SuperGen Reports 2008 Fourth Quarter and Year-End Financial Results

... the single-dose pharmacokinetics of oral MP-470 capsules. Abstract 480: MP-470, a novel multi-targeted tyrosine kinase inhibitor targeting rad51 is not toxic to human primary marrow stem cells at clinically relevant concentrations. Abstract 571: Modulation of JAK2 signaling pathways ...

Rad51 in Medical Technology

Data Show SuperGen's Multi-Targeted Tyrosine Kinase Inhibitor Suppresses Critical Double-Stranded DNA Repair Protein, Rad51

Other Presentations at AACR Highlight Progress in SuperGen's Oncology-Focused Pre-Clinical Pipeline LOS ANGELES, April 19, 2007 /PRNewswire-FirstCall/ -- SuperGen Inc. today announced that MP470, its multi-targeted tyrosine kinase inhibitor, suppresses the Rad51 protein, a critical component of do...

Pharmacyclics announces Global Strategic Alliance with Les Laboratoires Servier

...tumors will often turn on DNA repair genes such as rad51 as an adaptive strategy to help the tumor repair t...re-clinical models, PCI-24781 was able to turn off rad51 (and other DNA repair genes), effectively blocking...C has patented the predictive use of the biomarker rad51 which was found by Pharmacyclics' scientists to po...

Data Show SuperGen's MP-470 is Safe in Humans

...ract No. 4083). Entitled, "MP-470, a potent oral rad51 suppressor is safe and tolerable in first-in-human...to 900 mg per day. Additionally, it was found that rad51 expression is modulated in a dose-dependent manner... of DNA double strand breaks. "This is the first rad51 suppressor that has advanced into Phase 1 clinical...

SuperGen to Highlight Oncology Pipeline Data in Multiple Presentations at the AACR Annual Meeting

... efficacy due to enhanced drug delivery and stability Tuesday, 8 a.m. - noon #4083 -- MP-470, a potent oral rad51 April 15 suppressor is safe and tolerable in first-in-human study Tuesday, 2:25 p.m. - ...

SuperGen Reports Initiation of Multi-arm Phase 1b Trial of Novel Tyrosine Kinase Inhibitor

...-targeted tyrosine kinase inhibitor that inhibits the mutant forms of c-KIT, PDGFR and FLT3, and suppresses c-MET and c-RET. MP470 also suppresses the rad51 protein, a critical component of double- stranded DNA repair in cancer cells. Preclinical testing of MP470 has identified anti-tumor activity against ...

Pharmacyclics Announces Presentations on Its Novel and Selective HDAC and Bruton's Tyrosine Kinase Inhibitor Compounds

...Session: DNA Repair and Chemotherapeutic Agent Resistance Poster Presentation: Novel histone deacetylase (HDAC) inhibitor PCI-24781 disrupts rad51 foci and inhibits homologous recombination Abstract #1966: 8:00 a.m. -12:00 p.m. Presenter: Shanthi Adimoolam, Ph.D., Pharmacyclics, Inc. ...

Pharmacyclics Identifies Functional Biomarkers for its Novel HDAC Inhibitor and Demonstrates Preclinical Anti-Tumor Activity with Bruton's Tyrosine Kinase Inhibitors

... recombination, a cellular mechanism of DNA repair, by both down-regulating rad51 gene expression, and by affecting the ability of the cell to form rad51 foci at the site of the lesion. The RAD51 gene provides instructions for ma...

Rad51 in Biological News

Human DNA repair process recorded in action

...are mobilized into action whenever it occurs. rad51 takes a leading role in the action. Always on call...y to watch the assembly of individual filaments of rad51 in real time, Kowalczykowski's team made a number ...that, in contrast to their bacterial counterparts, rad51 filaments don't grow indefinitely. This indicates ...

Modified gene targets cancer cells a thousand times more often than healthy cells

...ing very unexpected. "We stripped off some of the rad51 gene and replaced it with a marker protein DNA to see why rad51 was five times more abundant in cancer cells," say... we saw the cancer cells expressing the engineered rad51 around a thousand times more." When Gorbunova fir...

