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RNase in Medical News

Enzyme with a sugar antenna

... sugar moieties can thus have different functions. rnase is an enzyme that occurs in various glycosylated f...it makes an interesting model system for research. rnase C contains a complex sugar component in the form o...de reactions. Unverzagt and his team thus built up rnase C sequentially from several fragments, connecting ...

Alfacell Announces Receipt of NASDAQ Panel Decision

...product candidate that works in a manner similar to RNA interference (RNAi) through late-stage clinical trials. The product candidate, ONCONASE, is an rnase that overcomes the challenges of targeting RNA for therapeutic purposes while enabling the development of a new class of targeted therapies for cancer...

Alfacell Announces Management Update

...product candidate that works in a manner similar to RNA interference (RNAi) through late-stage clinical trials. The product candidate, ONCONASE, is an rnase that overcomes the challenges of targeting RNA for therapeutic purposes while enabling the development of a new class of targeted therapies for cancer...

Alfacell Reports Financial Results for First Quarter of Fiscal 2009

...product candidate that works in a manner similar to RNA interference (RNAi) through late-stage clinical trials. The product candidate, ONCONASE, is an rnase that overcomes the challenges of targeting RNA for therapeutic purposes while enabling the development of a new class of targeted therapies for cancer...

Alfacell to Host Fiscal First Quarter 2008 Financial Results Conference Call and Webcast

...duct candidate that works in a manner similar to RNA interference (RNAi) through late-stage clinical trials. The product candidate, ONCONASE(R), is an rnase that overcomes the challenges of targeting RNA for therapeutic purposes while enabling the development of a new class of targeted therapies for cancer...
RNase in Medical Technology

Alfacell Provides Shareholder Update

...product candidate that works in a manner similar to RNA interference (RNAi) through late-stage clinical trials. The product candidate, ONCONASE, is an rnase that overcomes the challenges of targeting RNA for therapeutic purposes while enabling the development of a new class of targeted therapies for cancer...

Alfacell Provides ONCONASE(R) NDA Submission Update

...product candidate that works in a manner similar to RNA interference (RNAi) through late-stage clinical trials. The product candidate, ONCONASE, is an rnase that overcomes the challenges of targeting RNA for therapeutic purposes while enabling the development of a new class of targeted therapies for cancer...

Paper in Molecular Cancer Therapeutics Reports that a Novel Combination of Alfacell's ONCONASE(R) and Rosiglitazone Induces a Synergistic Apoptotic Effect in Several Cancer Cell Lines

...product candidate that works in a manner similar to RNA interference (RNAi) through late-stage clinical trials. The product candidate, ONCONASE, is an rnase that overcomes the challenges of targeting RNA for therapeutic purposes while enabling the development of a new class of targeted therapies for cancer...

Alfacell Announces ONCONASE(R) Distribution and Marketing Agreement with Megapharm for Israel

...product candidate that works in a manner similar to RNA interference (RNAi) through late-stage clinical trials. The product candidate, ONCONASE, is an rnase that overcomes the challenges of targeting RNA for therapeutic purposes while enabling the development of a new class of targeted therapies for cancer...

Strativa Pharmaceuticals Announces Preliminary Results from ONCONASE(R) Phase IIIb Clinical Trial

...duct candidate that works in a manner similar to RNA interference (RNAi) through late-stage clinical trials. The product candidate, ONCONASE(R), is an rnase that overcomes the challenges of targeting RNA for therapeutic purposes while enabling the development of a new class of targeted therapies for cancer...

Alfacell Corporation Announces Preliminary Results From ONCONASE(R) Phase IIIb Clinical Trial

...product candidate that works in a manner similar to RNA interference (RNAi) through late-stage clinical trials. The product candidate, ONCONASE, is an rnase that overcomes the challenges of targeting RNA for therapeutic purposes while enabling the development of a new class of targeted therapies for cancer...

