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RTKs in Medical News

Study suggests brain tumors need treatment with multiple 'targeted' drugs

... also found similar patterns of multiply activated rtks in other common cancers of the pancreas and lung. ...M cells to find the sources of abnormal growth. rtks are located on the surface of both normal and canc...e cell to divide and grow. Signals received by the rtks are transmitted to the cell's nucleus via a pathwa...
RTKs in Biological News

GEN reports on novel tools for deciphering biological networks

...Assessments and Methods (DREAM)." A team at Harvard University is investigating signaling pathways for receptor tyrosine kinases (RTKs). Since many rtks are oncogenes, the group in trying to find out which pathways get turned on and to understand the impact of mutations in the RTKs. The scientists reas...
RTKs in Biological Technology

Ortho Biotech Oncology Research & Development Unites Johnson & Johnson Biopharmaceutical Oncology R&D Assets

... shown to be specifically important in regulation of cell migration and invasion, cell proliferation, survival and angiogenesis. Deregulation of c-Met rtks has been implicated in the development and progression of numerous human cancers. The c-Met RTK inhibitors prevent receptor activation and thus inhibi...

TKB1 Cells Identify Receptor Tyrosine Kinase Interacting Proteins

...s) are activated, a number of proteins within the cell are rapidly phosphorylated, with the predominate tyrosine-phosphorylated proteins being the rtks themselves. RTK tyrosine phosphorylation primarily functions to generate binding sites for cytoplasmic- or plasma membrane-associated proteins inv...
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