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RNA in Medical News

Quark Pharmaceuticals Announces the Presentation of Data Indicating Potential Utility of QPI-1002 in Chronic Kidney Disease at the RNA Interference Summit

FREMONT, Calif., June 9 /PRNewswire/ -- Quark Pharmaceuticals, Inc., a development-stage pharmaceutical company discovering and developing novel RNA interference (RNAi)-based therapeutics, today announced that Bruce A. Molitoris, M.D., Director, Division of Nephrology and Professor of Medicine, I...

Intradigm Announces Issuance of RNA Interference (RNAi) Patent Covering Potent siRNA Sequence

First Patent to be Issued from Among Intradigm's Large Collection of Pending siRNA Sequence Patents PALO ALTO, Calif., May 19 /PRNewswire/ -- Intradigm Corporation, a leading developer of targeted, systemic RNA interference (RNAi) therapeutics, today announced the issuance of United States pa...

Study first to show that RNA interference can facilitate vaccine development

Athens, Ga. - Pharmaceutical companies and universities are racing to develop drugs that use the gene silencing mechanism known as RNA interference to treat a host of diseases. Now, a new study opens up an entirely new possibility for this powerful tool: Researchers at the University of Georgia ha...

Scientists at CSHL uncover new RNA processing mechanism and a new class of small RNAs

A very small fraction of our genetic material--about 2%-- performs the crucial task scientists once thought was the sole purpose of the genome: to serve as a blueprint for the production of proteins, the molecules that make cells work and sustain life. This 2% of human DNA is converted into interm...

Caltech engineers build first-ever multi-input 'plug-and-play' synthetic RNA device

PASADENA, Calif.--Engineers from the California Institute of Technology (Caltech) have created a "plug-and-play" synthetic RNA device--a sort of eminently customizable biological computer--that is capable of taking in and responding to more than one biological or environmental signal at a time. ...

The 'febit science lounge' presents: Webinar About Role of Non-Protein-Coding RNA in Human Genome Set for 11 a.m. EDT on June 12

'The human genome as an RNA machine' with Prof. John Mattick with Institute for Molecular Bioscience at University of Queensland, Australia LEXINGTON, Mass. and HEIDELBERG, Germany, June 5 /PRNewswire/ -- febit holding gmbh today unveiled plans for the first of a series of educational Webinar...

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RNA in Medical Technology

Another LNA-based RNA Inhibitor Enters Clinical Trials

COPENHAGEN, March 20 /PRNewswire/ -- Santaris Pharma announced today that the fourth LNA-based drug has been brought into the clinic. In the USA several patients with cancer have now been treated with the Company's Survivin inhibitor, which is jointly developed by Santaris Pharma and Enzon Pha...

Isis Reports Strong Financial Results and Highlights for Second Quarter of 2009

...e Isis' technology. Isis co-exclusively licensed its single-stranded rna interference (ssRNAi) technology to Alnylam as part of a new strategic init... About Isis Pharmaceuticals, Inc. Isis is exploiting its expertise in rna to discover and develop novel drugs for its product pipeline and for its pa...

Pharmasset Reports Positive Preliminary Antiviral Data With PSI-7851 for the Treatment of Hepatitis C

...--------- Dose N Mean Change in HCV rna at Day 3 (Log(1...- PSI-7851 demonstrated potent antiviral activity with a mean HCV rna decrease of -0.49 log(10) IU/mL, -0.61 log(10) IU/mL and -1.01 log(10) IU/m...

Idenix Pharmaceuticals Successfully Completes Proof-of-Concept Study of IDX184 for the Treatment of Hepatitis C Virus (HCV)

... accumulation. The table below summarizes mean HCV rna reductions observed in this study per cohort: ... log10 or Change in HCV rna Greater Reduction in HCV Cohort Dose (log10) rna at End of Treatment ------ ---- ----...

Schering-Plough Expands Vicriviroc Phase II Study in Treatment-Naive Patients With HIV

... from baseline in viral load (log10 HIV RNA) at week 48 of treatment. A key secondary efficacy endpoint is the proportion of patients with plasma HIV rna less than 50 copies/mL at week 48 of treatment. Atazanavir boosted by ritonavir was selected for use in this study because it is recommended ...

Alfacell Provides Shareholder Update

...d as routine tool to detect the gene silencing via rna interference (RNAi) mechanism. Currently, there a...roduct candidate that works in a manner similar to rna interference (RNAi) through late-stage clinical tr...n RNase that overcomes the challenges of targeting rna for therapeutic purposes while enabling the develo...

