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RET in Medical News

Drug therapy reduces neuroblastoma tumor growth in pre-clinical investigation

...was even greater on tumor growth." Vandetanib blocks a family of endothelial growth factors and receptors that promote tumor growth as well as the ret oncogene, which can signal neuroendocrine cells to develop into neuroblastoma cells. Although commonly used in treatment for neuroblastoma, CRA by its...

The Little Known Facts of Junk DNA

...ved in turning on a gene. They took the particular ret gene which is associated with Hirschsprung disease...earchers identified DNA sequences that can control ret by using the technique that they have developed. H...o control expression consistent with the zebrafish ret gene. Shannon Fisher, M.D., Ph.D., the study’s fir...

Another Cause of Thyroid Cancer Discovered

..., one of three genetic changes // happen. The genes affected include BRAF, ret or RAS. When patients have not been exposed to radiation, the changes gener...ver, in patients who are exposed to radiation the gene changes occur in the ret gene. In both cases, the gene changes or mutations transform normal cells i...

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RET in Medical Technology

Exelixis Reports Encouraging Phase 1 Data for XL184 at ASCO

...y available at this time. Targeted therapeutics, such as dual inhibitors of ret and VEGFR2, are the first compounds showing activity in this disease. The p...argets. The compound has also shown activity against common mutant forms of ret and MET. XL184 has exhibited dose-dependent tumor growth inhibition and tum...

Exelixis Initiates Phase 1/2 Trial of XL184 in Patients With Non-Small Cell Lung Cancer

...er (NSCLC) who have had progressive disease while on a regimen containing erlotinib. XL184 is a small molecule that simultaneously inhibits the MET, ret and VEGFR receptor tyrosine kinases. In the initial phase 1 part of the study, safety and pharmacokinetics of combining XL184 with erlotinib will be e...

Updated Phase 1 Data for Exelixis' XL184 Demonstrate Pharmacodynamic and Clinical Anti-Tumor Activity

...ary thyroid cancer and tumor shrinkage in a patient with papillary renal cell cancer, which frequently have mutational activation or overexpression of ret or MET, respectively," said George A. Scangos, Ph.D., president and chief executive officer of Exelixis. "We believe the data to date demonstrate the ...

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RET in Medical Products

SE-9500

Features:... Performs real-time random access for CBC, DIFF, and ret testing for ensuring labor and cost savings. ret can be analyzed by connecting optional RAM-1, up to 120 samples per hour of...
Company:Sysmex America, Inc.

SE-9000

Features:... Performs real-time random access for CBC, DIFF, and ret testing for ensuring labor and cost savings. ret can be analyzed by connecting optional RAM-1, up to 120 samples per hour of...
Company:Sysmex America, Inc.

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RET in Medical Dictionary

Intracellular

...acellular , while others tend to be outside cells, or are extracellular. ret encodes a receptor tyrosine kinase with extracellular, trans membrane , and intracellular domains. Details of ret receptor and ligand interaction in this signalling pathway have been review...

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RET in Biological News

Infused spleen cells found not to impact islet recovery and reversal of type 1 diabetes in mice

...the team identified DNA sequences that can control ret but had not been identified using standard methods...led to identify any potential enhancers around the ret gene because the DNA sequences differ too much. ...o control expression consistent with the zebrafish ret gene. Zebrafish have become the ideal system fo...

Junk DNA may not be so junky after all

...the team identified DNA sequences that can control ret but had not been identified using standard methods...led to identify any potential enhancers around the ret gene because the DNA sequences differ too much. ...o control expression consistent with the zebrafish ret gene. Zebrafish have become the ideal system fo...

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RET in Biological Technology

Exelixis Reaches Agreement with FDA on Special Protocol Assessment for XL184 Phase 3 Trial

...also shown activity against common mutant forms of ret and MET. XL184 has exhibited dose-dependent tumor ...m of MTC invariably have an activating mutation in ret in their germline DNA. Activating mutations in ret are also present in the tumor DNA of up to 50% of ...

AstraZeneca Completes Enrollment in Two Pivotal Phase III Studies of the Investigational Drug Vandetanib (ZACTIMA(R)) in Non-Small Cell Lung Cancer (NSCLC)

...ng the epidermal growth factor receptor (EGFR), which may lead to direct inhibition of cancer cell growth and survival.(3)(4) Vandetanib also inhibits ret kinase activity which may be important to the growth and development of certain tumors.(5) Vandetanib is currently being investigated alone and in c...

Reliable Assessment of Micronuclei for Genotoxicity Testing in Mice or Rats

... other erythrocyte populations ( Figure 1 ). Achieving this high resolution facilitated quantitative determination of MN-RET and ret frequencies. Figure 3 shows a dose-dependent increase in MN-RET frequencies; the control group was low, compared to ...

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RET in Biological Dictionary

Proto-oncogene

... turn a normal cell into a cancer cell. The ret proto - oncogene encodes a receptor tyrosine ...or family of extracellular signalling molecules. ret loss of function mutations are associated with the... ... of this gene is "ret proto - oncogene ." ret is the gene's official symbol. ......

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