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Rational in Medical News

PRA International Speaking Event: Rational Drug Design and Development in Infectious Diseases

A Historic Perspective and Future Directions RALEIGH, N.C., Feb. 12 /PRNewswire/ -- PRA International, a leading Clinical Research Organization, will host a prominent panel of infectious disease experts in Boston at 9:00 a.m. on February 25. Discussions will include case scenarios on cut...

"Active" Brain Makes Rational Decisions!!

According to a new research, conducted at UCL (University College London) thatis funded by the Wellcome Trust, emotional responses in a tight situation results// in irrational behaviour. The ability to control the emotions, than the emotions being absent, will result in rational behaviour. The ...

Ex- White House Drug Spokesman Urges 'Double Drug Treatment'; Bob Weiner and Policy Analyst Zoe Pagonis Highlight 'Drug War's Wrong Focus'

... and analyst Zoe Pagonis. They assert that "increasing drug treatment to stop the main catalyst of crime and save families would be an extraordinarily rational policy shift." In an op-ed column in today's Baltimore Sun , "Drug War's Wrong Focus," Weiner and Pagonis contend, "This $5 billion investmen...

HIMSS Electronic Health Record Association Supports Achievable 'Meaningful Use' Criteria in Comments to ONC

..." said Mark Segal, PhD (GE Healthcare), EHR Association Vice Chairman. "We believe that 2011 'meaningful use' criteria should reflect an incremental, rational approach to achieving full CPOE over time." "Quality reporting is another area that requires consideration," Barnes went on to say. "Much go...

Your Surroundings Mirror Your Beliefs

... at Irvine, said the study "confirms a lot of previous scientific work -- and conforms nicely to most people's intuitions." Ditto said, "We are not rational information processors -- or information seekers. We perceive ourselves as seekers of the truth. We don't try to just seek out information that will c...

Damon Runyon Cancer Research Foundation awards $2.7M to 7 top young clinical investigators

...anscription factor IRF4 in T-cell lymphomas (TCLs), aggressive cancers that are fatal in the majority of patients. He proposes that IRF4 represents a rational therapeutic target for TCLs and aims to develop new strategies to block IRF4 in lymphoma cells. Novel targeted therapies for TCL could greatly improv...

The Time To Rethink Male Circumcision Is Now, Group Says In Launching www.intactamerica.org

...e their births, were pressured by Illinois doctors to perform a circumcision if they had a son. "My wife and I did our research and could find no rational or persuasive argument to subject a baby to surgery that had no medical benefit," said Pisani. "No doctor could substantiate the medical necessity to ...

Intact America Launches Campaign to Change How America Thinks About Male Circumcision

...e their births, were pressured by Illinois doctors to perform a circumcision if they had a son. "My wife and I did our research and could find no rational or persuasive argument to subject a baby to surgery that had no medical benefit," said Pisani. "No doctor could substantiate the medical necessity to ...

When young men are scarce, they're more likely to play the field than to propose

...er young men than women would naturally lead to proportionately more young men getting married, but that's not the case. "Marriage patterns aren't rational because men and women have somewhat different reproductive strategies," Kruger said. "Men have a greater reproductive benefit than women from having a...

Key Stakeholders Convene Capitol Hill Symposium To Advance Convergence of Behavioral Economics and Healthcare

...ve Consumerism has led to practical programs that are driving significant results for plan sponsors." Classical economics assumes that people are rational and act in their own self interest; behavioral economics looks at the real world, focusing not on how people ought to act but instead on how they do a...
Rational in Medical Technology

Unlikely Treatment Identified by BrainCells Neurogenesis Platform Improved Clinical Outcomes in Patients Suffering From Depression

... BrainCells Inc. "The platform was able to identify the pathway, ratio of drug and dosing that shaped the clinical trial protocol, directing the first rational approach to drug development in the area of psychiatry." The double blind, placebo-controlled, randomized study evaluated the efficacy of BCI-9...