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RNA in Medical Products

QuantiGene 2.0 RNA Quantification System

Description: QuantiGene 2.0 is a reagent and probe system used together to quantify gene expression knockdown. The high throughput plate based system is a sandwich nucleic acid hybridization assay that provides a unique approach for RNA detection and quantification, by amplifying the reporter signal using branc...
Company:Sigma-Aldrich

West Nile Virus RNA by RT-PCR

Description: ARUP Laboratories is a national reference laboratory and a worldwide leader in innovative laboratory research and development. ARUP offers an extensive test menu of highly complex and unique medical tests in clinical and anatomic pathology. Owned by the University of Utah, ARUP Laboratories' client...
Company:ARUP Laboratories

Human Immunodeficiency Virus 1 Ultrasensitive RNA Quantitative PCR

Description: ARUP Laboratories is a national reference laboratory and a worldwide leader in innovative laboratory research and development. ARUP offers an extensive test menu of highly complex and unique medical tests in clinical and anatomic pathology. Owned by the University of Utah, ARUP Laboratories' client...
Company:ARUP Laboratories

Human Immunodeficiency Virus 1 RNA Quantitative PCR

Description: ARUP Laboratories is a national reference laboratory and a worldwide leader in innovative laboratory research and development. ARUP offers an extensive test menu of highly complex and unique medical tests in clinical and anatomic pathology. Owned by the University of Utah, ARUP Laboratories' client...
Company:ARUP Laboratories

Human Immunodeficiency Virus 1 RNA Quantitative PCR with Reflex to Ultrasensitive RNA Quantitative PCR

Description: ARUP Laboratories is a national reference laboratory and a worldwide leader in innovative laboratory research and development. ARUP offers an extensive test menu of highly complex and unique medical tests in clinical and anatomic pathology. Owned by the University of Utah, ARUP Laboratories' client...
Company:ARUP Laboratories

Human Immunodeficiency Virus 1 RNA Quantitative bDNA

Description: ARUP Laboratories is a national reference laboratory and a worldwide leader in innovative laboratory research and development. ARUP offers an extensive test menu of highly complex and unique medical tests in clinical and anatomic pathology. Owned by the University of Utah, ARUP Laboratories' client...
Company:ARUP Laboratories

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RNA in Medical Dictionary

Virus

... only three have been mentioned. ... Original Article from The New England Journal of Medicine -- Screening the Blood Supply for West Nile Virus rna by Nucleic Acid Amplification Testing Because it is highly susceptible to West Nile virus , the ... In 1999, the virus was first recognized i...

Viral Hemorrhagic Fever

... The viral hemorrhagic fevers (VHFs) are a diverse group of animal and human illnesses that are caused by five distinct families of rna viruses: the Arenaviridae, Filoviridae, Bunyaviridae, Togaviridae, and Flaviviridae. All types of VHF are characterized by fever and... Viral ...

Viral

...viral processes, analogous to the spread of... Article detailing the etymology, origins, anatomy, and replication of ... Negative-sense viral rna is complementary to mRNA and thus must be converted to ... virus n. , pl. -ruses . Any of various simple submicroscopic parasites of plants, ani...

Uric acid

... Uric acid is the end product of purine metabolism (purines are building blocks of rna and DNA). Most uric acid produced in the body is excreted by the kidneys. ... Gout, how to articles and videos including lternative Treatments...

Rotavirus

... Rotavirus is a genus of double-stranded rna virus in the family Reoviridae. It is the leading single cause of severe diarrhoea among infants and young children, and is one of several viruses...

Retrovirus

...ype of retrovirus . ... During the life cycle of the retrovirus , the rna is converted to DNA by a unique ... HIV is a retrovirus that begins its ...rovirus that is native to. rodents. ... Retroviruses contain viral rna and several copies of reverse transcriptase (DNA polymerase) ... replicatio...
RNA in Biological News

New DNA and RNA aptamers offer unique therapeutic advantages

New Rochelle, NY, August 5, 2009A novel class of drugs composed of single strands of DNA or RNA, called aptamers, can bind protein targets with a high strength and specificity and are currently in clinical development as treatments for a broad range of common diseases, as described in a comprehens...

New tool isolates RNA within specific cells

A team of University of Oregon biologists, using fruit flies, has created a way to isolate RNA from specific cells, opening a new window on how gene expression drives normal development and disease-causing breakdowns. While DNA (deoxyribonucleic acid) provides an identical genetic blueprint in...

