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Purine in Medical News

BioCryst Reports Second Quarter 2009 Financial Results And Provides Corporate Update

...ous and autoimmune diseases. BioCryst has two product candidates in pivotal clinical trials; peramivir, an anti-viral for influenza, and forodesine, a purine nucleoside phosphorylase (PNP) inhibitor for cutaneous T-cell lymphoma (CTCL). Utilizing crystallography and structure-based drug design, BioCryst c...

Pharmasset Nominates PSI-938 as a New Nucleotide Analog Inhibitor of Hepatitis C for Preclinical Development

...as a lead development candidate from two series of purine analogs for the treatment of chronic hepatitis C v...)ides in clinical development in the future." purine nucleos(t)ide analogs have many of the benefits of...cting antivirals targeting HCV. In addition, these purine analogs are also active against the S282T resistan...

BioCryst Pharmaceuticals Announces Presentation of Forodesine Data at the 45th Annual Meeting of the American Society of Clinical Oncology

...a from May 29-June 2. Forodesine is a transition-state analog inhibitor of purine nucleoside phosphorylase (PNP), a purine salvage pathway enzyme that is essential for the proliferation of T-cells a...

Hard To Treat Diseases (HTDS) Slavica BioChem Update on Research Activities

...e Field of Scientific and Technical Research (COST) organization. Dr. Pekovic also reported the scientific team has started some in vitro studies of purine nucleoside analogues (ribavirin, tiazofurin, the drugs we are investigating) effects on microglial cell culture (there is no current data in the liter...

FDA approves ULORIC (febuxostat) for the chronic management of hyperuricemia in patients with gout

...ophi. About ULORIC (febuxostat) ULORIC works by blocking the enzyme xanthine oxidase. Xanthine oxidase is responsible for the breakdown of the purine base, hypoxanthine, to xanthine, and then to uric acid. By blocking this enzyme, ULORIC helps prevent uric acid production, thereby lowering elevated ...

Targeted Anticancer Drugs - In Vitro Assessment and Non-Invasive Imaging of Patient and Tumor Status Will Determine Clinical and Commercial Success

...ostate stem cell antigen (PSCA); prostate-specific membrane antigen (PSMA); proteasome; protein kinase A type I (PKAI); protein kinase C (PKC); PKC-B; purine nucleoside phosphorylase (PNP); ras; R1 mRNA; R2 mRNA; Raf/B-Raf; Rad51; RET; ribonucleotide reductase (RNR); ribonucleotide reductase M2 polypeptide ...

Enzyme complex could be key to new cancer treatments

...h shows that these enzymes form a cluster prior to purine formation," said Erin Sheets, an assistant profess...t, cells also can produce purines by recycling old purine material. Owing to this salvage process, cells do...imately, for cell replication, the ability to halt purine synthesis could prove to be a valuable method for ...

TREANDA New Drug Application for the Treatment of Chronic Lymphocytic Leukemia Granted Priority Review Status by FDA

...riod of marketing exclusivity in the United States, if the product is approved for this indication. About TREANDA TREANDA is a rationally designed purine analog/alkylator hybrid. Preclinical data demonstrate that this rationally designed hybrid acts in two ways to kill cancer cells. TREANDA damages the ...

Cephalon Submits New Drug Application for TREANDA for the Treatment of Chronic Lymphocytic Leukemia

...DA for CLL, the company will make a $15 million milestone payment to former shareholders of Salmedix. About TREANDA TREANDA is a rationally designed purine analog/alkylator hybrid. Preclinical data demonstrate that TREANDA induces rapid, sustained single- and double-strand DNA damage, which results in apo...

Protein Folds Research Offers Insight into Metabolic Evolution

...ams of metabolic networks (for an example, see the purine metabolism network in MANET). The result is a mult...etabolism, particularly the interconversion of the purine and pyrimidine nucleotides that create the core of... We see that all the enzymes that were involved in purine synthesis, for example, were very recent. Since th...
Purine in Medical Technology

Cordex Signs European Development Partnership for ATPotent(TM) Sperm Motility Drug

...ndidate for the in vitro treatment of human and animal sperm, in which the active ingredient is adenosine 5'-triphosphate (ATP). ATP is a ubiquitous purine nucleotide found in every cell of the human body where it plays a critical role in cellular metabolism and constitutes the source of energy for all bo...

Pharmasset Voluntarily Halts Clinical Studies with Clevudine in Hepatitis B Infected Patients

... to report the first antiviral data in the second half of 2009. In addition, we are collecting preclinical data from our research efforts to select a purine nucleos(t)ide for clinical development." Phase III QUASH Studies The QUASH studies are international, multi-center, randomized, double-blind ...

New Study Shows PCR and FCR Have Significant Activity in B-cell Chronic Lymphocytic Leukemia

... investigator and serves as co-chairman, and chairman for new protocol development, of US Oncology's National Lung Cancer Research Committee. purine analog-based regimens have emerged as highly active regimens in the treatment of chronic lymphocytic lymphoma (CLL). Promising results have been repor...