Pixantrone in Combination with Chemotherapy Regimens Produces Overall Response Rates of 58-74% with Complete Remission Rates of 37-57% in Relapsed/Refractory Aggressive or Indolent NHL

...UK. The review focuses on the impressive preclinical anti-tumor activity demonstrated in hematologic cancers over standard anthracyclines and the rational design modifications to the chemical compound believed to be responsible for enhanced DNA damage and binding to topoisomerase II enzyme, a key target ...

Induction Chemotherapy Followed by ChemoRadiotherapy Increased Time-to-Treatment Failure Compared to ChemoRadiotherapy Alone in Patients With Unresectable Locally Advanced Head & Neck Cancer

...RT vs. 1% for CRT). Other adverse events included neutropenia and asthenia. "These study results illustrate that this complex disease deserves a rational and comprehensive management strategy to overcome its pathologic mechanism and the inherent possibility of failure of clinical control, " said Prof....

Genes Identified That Enhance Tumor Cell Sensitivity to CTI's Cancer Drug Brostallicin

...gets were tested for synergistic activity in combination with brostallicin. The outcome of this validation work has identified important contexts and rational drug combinations that will be critical for the clinical development of brostallicin. To review the poster and see more detailed information abou...

SYNTAX Analysis Finds Treatment With TAXUS(R) Express2(TM) Stents More Cost Effective Than Bypass Surgery in Many Patients With Complex Coronary Artery Disease

... Officer of Boston Scientific. "Today's finding that PCI was more cost effective than CABG at one year in these same patient groups supports PCI as a rational alternative treatment option for these patients." SYNTAX is the first randomized, controlled clinical trial to compare PCI using the TAXUS(R) Exp...

Semafore Achieves a Preclinical Milestone with SF2626, a PI3K-MEK Dual Pathway Kinase Inhibitor

...of cancer biology and further understanding of the mechanisms of drug resistance Semafore's CRIMP platform technology offers a distinctive approach to rational drug design for combination pathway kinase inhibitors. Semafore's dual PI3K-MEK kinase inhibitor, SF2626, is a promising lead for targeting can...

Avineuro Pharmaceuticals, Inc. Announces Beginning of Phase I Clinical Studies of AVN-211, Potent Small Molecule for Treatment of Schizophrenia.

...maceuticals, Inc.: Avineuro discovers and develops novel small molecules for unmet medical needs in neurology and psychiatry. Avineuro emphasizes a rational approach to drug discovery that combines modern medicinal chemistry with streamlined pre-clinical and clinical development studies, thus allowing a fa...

Synvista Therapeutics Announces First Dosing of SYI-2074 in Clinical Trial for Psoriasis

...rial and look forward to reporting results in the first quarter of 2009." About SYI-2074 Synvista's GPx mimetic program is based on the rational design of oral and topical drugs that mimic the activity of glutathione peroxidase (GPx), the only enzyme in the human body that reduces oxidized lipi...

Anavex presents neuroprotective effects of Anavex 1-41 at the International Conference on Alzheimer's Disease 2008

...ncer and neurological diseases such as Alzheimer's, epilepsy and depression. The company's proprietary SIGMACEPTOR(TM) Discovery Platform involves the rational design of drug compounds that fulfill specific criteria based on unmet market needs and new scientific advances. Selected drug candidates demonstrate ...

New Study: Pine Bark Significantly Reduces Menstrual Pain

... it is patent protected for this application. Additional studies reveal Pycnogenol(R) is a natural anti-inflammatory, which provides the basis for the rational to use Pycnogenol(R) to naturally moderate inflammatory pain sensation involved in menstruation. A study published last year in the Journal of Reprodu...
Rational in Medical Products

PhotoLight/Photosilk-

Description:... PhotoLight is an exceptional condensate of technology streamlined into compact, functional dimensions for ensuring a rational and immediate approach to a constantly evolving professional market. PhotoLight is ideal for those working in different studios who require greater pr...
Company:DEKA Research & Development Corp.
Rational in Biological News

Ants more rational than humans

In a study released online on July 22 in the journal Proceedings of the Royal Society: Biological Sciences , researchers at Arizona State University and Princeton University show that ants can accomplish a task more rationally than our multimodal, egg-headed, tool-using, bipedal, opposing-thumbe...