MIT reels in RNA surprise with microbial ocean catch

CAMBRIDGE, Mass.--An ingenious new method of obtaining marine microbe samples while preserving the microbes' natural gene expression has yielded an unexpected boon: the presence of many varieties of small RNAs snippets of RNA that act as switches to regulate gene expression in these single-celled...

Researchers find snippet of RNA that helps make individuals remarkably alike

"No two people are alike." Yet when we consider the thousands of genes with frequent differences in genetic composition among different people, it is remarkable how much alike we are. Uniformity, or singleness of form, is not unique to humans but a general property of life. Biologists have lon...

NYU Langone Medical Center researchers find micro RNA plays a key role in melanoma metastasis

NEW YORK CITY (February 5, 2009)Scientists have long wondered how melanoma cells travel from primary tumors on the surface of the skin to the brain, liver and lungs, where they become more aggressive, resistant to therapy, and deadly. Now, scientists from NYU Langone Medical Center have identifi...

Scripps scientists develop first examples of RNA that replicates itself indefinitely

Now, a pair of Scripps Research Institute scientists has taken a significant step toward answering that question. The scientists have synthesized for the first time RNA enzymes that can replicate themselves without the help of any proteins or other cellular components, and the process proceeds ind...

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RNA in Biological Technology

Santaris Pharma Director Appointed Adjunct Professor in RNA Biology at the University of Aalborg, Denmark

COPENHAGEN, June 3 /PRNewswire/ -- Santaris Pharma and Copenhagen Institute of Technology, Aalborg University, Denmark, announced today that Director of microRNA, Santaris Pharma, Sakari Kauppinen, has been appointed Adjunct Professor in RNA Biology at Copenhagen Institute of Technology. The a...

MIT reels in RNA surprise with microbial ocean catch

CAMBRIDGE, Mass.--An ingenious new method of obtaining marine microbe samples while preserving the microbes' natural gene expression has yielded an unexpected boon: the presence of many varieties of small RNAs snippets of RNA that act as switches to regulate gene expression in these single-celled...

Santaris Pharma Delivers Six LNA-Based RNA Inhibitors to Enzon Pharmaceuticals Ahead of Schedule

COPENHAGEN, April 27 /PRNewswire/ -- As a testimony to the strength of Santaris Pharma's efficient Drug Discovery Engine, the Company announced today the completion of the delivery of six cancer target drug candidates to their collaboration partner Enzon Pharmaceuticals. All six drug candidate...

LNA-Based RNA oligonucleotides Potently Inhibit Cancer microRNAs

COPENHAGEN, April 20 /PRNewswire/ -- Santaris Pharma announced today promising findings on the in vitro and in vivo activity of microRNA-targeted therapeutics against cancer developed on the basis of its proprietary Locked Nucleic Acid (LNA) Drug Platform. In both in vitro and in vivo models S...

Nobel Laureates to Speak at Keystone Symposia RNA Silencing Conference

SILVERTHORNE, Colo., April 17 /PRNewswire-USNewswire/ -- Keystone Symposia on Molecular and Cellular Biology will convene its conference on "The Biology of RNA Silencing" on April 25, 2009 at the Fairmont Empress Victoria in Victoria, British Columbia. This will be an opportunity to hear two Nobel...

Researchers develop new way to see single RNA molecules inside living cells

Biomedical engineers have developed a new type of probe that allows them to visualize single ribonucleic acid (RNA) molecules within live cells more easily than existing methods. The tool will help scientists learn more about how RNA operates within living cells. Techniques scientists currently...

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RNA in Biological Products

Mouse Anti-Bacteria RNA polymerase sigma 70 Monoclonal Antibody, Unconjugated, Clone 2G10 from ABR-Affinity BioReagents

Description: RNA polymerase sigma 70 Immunogen: Recombinant, full length protein. Storage: -20 C, Avoid Freeze/Thaw Cycles...
Company:ABR-Affinity BioReagents

Quant-iT RiboGreen RNA Assay Kit from Molecular Probes (Invitrogen)

Description: The RiboGreen RNA Quantitation Kit is one of the most sensitive detection systems for the quantitation of RNA in solution. The assay is approximately 1000-fold more sensitive than absorbance measurements. As little as 1 ng/mL can be detected with fluorescence microplate readers and fluorometers us...
Company:Molecular Probes (Invitrogen)

