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Rearrangement in Medical News

Reduction in antibody gene rearrangement in B cells related to type 1 diabetes, lupus

PHILADELPHIA More drafts usually mean a better product and so it also seems to go with the human immune system. As B cells develop, genes rearrange to allow antibodies to recognize different foreign invaders or pathogens. But sometimes antibodies are created that recognize and attack the body's o...

Do patients at risk for B-cell malignancy need antiviral treatment?

...ious Disease of the People's Liberation Army 161 Hospital in Wuhan used IgH rearrangement and immunohistochemistry. Various research studies indicated a relationship...iver were more frequent in the HCV-infected patients (P=0.000).A clonal IgH rearrangement was detected in 5 (71.4%) of 7 liver biopsy specimens with monoclonal B-cel...

New Procedure To Correct Pelvic Prolapse Has Faster Recovery, Shorter Hospital Stay

... Maybe you've been too embarrassed to talk about it with your doctor, but if childbirth left you with a very unpleasant rearrangement of your pelvic organs, you need to know help is possible. Urogynecologists Robert Harris, MD, and Steven Speights, MD, at Southeast Urogynecology at W...

Some Hiroshima Survivors at Thyroid Cancer Risk

... different and relatively rare disease trigger -- involving the chromosomal rearrangement of the RET/PTC gene -- seems to be to blame. Though both mechanisms spur...yed a role in the development of PTC among patients who had the chromosomal rearrangement before they were diagnosed with the disease. Hamatani noted that, among chi...

Study links gastric bypass surgery to increased risk of kidney stones

...ihood of the development of kidney stones following this type of gastric bypass surgery is not entirely understood. A possibility is that the anatomic rearrangement caused by the operation establishes a mildly malabsorptive state, which may be responsible for the increase in the excretion of urinary electrolytes. ...

Microenvironment a main driver of aggressive multi-lineage leukemia disease type

...ventions prevented MLL-AF9 cell growth and induced programmed cell death (apoptosis), suggesting Rac as a possible therapeutic target in AML involving rearrangement of the MLL gene, according to Dr. Mulloy and his fellow researchers. "The exquisite sensitivity of the leukemia cells to Rac inhibition indicates t...

Cells on path to becoming mature T-cells more flexible than commonly thought

...us normally arise from ETPs. The process of T-cell development in the thymus requires progenitor cells to rearrange pieces of DNA. This process of DNA rearrangement is required to build the antigen receptor used by T cells, and permanently marks ETPs. Bell and Bhandoola found that permanent marks of past DNA rearr...

UCLA researchers examine human embryonic stem cell genome

...y. Forms of variation include single DNA base pair alterations, duplications or deletions of genes or sets of genes, and translocations, a chromosomal rearrangement in which a segment of genetic material from one chromosome becomes heritably linked to another chromosome. These changes can be benign, but they can a...

U of Minn researchers discover genetic cancer link between humans and dogs

...nd the dog genome contains 78 chromosomes. Sometimes, in the normal duplication process of cells, chromosomes can become rearranged or relocated. This rearrangement or relocation is called translocation. It can lead to a cell losing its normal function, becoming abnormal, and possibly developing into cancer. Inte...

Inverted DNA turns quiet developmental gene into a potent driver of t-cell lymphoma

...ch genes are almost entirely inactive. Unfortunately, in white blood cells, such as T cells, Dlx5 moves to a region of DNA involved in the genetic rearrangement that allows immune cells to switch genes around in order to create new combinations of proteins to respond to disease threats. This recombination proc...
Rearrangement in Medical Technology

Research Teams at J. Craig Venter Institute and Ludwig Institute for Cancer Research Uncover New Chromosomal Alterations in Cancer Using Transcriptome Sequencing Approach

...udies showing that genomic instability in this area is implicated in breast and prostate cancers. Most genes involved in the discovered chromosomal rearrangement events in this study have been implicated in cancers, such as the MRE11A protein that is associated with mutations in many types of tumors including i...

Genmab A/S - Company Announcement: Novel Insights into HuMax-EGFr Mechanisms of Action Published in PNAS

...ifficult for cancer cells to grow, multiply, and survive. By using an electron microscope based technique, called protein tomography, the structural rearrangement accompanying inhibition of individual EGFr molecules was studied. Biochemical analyses showed that HuMax-EGFr binds bivalently to the EGFr and, furthe...
Rearrangement in Medical Definition

Thymocyte

...egative 3 Lineage-CD44-CD25+ cortex TCR beta rearrangement Double negative 4 Lineage-CD44-CD25- cor...hogens. [4] . The cellular disadvantage in the rearrangement process is that many of the combinations of the T...ctive thymocytes. The key disadvantage in a gene rearrangement process for T cell receptors is that by random c...
Rearrangement in Medical Dictionary

Rhabdomyosarcoma

...rapy, ... The risk of rhabdomyosarcoma is increased in children with the genetic disorder ... Alveolar rhabdomyosarcoma cells usually have a rearrangement of chromosomes 2 ... CHOP is dedicated to helping you learn more about Rhabdomyosarcoma . ... What are the signs and symptoms of rhabdomyosarc...
Rearrangement in Biological News

Are there rearrangement hot spots in the human genome?

