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Quinolone in Medical News

Levaquin is the Preferred Quinolone Among More Than Half of All General Medical-Surgical Hospitals in the United States

MALVERN, Pa., Dec. 2 /PRNewswire/ -- Arlington Medical Resources (AMR), a provider of premier market intelligence for the pharmaceutical and diagnostic imaging industries, finds that Ortho-McNeil-Janssen Pharmaceuticals' Levaquin is the preferred quinolone antibiotic among more than half of all ge...

Topical Quinolone effective in controlling eardrum perforations

Topical administration of Quinolone antibiotics for eardrum perforations has been found to be more effective in treating the disease than the use of systemic antibiotics//. Dr. Carolyn Macfadyen, Research Associate, International Health Research Group in the Liverpool School of Tropical Medicine, U...

Availability in Both Intravenous and Oral Formulation is a Leading Drug Attribute Surveyed Physicians Prefer for the Treatment of Urinary Tract Infections in the Hospital Setting

...therapy and discharge from the hospital to the outpatient setting. "Physicians prescribe a wide variety of antibiotics for UTIs, mainly from the quinolone and cephalosporin classes," stated Lisa Arias, analyst at Decision Resources. "These broad-spectrum agents are popular first-line agents in UTIs, and ...

Sunesis Announces New Data on Voreloxin for Acute Myeloid Leukemia and Ovarian Cancer Will Be Presented at ASCO

...e recorded and available for replay on the company's website until June 15, 2009. About Voreloxin Voreloxin is a first-in-class anticancer quinolone derivative, or AQD, a class of compounds that has not been used previously for the treatment of cancer. Voreloxin both intercalates DNA and inhibits t...

Sunesis Reports Financial Results for the First Quarter 2009

... a reported net loss of $9.6 million for the same period in 2008. About Voreloxin Voreloxin is a first-in-class anticancer quinolone derivative, or AQD, a class of compounds that has not been used previously for the treatment of cancer. Voreloxin both intercalates DNA and inhibits t...

First look at an enzyme target for antibacterial and cancer drugs

...erstand and improve anti-topoisomerase therapeutics. Antibacterial and anticancer drugs that target topo IIs and other topoisomerases, such as the quinolone family of antibiotics (of which the commonly-used ciprofloxacin is a member), work by preventing the enzymes from completing their tasks. In the case ...

New therapeutic options for newly diagnosed multiple myeloma patients

...otein present in blood of myeloma patients) and a significantly higher rate of good or complete responses than L-Dex. Prophylactic use of acyclovir, a quinolone and antifungal prophylaxis was highly recommended for all patients on the study. ...

FDA Approves LEVAQUIN(R) Short-Course Therapy for Treatment of Complicated Urinary Tract Infections and Acute Pyelonephritis

... The Only quinolone Now Approved with Four Indications for Five-Day Regimen RARITAN, N.J., Se...raindicated in persons with known hypersensitivity to levofloxacin or other quinolone antibacterials. Serious and occasionally fatal events, such as hypersensiti...
Quinolone in Medical Technology

Rib-X Pharmaceuticals Reports Positive Top-Line Results from Phase 2 Study of Delafloxacin

...rom a Phase 2 clinical trial with the intravenous form of its novel anionic quinolone antibiotic, delafloxacin (RX-3341). The double-blind study showed that both...uinolones against Gram-positive bacteria, including potent activity against quinolone resistant Gram-positive bacteria including MRSA. The compound has been show...

Novexel Reports Positive Phase II Trial Results With NXL103 in Adult Patients With Community Acquired Pneumonia

...cteria including methicillin resistant Staphylococcus aureus (MRSA) as well as the important respiratory pathogens including penicillin, macrolide and quinolone resistant strains. The NXL103 Phase II study was a double-blind, multinational, randomized, comparative study that evaluated this novel oral antibac...

TaiGen Biotechnology Successfully Completes Patient Recruitment for Phase II Trial of Nemonoxacin for Treatment of Adult Community Acquired Pneumonia (CAP)

...the trial data analysis is expected in the last quarter of 2007. In this trial, the effect of Nemonoxacin in comparison with levofloxacin, the leading quinolone on the market, is evaluated with both clinical and bacteriological success rates in treating adult patients with CAP. "We are pleased with the effici...

