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RNAs in Medical News

Discoverers of Small Regulatory RNAs and Cholesterol-Lowering Drugs to Receive Lasker Awards for Medical Research

Pioneer in Understanding Harmful Bacteria Honored with Special Achievement Award NEW YORK, Sept. 13 /PRNewswire/ -- The 2008 Albert Lasker Medical Research Awards ( http://www.laskerfoundation.org ) were announced today. First presented in 1946, the Lasker Awards...

Small RNAs can prevent spread of breast cancer

Howard Hughes Medical Institute researchers have identified small pieces of ribonucleic acid (RNA) that suppress the spread of breast cancer to the lungs and bone. The new research shows that the most invasive and aggressive human breast cancer tumors are missing three critical microRNA molecules....

Scientists discover tiny RNAs play a big role in controlling genes

New Haven, Conn.A study by researchers at the Yale Stem Cell Center for the first time demonstrates that piRNAs, a recently discovered class of tiny RNAs, play an important role in controlling gene function, it was reported this week in Nature. Haifan Lin, director of the stem cell center an...

Altered expression of ultraconserved noncoding RNAs linked to human leukemias and carcinomas

A new study provides evidence that noncoding RNAs and interactions between noncoding genes play a much greater role in human cancer than was previously understood. The research, published by Cell Press in the September issue of the journal Cancer Cell, may be useful for identifying tumor-specific ...

Scientists at CSHL uncover new RNA processing mechanism and a new class of small RNAs

A very small fraction of our genetic material--about 2%-- performs the crucial task scientists once thought was the sole purpose of the genome: to serve as a blueprint for the production of proteins, the molecules that make cells work and sustain life. This 2% of human DNA is converted into interm...

Scientists Discover New RNAs in Mouse Testicles

London, June 6. A genetic cousin of DNA has been discovered in mouse testicles. These are a new class of small RNAs. Small RNAs are known to regulate key processes in human health //. RNA interference is one important way that the body can shut off genes of the invading pathogens. Gre...
RNAs in Medical Technology

New Small and Medium Sized Enterprises Join TI Pharma by Signing Two New Projects

... The recent discovery that non-coding RNAs, called microRNAs (miRNAs), play a critical role in gene regulation provides new opportunities to discover rnas that can control angiogenesis. The major aim of this project is to establish a technology platform for the development of (anti-cancer) therapeutics b...

Prometheus and Rosetta Genomics Announce License and Collaboration Agreement

...ces, primarily asbestos particles and heavy metals. About MicroRNA MicroRNAs (miRNAs) are recently discovered, naturally occurring, small rnas that act as master regulators and have the potential to form the basis for a new class of diagnostics and therapeutics. Since many diseases are caused...

Previous Claims of siRNA Therapeutic Effects Called into Question by Report in 'Human Gene Therapy'

... NEW ROCHELLE, N.Y., Sept. 2 /PRNewswire/ -- The many recent reports documenting the therapeutic efficacy of short interfering rnas (siRNAs) in animal models of human disease may actually be describing non-specific therapeutic effects related to the ability of siRNA to activate an ...

Study Shows Intradigm's RNAi Nanoplex Technology To Be Effective Systemic siRNA Delivery Platform for the Treatment of Various Cancer Models

... study results that demonstrated the company's RNAi Nanoplex (NPX) delivery technology platform is capable of effectively delivering small interfering rnas (siRNAs) targeting both vascular endothelial growth factor (VEGF) and epidermal growth factor (EGF) pathways, two clinically validated pathways in the...

Gen-Probe Begins U.S. Clinical Study of Molecular Test for Human Papillomavirus, Which Causes Cervical Cancer

...ied nucleic acid test that detects 14 high-risk HPV types that are associated with cervical cancer. More specifically, the assay detects two messenger rnas (mRNAs), E6 and E7, that are made in higher amounts when HPV infections progress toward cervical cancer. Gen-Probe believes that targeting these mRNAs...

Nastech Completes Enrollment of Phase 2 Clinical Trial of PYY3-36 Nasal Spray to Treat Obesity

...harnessing the power of RNA interference, a cellular mechanism that can turn off the production of a specific protein through use of small interfering rnas (siRNAs), to develop a new class of therapeutics by identifying key protein targets, designing the siRNAs that will turn off the production of the tar...
RNAs in Biological News

Small RNAs can play critical roles in male infertility/contraception

RENO, Nev. University of Nevada School of Medicine scientists in the Department of Physiology and Cell Biology have discovered insight into the reproductive workings of the male sex chromosome that may have significant implications for male infertility and contraception. This import...