22nd Congress of the European College of Neuropsychopharmacology, Sept. 12-16, 2009, Turkey

...S) and their use in treating disorders such as anxiety, mania, depression, schizophrenia, dementia or neurological and addictive disorders in the most rational and empirical manner. Neuropsychopharmacological research provides data that are required to develop drugs, which act on specific receptors within...

Our 'caveman logic' embraces ESP over evolution

...rtion of our meal for $37,000 on eBay. We believe in ESP, ghosts, and angels over the scientific theory of evolution. While science offers a wealth of rational explanations for natural phenomena, we often prefer to embrace the fantasies that reassured our distant ancestors. And we'll even go to war to protect...

An easy way to find a needle in a haystack by removing the haystack

.... The researchers succeeded with the help of physical and organic chemistry, based on the BrnstedLowry acid-base theory, and formulated conditions for rational selection of matrices that did not generate interfering ions but provided rich mass spectra of particular kinds of metabolites in real samples. Wi...

International team tracks clues to HIV

... "This is interesting because we're tackling an important problem in a very rational way." The groups reported their findings in a paper published on the Ame...he good ones is "the least time-consuming low-cost procedure for efficient, rational drug design," the team wrote. "A long time ago, people noticed that C-60...

How an enzyme tells stem cells which way to divide

... not just stem cells. "It's a basic-research question. How does this polarity occur? In order to develop stem cell-specific therapeutics based on a rational methodology you have to understand the mechanism," he said. If Miranda is improperly isolated into other regions by aPKC, the stem cell divides sym...

Rumbaugh's theory links positions of Wilson, Skinner

... Scientist Emeritus Dr. Duane Rumbaugh's theory of rational behaviorism and emergents as a bridge between two ...class of behaviors called emergents. "Rumbaugh's rational behaviorism can connect the (operant) behavioral b... has been one long and elegant argument supporting rational behaviorism and its essential concept of emergents...

Joint statement by German science organizations on green genetic engineering

... the risks of green genetic engineering versus classical plant breeding methods. The ban poses the danger that unfounded fear could take the place of rational scientific information. The minister's comment that the ban is an isolated decision on a particular case cannot compensate for the negative impact it ...

NIH funds development of resistance-breaking insecticides to reduce malaria transmission

...ymes in native form, is responsible for expressing, purifying, and crystallizing various Anopheles gambiae acetylcholinesterases. Totrov, an expert in rational computer-aided drug design methods and in the biophysics of protein-ligand interactions, has worked with Carlier and Bloomquist on the FNIH award sinc...

New technique used to profile anthrax genome

...ne another," said Bergman. Combining the structure and abundance information for every gene in a bacterial genome allows researchers to take a more rational approach to tasks like antibiotic discovery and microbial engineering, Bergman noted. "Sequencing-based transcriptome profiling has several huge ...
Rational in Biological Technology

CEL-SCI Corporation Releases Letter to Shareholders

...hese critical needs. In developing these vaccines, we recognize, as WHO's Director General said in Cancun, "We have the advantages of science, and of rational and rigorous investigation, on our side." We are going to continue leveraging these assets as we try to tackle this persisting and deeply-troubling p...

Frost & Sullivan Awards Precision Biosciences for Technology Innovation and Molecular Design Process in the Genomics Market

...chnology is an amalgamation of core enzyme catalysis, high-specificity DNA targeting, computational molecular simulations for structural modeling, and rational mutagenesis to design a set of extremely specific 'molecular scissors' for the precise engineering of large genomes." The DNE technology is so sp...

