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Purpura in Medical News

Rigel R788 Raises Platelet Counts in Immune Thrombocytopenic Purpura (ITP) Patients in Phase 2 Study

SOUTH SAN FRANCISCO, Calif., Nov. 9 /PRNewswire-FirstCall/ -- Rigel Pharmaceuticals, Inc. (Nasdaq: RIGL ) today announced results of its Phase 2 clinical study of R788, a novel, oral Syk kinase inhibitor, in patients with Immune Thrombocytopenic Purpura (ITP). The single-center, open-label, d...

Eltrombopag studied in Idiopathic Thrombocytopenic Purpura

NEW YORK (Nov. 29, 2007) -- There are estimated to be between 50,000 -- 100,000 individuals in the U.S. diagnosed with chronic Immune Thrombocytopenic Purpura (ITP), an autoimmune disease that dramatically reduces the number of platelets in their blood -- causing bruises, nosebleeds and, sometim...

Drug Boosts Platelet Production, Reversing Immune Thrombocytopenic Purpura

Attacking a platelet-depleting autoimmune disease in a whole new way, an experimental drug is helping patients with immune thrombocytopenic purpura (ITP) once again// produce healthy amounts of platelets -- with no major side effects. That's the conclusion of a new, multicenter study led by D...

New Data Demonstrate RISPERDAL(R) CONSTA(R) (Risperidone) Long-Acting Treatment May Improve Health Outcomes and Reduce Hospitalizations in Patients with Schizophrenia

...risk for aspiration pneumonia. Priapism has been reported. Severe priapism may require surgical intervention. Thrombotic Thrombocytopenic purpura (TTP) has been reported. Administration: Care should be taken to avoid inadvertent injection into a blood vessel. Suicide: The possibil...

FDA Grants Approval for Use of RISPERDAL(R) CONSTA(R) as Both a Monotherapy and Adjunctive Therapy in the Maintenance Treatment of Bipolar I Disorder

...risk for aspiration pneumonia. Priapism has been reported. Severe priapism may require surgical intervention. Thrombotic Thrombocytopenic purpura (TTP) has been reported. Administration: Care should be taken to avoid inadvertent injection into a blood vessel. Suicide: The possibil...

Einstein scientists propose new theory of autism

...rs that are involved in complex cognitive tasks," says Dr. Mehler. Drs. purpura and Mehler hypothesize that in autism, the LC-NA system is dysregulated by ...ms at mid-gestation resulted in the highest prevalence of autism. Drs. purpura and Mehler believe that, in autistic children, fever stimulates the LC-NA s...

3SBio Inc. Files for SFDA Approval for TPIAO Label Extension for the Treatment of ITP

...08 with the Chinese State Food and Drug Administration (SFDA) for approval of a TPIAO label extension for the treatment of idiopathic thrombocytopenic purpura (ITP) in China. If the extension is approved, 3SBio expects that TPIAO for ITP will be the only treatment of this kind available in China. Lau...

Novel therapeutic approaches may improve patient outcomes in several platelet disorders

...r previously untreated idiopathic thrombocytopenic purpura (ITP), an investigational oral treatment for chron...h previously untreated idiopathic thrombocytopenic purpura (ITP). The results of this study indicate that thi... Patients With Chronic Idiopathic Thrombocytopenic purpura (ITP): Results of a Phase III, Double-Blind, Place...

Rigel to Webcast Investor Update on October 27, 2008

...y being evaluated in two Phase 2b clinical trials in patients with rheumatoid arthritis, as well as Phase 2 clinical trials in immune thrombocytopenic purpura and B-cell lymphomas. The event will be webcast live and can be accessed from Rigel's website at http://www.rigel.com . Please connect to Rigel's w...

PROMACTA(R) (eltrombopag) RECEIVES UNANIMOUS RECOMMENDATION BY FDA ADVISORY PANEL

...m Treatment of Chronic Idiopathic Thrombocytopenic purpura (ITP) CHICAGO, May 30 /PRNewswire-USNewswire/ --... patients with chronic idiopathic thrombocytopenic purpura (ITP). The FDA advisory committee was held onsite ...mates of adult chronic idiopathic thrombocytopenic purpura (ITP). J Thromb Haemost. 2008 doi: 10.1111/j.1538-...
Purpura in Medical Technology

Nplate(R) Approved in the European Union for the Treatment of Chronic Immune (Idiopathic) Thrombocytopenic Purpura (ITP)

First and Only Approved Platelet Producer in Europe Represents New Treatment Approach for Serious Chronic Autoimmune Disorder ZUG, Switzerland, Feb. 6 /PRNewswire-FirstCall/ -- Amgen (Nasdaq: AMGN ) today announced that the European Commission (EC) has granted marketing authorisation for Np...

