Finding key to cancer drug Gleevec's limitations

.... She and her team are currently testing several two-drug combinations using their mouse model. Imatinib is being combined either with interferon, rapamycin (also known as sirolimus), arsenic or GM-CSF (marketed as Neupogen). They hope to find combinations that will make the initiating cells more vulnerabl...

Teaming Up to Tackle a Deadly Cancer

...the involvement of the so-called mTOR genetic pathway in chordomas. The findings led to a study in Italy treating chordoma patients with a drug called rapamycin that is active in the mTOR pathway. Results published on July 1 in the Annals of Oncology demonstrated that patients benefited significantly from th...

'Easter Island' Drug Adds Years to Mice

... too. Middle-age mice that were given the drug rapamycin (Sirolimus) lived as much as 38 percent longer tha...o well while taking the drug, but it is unclear if rapamycin would have a similar effect in humans. Also, the d...easible option for many humans who like to eat. rapamycin is a compound discovered in the soil on Easter Isl...

Study pinpoints novel cancer gene and biomarker

...ulnerable to rapamycin, just as excess GOLPH3 can. rapamycin is known to interfere with a protein called TOR, w...hat knocking down GOLPH3 reduced cell size just as rapamycin did. They followed those experiments with biochemi...levels cause tumor cells to be more susceptible to rapamycin in animal studies. They took two sets of human mel...

Transplant drug stimulates immune memory

...In experiments conducted in both mice and monkeys, rapamycin can stimulate the formation of memory CD8 T cells,...d chair of the Department of Surgery, to show that rapamycin had similar effects in rhesus macaques infected wi...apa Nui. Transplant patients usually don't take rapamycin by itself, so rapamycin's paradoxical effects may ...

Grapefruit Juice Boosts Anti-Cancer Drug's Effects

...l study finds 8-ounce glass enhances absorption of rapamycin 3 to 4 times MONDAY, April 20 (Health...y tumors to grow. However, less than 15 percent of rapamycin is absorbed by the body when the drug is taken by ...led furanocoumarins that decrease the breakdown of rapamycin and increase blood levels of the drug three- to fo...

Grapefruit juice boosts drug's anti-cancer effects

...ing eight ounces of grapefruit juice with the drug rapamycin can increase drug levels, allowing lower doses of ...e ( Citius paradisi ), taken immediately after the rapamycin and then once a day for the rest of the week. T...clinical trials. The most appealing to her was the rapamycin plus grapefruit juice study. She took her first do...

Mayo Clinic researchers formulate treatment combination lethal to pancreatic cancer cells

...Mayo Clinic Cancer Center investigators found that rapamycin and panobinostat (also known as LBH589) act synerg... therapy for cutaneous T cell lymphoma (CTCL), and rapamycin is best known as an immunosuppressant to help prev...or how these agents together are so powerful. rapamycin and a closely related drug, everolimus (RAD001), h...

Science Makes Inroads Against Prostate, Other Cancers

...ycin. When used together, the two drugs appeared to provide more anti-cancer punch than they would have singly, the team said. While treatment with rapamycin alone only resulted in a tumor cell death rate of about 10 percent, the two drugs in combination elicited a 60 percent to 70 percent death rate. Any ...

TB breakthrough could lead to stronger vaccine

...eletion of the fpbA gene has similar effects." rapamycin is a drug used to fight cancer and inflammation. I...nter at the UT Medical School was first to conduct rapamycin clinical trials. The UT group led by Barry D. Kaha..., M.D., Ph.D., now professor emeritus, showed that rapamycin significantly reduces the frequency of acute kidne...

Rapamycin in Medical Technology

Afinitor(R) Phase II Data Show Positive Results for Patients With Multiple Types of Lymphoma, Leading to Phase III Trial

... in the US. Afinitor important safety information Afinitor is contraindicated in patients with hypersensitivity to everolimus, to other rapamycin derivatives or to any of the excipients. Potentially serious adverse reactions include non-infectious pneumonitis and infections for which patients sh...

Video: Data on More Than 15 Novartis Oncology Compounds at ASCO Highlight Progress Toward Targeted Therapies for Diverse Tumor Types

...arcinoma after failure of treatment with sunitinib or sorafenib. Afinitor is contraindicated in patients with hypersensitivity to everolimus, to other rapamycin derivatives or to any of the excipients. Potentially serious adverse reactions include non-infectious pneumonitis and infections for which patients sh...

Paloma Pharmaceuticals Presents at the Association for Research in Vision and Ophthalmology 2009 Meeting

...without toxicity to normal tissues since loss of TORC2 in genetically altered mice does not appear to affect normal tissue. TORC1 antagonists such as rapamycin (Sirolimus) have shown activity in both animal models of ocular disease and in human clinical trials. The inhibition of both TORC1 and TORC2 should r...

