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Receptors in Medical News

Nicotine Receptors Could Be Lung Cancer Treatment Target

Compound inhibited receptors and led to cancer cell death in mouse study MONDAY, June 15 (HealthDay News) -- In a study of mice with lung cancer, a treatment that targeted nicotine receptors more than doubled the animals' survival time, Italian researchers say. Nicotine plays a dual...

Protein that suppresses androgen receptors could improve prostate cancer diagnosis, treatment

AUGUSTA, Ga. A protein that helps regulate expression of androgen receptors could prove a new focal point for staging and treating testosterone-fueled prostate cancer, Medical College of Georgia researchers say. Levels of the protein, βarrestin2, are lower in some prostate cancer cells t...

Abbott Researchers Target Neuronal Nicotinic Receptors for Treatment of Pain and Cognition

Scientists to Present Data and Discuss Emerging Advances in Basic Research and Clinical Science at Neuroscience 2007 Satellite Symposium ABBOTT PARK, Ill., Nov. 1 /PRNewswire-FirstCall/ -- The human brain relies on chemicals called "neurotransmitters" that nerve cells use to communicate to ...

Investigational Agent Targeting Metabotropic Glutamate 2/3 Receptors Demonstrates Antipsychotic Activity in Humans, Study in Nature Medicine Finds

New approach for treatment of schizophrenia INDIANAPOLIS, Sept. 2 /PRNewswire-FirstCall/ -- An investigational, phase II study published in the scientific journal Nature Medicine demonstrates that for the first time in humans a drug that acts on certain proteins in the brain call...

Researchers create first model for retina receptors

A team of scientists at the University of Oklahoma Health Sciences Center has created the first genetic research model for a microscopic part of the eye that when missing causes blindness. The research appears in a recent issue of the Journal of Biological Chemistry . The team led...

Food peptides activate bitter taste receptors

PHILADELPHIA (January 22, 2008) -- Researchers from the Monell Center and Tokyo University of Agriculture have used a novel molecular method to identify chemical compounds from common foods that activate human bitter taste receptors. The findings, published in the journal Biochemical and Bioph...

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Receptors in Medical Technology

Arena Pharmaceuticals Announces APD668 Initial Clinical Study Results Suggest Glucose-Dependent Insulinotropic Receptors May Improve Glucose Control in Patients With Type 2 Diabetes

Ortho-McNeil to Continue Investigation of GDIR Agonists Under its Partnership with Arena SAN DIEGO, Jan. 7 /PRNewswire-FirstCall/ -- Arena Pharmaceuticals, Inc. (Nasdaq: ARNA ) announced today that initial clinical study results for APD668, an oral drug candidate di...

Medarex Receives Milestone Payment for Investigational Antibody Targeting Integrin Receptors

PRINCETON, N.J., Nov. 5 /PRNewswire-FirstCall/ -- Medarex, Inc. (Nasdaq: MEDX ) today announced that it has received a milestone payment of an undisclosed amount from its licensing partner, Centocor R&D Inc., for the completion of a Phase 2 trial of CNTO 95, a fully human antibody targeting t...

Popular Breast Cancer Drug Used with Certain Antidepressants Puts New Jersey Women at Risk

...used treatments for reducing the risk of breast cancer recurrence among women with estrogen-dependent tumors. The drug works by blocking the estrogen receptors in the breast cells and can reduce the risk of a breast cancer recurrence by up to 50 percent. It's the only anti-estrogen available for prevention o...

FDA Issues Complete Response Letter for INTUNIV(TM) (guanfacine) Extended Release for the Treatment of ADHD in Children and Adolescents

..., is thought to work directly by binding selectively to alpha-2A adrenergic receptors located in the prefrontal cortex - an area of the brain that has been linked to ADHD.(4-6) Stimulation of the postsynaptic alpha-2A receptors is thought to strengthen working memory, reduce susceptibility to distracti...

5-Year Study Published in Diabetologia Demonstrated Long-Term Safety of Lantus(R) Compared to NPH

...e of blindness in patients with diabetes. It is a progressive disease that results from cellular proliferation within the eye. The stimulation of IGF1 receptors is involved in this process. In the study of patients with retinopathy, the progression of diabetic retinopathy was similar in the two treatment group...

Cordex Signs European Development Partnership for ATPotent(TM) Sperm Motility Drug

...eased from cells under physiologic and pathophysiologic conditions; extracellular ATP acts as a local physiologic regulator by activating cell surface receptors called P2 receptors. Extracellular ATP plays an important role in sperm maturation in the male reproductive tract and is a mandatory co-factor of fert...
Receptors in Medical Products

IGFBP-4 ELISA Test

Description:...stoma, prostate and bone cells [1,2]. IGFBP-4 appears to be inhibitory to IGF action by binding the IGFs and preventing their interaction with the IGF receptors [1]. This inhibitory function of IGFBP-4 is protease dependent [2]. The regulatory mechanisms that control IGFBP-4 expression are still poorly underst...
Company:Diagnostic Systems Laboratories, Inc.

