imidazolium salts in medicine and alternative energy

...new properties of imidazolium salts (IMSs), which suggest that they could play a vital role in disease prevention and treatment. The report on the redox properties of IMSs was published in the Journal of the American Chemical Society . In a separate study published in Angewandte Chemie Internation...

Duska Therapeutics Provides Program Update and Reports Third Quarter 2008 Financial Results

...s, and cancer. CDP-1050 is an investigational drug candidate for the treatment of heart failure. The drug is designed to correct NO and redox imbalance in the failing heart and the cardiovascular system. CDP-1050 has a dual mechanism of action; it inhibits the creation of exces...

Edison Pharmaceuticals Receives Commendation From the City of San Jose

...r, is focused on developing drugs for rare diseases that impair energy metabolism. Edison possesses a technology platform and specialized knowledge in redox therapeutics -- pivotal to targeting genetic defects in the mitochondria. The Company's initial focus is on inherited diseases of the mitochondrial re...

Optimizing Your Benchscale Fermentation Process

...ased on real-time data from your exhaust gas analyzer Automating changes to your gas supplementation strategy using pH, DO, turbidity, and redox readings or those from an off-gas or dissolved-gas analysis. The BioFlo 310 can handle it all. There are seven analog input and seven analo...

The measurement of DNA condensation and mitochondrial changes during apoptosis and necrosis in cell based assays

...benchmark assay to compare the sensitivity of the nuclear and mitochondrial status assays (1). Alamar Blue is a tetrazolium salt sensitive to cellular redox levels and is widely used to assess cytotoxicity.

For all data plots shown, the results are expressed as a percentage of control va...

Detection of Mutations in the CYP21 Gene Using the DCode System

...Lundberg, Y., Partanen, J., and Wedell, A., A cluster of missense mutations at Arg356 of human steroid 21-hydroxylase may impair redox partner interaction, Hum. Genet., 99 (6):7049 (1997). 9. Guldberg, P., and Guttler, F., A simple method for identification ...
Redox in Biological Definition

Redox

The most fundamental reactions in chemistry are the redox processes . The term redox process accounts for all processes in which atoms have their oxidation number (oxidation state) changed. This can be a simple redox process, such as the combustion of carbon by oxygen to yield carbon dioxide, i...

Redox

The most fundamental reactions in chemistry are the redox processes . The term redox process accounts for all processes in which atoms have their oxidation number (oxidation state) changed. This can be a simple redox process, such as the combustion of carbon by oxygen to yield carbon dioxide, i...

Mitochondrion

...bolic tasks, such as: Apoptosis Glutamate -mediated excitotoxic neuronal injury Cellular proliferation Regulation of the cellular redox state Heme synthesis Steroid synthesis Heat production (enabling the organism to stay warm) Some mitochondrial functions are perform...

Mitochondrion

...bolic tasks, such as: Apoptosis Glutamate -mediated excitotoxic neuronal injury Cellular proliferation Regulation of the cellular redox state Heme synthesis Steroid synthesis Heat production (enabling the organism to stay warm) Some mitochondrial functions are perform...

Origin of life

...ation), "Wchtershuser systems" come with a built-in source of energy, sulfides of iron and other minerals (e. g. pyrite). The energy released from redox reactions of these metal sulfides is not only available for the synthesis of organic molecules, but also for the formation of oligomers and polymers. ...

Signal transduction

... NO can also act through covalent modification of proteins or their metal cofactors. Some of these modifications are reversible and work through a redox mechanism. In high concentrations, NO is toxic, and is thought to be responsible for some damage after a stroke . NO serves three main functions: ...
Redox in Biological Dictionary

Reducing agent

... A reducing agent is the element or compound in a redox reaction that reduces another species. In doing so, it becomes oxidized, and is therefore the electron donor in the redox. For example consider the f...

Reduction

...piler optimization where a function of some ... redox describes all chemical reactions in which atoms ha...ation number changed. This can be either a simple redox process such as the oxidation of carbon to yield...nition of reduction is that it represents ... redox ( ) n. Oxidation- reduction . [ RED(UCTION) + OX(I...

Redox reaction

... redox (shorthand for reduction-oxidation reaction ) describes all chemical ... Non- redox reactions , which do not involve changes in formal charge, are known as ... Organic redox reaction . From Wikipedia, the free encyclope...

Proton-motive force

... The existence of proton - motive force enabled the evolution of porters driven ... ... of proton motive force and an energy conserving redox loop,2 another ... Huang3 describe mitochondrial chemiosmosis and proton motive force in action. ... ...

Oxidation

... redox describes all chemical reactions in which atoms ha...ation number changed. This can be either a simple redox process such as the oxidation of carbon to yield...es like sherry and madeira it's undesirable ... redox ( ) n. Oxidation -reduction. [ RED(UCTION) + OX(I...

NADPH

...ane of phagosome. nicotinamide adenine ... wet weight, about 10 times the concentration of NADP+ and NADPH ... Since NADPH is needed to drive redox reactions as a strong ... NADPH ( ) n. The reduced form of NADP. [ NADP + H. ... You measure the amount of atp and nadph consumed by the calv...

Erythrocyte

... the other domain of the erythrocyte membrane. ... It has been hypothesized that a link exists between erythrocyte metabolism (particularly redox metabolism) and erythrocyte shape and that both are related to eryth ... Erythrocyte sedimentation rate summary with 4 pages of encyclopedia en...

Cytochromes

...erences. All Scientists. All Laboratories ... Figure 1: Metabolism of arachidonic acid by cytochromes P450 ... Three cytochromes gave different redox behaviors reflected from the respective structural in ... case of cyt c. Though three cytochromes play similar role in ... ...

Chloroplast DNA

... The chloroplast has its own DNA which codes for redox proteins involved in ... Direct measurement of the transfer rate of chloroplast DNA into the nucleus" ... Discusses the evolution ...

Active transport

... Types of active transport . ... case of active transport , the proteins are ... ... sources of energy for Primary active transport are redox energy and photon ... An example of primary active transport using light energy are the proteins ... Primary Active Transport directly ...
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