Video: Afinitor(R) Approved in US as First Treatment for Patients With Advanced Kidney Cancer After Failure of Either Sunitinib or Sorafenib

...e website for Afinitor. Important safety information Afinitor is contraindicated in patients with hypersensitivity to everolimus, to other rapamycin derivatives or to any of the excipients. Potentially serious adverse reactions include non-infectious pneumonitis and infections for which patients sh...

SuperGen's PIM Kinase Inhibitor, SGI-1776, Effective in Pre-Clinical Models of Acute Lymphoblastic Leukemia

...y of Pennsylvania demonstrated that SGI-1776 inhibited human ALL cell lines in a dose-dependent manner. Furthermore, SGI-1776 and the m-tor inhibitor rapamycin acted synergistically to inhibit ALL cell proliferation. In a clinically relevant in vivo model, NOD/SCID mice xenografted with human primary ALL cell...

Semafore's PI3 Kinase Inhibitor SF1126 is a Vascular Targeted Conjugate in Phase I Clinical Trials in Solid Tumors and Multiple Myeloma

...cinoma mouse model. The combination of SF1126 (20 mg/kg i.v., 3x/week) with rapamycin (1.5 mg/kg i.p., 3x/week) administered simultaneously showed a 54 percent r...utive Officer. "The combination of SF1126, our lead product candidate, with rapamycin exhibited synergistic anticancer effects, and this increased effect was opt...

Immunosuppressant Drug Prevents Tobacco Induced Lung Cancer in Mice

... of Health, found that mice that were administered rapamycin one week after exposure to a very common tobacco-s...after NNK administration. The group that was given rapamycin at week one was used to test the drug as a prevent...r-day administration. Importantly, the levels of rapamycin achieved in mice were comparable to those in human...

Abraxis BioScience Presents Results from Pre-Clinical Study That Demonstrates nab-Rapamycin's Robust Antitumor Properties and Ability to Target Intracellular Sites Such as the mTOR Pathway

... (Abstract #4719; Nanoparticle Albumin-bound (nab) rapamycin as an Anticancer Agent). Leveraging Nab Technology with rapamycin to Target mTOR Pathway The mammalian target of rapamycin (mTOR) is a cell-signaling protein that regulates ...

Velcade (bortezomib) for Injection Survival Data in Front-Line Multiple Myeloma Patients to be Featured at 11th International Myeloma Workshop

...Farber Cancer Institute * Abstract #608; Poster session: Thursday 28th June, 4:30 p.m. -- Combination of the mTOR-Inhibitor rapamycin and Proteasome Inhibitor VELCADE is Synergistic In Vitro in Multiple Myeloma * Lead investigator: Xavier Leleu, M.D., Centre Hospita...

Rapamycin in Biological News

Rutgers research tackles childhood epilepsy

...eady shown promise in a different mouse model for treating tuberous sclerosis complex (TSC), a subtype of cortical dysplasia. "We demonstrated that rapamycin is a novel and effective anti-epileptic agent that suppresses seizures in our mice, as well as in the TSC model, and this has raised some hope for the...

ASBMB Annual Meeting to feature talks on the biochemistry of aging

...a fruit fly model to study the genes and environmental factors responsible for mediating HFD induced obesity. They found that inhibiting the Target of rapamycin (TOR) pathway, involved in nutrient sensing, can block the detrimental effects of a HFD. They also found that reducing the levels of TOR can mimic a c...

Calculating gene and protein connections in a Parkinson's disease model

...wo pathways could affect alpha-synuclein toxicity, researchers added either rapamycin or the statin lovastatin to yeast model cultures. When the researchers added a low dose of rapamycin to the yeast model, the drug was toxic to the yeast. When lovastatin was ad...

A link between mitochondria and tumor formation in stem cells

...e, but these results may have at least uncovered the mechanism behind it. In fact, when Finkel and colleagues administered the mitochondrial inhibitor rapamycin to high metabolism stem cells, their teratoma capacity decreased significantly. While this work was done with mouse cells, the researchers believe ...

Rare genetic disorder gives clues to autism, epilepsy, mental retardation

...eeing an exuberance of connections." In laboratory experiments, the researchers were able to limit multiple axon formation by using the cancer drug rapamycin to suppress production of a protein called SAD-A kinase. This protein is produced in excess when the TSC1 and TSC2 genes are inactivated, and is found...

Drug reverses mental retardation caused by genetic disorder

...ght tissue rejection following organ transplants. rapamycin is well-known for targeting an enzyme involved in ...is is the first study to demonstrate that the drug rapamycin can repair learning deficits related to a genetic ...quickly as the healthy mice," said Ehninger. "The rapamycin corrected the biochemistry, reversed the learning ...

Distinguishing friend from foe in the battle against cancer

...shows that resistance to the chemotherapeutic drug rapamycin is mediated by the survival factor NF-kB. Rapam...o explained a paradox: TSC null cells treated with rapamycin actually survived cellular insult better than untr...cancer cells. The Hunter and Verma team found that rapamycin did that by increasing NF-kB activity in the TSC n...