Human RecQ helicases, homologous recombination and genomic instability

...eagues demonstrate that another member of the human RecQ family, RECQL5, can also interfere with HR, by disrupting a particular step (formation of the rad51 presynaptic filament) in the pathway. Dr. Sung emphasizes that These results elucidate hoe RECQL5 proetin helps avoid deleterious chromosome rearrange...

Yale receives $8.4 million to study DNA repair in cancer cells

... DNA lesions. Glazer will lead a study of the cancer DNA repair genes, rad51 and BRCA1, in cancer cells. His goal is to devise strategies to render canc...r cells vulnerable to therapies that target interconnected repair pathways. rad51 creates a protein that performs DNA repair and BRCA1 is a tumor suppressor ...

Enhanced DNA-repair mechanism can cause breast cancer

...ng the amount of the DNA repair protein RAD51. rad51 is involved in homologous recombination, a method ...nsate for the BRCA1 defect in repair by ramping up rad51 levels are likely to be less genetically stable th...hey found that the level of RNA for three genes -- rad51 and two of its key accessory factors -- was signif...

Rad51 in Biological Technology

SuperGen Reports 2008 Third Quarter Financial Results

...he single-dose pharmacokinetics of oral MP-470 capsules. -- Abstract 480: MP-470, a novel multi-targeted tyrosine kinase inhibitor targeting rad51 is not toxic to human primary marrow stem cells at clinically relevant concentrations. -- Abstract 571: Modulation of JAK2 signaling pathways in...

SuperGen's MP-470 Demonstrates Clinical Tumor Regression When Combined with Standard of Care Chemotherapy

... food on the single-dose pharmacokinetics of oral MP-470 capsules Abstract 480: MP-470, a novel multi-targeted tyrosine kinase inhibitor targeting rad51 is not toxic to human primary marrow stem cells at clinically relevant concentrations Abstract 571: Modulation of JAK2 signaling pathways in vitro ...

SuperGen Reports 2008 Second Quarter Financial Results

...ulti-targeted tyrosine kinase inhibitor and rad51 suppressor, was shown to be bioavailable and ... presentation entitled, "MP-470, a potent oral rad51 suppressor is safe and tolerable in first-i...o 900 mg per day. Additionally, it was found that rad51 expression is modulated in a dose-dependent...

SuperGen Reports 2008 First Quarter Financial Results

...ulti-targeted tyrosine kinase inhibitor and rad51 suppressor, was shown to be bioavailable and safe ...esentation entitled, "MP-470, a potent oral rad51 suppressor is safe and tolerable in first-in-human...g per day. Additionally, it was found that rad51 expression is modulated in a dose-dependent manner...

Rad51 in Biological Products

Rabbit Anti-Human Rad51 Polyclonal Antibody, Unconjugated from Abcam

Description: Rabbit polyclonal to Rad51 ( Abpromise for all tested applications). Antigen: Synthetic peptide: VEEESFGPQPISRLE conjugated to KLH, corresponding to N terminal amino acids 15-29 of Human Rad51 Entrez Gene ID: 5888 Swiss Protein ID: Q06609...
Company:Abcam

Rad51 in Biological Dictionary

RecA protein

... and ATP binding ... RecA protein can assemble a nucleoprotein filament on ssDNA that accumulates as a ... The ubiquitous presence of RecA and rad51 protein homologs raises the question ... supported the notion that a RecA protein -like mechanism for DNA strand exchange ... The RecA pr...

Homologous recombination

... the core reaction ... Regulation of homologous recombination in mammalian cells ... Finally, homologous recombination contributes to ... rad51 supports spontaneous non- homologous recombination in mammalian cells, but ... The pathway of non- homologous recombination used in DNA double-s...

Heteroduplex

...rin-stable complexes formed with ... Heteroduplex with early melted sequences. ... ... Mer3 Helicase Stimulates 3′–5′ Heteroduplex Extension by rad51 ... Conversely, Mer3 helicase blocks DNA heteroduplex extension in the 5′ 3′ direction. ... ... exchange appeared to cause heteroduplex joint...