IGF-II, w/ Extraction IRMA Test

Description:...ate [1]. However, it is believed that binding to the Type I IGF and insulin receptors may mediate the mitogenic actions of IGF-II [2,3]. In the circulation, the interaction of IGF-II with these receptors appears to be regulated by IGF-binding proteins (IGFBPs). IGF-II is mainly ...
Company:Diagnostic Systems Laboratories, Inc.

IGF-II, w/ Extraction ELISA Test

Description:...ate [1]. However, it is believed that binding to the Type I IGF and insulin receptors may mediate the mitogenic actions of IGF-II [2,3]. In the circulation, the interaction of IGF-II with these receptors appears to be regulated by IGF-binding proteins (IGFBPs). IGF-II is mainly ...
Company:Diagnostic Systems Laboratories, Inc.

IGF-II, Non-Extraction IRMA Test

Description:...ate [1]. However, it is believed that binding to the Type I IGF and insulin receptors may mediate the mitogenic actions of IGF-II [2,3]. In the circulation, the interaction of IGF-II with these receptors appears to be regulated by IGF-binding proteins (IGFBPs). IGF-II is mainly ...
Company:Diagnostic Systems Laboratories, Inc.

IGF-II, Non-Extraction ELISA Test

Description:...ate [1]. However, it is believed that binding to the Type I IGF and insulin receptors may mediate the mitogenic actions of IGF-II [2,3]. In the circulation, the interaction of IGF-II with these receptors appears to be regulated by IGF-binding proteins (IGFBPs). IGF-II is mainly ...
Company:Diagnostic Systems Laboratories, Inc.

Leptin Soluble Receptor ELISA Test

Description:...[3]. Leptin operates at the level of the hypothalamus and acts via specific receptors to control the expression of the appetite stimulator, neuropeptide Y (NPY)....nce" and an inability of leptin to enter the cerebral spinal fluid to reach receptors in the hypothalamus. Circulating leptin is also believed to be bound to a c...
Company:Diagnostic Systems Laboratories, Inc.
Receptors in Medical Definition

Depolarization-induced suppression of inhibition

...rkinje cells of the cerebellum. Activation of GABA receptors on these cells, whether they are ionotropic or ...loid transient receptor potential vanilloid type 1 receptors in the mouse brain. Neuroscience. Apr 5; In Press....harmacological separation of cannabinoid sensitive receptors on hippocampal excitatory and inhibitory fibers. N...

Thymocyte

...vantage in having a large number of unique T cell receptors is that each T cell is capable of recognising a d...ling on the surface. However many of these T cell receptors will still be non-functional, due to an inability...antage in a gene rearrangement process for T cell receptors is that by random chance, some arrangements of ge...
Receptors in Medical Dictionary

Viscera

...omuscular therapy for issues such as Sciatica, ... of the viscera ("function follows ... Posture involves motor responses to sensory inputs. ... receptors in the limbs, body, viscera , vestibular apparatus, and central nervous ... ...

Soy

... A possible relationship between dietary soy and the prevention of hormone ... Soy phytoestrogens are very complex -- they bind to estrogen receptors and ... Mayo Clinic offers award-winning medical and health information and tools for healthy living. ... Soy has been a dietary staple in Asian...

Smell

...lated by the odors around us--the ... Your nose helps you breathe, smell , and taste. Find out how in this article for kids. ... When the smell receptors are stimulated, signals travel along the olfactory ... smell v. , smelled or smelt , smelling , smells . v.tr. To perceive the scent o...

Serotonin

... been one of the factors to blame for ailments such ... The serotonin receptors modulate the release of many neurotransmitters, ... The serotonin receptors are the target of a variety of pharmaceutical and ... Serotonin , neur...

Platelet

...opathic) Thrombocytopenia Purpura. ... appeared in The Platelet News, vol.4, no ... Abnormalities in either platelet number or function ... as receptors for components that trigger platelet . activation and as substrates for adhesion ( platelet ... Platelets are irregularly-shaped, colorless ...

Physiology

... online site for books: new ~ used ~ paperbacks ~ NYTBS. Buy Human Physiology for $134.99 now & save. ENDOCRINE PHYSIOLOGY AND METABOLISM. receptors AND SIGNALING PATHWAYS ... COMPARATIVE AND EVOLUTIONARY PHYSIOLOGY . SLEEP AND BIOLOGICAL RHYTHMS ... In October 2002, The Nobel Prize in Physio...
Receptors in Biological News

Light receptors in eye play key role in setting biological clock, study shows

Biologists at the University of Virginia have discovered a switching mechanism in the eye that plays a key role in regulating the sleep/wake cycles in mammals. The new finding demonstrates that light receptor cells in the eye are central to setting the rhythms of the brain's primary timekeeper,...