Alfacell's ONCONASE(R) Shows Potential as Radiation Sensitizer for Lung Cancer Treatment

...product candidate that works in a manner similar to RNA interference (RNAi) through late-stage clinical trials. The product candidate, ONCONASE, is an rnase that overcomes the challenges of targeting RNA for therapeutic purposes while enabling the development of a new class of targeted therapies for cancer...

Pre-Clinical Data Show Intracellular Pathways Affected by ONCONASE(R)

...product candidate that works in a manner similar to RNA interference (RNAi) through late-stage clinical trials. The product candidate, ONCONASE, is an rnase that overcomes the challenges of targeting RNA for therapeutic purposes while enabling the development of a new class of targeted therapies for cancer...

Alfacell Updates Status of ONCONASE(R) Phase III Clinical Program

...product candidate that works in a manner similar to RNA interference (RNAi) through late-stage clinical trials. The product candidate, ONCONASE, is an rnase that overcomes the challenges of targeting RNA for therapeutic purposes while enabling the development of a new class of targeted therapies for cancer...

Alfacell Reports Financial Results for First Quarter of Fiscal 2008

...product candidate that works in a manner similar to RNA interference (RNAi) through late-stage clinical trials. The product candidate, ONCONASE, is an rnase that overcomes the challenges of targeting RNA for therapeutic purposes while enabling the development of a new class of targeted therapies for cancer...
RNase in Medical Products

GenCatch™ Viral RNA Mini-Prep Kit

Description:...dine thiocyanate and 2-mercaptoethanol for their capabilities to inactivate rnase and denature proteins. Purified viral RNA is suitable fro applications such as RT-PCR, Northern and rnase protection assays. This system is ideal for isolation of RNA from pathogeni...
Company:Epoch Biolabs, Inc

UltraClean™ Forensic Agarose

Description:... clear sharp bands, with no smearing and no background. Each lot of UltraClean Forensic Agarose is tested and certified to be free of DNase activity, rnase activity and DNA contamination. Meets all requirements for DNA identity applications....
Company:Mo Bio Laboratories, Inc.

UltraClean™ Agarose

Description:...leic acids. It can be used to isolate DNA fragments from 0.2 to 40 kb. Each lot of UltraClean Agarose is tested and certified to be free of DNase and rnase activity....
Company:Mo Bio Laboratories, Inc.

Avant Premium Eppendorf Style Low Binding, Graduated, Pipet Tips

Description:... to fit Eppendorf Style Pipettors.Reduces DNA and protein binding. Non-reactive. Beveled and referenced. Produced & packaged completely by automation. rnase & DNAse free. AVR100S is the Sterile Racked packaged 96 tips/rack and 10 racks/cs. AVR100 is the Cell Rack packaged 96 tips/rack and 10 racks/cs. AVR1...
Company:MIDSCI

Avant Premium Low Binding, Graduated, Long Reach Pipet Tips (P2 - P10)

Description:... binding. Non-reactive. Beveled and referenced. Fits a wide variety of Ultra-Micro Pipettors up to 10 L. Produced & packaged completely by automation. rnase & DNAse free. AVR9LS is the Sterile Racked packaged 96 tips/rack and 10 racks/cs. AVR9L is the Cell Rack packaged 96 tips/rack and 10 racks/cs. AVR12 ...
Company:MIDSCI

Avant Premium Low Binding, Graduated, Pipet Tips (P2 - P10)

Description:... binding. Non-reactive. Beveled and referenced. Fits a wide variety of Ultra-Micro Pipettors up to 10 L. Produced & packaged completely by automation. rnase & DNAse free. AVR10S is the Sterile Racked packaged 96 tips/rack and 10 racks/cs. AVR10 is the Cell Rack packaged 96 tips/rack and 10 racks/cs. AVR11 ...
Company:MIDSCI