The debate over the validity of genomic rearrangement hotspots has its most recent addition in a new theory put forth by researchers at the University of California San Diego. The study, published on November 9 in PLoS Computational Biology, holds that there are indeed rearrangement hotspots in t...

DNA template could explain evolutionary shifts

...gnificance of the event. The researchers noted that finding this mitotic rearrangement of the gene in the mother, who did not have the disorder, of two children w... for an apparent mitotically generated, FoSTeS/MMBIR-mediated complex PMP22 rearrangement in the unaffected mother of two children with neuropathy suggests this mech...

Research team finds important role for junk DNA

...r the organism. They have concluded that the genes spur an almost acrobatic rearrangement of the entire genome that is necessary for the organism to grow. It al... from parent to offspring and these maternal RNAs provide templates for the rearrangement process," Landweber said. "Now we've been studying the actual machinery inv...

CSHL team develops mouse models of leukemia that predict response to chemotherapy

...leukemia became drug-resistant and aggressive. "These results in the new animal models suggest that AML patients diagnosed with the MLL chromosome rearrangement will not show durable responses to standard chemotherapy," according to Lowe, Zuber, and colleagues. "These patients should be offered alternative the...

New journal shows half-broken gene is enough to cause cancer

...isease phenotype". PathoGenetics will focus on both in vitro and in vivo studies on the cascade of events leading from gene mutations or genomic rearrangement to disease. The discovery of novel molecular and metabolic pathways relevant to disease pathogenesis will be given specific emphasis. The first issue ...

Aberrations in region of chromosome 1q21.1 associated with broad range of disorders in children

...plained developmental abnormalities consider the identification of a 1q21.1 rearrangement in a patient a significant clinical finding and probably an influential gen...arrangement. Keeping in mind the many possible repercussions of having this rearrangement in the chromosome, the authors suggest that young carriers should be monito...

Researchers discover atomic bomb effect results in adult-onset thyroid cancer

...to the blast sites, were comparably young at the time, and developed the cancer quickly once they reached adulthood, were likely to have a chromosomal rearrangement known as RET/PTC that is not very frequent in adults who develop the disease. "Recent in vitro and in vivo studies suggest that a single genetic ev...

Duke-NIEHS team shows how DNA repairs may reshape the genome

...e broken ends on the same chromosome. Chromosome aberrations are a change in the normal chromosome complement because of deletion, duplication, or rearrangement of genetic material. On rare occasions, the development of one of these new chromosome structures is beneficial, but more often DNA changes can be det...

New route for heredity bypasses DNA

...ecise. Landweber and her colleagues have postulated that this programmed rearrangement of DNA fragments is guided by an existing "cache" of information in the for...raging results, disrupting the process of development, and even halting DNA rearrangement in some cases. In a second experiment, Nowacki and Yi Zhou, both postdoc...

Mutant sperm guide clinicians to new diseases

...d snapshot of CNVs: using our new highly-sensitive assays we can detect one rearrangement in a million cells." The team looked at regions known to be affected by rearrangement in Williams-Beuren Syndrome, Charcot-Marie-Tooth disease Type 1A, Smith-Mag...
Rearrangement in Biological Technology

Quest Diagnostics to Present Genomic Studies Related to New Testing Techniques for Leukemia and Prostate Cancer at 2009 ASCO Meeting

...to kinase inhibitors." (Abstract No: 7028) Link to ASCO abstract: http://www.abstract.asco.org/AbstView_65_33182.html . -- Testing for gene rearrangement and partner genes to enhance detection of prostate cancer: TMPRSS2 gene rearrangements have been reported in 40%-85% of prostate cancer (PCa) patient...

Chromosome breakpoints contribute to genetic variation

...particularly embryonic development. Disruptions to these genes would probably be harmful to the organism as a whole, Lewin said. "If the chromosome rearrangement is really bad for the organism, it will be eliminated. It won't survive," he said. "So if something persists in the genome, it generally has to either...

Spring 'blockbuster' movie now showing

...the size of the hole grows. The researchers used the same TEAM 0.5 electron beam to record for analysis a movie showing the growth of the hole and the rearrangement of the carbon atoms. "Atoms that lose their neighbors become highly volatile, and move around rapidly, continually repositioning themselves from on...

Shire Expands its Gastrointestinal Portfolio Through In-Licensing Celiac Disease Phase 2 Product From Alba Therapeutics Corporation

...ern world. About AT-1001: AT1001 is a novel peptide that inhibits intestinal paracellular permeability by inhibiting stimulus-induced cytoskeletal rearrangement in epithelial cells that leads to the disassembly of tight junctions. It is currently under investigation in a multi-centre, double blind, placebo con...