Integrins as receptors give insight into rotavirus and diarrhea

Eleven years ago, Dr. Mary Estes of Baylor College of Medicine and her colleagues discovered the first viral enterotoxin, rotavirus NSP4, a toxic protein that affects the intestines, causing diarrhea. The next step was to find the cellular receptor on intestinal cells through which the enterot...

Nicotinic receptors may be important targets for treatment of multiple addictions

For years, scientists have known that some people are biologically more susceptible to drug addiction than others, but they have only been able to speculate why. In the August 15, 2007 issue of the Journal of Neuroscience, researchers at the University of Chicago report on a study that may help...

Neural mapping paints a haphazard picture of odor receptors

CAMBRIDGE, Mass., Feb. 3, 2009 -- Despite the striking aromatic differences between coffee, peppermint, and pine, a new mapping of the nose's neural circuitry suggests a haphazard patchwork where the receptors for such disparate scents are as likely as not to be neighbors. Inexplicably, this se...

Your gut has taste receptors

Researchers in the Department of Neuroscience at Mount Sinai School of Medicine have identified taste receptors in the human intestines. The taste receptor T1R3 and the taste G protein gustducin are critical to sweet taste in the tongue. Research now shows these two sweet-sensing proteins are als...

Can you hear me now? Scientists find previously unknown receptors on adult stem cells

For many years, researchers believed that stem cells in the bone marrow spent most of their existence in a slumber-like state, unaware of -- and unaffected by -- the daily battles fought by the body's immune system. Not so. Scientists at the Oklahoma Medical Research Foundation have discovered...
Receptors in Biological Technology

CeNeRx BioPharma Awarded New Patent for its Innovative Compounds That Selectively Target Peripheral Cannabinoid Receptors

--By Avoiding the CNS, These Compounds May Be Free of the Side Effects Associated with Traditional Cannabinoid Compounds-- RESEARCH TRIANGLE PARK, N.C., April 1 /PRNewswire/ -- CeNeRx BioPharma, Inc., a clinical stage company developing and commercializing innovative treatments for diseases o...

Development of a sensitive enzyme fragment complementation assay for cyclic adenosine 3', 5' monophosphate and its validation for pharmacological screening at G protein-coupled receptors

Key words: cAMP • GPCR • enzyme fragment complementation • LEADseeker • assay miniaturization G protein-coupled receptors (GPCRs) are the largest family of transmembrane receptors and are responsible for the transduction of ...

Palatin Technologies, Inc. Receives U.S. Patent Allowance for Heart Failure Drug Candidate

...ary amino acid mimetic developed by scientists at Palatin. PL-3994 has an extended half-life, with reduced affinity for natriuretic peptide clearance receptors and increased resistance to neutral endopeptidase, an endogenous enzyme that degrades natriuretic peptides. The result is a drug candidate with improv...

Debiopharm and MSM Protein Technologies Sign Agreement for Research and Development of Debio 0929, a Novel Oncology Biologic

...www.msmprotein.com About G-protein Coupled receptors (GPCRs) GPCRs comprise a large protein family of transmembrane receptors that sense molecules outside the cell and activate... are the largest, most versatile group of membrane receptors and also the most pharmaceutically important, as m...

AEterna Zentaris: New Data Published on its Ghrelin Antagonist Compound, AEZS-123 (JMV2959), Supports its Use in Alcohol Addiction

... is a natural peptide hormone produced by the stomach that increases appetite and induces accumulation of fat tissue. The discovery of ghrelin and its receptors opens up new opportunities for the treatment of obesity and eating disorders through the use of ghrelin antagonists to suppress appetite and fat depos...

SEP Signs REGURIN(R) Deal

...s been recommended by NICE for the second line treatment of UI in women after immediate release oxybutynin.[14] Regurin has a high selectivity for two receptors in the detrusor muscle, M sub(2) and M sub(3).[15] Regurin is a quaternary amine: as such it is a positively charged molecule that does not cro...
Receptors in Biological Products

Rabbit Anti-Glutamate receptor 1, phospho (Ser845) Polyclonal Antibody, Unconjugated from GeneTex

Description:...ed receptor channels-termed NMDA, AMPA and kainate receptors that are involved in the fast excitatory synaptic ...e enzymes producing second messengers via specific receptors coupled to G-proteins. These receptors are called metabotropic glutamate receptors. In ex...
Company:GeneTex

Prostaglandin E2-d4 from Cayman Chemical

Description:...ne modulation. The effects of PGE2 are transduced by at least four distinct receptors designated EP1, EP2, EP3, and EP4. The affinity constants (Kd) of PGE2 for these receptors range from 1-10 nM depending on the receptor subtype and tissue....
Company:Cayman Chemical