Eppendorf Filtertips epT.I.P.S. 76 mm

Description:...s sample recovery after accidental over-pipetting. All filters are sterile (to USP, DAB, Ph.Eur. standards) and PCR clean (free from human DNA, DNase, rnase and PCR inhibitors)...
Company:Sigma-Aldrich

Eppendorf Filtertips epT.I.P.S. 55 mm

Description:...s sample recovery after accidental over-pipetting. All filters are sterile (to USP, DAB, Ph.Eur. standards) and PCR clean (free from human DNA, DNase, rnase and PCR inhibitors)...
Company:Sigma-Aldrich

Eppendorf Filtertips epT.I.P.S. 53 mm

Description:...s sample recovery after accidental over-pipetting. All filters are sterile (to USP, DAB, Ph.Eur. standards) and PCR clean (free from human DNA, DNase, rnase and PCR inhibitors)...
Company:Sigma-Aldrich

Eppendorf Filtertips epT.I.P.S. 46 mm

Description:...s sample recovery after accidental over-pipetting. All filters are sterile (to USP, DAB, Ph.Eur. standards) and PCR clean (free from human DNA, DNase, rnase and PCR inhibitors)...
Company:Sigma-Aldrich

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RNase in Biological News

Loss of a universal tRNA feature reported

...anism by an aminoacyl-tRNA synthetase. It will be of special interest to examine if the loss of this tRNA feature has resulted from the presence of an rnase P enzyme that is no longer capable of catalyzing abnormal cleavage at the -1 position in the tRNAHis precursor. It will also be revealing to see how d...
RNase in Biological Technology

Alfacell to Host Webinar on RNA Interference-Like Mechanics of RNase Therapeutics on Nov. 29

Presenters will Include World-Renowned RNase and RNA Researchers SOMERSET, N.J., Oct. 25 /PRNewswire-FirstCall/ -- The RNA interference- like mechanics of ribonuclease (RNase) therapeutics will be the focus of scientific presentations in a Nov. 29 Webinar hosted by Alfacell Corporation (Na...

Measuring RNase Activity A Real-time Kinetic Analysis

The RNaseAlert QC System, when used in conjunction with a fluorometer capable of kinetic analysis, provides a rapid and ultra-sensitive assay for determining RNase A specific activity. The RNaseAlert QC System also detects a variety of other ...

Combat RNase Contamination in the Lab

Trace amounts of ribonuclease (RNase) contamination can sabotage experiments. Since RNases are ubiquitous in the laboratory environment--on your skin, in the air, on anything touched by bare hands or on anything ...

Dicer vs. RNase III for Preparation of siRNA Cocktails

Both recombinant human Dicer and Escherichia coli RNase III can be used in vitro to cleave long dsRNA, producing siRNA cocktails that are effective mediators of gene silencing (1-6). Dicer is an endoribo...

Inducing RNAi with siRNA Cocktails Generated by RNase III

Mike W. Byrom, Angie M. Cheng and Lance P. Ford* Ambion, Inc. 2130 Woodward Street Austin, TX 78744-1832 *Corresponding author email: lford@ambion.com Abstract Small interfering RNA (siRNA) is ...

Protector RNase Inhibitor Enhance the Protection of RNA against Degradation

Protector RNase Inhibitor Is a new type of RNase inhibitor and inhibits a wide known spectrum of RNases. Does not interfere with the performance of enzymes in an assay - even when high amounts (e.g., up to 1...

Protector RNase Inhibitor

from rat lung, recombinant Catalog Number Pack Size 3335399 2000 units 3335...

AcroMetrix Announces the Release of OptiQuant-S Hepatitis C Virus (HCV) Panel

...logy allows insertion of synthetic sequences into a mammalian RNA virus which were shown to be stable in replication and capable of forming infectious rnase resistant virus particles. This new proprietary system can be used for designing defined RNA positive controls, quantification standards, internal co...