Scientists at CSHL discover mobile small RNAs that set up leaf patterning in plants

Cold Spring Harbor, N.Y. -- A key item in the developmental agenda of a plant leaf is the establishment of an axis that makes a leaf's top half distinct from its bottom half. This asymmetry is crucial for the leaf's function: it ensures that the leaf develops a flattened blade that is optimized fo...

Scientists at CSHL discover mobile small RNAs that set up leaf patterning in plants

Cold Spring Harbor, N.Y. -- A key item in the developmental agenda of a plant leaf is the establishment of an axis that makes a leaf's top half distinct from its bottom half. This asymmetry is crucial for the leaf's function: it ensures that the leaf develops a flattened blade that is optimized fo...

CSHL scientists find a new class of small RNAs and define its function

Cold Spring Harbor, NY Researchers at Cold Spring Harbor Laboratory (CSHL) announced today the discovery of a new class of small RNAs. At the same time, they reported that their discovery suggests the presence of a strikingly novel biochemical pathway for RNA processing in which these and possibl...

UT Southwestern researchers identify new targets for RNAs that regulate genes

DALLAS July 6, 2008 Tiny strands of genetic material called RNA a chemical cousin of DNA are emerging as major players in gene regulation, the process inside cells that drives all biology and that scientists seek to control in order to fight disease. The idea that RNA (ribonucleic acid) is...

Scientists discover small RNAs that regulate gene expression and protect the genome

RNA is best known as a working copy of the DNA sequence of genes. In this role, its a carrier of the genes instructions to the cell, which manufactures proteins according to information in the RNA molecule. But molecular biologists have increasingly realized that many RNA snippets -- so-called...

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RNAs in Biological Technology

Gladstone scientists identify role of tiny RNAs in controlling stem cell fate

SAN FRANCISCO, CA March 6, 2008--Researchers at the Gladstone Institute of Cardiovascular Disease (GICD) and the University of California, San Francisco have identified for the first time how tiny genetic factors called microRNAs may influence the differentiation of pluripotent embryonic stem (ES)...

Santaris Pharma - Interim Report for the Period 1 January to 30 June 2009

...er and teratoma samples using deep sequencing. During H1 2009 the Company made presentations at several scientific conferences: - Small rnas and cancer/Paris/France - Keystone, Scientific Advisory Board Meeting/Colorado/USA - Executing the promise of RNAi/Cambrigde/MA/USA - C...

Stem cells' 'suspended' state preserved by key step, scientists report

...ther candidate genes. (RNAi is a naturally occurring process in which small rnas bind to other rnas to increase or decrease their activity.) In this case, the scientists used ...

febit First to Offer Newly Published Mouse Genome on a Chip for DNA/RNA Detection and Enrichment

...ntifies 439 long, non-coding RNAs. Thus, a complete analysis of protein gene expression, microRNA profiles and expression patterns of long non-coding rnas is possible and can reveal many previously hidden secrets of mammalian biology and disease processes. Flexibel technology for fast-paced researc...

Monsanto, BASF Scientists Disclose Discovery of Gene Conferring Drought Tolerance in Corn Plants

...orn contains the cspB gene, from Bacillus subtilis . CspB codes for an RNA chaperone, which are commonly occurring protein molecules that bind to rnas and facilitate their function. The gene was first identified in bacteria subjected to cold stress conditions and further research has demonstrated tha...

MIT reels in RNA surprise with microbial ocean catch

...ion has yielded an unexpected boon: the presence of many varieties of small rnas snippets of RNA that act as switches to regulate gene expression in these ...a tough situation, for instance? The discovery of naturally occurring small rnas is a first step towards addressing such questions." ...

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RNAs in Biological Products

ShortCut RNase III from New England Biolabs

Description:...ase III, used with its manganese-containing reaction buffer, converts long double-stranded RNA into a heterogeneous mix of short (1825 bp) interfering rnas (siRNA) suitable for RNA interference in mammalian cells. 1.3 units (1 l) of ShortCut RNase III is sufficient to convert 1 g of dsRNA into siRNA suita...
Company:New England Biolabs

Rice microRNA Microarray from LC Sciences

Description:...nces. These products significantly reduce the cost and increase the speed of highly multiplexing genome-scale experiments such as exploration of small rnas and designer gene/DNA library synthesis....
Company:LC Sciences