RISPERDAL(R) CONSTA(R) (Risperidone) Long-Acting Treatment Delayed the Time to Relapse in Patients with Bipolar I Disorder

...risk for aspiration pneumonia. Priapism has been reported. Severe priapism may require surgical intervention. Thrombotic Thrombocytopenic purpura (TTP) has been reported. Administration: Care should be taken to avoid inadvertent injection into a blood vessel. Suicide: The possibil...

Long-term Follow Up Interim Data Show Nplate(TM) Increased and Sustained Platelet Counts in Adult Chronic ITP Patients

...te(TM) (romiplostim) in adult patients with chronic immune thrombocytopenic purpura (ITP). Chronic ITP is a chronic and serious autoimmune disorder characteriz...ombocytopenia in patients with chronic immune (idiopathic) thrombocytopenic purpura (ITP) who have had an insufficient response to corticosteroids, immunoglobu...

Novel Therapeutic Approaches May Transform Treatment and Improve Patient Outcomes in Several Platelet Disorders

...r previously untreated idiopathic thrombocytopenic purpura (ITP), an investigational oral treatment for chron...h previously untreated idiopathic thrombocytopenic purpura (ITP). The results of this study indicate that thi... Patients With Chronic Idiopathic Thrombocytopenic purpura (ITP): Results of a Phase III, Double-Blind, Place...

GSK Reports PROMACTA(R) (eltrombopag) Significantly Increased Platelet Counts and Reduced Bleeding in Long-Term Study of Patients With Chronic ITP

...html . Accessed November 12, 2007. 2. Feudjo-Tepie M, Robinson N, Bennett D. Prevalence estimates of adult chronic idiopathic thrombocytopenic purpura (ITP). J Thromb Haemost. 2008; 6(4): 711 - 712. ...

Nplate(TM) (Romiplostim) Receives Positive Opinion for Marketing Authorisation in the European Union

...horisation for Nplate(TM) (romiplostim) in the European Union (EU). The CHMP recommends Nplate for adult chronic immune (idiopathic) thrombocytopenia purpura (ITP) splenectomised patients who are refractory to other treatments (e.g. corticosteroids, immunoglobulins). Nplate may be considered as second line...

FDA Approves Promacta(R) (Eltrombopag), the First Oral Medication to Increase Platelet Production for People With Serious Blood Disorder

...ombocytopenia in patients with chronic immune (idiopathic) thrombocytopenic purpura (ITP) who have had an insufficient response to corticosteroids, immunoglobu...ennett D. Prevalence estimates of adult chronic idiopathic thrombocytopenic purpura (ITP). J Thromb Haemost. 2008; 6(4): 711 - 712. ...

Rigel's R788 Slows Progression of Murine Lupus in Preclinical Studies

...ilable syk kinase inhibitor, which has shown clinically significant results in treating patients with rheumatoid arthritis and immune thrombocytopenic purpura in clinical trials. A third clinical trial of R788 in patients with B-cell lymphoma will be completed later this year. Rigel also expects to initiate ...

Vermillion and the Ohio State University Report That Novel Diagnostic Test May Help Predict Risk for Relapse of TTP, A Serious Blood Disorder

...y (OSU) clinical study that indicated that a surface-enhanced laser desorption/ionization time of flight (SELDI-TOF)-based thrombotic thrombocytopenic purpura (TTP) diagnostic test could be used to help estimate the risk of TTP relapses during clinical remission. OSU currently offers the TTP test as a labora...

FDA Grants Priority Review for PROMACTA(R) (eltrombopag)

...e short-term treatment of patients with chronic idiopathic thrombocytopenic purpura (ITP). PROMACTA is an investigational, once-daily oral treatment that induc...ennett D. Prevalence estimates of adult chronic idiopathic thrombocytopenic purpura (ITP). J Thromb Haemost. 2008 doi: 10.1111/j.1538-7836.2008.02911.x. ...
Purpura in Medical Definition

Hematopathology

...l aplasia , Fanconi anemia ) • Hemochromatosis Coagulation / platelets DIC • Hemophilia ( A , B , C ) • Von Willebrand disease • purpura ( Henoch-Schönlein , ITP , TTP ) other Methemoglobinemia - Langerhans cell histiocytosis ...