Alfacell Provides ONCONASE(R) NDA Submission Update

...product candidate that works in a manner similar to RNA interference (RNAi) through late-stage clinical trials. The product candidate, ONCONASE, is an rnase that overcomes the challenges of targeting RNA for therapeutic purposes while enabling the development of a new class of targeted therapies for cancer...

Alfacell's ONCONASE(R) and R-Amphinase Show Anti-Tumor Activity in Chronic Lymphocytic Leukemia and Acute Myeloblastic Leukemia Cells

...product candidate that works in a manner similar to RNA interference (RNAi) through late-stage clinical trials. The product candidate, ONCONASE, is an rnase that overcomes the challenges of targeting RNA for therapeutic purposes while enabling the development of a new class of targeted therapies for cancer...

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RNase in Biological Products

SuperScript III RNase H- Reverse Transcriptase from Invitrogen

Description: SuperScript™ III RNase H- Reverse Transcriptase (RT) is an improved version of SuperScript™ II RNase H- RT. Like SuperScript™ II it synthesizes a complementary DNA strand from single-stranded RNA DNA or an RNA:DNA hybrid. SuperScript™ III is genetically e...
Company:Invitrogen

SuperScript II RNase H- Reverse Transcriptase from Invitrogen

Description: SuperScript™ II RNase H- Reverse Transcriptase (RT) is an improved version of the SuperScript™ RNase H- RT. It is a DNA polymerase that synthesizes a complementary DNA strand from single-stranded RNA DNA or an RNA:DNA hybrid. This enzyme is genetically engineered by the introduction of ...
Company:Invitrogen

SuperScript II RNase H- Reverse Transcriptase from Invitrogen

Description: SuperScript™ II RNase H- Reverse Transcriptase (RT) is an improved version of the SuperScript™ RNase H- RT. It is a DNA polymerase that synthesizes a complementary DNA strand from single-stranded RNA DNA or an RNA:DNA hybrid. This enzyme is genetically engineered by the introduction of ...
Company:Invitrogen

ShortCut RNase III from New England Biolabs

Description: ShortCut RNase III, used with its manganese-containing reaction buffer, converts long double-stranded RNA into a heterogeneous mix of short (1825 bp) interfering RNAs (siRNA) suitable for RNA interference in mammalian cells. 1.3 units (1 l) of ShortCut RNase III is sufficient to convert 1 g of dsRN...
Company:New England Biolabs

QIAGEN RNase Inhibitor (7500 U) from QIAGEN

Description: For potent inhibition of RNase A-type ribonucleases Product Description: QIAGEN RNase Inhibitor is a protein of nonhuman origin that binds noncovalently and inactivates a variety of ribonucleases (e.g., RNase A, B, and C). It does not interfere with RNase T1, T2, H, U1, U2, or CL3. QIAGEN RNase In...
Company:QIAGEN

DEPC water from Mo Bio Laboratories, Inc.

Description:... Dnase and rnase free...
Company:Mo Bio Laboratories, Inc.

RNase III, E. coli from EPICENTRE Biotechnologies

Description:...s double-stranded RNA (dsRNA) to dsRNA fragments that have 2-base, 3'-overhangs. Complete digestion of dsRNA results in dsRNA fragments of 12-15 bp. rnase III can digest double-stranded RNA composed of canonical ribonucleotides as well as DuraScript™ RNA, produced using EPICENTRE's DuraScribe™ ...
Company:EPICENTRE Biotechnologies

Disposable Tips for OneTouch Plus from The Gel Company

Description:... Disposable tips with floating filter (US Patent 6,702,990) for PDM1.5 OneTouch Plus spotpicker, 10 racks of 96, DNAse and rnase free...
Company:The Gel Company

UltraPure DNase/RNase-Free Distilled Water from Invitrogen

Description:...ure DNase/RNase-Free Distilled Water is designed for use in all molecular biology applications. It is 0.1-m membrane-filtered and tested for DNase and rnase activity....
Company:Invitrogen

UltraPure DNase/RNase-Free Distilled Water from Invitrogen

Description:...ure DNase/RNase-Free Distilled Water is designed for use in all molecular biology applications. It is 0.1-m membrane-filtered and tested for DNase and rnase activity....
Company:Invitrogen

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RNase in Biological Definition

Enzyme

...ptase : used by retroviruses to transcribe information from RNA into DNA Ribulose bisphosphate carboxylase : fixes carbon in green plants. rnase : those enzymes which can break down RNA into the component nucleotides Superoxide dismutase : transforms superoxide into oxygen and hydroge...