Arabidopsis microRNA Microarray from LC Sciences

Description:...nces. These products significantly reduce the cost and increase the speed of highly multiplexing genome-scale experiments such as exploration of small rnas and designer gene/DNA library synthesis....
Company:LC Sciences

Fishes microRNA Microarray from LC Sciences

Description:...nces. These products significantly reduce the cost and increase the speed of highly multiplexing genome-scale experiments such as exploration of small rnas and designer gene/DNA library synthesis....
Company:LC Sciences

Cow microRNA Microarray from LC Sciences

Description:...nces. These products significantly reduce the cost and increase the speed of highly multiplexing genome-scale experiments such as exploration of small rnas and designer gene/DNA library synthesis....
Company:LC Sciences

Maize microRNA Microarray from LC Sciences

Description:...nces. These products significantly reduce the cost and increase the speed of highly multiplexing genome-scale experiments such as exploration of small rnas and designer gene/DNA library synthesis....
Company:LC Sciences

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RNAs in Biological Definition

Barr body

...ion centre or Xic , usually found near the centromere . The centre contains twelve genes, seven of which code for proteins , five for untranslated rnas , of which only two are known to play an active role in the X inactivation process, Xist and Tsix. The centre also appears to be important in chro...

Genetic code

...ich is better suited for protein synthesis. This in turn is translated , by mediation of a machinery consisting of ribosomes and a set of transfer rnas and associated enzymes , into an amino acid chain ( polypeptide ), which will then be folded into a protein . The gene sequence inscribed in DN...

Gene

...actually the functional end products. For example, rnas known as ribozymes are capable of enzymatic function , or small interfering rnas have a regulatory role. The DNA sequences from which such rnas are transcribed are known as non-coding RNA , or ...

Genetic code

...ich is better suited for protein synthesis. This in turn is translated , by mediation of a machinery consisting of ribosomes and a set of transfer rnas and associated enzymes , into an amino acid chain ( polypeptide ), which will then be folded into a protein . The gene sequence inscribed in DN...

Genomics

...xperimental investigation of some of these sequences has shown that some are transcribed into small RNA molecules, although the functions of these rnas were not immediately apparent. The identification of similar sequences (including many genes) in two distantly related organisms, but not in other m...

Har Gobind Khorana

...ynthesis . Khorana's synthetic RNA approach rnas with two repeating units (UCUCUCU → UCU CUC U... showed that UCU codes for Ser and CUC for Leu. rnas with three repeating units (UACUACUA → UAC UA...roduced three different strings of amino acids. rnas with four repeating units including UAG, UAA, or U...
RNAs in Biological Dictionary

Triplet repeat expansion

...tion. ... ... dominant, was found to result from expansion of a triplet repeat (CAG) as well. ... mutations give rise to repeat expansion rnas that form nuclear ... Recently, the CTG repeat expansion in the DMPK gene causing myotonic dystrophy ... in two patients by triplet repeat...

Spliceosome

...pliceosome . splicer. splicing. spliff. spline. Splining. Splining machine. splint. Splice ... The spliceosome is comprised of five small nuclear rnas (snRNAs)—U1, U2, U4, U5, ... In determining the list of spliceosome proteins, we used peptides that ... Nature is the international weekly jour...

Small nuclear RNA

...NA ( in nucleic acid (chemical compound): Other rnas ) Many other small RNA molecules with specialize...are present in cells. For example, small nuclear rnas (snRNAs) are involved in RNA splicing (see below... vitro as ... Reddy R, Busch H. Small nuclear rnas and RNA processing. Prog Nucleic Acid Res ... ...

Satellite RNA

...ncoded nonstructural protein preferentially ... ... to the satellite rnas (sat- RNA ) of other necroviruses (39) has been found in ... 3. cDNA synthe...ifferent helper virus ... TCV (turnip crinkle virus) RNA C, satellite rnas exhibit only limited ... ...

RNA interference

...rence that enable expression of short hairpin rnas in vivo. ... The RNA Interference chapter in o...iew of the process by which long double-stranded rnas silence the expression of target genes. ... refe...is a technique in which exogenous, double-stranded rnas ... RNA interference was known by other names,...

RNA editing

...A editing by adenosine (A) to inosine (I) ... RNA editing of micro rnas ... If you know of any A-to-I RNA editing lab information not listed he... variety of novel mechanisms for the ... The A-to-I editing observed in rnas encoding ... Mechanistically, there are many diverse types of editing ...
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