Exciting discovery could 'stop cancer from killing people'
...hat PLCγ1 is required for breast cancer cell invasion and activation of the protein Rac1. They revealed a functional link between PLCγ1 and rac1
that provides insight into processes regulating cell invasion.
Professor Falasca explained: "Consistent with these data we detected an increase in...
Microenvironment a main driver of aggressive multi-lineage leukemia disease type
Relatively little is known about the important molecular events that are downstream of the MLL fusion gene. Previous research indicates that rac1
a protein that helps regulate cell growth has increased activity in mice with AML expressing MLL-AF9. To test the importance of Rac1's downstream re...
JCI table of contents: Jan. 24, 2008
...o which it is converted, hydrogen peroxide, increased SOD1 dissociated from rac1
and Nox stopped making superoxide. However, mutant forms of SOD1 found in individuals with ALS never dissociated from rac1
and so Nox never stopped making superoxide. Treating mice that develop an A...
Surprise in Lab Helps ID Drug to Fight ALS
...s effective in people.
The discovery of the interaction between SOD1 and rac1
may prove to have widespread importance.
"It is exciting not only from t... but also because of its implications for understanding basic cell biology. rac1
is implicated in many cellular processes including cellular migration, prol...
Eliminating Influence of Hyperactive Genes That Help Regulate Cell Development Shows Potential as Additional Target Therapy for Chronic Myelogenous Leukemia
(CML) in mice. When these genes, rac1
and Rac2, become hyperactive, they prompt a
protei...e study, mice transplanted with normal functioning rac1
genes and expressing the BCR-ABL leukemia...n 40 days. In mice
transplanted with BCR-ABL where rac1
and Rac2 hyperactivity was inhibited,
50 percent w...
...ge responses observed were clearly due to P8 PGLC, as LPS ... WT L. pifanoi-infected macrophages at the same amastigote/ macrophage ratio. ... rac1
and Rac2 regulate macrophage morphology but are not essential for migration ... Effect of Rac deletion on macrophage migration ... ( L.) chaga...
Study illuminates how the plague bacteria causes disease
...A domain, the "Rho-GTPase binding domain" along with the host protein, "Rac1," with which it interacts.
"The Yersinia structure was doing things to rac1
that the host proteins normally do," Stebbins said, suggesting that the domain acted as a mimic.
Further examination confirmed the domain to be a m...