Pathology

...l aplasia , Fanconi anemia ) • Hemochromatosis Coagulation / platelets DIC • Hemophilia ( A , B , C ) • Von Willebrand disease • purpura ( Henoch-Schönlein , ITP , TTP ) other Methemoglobinemia - Langerhans cell histiocytosis v • d • e En...
Purpura in Medical Dictionary

Purpura

Purpura is the appearance of red or purple discolorations on the skin that do not blanch on applying pressure. They are caused by bleeding underneath the skin. Purpura measure 0.3-1 cm, whereas petechiae measure less than 3... Purpura is the result of hemorrhage into the skin or m...

Thrombocytopenia

... thrombocytopenia . thrombocytopenic purpura. thrombotic thrombocytopenic purpura ... diseases can cause thrombocytopenia . Thrombocytopenia can occur wh...ber of circulating platelets. ... INTRODUCTION Immune thrombocytopenic purpura (idiopathic thrombocytopenic ... Approach to the adult patient with throm...

Nephrotic syndrome

...view: Nephrotic syndrome (NS), also known as nephrosis, is defined by the ... Secondary causes of nephrotic syndrome include Henoch-Schönlein purpura (HSP) ... NEPHROTIC SYNDROME OVERVIEW The term nephrotic syndrome refers to a group of ... Renal vein thrombosis and hypercoagulable ...

Itp

... Idiopathic thrombocytopenic purpura ( ITP ) is the condition of having a low platele... ITP is also known as immune thrombocytopenic purpura or immune-mediated... Providing news, product...ts,Hardware , ... Idiopathic thrombocytopenic purpura ( ITP ) is a bleeding condition in which the .....

Idiopathic

..."a disease of its own kind." Idiopathic thrombocytopenic purpura (ITP) is the condition of having a low platelet count of no known cause ...tibodies against platelets, ITP is also known as immune thrombocytopenic purpura or immune-mediated... " Idiopathic Dilated Cardiomyopathy" is more co...

Hus

... HUS , thrombi caused by clumps of platelets block small blood vessels. ... Hemolytic-uremic syndrome ( HUS ) and thrombotic thrombocytopenic purpura (TTP) ... Home " HUS /TTP " Overview, Causes and Risk Factors, Symptoms, Diagnosis, Treatment ... HUS symptoms, causes, diagnosis, and treatm...

Henoch

...Although the cause is unknown, Henoch -Schönlein purpura is often associated with ... Introductory art...le of Methuselah's father. Henoch -Schonlein purpura is a disease that involves purple spots on the ...f the immune system. ... Henoch -Schonlein purpura — Comprehensive overview covers symptoms, causes,...

Hemolytic anemia

... Hemolytic disease of the newborn Also known as erythroblastosis neonatorum, ... Autoimmune hemolytic anemia · Idiopathic thrombocytopenic purpura · Bullous ... Hemolytic anemia is a disorder in which the red blood cells are destroyed faster than the bone marrow can produce them. ......

Ecchymosis

...skin discoloration caused ... general: Petechia - purpura - Ecchymosis - Hematoma ... Retrieved from &qu... skin ( ecchymosis ) Idiopathic thrombocytopenic purpura (petechiae and purpura) ... Bleeding into the... skin ( ecchymosis ) Idiopathic thrombocytopenic purpura (petechiae ... Eye injuries can be serious,...

Bleeding into the skin

... apparent reason ... Conditions causing symptom Bleeding under skin including possible medical causes, diseases, ... bleeding into skin . purpura ... bleeding under the skin ... Aside from the common bruise, bleeding into the skin or mucous membranes is a ... Redness of the ...
Purpura in Biological News

Lancet study supports new, highly effective treatment for blood disorder

....S. diagnosed with chronic immune thrombocytopenic purpura (ITP), an autoimmune disease that dramatically red... with chronic immune (idiopathic) thrombocytopenic purpura who have had an insufficient response to corticost...hip in GlaxoSmithKline. Immune thrombocytopenic purpura (ITP) is an autoimmune disease in which anti-plate...