Okazaki fragment

...ly short fragment of DNA that is created by primase and Pol III along the lagging strand (see DNA replication ). They are later removed by rnase H , and the last ribonucleotide is removed by and synthesized by Pol I . The nick, or a broken phosphodiester bond remaining between the fragments ...
RNase in Biological Dictionary

RNase

Ribonuclease (commonly abbreviated RNase ) is a type of nuclease that catalyzes ... RNase P is one of two known multiple turnover ribozymes in nature (the other ... Ribonuclease P ( RNase P) is a type of Ribonuclease which cleaves RNA. RNase P is unique from other RNases in that it...

Small nuclear RNA

...ells. ... Small nuclear RNA · Small nucleolar RNA · Guide RNA · rnase P · rnase MRP · Y RNA ... RNA ( ) n. A polymeric constituent of all living ce...

RT-PCR

... The AccessQuick™ RT - PCR System saves you four pipetting steps ... cDNA Synthesis Reverse Transcriptases Reverse Transcription Systems RT - PCR rnase Inhibitors ... Methods, protocols, techniques, tutorials and other information for biomedical students ... One-tube RT - PCR reaction mixes are s...

Ribonuclease

...A) is an endonuclease that cleaves single-stranded RNA. Bovine pancreatic rnase A is one of the classic model systems of protein science. Ribonucleas...1-4419-1141-4 Ribonuclease protection assays. Used in conjunction with rnase A (2) ... Takahashi K., Moore S., Ribonuclease T1, The Enzymes, V, (Boyer...

Reverse transcription

...I™ Reverse Transcription System is excellent for reproducible ... cDNA Synthesis Reverse Transcriptases Reverse Transcription Systems RT-PCR rnase ... ied the reverse transcription reaction and its conse ... and gene-specific reverse transcription primers. ... sample must be copied to ...

Monocistronic

...ck of detectable monocistronic transcript from Sno and Bad would ... Figure 6 Promoter activity of p27 5'-UTR in monocistronic constructs and rnase protection assay. ... These shorter monocistronic RNA transcripts are likely ... ...

Gel shift assay

... with P-FILM in a gel - shift assay . ... RNA-protein gel mobility shift assay . Munro's binding buffer. 10mM Hepes, pH 7.6. 3 mM MgCl2 ... rnase free H20. Lysis buffer. Munro's buffer + 0.2% NP-40 in ... A gel shift assay , also referred to as an EMSA is an electrophoretic mobility a...

Exonuclease

...gues in DNA ... The European Bioinformatics Institute ... Exonuclease , rnase T and DNA polymerase III. Example proteins. Open in usermanual ... IPR006...'3' exodeoxyribonuclease that ... Exonuclease T (Exo T), also known as rnase T, is a single-stranded RNA (1,2) or ... What is the molecular weight of E...

Dicer

... Dicer is an endoribonuclease in the rnase III family that cleaves double-stranded RNA (dsR...an produce putative guide RNAs, is a member of the rnase ... Human Dicer preferentially cleaves dsRNAs...ng food. ... Dicer is an endoribonuclease in the rnase III ... Structural basis for double-stranded RNA ...

Copy number control

...ning CEN3 plus the yeast 2 mu plasmid, the CEN3 copy number control is ... Copy number control using ... Samples were then treated with rnase and analyzed on an ... can see an increase in the copy number of the plasmid when grown at ... 010: Library of Congress control number (n...
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