Yale Scientists Find MicroRNA Regulates Ras Cancer Gene
Research in the laboratory of Assistant Professor Frank J. Slack at Yale University has identified a new way that a familiar gene is regulated in lung cancer, presenting new possibilities for diagnosis and treatment. The work is reported in March issues of the journals Cell and Developmental Cell. The oncogene Ras is out of control in about 20 percent of cancers where it is over-expressed...Introduced foxes transformed vegetation on Aleutian Islands from lush grasslands to tundra
Huge colonies of seabirds accustomed to nesting on islands free of predators began disappearing when fur traders started introducing foxes onto islands in the Aleutian archipelago in the 18th century. The ground-nesting birds made easy meals for the foxes. A study published this week in the journal Science now shows that the effects of the introduced foxes rippled through entire island ecosystems...Scientists reveal molecular secrets of the malaria parasite
In an innovative project with implicationsfor malaria vaccine development, scientists have used genomics,proteomics and gene expression studies to trace how malaria parasitesevolve on a molecular level as they move between their hosts and insectvectors.That focus on the parasites' complex life cycle is helping researchersunderstand when different genes switch on and off as the pathogensmet...New RNA polymerase discovered in plants
Biologists at Washington University in St. Louis have discovered an entirely new cellular "machine" in plants that plays a significant role in plant flowering and DNA methylation, a key chemical process essential for an organism's development. A team headed by Craig Pikaard, Ph, D., Washington University professor of biology in Arts & Sciences, has discovered a fourth kind of RNA poly...In the migratory marathon, parasitized monarchs drop out early
A little-stud...Glutathione-S-Transferase (GST) Colorimetric Assay Kit from Sigma-Aldrich
Description:Biochem/physiol Actions: Glutathione-S-transferases (GSTs) are a group of enzymes important in the detoxification of many xenobiotics in mammals. The enzymes protect cells against toxicants by conjugating the thiol group of the glutathione to electrophilic xenobiotics, and thereby defend cells against the mutagenic, carcinogenic, and toxic effects of the compounds. GST activity is presen...Baker's yeast (S. cerevisiae) Phosphoglucose isomerase from Sigma-Aldrich
Description:Physical form: Essentially sulfate-free, powder containing carbohydrate and citrate buffer salts Chem comp: Protein ~ 50% (modified Warburg-Christian)...pMIR-mU6-Luc, Mouse U6 Luciferase Control Vector from Mirus Bio Corporation
Description:The potential applications for the use of small interfering RNA (siRNA) molecules to silence gene expression via the RNA interference (RNAi) pathway have generated tremendous interest in the cellular and molecular biology fields. siRNA for experimental use can be synthesized in vitro, either chemically or enzymatically, and then transfected into the target cells in vitro or in vivo. A convenient...Novel PCR Enhancing Factor Improves Performance of Pfu DNA Polymerase
pfuturbo DNA polymerase for robust, high-fidelity PCRamplification Holly Hogrefe Brad Scott Kirk Nielson ValerieHedden Connie Hansen Janice Cline Frances Bai Jeff Amberg RondaAllen Mark Madden Stratagene an improved version of Pf...Pfu DNA Polymerase as a Hot Start Alternative
Stratagene Cloning Systems, Inc. This article describes the important, novel application of Stratagenes PfuDNA polymerase for minimizing PCR cold start mismatched primer-extensionreactions. These mismatched extension rea...PCR Performance Comparisons Between pfuturbo and Taq DNA Polymerases
pfuturbo DNA polymerase is the superior choice for robusthigh-fidelity PCR amplification Stratagene In this update, we compare the PCR performances of pfuturbo DNApolymerase * ,</...pfuturbo DNA Polymerase: A High-Performance, High-Fidelity Enzyme Ideal for PCR Cloning
A High-Performance, High-Fidelity Enzyme Ideal for PCR Cloning Stratagene was cloned into the PC...Stable HeLa Luciferase Reporter Cell Lines Expressing GAL4 Fusion Transactivators
Lisa Hexdall Li Xu Alan Greener Mary Buchanan John Bauer Chao-Feng Zheng Stratagene HLR-CREB, HLR-Elk1, and HLR-cJun, cell lines for...Feeding channel created by malaria parasite - a new target for malaria treatments
Researchers have found pore-like holes in the membranes of red blood cells infected by the deadliest form of the malaria parasite. The parasite, Plasmodium falciparum, apparently uses these holes to supply itself with the nutrients it needs to grow and reproduce. The discovery may lead to the development of new treatments for malaria, a widespread and devastating disease. Mala...Right drugs drastically cut stroke risk
In the biggest breakthrough, the incidence of the disease was found to have been cut to half by a combination of drugs that keeps blood pressure in check. The study involving about 6,000 patients over six years in many countries showed that strokes were cut by at least a quarter among patients given the drugs. // The drugs are inexpensive and easily available. Use of the drugs cut b...Telomerase Vital In Maintaining Ability of Stem Cell to Multiply
Carol Greider, Ph.D., director and professor of molecular biology and genetics in the Johns Hopkins Institute of Basic Biomedical Sciences and colleagues have found that the length of telomeres is important// in ensuring that stem cells are able to divide indefinitely. Telomeres are the ends of the chromosomes that protect genetic information while the chromosome is undergoing division....Raspberries Are Richer In Anti-Oxidants Than Tomatoes Or Broccoli
Raspberries are said to possess ten times more anti-oxidants than in any other products like tomatoes or broccoli, according to Dutch researchers.// According to foodconsumer.org, researchers from Plant Research International in Wageningen, the Netherlands, said flash freezing raspberries in liquid nitrogen and storing them at minus 20 degrees Celsius destroys much of the vitamin C, but...Parasite infections linked to organ transplants
Three transplant patients contracted a dangerous parasitic disease from their new organs in the United States.Two of the three women died, but only one recovered after antibiotic treatment.// A second study also released by the Centers for Disease Control and Prevention turned up 26 bacterial infections traced to tissue grafts that had come from cadavers in the United States. This show...Compact Ultrasonic Phacoemulsification System
Description:Compact ultrasonic phacoemulsification system....Positive Aggrastat Results Featured in the Journal of the American College of Cardiology
WINNIPEG, Manitoba - (July 11, 2007) Medicure Inc. (TSX:MPH;Amex:MCU), a cardiovascular focused, biopharmaceutical company,today announced that the two-year, follow-up results from theSTRATEGY (Single High-Dose Bolus Tirofiban and Sirolimus-ElutingStent Versus Abciximab and Bare Metal Stent In Acute MyocardialInfarct...Skin Rash Actually Signifies Better Outcomes for Pancreatic and Lung Cancer Patients
PHILADELPHIA, July 3, 2007-- – The appearance of arash in cancer patients treated with erlotinib (Tarceva) isstrongly associated with longer survival, according to researchersfrom the drug’s developer, OSI Pharmaceuticals, Inc. This isnot the first time that rash has been associated with a survivaladvantage with EGFR inhibitors – a class of drugs whichincludes erlotinib...Ultrasound-enhanced systemic thrombolysis
) to treat stroke-causing blood clots. It is thought that transcrania...