Eltrombopag effective for hepatitis C patients with low blood-platelet counts

...of Medicine, finding the platelet growth factor successfully increased platelet counts and decreased bleeding in patients with Immune Thrombocytopenic purpura (ITP), an autoimmune disease that dramatically reduces the number of platelets in their blood. (Dr. Bussel is an Advisory Board Member for GlaxoSmithK...

U of M researcher examines newly emerging deadly disease

...ied a newly emerging illness, named staphylococcal purpura fulminans. The disease begins as a respiratory tra...en leading to death due to hypertension and shock. purpura fulminans has been identified in five cases in the...12 known cases, only two patients have survived. purpura fulminans is an acute illness commonly associated ...
Purpura in Biological Technology

Amgen's Third Quarter 2008 Adjusted Earnings Per Share Increased 14 Percent to $1.23

...production for the treatment of thrombocytopenia in splenectomized (spleen removed) and non-splenectomized adults with chronic immune thrombocytopenic purpura (ITP). Nplate, the first FDA-approved peptibody protein, works by raising and sustaining platelet counts, representing a novel approach for the treatm...

3SBio Inc. Announces Second Quarter 2008 Results

...ent options. TPIAO for ITP We have achieved our enrollment goal for the Phase III trial for TPIAO for the treatment of idiopathic thrombocytopenic purpura (ITP). We remain on track to file the application for approval with the SFDA in the fourth quarter of 2008. TPIAO Phase IV Studies To maximize the...

ProMetic announces Octapharma publication of PRDT'S prion removal resin in Octaplas(R) manufacturing process at 30th International Congress of the International Society for Blood Transfusion meeting in Macao SAR, China

... coagulation disorders - both congenital and acquired - where no specific coagulation factor concentrate is available, and thrombotic thrombocytopenic purpura ("TTP") - usually in conjunction with plasma exchange. Octaplas(R) is fully licensed in 29 countries worldwide, and roughly 6 million bags have been u...

Vermillion Announces First Quarter 2008 Financial Results and Business Progress

...stic tests are commercialized. During the first quarter of 2008, products revenue of $5,000 was generated from the sale of thrombotic thrombocytopenic purpura ("TTP") test component materials to The Ohio State University Research Foundation ("OSU"). Total operating expenses decreased in the first quarter o...

CSL Behring Signs Agreements With Canadian Blood Services and Hema-Quebec to Supply Life-Saving Therapies

...or a period of 24 months. Privigen(R) is indicated for the treatment of primary and secondary immune deficiencies as well as immune thrombocytopenic purpura (ITP), a disorder characterized by low platelet counts due to the presence of auto-antibodies directed against the patient's own platelets. Privigen...

Vermillion Summarizes Recent Accomplishments and 2007 Financial Results; Outlines 2008 Business Milestones

...nt clinical and commercial advancements in our diagnostic programs for peripheral artery disease (PAD), ovarian cancer and thrombotic thrombocytopenic purpura (TTP)," said Gail Page, President and CEO of Vermillion. "Our vision is to provide novel diagnostic tools to physicians in an effort to improve patien...

3SBio Inc. Announces Unaudited Fourth Quarter and Fiscal Year 2007 Results

...uct and expect filing with SFDA in Q3 of 2008. The initial results of the Phase III trial for TPIAO for the treatment of idiopathic thrombocytopenic purpura (ITP) demonstrated excellent efficacy and a high safety profile based on our data to date. Enrollment has been completed, but we experienced a higher ...

FDA Approves New 300mg Loading Dose Tablet for PLAVIX(R) (clopidogrel bisulfate)

...SE REACTIONS.*) -- As part of the worldwide post marketing experience with PLAVIX, there have been cases of reported thrombotic thrombocytopenic purpura (TTP), some with fatal outcome. TTP has been reported rarely following use of PLAVIX, sometimes after a short exposure ( condition that c...
Purpura in Biological Dictionary

Thrombocytes

..., the fluid systems, innate immunity ... leukocytes (white blood cells or WBCs), and thrombocytes (platelets) ... Idiopathic thrombocytopenic purpura (ITP) is a bleeding condition in which the ... Platelets also are called thrombocytes (THROM-bo-sites) ... What does it mean when a veterinarian ...
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