Prostaglandin E2-d4 from Cayman Chemical

Description:...ne modulation. The effects of PGE2 are transduced by at least four distinct receptors designated EP1, EP2, EP3, and EP4. The affinity constants (Kd) of PGE2 for these receptors range from 1-10 nM depending on the receptor subtype and tissue....
Company:Cayman Chemical

LabChip 3000 Drug Discovery System from Caliper Life Sciences

Description:...abChip 3000 includes: Serine/Threonine Kinases; Tyrosine Kinases; Phosphatases; Proteases; Lipid-modifying Enzymes; and G-protein coupled receptors (GPCRs). Caliper's most recent introduction, KiSS (Kinase Selectivity Screening) offers lead optimization and secondary screening laboratories a si...
Company:Caliper Life Sciences

Rabbit Anti-GluR4 Antibody, Unconjugated from Lab Vision

Description:... Glutamate receptors constitute the principal excitatory neurotransmitter receptors in brain. Two classes of glutamate receptors exist: Ionotropic receptors, and metabotropic rece...
Company:Lab Vision

PULSin Protein & Antibody Delivery Reagent from Polyplus Transfection

Description:... proprietary cationic lipid that noncovalently complexes with many proteins including antibodies. Complexes are internalized via anionic cell-adhesion receptors present on all cells and are released into the cytoplasm where they disassemble. The process is general, nontoxic and delivers unmodified, functional ...
Company:Polyplus Transfection
Receptors in Biological Definition

Antibody

... class of the antibody). It binds to various cell receptors and complement proteins. In this way it mediate...gG, IgA, IgM, IgD, and IgE constant binding domain receptors it can express on its surface. The antibodies a ...low they combine with different immunoglobulin receptors specific for them and exert effector functions. Th...

Apoptosis

... good fit, like a key and a lock, with specialized receptors in B and T cell membranes). For instance, "killer"...s and commit them to programmed cell death. The receptors in immature B and T cell membranes are not tailore...fective (because the almost random shapes of their receptors do not engage any antigen of significance), or dan...

Bone

...ation. Their functions include to varying degrees: formation of bone, matrix maintenance and calcium homeostasis. They possibly act as mechano-sensory receptors - regulating the bones response to stress. If osteoblasts can be described as bone forming cells, osteoclasts role is the reverse: its destruction. ...

Biophysics

...ists, chemists, and biologists by training. Topics in biophysics and related fields animal locomotion cellular biophysics channels , receptors and transporters electrophysiology membranes bioenergetics muscle and contractility nucleic acids photobiophysics and bioph...

Brain

...ncludes the antennal lobes, which are similar to the mammalian olfactory bulb , and the mechanosensory neuropils which receive information from touch receptors on the head and antennae. The antennal lobes of flies and moths are quite complex. In cephalopods, the brain is divided into two regions: the su...

Cilium

...ted to its cell body with a specialized non-motile cilium. The terminal fiber of the olfactory neuron is also a non-motile cilium, where the odorant receptors locate. Almost all types of the mammalian cells have a single non-motile cilium called " Primary cilium " that has been neglected for a long time. Rec...
Receptors in Biological Dictionary

Vitelline membrane

...rane of an ovum. It is composed mostly of protein fibers, with protein receptors needed for sperm binding, binding to sperm plasma membrane receptors. The species-specificity between these receptors contributes to prevention of breeding between different species. Aspects...

Transmembrane receptor

... Membrane or Transmembrane receptors are specialized integral membrane proteins that ...the receptor , triggering... G protein-coupled receptors (GPCRs), also known as seven- transmembrane domai...ptors, serpentine receptor , and G protein-linked receptors (GPLR), comprise a large protein family of... ...

Transmembrane proteins

...gregate and precipitate in water. They require detergents or nonpolar solvents for extraction, although some of them... Membrane or Transmembrane receptors are specialized integral membrane proteins that take part in communication between the the cell and the outside world. Extracellular signaling mol...

Transduction

... Association Medical Terms ... 3.1.3 Signal transduction of transmembrane receptors that are ion channels ... Transduction summary with 12 pages of encycl...erms,biology abbreviations ... 3.1.2 Signal transduction of transmembrane receptors by structural changes ... Signal transduction will involve a receptor...

Thalamus

.... ... Thalamus - Definition of Thalamus at Dictionary.com a free online dictionary ... The thalamus translates neural impulses from various receptors to the cerebral ... Welcome to the Department of Anatomy and Neurobiology at Washington University Medical School! ... Our faculty study a variety...

T lymphocytes

...te ... T cell n. Any of the lymphocytes that mature in the thymus and have the ability to recognize specific peptide antigens through the receptors on their T lymphocytes Specialized blood cells that recognize invading organisms (helper T lymphocytes ) and destroy them (killer T ... ...
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