Quinine

Breakthrough in combating the side effects of quinine

Discovered back in the 1600s quinine was the first effective treatment in the fight against malaria and it continues to be a commonly used treatment against this devastating disease. But the drug is associated with a long list of side effects which can range from sickness and headaches to blindne...

Artesunate Is Better For Malaria Than Quinine

A research report published in the latest edition of The Lancet had found the drug artesunate more effective in treating adults with malaria than the common drug quinine. Quinine is the only drug recommended for the treatment // of severe malaria throughout Africa, South America, and most of A...

Huh, What Did You Say?: May is 'Better Hearing and Speech Month'

... contributed to their futures." What causes hearing loss? Hearing loss can be caused by certain intravenous antibiotics, high dose pain relievers, quinine or aspirin, autoimmune diseases, viral infection, genetics or a simple blow to the head. Hearing loss is the #1 chronic birth defect today. But the la...

They were right after all

...g (Harvard University) described how to synthesize quinine in the laboratory. The last step of this formal to...944. Based on the conversion of d-quinotoxine into quinine described by Rabe and Kindler in 1918, they claime...by Gilbert Stork (Columbia University) in 2001. quinine and the cinchona bark alkaloids play an important ...

A Wristwatch For Detecting Malaria

...to three million lives a year. Traditionally when signs of malaria become apparent, the parasite count is at approximately 3,000, at which stage quinine (the malaria drug) needs to be administered which is reported to be more dangerous than the parasite itself. Lubbe's company Gervans Trading is now de...

Quinine in Medical Dictionary

Nocturnal leg cramps

...bsolute reduction in nocturnal leg cramps (95% CI) in patients taking quinine ... sudden cramps in the leg that wake people up. ... But people of... in recumbent nocturnal leg cramps in the elderly. ... blind trial of quinine sulphate for nocturnal leg cramps . ... Nocturnal Leg Cramps ...

Quinine in Biological News

Tryptophan deficiency may underlie quinine side effects

Researchers have found that the anti-malarial drug quinine can block a cell's ability to take up the essential amino acid tryptophan, a discovery that may explain many of the adverse side-effects associated with quinine. Once confirmed, these findings would suggest that dietary tryptophan suppleme...

Brain tweak lets sleep-deprived flies stay sharp

...e runs of a maze with two options: one lighted vial with the bitter-tasting quinine in it and one darkened but quinine-free vial. Flies are instinctively drawn...s: First, they've got to remember that the lighted vial is the one that has quinine in it, and then they've got to suppress their natural instinct to fly towar...

Taking a cue from breath fresheners, researcher develops new method for taste testing

... a small amount of a taste stimulus that will give each strip the desired taste: sodium chloride for salty, sucrose for sweet, ascorbic acid for sour, quinine for bitter, and monosodium glutamate for umami taste. Once the solution is cool, it is then poured onto Teflon-coated pans and allowed to dry five t...

Psst! Coffee drinkers: Fruit flies have something to tell you about caffeine

...the Gr66a protein, causes the neurons to produce electrical current "spikes" at a frequency of about 20 spikes per second. Other bitter compounds like quinine generated electrical current spikes at about the same frequency in the mutants. Only flies missing the Gr66a taste receptor protein were unable to...

Great (taste) expectations: Study shows brain anticipates taste, shifts gears

...e of anticipation. The work, conducted at the UW-Madison Waisman Center using state-of-the-art brain imaging techniques and distasteful concoctions of quinine on a cohort of college students, reveals in detail how the brain responds to a manipulation intended to mitigate an unpleasant experience. "There i...

Quinine in Biological Technology

Sub-Picomolar Fluorescein

...tes the O-H and H-O-H modes. The Standard Test Method according to the ASTM was intended to establish the minimum detectable fluorescence of quinine sulfate. We applied this method to fluorescein because a number of customers specifically requested detection limits for that compound. The MDC ...

Quinine in Biological Definition

Biodiversity

...ity has a role in medication . Wild plant species have been used for medicinal purposes since before the beginning of recorded history. For example, quinine comes from cinchona tree (used to treat malaria ), digitalis from the foxglove plant (chronic heart trouble), and morphine from the poppy ...

Ebola

...a fever . One of the nurses assumed Lokela had malaria and gave him a quinine shot. When Lokela returned home from the hospital and died, the women of h...spital had an Ebola epidemic on their hands. The needle used for Lokela's quinine injection was inadequately sterilized, so Ebola had spread from patient to ...

Malaria

...asite are widely used by visitors to the tropics. Since the 17th century quinine has been the prophylactic of choice for malaria. The development of quina...nnua ), containing the compound artemisinin , a substance unrelated to the quinine derivatives, offer some future promise. Prospects of disease control ...