Individual differences caused by shuffled chunks of DNA in the human genome

...or of the study, which was published in Science Express. Our study shows that a considerably greater amount of variation between individuals is due to rearrangement of big chunks of DNA. Although the original human genome sequencing effort was comprehensive, it left regions that were poorly analyzed. Recently, ...

When proteins, antibodies and other biological molecules kiss, a new kind of biosensor can tell

...s a measure of how fast the light travels through the liquid in the chamber compared to its speed in a vacuum. They suspect that it has to do with the rearrangement in the water molecules that cover the surface of the proteins: When two proteins react they squeeze the water molecules out of the area where they bin...

When proteins, antibodies and other biological molecules kiss, a new kind of biosensor can tell

...s a measure of how fast the light travels through the liquid in the chamber compared to its speed in a vacuum. They suspect that it has to do with the rearrangement in the water molecules that cover the surface of the proteins: When two proteins react they squeeze the water molecules out of the area where they bin...

UW-Madison technology to advance cell phones

...was to rearrange the energy cells within a power amplifier so that any heat produced dissipates uniformly, rather than moving towards the center. This rearrangement reduces the overall temperature, which enhances overall performance. "We have found a new power device structure that can counterbalance heat trans...

Analysis of a Verapamil Microsomal Incubation using Metabolite ID and Mass FrontierTM

...an be subjected to further fragmentation simulations. This module of Mass Frontier makes its structural assignments using a known list of unimolecular rearrangement and fragmentation reactions. The user is able to control which of these reactions will actually be considered. The Spectra Manager and Fragments & Mec...

MicroRNA Profiling by Array Analysis Reveals Critical BioMarkers

...uence analysis of tumor cells from eleven Burkitt lymphoma patients revealed that every one had a chromosome rearrangement in the miR-155 gene [3]. None of the twenty-one normal (negative control) individuals tested had the rearran...
Rearrangement in Biological Products

ISOQUANT Isoaspartate Detection Kit from Promega

Description:...titative detection of isoaspartic acid residues in proteins and peptides, which can result from the gradual, nonenzymatic deamidation of asparagine or rearrangement of aspartic acid residues during storage or handling. Because the kit does not depend on the monitoring of charge differences for detection, charge he...
Company:Promega
Rearrangement in Biological Definition

Activation energy

... . If there is enough energy available, this repulsion is overcome and the molecules get close enough for attractions between the molecules to cause a rearrangement of bonds. The Arrhenius equation gives the quantitative basis of the relationship between the activation energy and the rate at which a reaction p...

Patau syndrome

...e due to a translocation can be inherited. An unaffected person can carry a rearrangement of genetic material between chromosome 13 and another chromosome. This rearrangement is called a balanced translocation because there is no extra material from ...
Rearrangement in Biological Dictionary

Translocation

... In genetics, a chromosome translocation is a chromosome abnormality caused by rearrangement of parts between nonhomologous chromosomes. A fusion gene may be created when the translocation joins two otherwise separated genes,... Tran...

Synteny

...e ... Synteny - Wikipedia, the free encyclopedia. Students of Genetics employ the term synteny to ... Cinteny - Server for Synteny and Genome rearrangement Analysis ... Synteny information including symptoms, causes, diseases, symptoms, treatments, and other medical ... Synteny : The relationship be...

Site-specific recombination

...onservative site - specific recombination systems have been described ... During site - specific DNA recombination , which brings about genetic rearrangement ... recombination n. The natural formation in offspring of genetic combinations not present ... through controlled and site - specific recom...

Recombination

...in an ... However, in molecular biology, recombination generally refers to the molecular ... Genetic recombination refers more to a large-scale rearrangement of a DNA molecule. ... It remains generally assumed that recombination events are rather random, and ... genetic recombination ... recombinati...

Permutation

...ion, one-line notation for permutations ... This is version 7 of permutation , born on 2001-10-20, modified 2007-10-22. ... A permutation is a rearrangement of objects. ... representation of a permutation as follows, where we assume they elements are ... Introduction into the Graph Theory and Permu...

Neural plate

...opedia article on neural plate (anatomy), ...of the nervous system from a part of ectoderm lying originally on the dorsal side of the ... rearrangement of neural plate cells drives mediolateral narrowing and ... Neural plate regions were cut from chick embryos with fine tungsten needles and ...

Genetic recombination

...in... Genetic recombination . From CreationWiki, the encyclopedia of creation science ... Genetic recombination refers more to a large-scale rearrangement of a DNA molecule. ... Genetic recombination Genetic recombination is the process by which a strand of genetic material (usually DNA ; ...

Gastrulation

...tus late gastrula, viewed from the ventral (oral) side. ... the first systems in which gastrulation was studied using ... Gastrulation is the rearrangement process that forms the three germ layers and ... During gastrulation the endoderm and mesoderm move to the inside of the embryo ... Argonau...
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