Targeted virus compels cancer cells to eat themselves

...riptase promoter regulated adenovirus) infected the glioma cells and induced autophagy by inactivating a molecular pathway -- the mammalian target of rapamycin (mTOR) pathway -- that is known to prevent cellular self-cannibalization. The result was a huge difference in tumor volume among mice with subcu...

Scientists use gene signatures to match cancer and other diseases with potentially effective drugs

...ssistant professor of pediatrics at Harvard Medical School. "Then we tested rapamycin to see if it made the ALL cells more sensitive to glucocorticoids, and in s...hat it does," he said, adding that a clinical trial is being planned to try rapamycin in children who have had recurrences of initially successfully treated ALL....

New study shows antibiotic may protect the heart

...at pretreatment with a clinically relevant dose of rapamycin induces a protective effect against heart attack i... of the mitochondrial KATP channel of heart cells, rapamycin enables cells to maintain ATP levels. Mitochondria...gy at VCU. Kukreja is lead author of the study. rapamycin blocks protein synthesis by inhibiting the mammali...

Rapamycin in Biological Technology

Trubion Announces Acceptance of Three Presentations on Its TRU-016 Product Candidate at the 2009 ASCO Annual Meeting

...s on cell lines in vitro and on tumors in vivo. Combination index analyses revealed that TRU-016 is synergistic with rituximab, bendamustine, or rapamycin and additive with doxorubicin in killing NHL cells in vitro. In vivo results show that treatment with the combination of TRU-016 and bendamustine resu...

Keryx Biopharmaceuticals Presents Encouraging Preclinical Data at Annual Meeting of the American Association of Cancer Research

...firmed results by Cirstea et al. that dual inhibition of the Akt pathway by rapamycin (ABI-009) and Perifosine induces synergistic anti-tumor activity in multipl.... The synergy of these combinations confirms Investigators' hypothesis that rapamycin is active only on mTORC1 and inhibition of mTORC2 by either Erlotinib or Pe...

Preclinical Data From Amgen's Oncology Pipeline to be Presented at AACR

...in sarcoma cell lines Overview: Evaluated whether AMG 479 could inhibit this feedback-loop mechanism and thus increase the efficacy of rapamycin and its analogs (mTOR inhibitors). Lead author: Beltran P. Abstract No. 2805 (Monday, April 20, 2009, 1:00 pm - 5:00 pm) ...

Oncolytics Biotech(R) Inc. Collaborators Present Reovirus Research at Replicating Oncolytic Virus Meeting

...on entitled "Combination of Oncolytic Reovirus and rapamycin in a B16.F10 Mouse Melanoma Model." In this study,...estigators concluded that in vitro synergy between rapamycin and reovirus is only seen when rapamycin is administered after reovirus, and that simultane...

Large-scale genetic study sheds new light on lung cancer

...rs had mutations affecting the mammalian target of rapamycin (mTOR) pathway raises the possibility that the drug rapamycin might be tested in lung adenocarcinoma. rapamycin is an mTOR-inhibiting compound approved for use in...

Bayer and Onyx Announce Nexavar Data Presentations at 44th American Society of Clinical Oncology Annual Meeting

...r 20, abstract #8039, poster discussion, Monday, June 2, 2008, 12 - 1 p.m., W375d Solid Tumors -- A drug interaction study of sorafenib and rapamycin in patients with advanced malignancies -- Tara Gangadhar, MD, fellow, University of Chicago, Chicago, IL -- Poster 10A, abstract #2545, po...

CV Therapeutics and Medlogics Device Corporation Sign Licensing Agreement for CVT's Innovative Stent Coating Technology

...all metal mesh devices which can be inserted into clogged blood vessels to reopen them. Commercially available stents with drugs such as paclitaxel or rapamycin in the coating have been shown to reduce the frequency of restenosis, which is the reclosure of the vessel after the stent has been implanted. Based o...

Rapamycin Optimized in 100 Liter Fermentor Using BioCommand Control Strategys

... culture environment for rapamycin production. Harvested dry cell weight recovered from the 100 liter fermentor was over 25 grams/L; intracellular rapamycin production was over 110 milligrams/L; and fermentation time was reduced by almost a day to 120 hours. Introd...

Rapamycin in Biological Products

Rabbit Anti-mTOR Monoclonal Antibody,, Clone ZMD.414 from Invitrogen

Description:... Clone/PAD: ZMD.414. Immunogen: Synthetic peptide derived from an internal region of human mouse and rat mTOR (Mammalian target of rapamycin FRAP RAFT1 RAPT1). Specificity: Specific for the human mTOR protein. On Western blots it identifies the target band at ~235 kDa. Reactivity: Human ...
Company:Invitrogen