0.5-10 Kb RNA Ladder from Invitrogen

Description: 0.5-10 Kb RNA Ladder is suitable for sizing single-stranded RNA ranging from 0.5 kb to 10 kb in glyoxal or formaldehyde agarose gels. The ladder consists of nine bands in even increments (0.5 1 1.5 2 3 4 6 8 and 10 kb) to simplify size estimation. The 1.5 kb band is more intense than the other band...
Company:Invitrogen

Luciferase Control RNA from Promega

Description: in vitro Translation, Accessory Products...
Company:Promega

ArrayControl RNA Spikes from Ambion

Description: PCR Spots, Oligo Spots and complementary RNA Spikes for the normalization and control of microarray experiments. Use for glass array printing and for protocol assessment and optimization. Control for reverse transcription, cDNA labeling, hybridization stringency and background. Normalize Cy3 and Cy...
Company:Ambion

Capped Xef-1 RNA 0.05 ml from Ambion

Description: ...
Company:Ambion

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RNA in Biological Definition

RNA

Ribonucleic acid ( RNA ) is a nucleic acid consisting of a string of covalently-bound nucleotides . It is biochemically distinguished from DNA by the presence of an additional hydroxyl group, attached to each pentose ring; as well as by the use of uracil , instead of thymine . O...

Abiogenesis

...h postulated the formation of complex organisms. Different hypotheses for modern abiogenetic processes are currently under debate; see, for example, rna world hypothesis , proteinoid , Miller experiment . Scientific critics of the theory Sir Fred Hoyle with Chandra Wickramasinghe proponent...

Antibiotic

... Metronidazole, quinolones, novobiocin Drugs which interfere with rna synthesis Rifampin (rifampicin) Drugs which interfere with cell...tracellular parasite, being stripped down to a few genes worth of DNA or rna and the minimal molecular equipment needed to enter a cell and actually ta...

Anticodon

... An anticodon is a unit made up of three nucleotides which play an important role in various DNA cycles, including rna translation . It is, specifically, the group of nucleotides on a strand of tRNA that is complementary to specific codons on a strand of mRNA . Se...

Antigenic shift

... If two different strains of influenza infect the same cell simultaneously, their protein capsids and lipid envelopes are removed, exposing their rna , which is then transcribed to DNA . The host cell then forms new viruses that combine antigens; for example, H3N2 and H5N1 can form H5N2 this way. S...

Avian influenza

... influenza (AI) virus . AI viruses all belong to the influenza virus A genus of the Orthomyxoviridae family and are negative-stranded, segmented rna viruses . Avian influenza spreads in the air and in manure . Wild fowl often act as resistant carriers , spreading it to more susceptible domes...
RNA in Biological Dictionary

RNA

Transcription is the synthesis of RNA under the direction of DNA. RNA synthesis, or transcription, is the process of transcribing DNA nucleotide sequence information into RNA sequence information. Both nucleic acid sequences... In living cells, RNA in different configurations fulfi...

Untranslated RNA

A non-coding RNA (ncRNA) is a functional RNA molecule that is not translated into a protein. Less-frequently used synonyms are non-protein-coding RNA (npcRNA), non-messenger RNA (nmRNA), small non-messenger RNA (snmRNA),... Messenger ribonucleic acid (mRNA) is a molecule of RNA e...

Transfer RNA

Transfer RNA is a small RNA molecule that transfers a specific active amino acid to a growing polypeptide chain at the ribosomal site of protein synthesis during translation. It has a 3' terminal site for amino acid... transfer RNA n. ( Abbr. tRNA ) One of a class of RNA...

Small nuclear RNA

Small nuclear RNA (snRNA) is a class of small RNA molecules that are found within the nucleus of eukaryotic cells. They are transcribed by RNA polymerase II or RNA polymerase III and are involved in a variety of important processes such as RNA splicing, regulation of transcription ...

Satellite RNA

A Satellite is a subviral agent composed of nucleic acid that depends on the coinfection of a host cell with a helper or master virus for their multiplication. When a satellite encodes the coat protein in which its nucleic acid is encapsidated it is referred to as a... The seque...

Ribosomal RNA

Ribosomal RNA (rRNA) is the central component of the ribosome, the protein manufacturing machinery of all living cells. The function of the rRNA is to provide a mechanism for decoding mRNA into amino acids and to interact... The 16S rRNA is a part of the ribosomal RNA −-- a 1542 nt long...

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