Five Days of LEVAQUIN(R) as Effective as 10 Days of Ciprofloxacin in Complicated Urinary Tract Infections and Acute Pyelonephritis

... contraindicated in persons with a history of hypersensitivity to LEVAQUIN, quinolone antimicrobial agents, or any other components of this product. Serious and ...patients receiving concomitant corticosteroids, especially the elderly. The quinolone should be discontinued in patients experiencing pain, inflammation, or rupt...
Quinolone in Biological News

To Stop Evolution: New Way Of Fighting Antibiotic Resistance Demonstrated By Scripps Scientists

...nt to vancomycin. Certain strains of Shigella dysenteriae, the cause of epidemic dysentery, have even become resistant to all but a single drug -- the quinolone ciprofloxacin -- and may soon become completely untreatable. This is a major concern for public health because, according to the World Health Organiza...
Quinolone in Biological Technology

Rib-X Pharmaceuticals Reports Positive Phase 2 Study Results for Radezolid in Community-Acquired Pneumonia

...dition to these internally developed programs, Rib-X is also currently preparing to enter Phase 3 clinical trials with delafloxacin (RX-3341), a novel quinolone that is effective against quinolone-resistant Gram-positive infections. For more information on the Rib-X mission and the pipeline, please vis...

Sunesis Reports Financial Results for the Second Quarter 2009

...d to $8.2 million and $18.7 million for the same periods in 2008. About Voreloxin Voreloxin is a first-in-class anticancer quinolone derivative, or AQD, a class of compounds that has not been used previously for the treatment of cancer. Voreloxin both intercalates DNA and inhibits t...

Sunesis Pharmaceuticals Reports Fourth Quarter and Full-Year 2008 Financial Results

... will be recorded and available for replay on Sunesis' website until April 15, 2009. About Voreloxin Voreloxin is a first-in-class anticancer quinolone derivative, or AQD, a class of compounds that has not been used previously for the treatment of cancer. Voreloxin both intercalates DNA and inhibits t...

TaiGen Biotechnology Secures 37 Million USD in Series C Round Financing

... cell transplantation, chemosensitization, critical limb ischemia and age-related macular degeneration. Nemonoxacin, a broad-spectrum non-fluorinated quinolone achieved the non-inferiority clinical cure rate compared with levofloxacin and both drugs have comparable safety profile in the phase II trial of comm...

Rib-X Pharmaceuticals to Present at the 2008 ICAAC/IDSA Joint Meeting

...pyogenes. Additionally, Rib-X is developing delafloxacin, (RX-3341), an anionic fluoroquinolone active against a broad spectrum of bacteria, including quinolone resistant Gram positive bacteria and MRSA. Both radezolid and delafloxacin are currently in Phase 2 clinical trials. For more information on the Rib...

Rib-X Pharmaceuticals, Inc. Announces Formation of Clinical Advisory Board

...pyogenes. Additionally, Rib-X is developing delafloxacin, (RX-3341), an anionic fluoroquinolone active against a broad spectrum of bacteria, including quinolone resistant Gram positive bacteria and MRSA. Both radezolid and delafloxacin are currently in Phase 2 clinical trials. For more information on the rib...

The QIAGEN Guide to Animal Cell Culture

...separate room. Elimination of mycoplasma is commonly achieved by treatment with various commercially available antibiotics such as a quinolone derivative (Mycoplasma Removal Agent), ciprofolxacin (Ciprobay), enrofloxacin (Baytril), and a combination of tiamulin and minocycli...
Quinolone in Biological Products

Sheep Anti-Quinolone Polyclonal Antibody, Unconjugated from Abcam

Description:... Sheep polyclonal to quinolone ( Abpromise for all tested applications). Antigen: Norfloxacin(N)conjugated to BSA...
Company:Abcam
Quinolone in Biological Definition

Antibiotic

...er side effects can result from interaction between the antibiotic and other drugs, such as elevated risk of tendon damage from administration of a quinolone antibiotic with a systemic corticosteroid . Antibiotic misuse Common forms of antibiotic misuse include taking an inappropriate antibiotic,...
Quinolone in Biological Dictionary

DNA gyrase

... covalent complexes, which are converted to ... quinolone binding to the gyrase - DNA complex induces a co... DNA gyrase is the intracellular target of the quinolone group of ... ... have used limited proteolysis...rcoiling with ... DNA gyrase is a target of quinolone antibacterial agents, but the molecular ... DNA ...
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