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Rac1 in Medical News

Exciting discovery could 'stop cancer from killing people'

...hat PLCγ1 is required for breast cancer cell invasion and activation of the protein Rac1. They revealed a functional link between PLCγ1 and rac1 that provides insight into processes regulating cell invasion. Professor Falasca explained: "Consistent with these data we detected an increase in...

Microenvironment a main driver of aggressive multi-lineage leukemia disease type

... said. Relatively little is known about the important molecular events that are downstream of the MLL fusion gene. Previous research indicates that rac1 a protein that helps regulate cell growth has increased activity in mice with AML expressing MLL-AF9. To test the importance of Rac1's downstream re...

JCI table of contents: Jan. 24, 2008

...o which it is converted, hydrogen peroxide, increased SOD1 dissociated from rac1 and Nox stopped making superoxide. However, mutant forms of SOD1 found in individuals with ALS never dissociated from rac1 and so Nox never stopped making superoxide. Treating mice that develop an A...

Surprise in Lab Helps ID Drug to Fight ALS

...s effective in people. The discovery of the interaction between SOD1 and rac1 may prove to have widespread importance. "It is exciting not only from t... but also because of its implications for understanding basic cell biology. rac1 is implicated in many cellular processes including cellular migration, prol...

Eliminating Influence of Hyperactive Genes That Help Regulate Cell Development Shows Potential as Additional Target Therapy for Chronic Myelogenous Leukemia

...ogenous leukemia (CML) in mice. When these genes, rac1 and Rac2, become hyperactive, they prompt a protei...e study, mice transplanted with normal functioning rac1 and Rac2 genes and expressing the BCR-ABL leukemia...n 40 days. In mice transplanted with BCR-ABL where rac1 and Rac2 hyperactivity was inhibited, 50 percent w...
Rac1 in Medical Dictionary

Macrophage

...ge responses observed were clearly due to P8 PGLC, as LPS ... WT L. pifanoi-infected macrophages at the same amastigote/ macrophage ratio. ... rac1 and Rac2 regulate macrophage morphology but are not essential for migration ... Effect of Rac deletion on macrophage migration ... ( L.) chaga...
Rac1 in Biological News

Study illuminates how the plague bacteria causes disease

...A domain, the "Rho-GTPase binding domain" along with the host protein, "Rac1," with which it interacts. "The Yersinia structure was doing things to rac1 that the host proteins normally do," Stebbins said, suggesting that the domain acted as a mimic. Further examination confirmed the domain to be a m...
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