Pulmo BioTech Inc. Announces Paper to be Presented at Symposium

...diolabeled Adrenomedullin Analogs Designed for Molecular Imaging of the Pulmonary Circulation", will be part of the session "From a Peptide to a Drug: rational Drug Design". This multidisciplinary and highly prestigious symposium aims to bring together outstanding scientists from around the world to disc...

Keryx Biopharmaceuticals Presents Encouraging Preclinical Data at Annual Meeting of the American Association of Cancer Research

... an important role in mammary stem cell self-renewal and that targeting of cancer stem cells through inhibition of this signaling pathway represents a rational therapeutic strategy. Abstract 4576: Potent antitumor effects of nab-rapamycin (ABI-009) in combination with kinase inhibitors Erlotinib and ...

New Brain Fitness Survey Reinforces Importance of Brain Awareness Week

...tunity is immense - but we will need to ensure the marketplace matures in a rational and sustainable manner, helping consumers and professionals separate hope f...her), and suggest actions to solve them and help the field mature in a more rational and structured manner. Everyone: Have a great Brain Awareness Week! ...

Biotechnology Value Fund Urges Stockholders to Remove and Replace Current Board of Avigen, Inc. in an Effort to Protect and Maximize Stockholder Value

... stockholder's investment in Avigen, as well as to take advantage of opportunities that exist to maximize stockholder value. Without Any Evident rational Motive, Avigen Has Not Aggressively Pursued The COMPELLING Merger Proposal By MediciNova That Offered BOTH Downside Protection AND Significant Upside ...

Opportunities and challenges in uncertainty quantification for complex interacting systems

...ectures and break-out sessions and will culminate in a report that summarizes participants perspective on challenges and opportunities in developing a rational path forward for Uncertainty Quantification and Model Validation in the context of complex interacting systems. The Workshop will be chaired by Rog...

Jubilant and BioLeap Announce New Partnership in Drug Discovery

...ovides a viable solution to this current paradigm. The combined strengths of JBL/BioLeap partnership would be most attractive to companies engaged in rational drug design in therapeutic areas where Structural Biology plays a key role, which includes but is not limited to any of the top twenty pharmaceutical ...

YM BIOSCIENCES RECEIVES CLEARANCE TO INITIATE RANDOMIZED DOUBLE-BLIND CLINICAL TRIALS OF NIMOTUZUMAB IN LUNG CANCER AND BRAIN METASTASES FROM LUNG CANCER

...treatments," said Dr. Leonardo Viana Nicacio, Director of Clinical Affairs for YM BioSciences. "Nimotuzumab combined with palliative radiotherapy is a rational step towards a better treatment regimen that is safe and has the prospect of improving survival in this population that has typically exhausted all ot...

Elsevier Introduces The American Journal of Medicine Blog

...ing opportunities offered by the web. Therefore we have launched the AJM blog. We welcome opinion, relevant statistics, quotations from other sources, rational and thoughtful commentary and academic debate. Our expectation is that the Journal's blog will spark informative - perhaps even spirited - discussions...
Rational in Biological Definition

Brain

... held that the brain was a cooling mechanism for the blood , while the heart was the seat of intelligence. Aristotle reasoned that humans are more rational than the beasts because they have a proportionally larger brain to cool their hot-bloodedness (Bear, 2001). During the Roman Empire , the anatomis...

Human

...d "person". The former refers to the species, while the latter refers to a rational agent : see, for example, John Locke 's Essay concerning Human Understand...ter and can solve human problems, and that science , freedom of speech , rational thought , democracy , and freedom in the arts are worthy pursuits or goals...
Rational in Biological Dictionary

Substitution

...ge referring to a ... In the case of template substitution the template call is replaced by the ... ... example of formal model with bounded rational consumers facing substitutes ... Substitution is perfect, according to neoclassical approach, since the ration of ... Shop for Substitution ...

Scientific method

...sentations. Show ... Understanding and using the scientific method for your science fair project ... The Scientific Method is a logical and rational order of steps by which ... Kids.Net.Au is a search engine / portal for kids, children, parents, and teachers. ... 1 A summary description of the...
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