TREANDA Demonstrates Substantial Efficacy in Patients with Relapsed Indolent Non-Hodgkin's Lymphoma

...2007 at 11:00 am during the ASH meeting [Abstract #385]. About TREANDA (bendamustine HCl) TREANDA is a novel chemotherapeutic agent, a hybrid of a purine analog and an alkylator. Preclinical data demonstrate that TREANDA acts in two distinct ways to kill cancer cells. TREANDA damages the DNA in cancer c...

TREANDA Significantly Improves Clinical Outcomes in Patients with Chronic Lymphocytic Leukemia Compared to Chlorambucil

...re assessed by an Independent Data Monitoring Committee. About TREANDA (bendamustine HCl) TREANDA is a novel chemotherapeutic agent, a hybrid of a purine analog and an alkylator. Preclinical data demonstrate that TREANDA acts in two distinct ways to kill cancer cells. TREANDA damages the DNA in cancer c...

Cephalon Announces Positive Results from Its Pivotal Study of TREANDA in Patients with Non-Hodgkin's Lymphoma

...f patients with chronic lymphocytic leukemia (CLL), for which the FDA has granted orphan drug status. About TREANDA TREANDA is a rationally designed purine analog/alkylator hybrid. Preclinical data demonstrate that TREANDA acts in two ways to kill cancer cells. TREANDA damages the DNA in cancer cells, whi...

BioCryst Initiates Enrollment in Pivotal Trial of Forodesine HCL in Patients with Cutaneous T-Cell Lymphoma (CTCL)

...said Jon P. Stonehouse, President and Chief Executive Officer of BioCryst. Forodesine HCL is a transition-state analog inhibitor of the target enzyme purine nucleoside phosphorylase (PNP). In addition to CTCL, the drug is currently being studied in clinical trials for indications including T and B- cell le...
Purine in Medical Definition

Pathology

...r of acid-base balance - H 2 O Dehydration / Hypervolemia - K + Hypokalemia / Hyperkalemia - Cl − Hyperchloremia / Hypochloremia purine and pyrimidine Hyperuricemia - Lesch-Nyhan syndrome - Xanthinuria Porphyrin Acute intermittent , Gunther's , Cutanea tarda , ...
Purine in Medical Dictionary

Uric acid

... Uric acid is the end product of purine metabolism (purines are building blocks of RNA and DNA). Most uric aci...blood levels of uric acid . ... Uric acid is the end-product of purine nucleotide metabolism in man. ... At the normal acidic region, uric ac...

Hyperuricemia

...ia will actually develop gout. ... Uric acid is the final product of purine metabolism in human beings. Hyperuricemia is a high level of uric acid... often than women. ... Lesch-Nyhan syndrome is a rare inborn error of purine metabolism ... Hereditary Hyperuricemia and Choreoathetosis Syndrome. H...
Purine in Biological News

New computational technique allows comparison of whole genomes as easily as whole books

...es," Kim said. Since these genomes are very large, the researchers translated the genome sequences using a reduced, two-letter alphabet - R for the purine nucleic acids, adenine and guanine, and Y for the pyrimidine nucleic acids, thymine and cytosine - to reduce the complexity of calculation. Using an o...

Study of protein folds offers insight into metabolic evolution

...ams of metabolic networks (for an example, see the purine metabolism network in MANET). The result is a mult...etabolism, specifically the interconversion of the purine and pyrimidine nucleotides that compose the core o..."We see that all the enzymes that were involved in purine synthesis, for example, were very recent. Since th...

Switching to new anti-bacterial targets: Riboswitches

...rithiamine and become resistant by acquiring mutations in their riboswitches. This work, in combination with the recently solved crystal structures of purine riboswitches, opens a path to the directed design of drugs targeting riboswitches for use as antibiotics. According to the researchers, it is inevi...
Purine in Biological Technology

BioCryst Pharmaceuticals to Announce Second Quarter 2009 Financial Results on July 30, 2009

...ous and autoimmune diseases. BioCryst has two product candidates in pivotal clinical trials; peramivir, an anti-viral for influenza, and forodesine, a purine nucleoside phosphorylase (PNP) inhibitor for cutaneous T-cell lymphoma (CTCL). Utilizing crystallography and structure-based drug design, BioCryst c...

Pharmasset Reports Fiscal Second Quarter 2009 Financial Results

...ond generation hepatitis C virus (HCV) product candidate, PSI-7851, and the purine series of compounds. Pharmasset reported a net loss of $15.5 million, ...Milestones: Announce selection of candidate(s) from our purine series of nucleos(t)ide analog for HCV in second half of 2009; Prov...

FDA Approves ULORIC(R) (febuxostat) for the Chronic Management of Hyperuricemia in Patients with Gout

...phi. About ULORIC (febuxostat) ULORIC works by blocking the enzyme xanthine oxidase. Xanthine oxidase is responsible for the breakdown of the purine base, hypoxanthine, to xanthine, and then to uric acid. By blocking this enzyme, ULORIC helps prevent uric acid production, thereby lowering elevated ...

BioCryst Reports Fourth Quarter and Year End 2008 Financial Results and Provides Corporate Update

... BCX-4208 A poster entitled, "A Phase 2 Study of the purine Nucleoside Phosphorylase (PNP) Inhibitor RO5092888 (BCX-4208) in Patients w... BioCryst also presented a poster at ASH entitled, "BCX-4208 (RO5092888), a purine Nucleoside Phosphorylase (PNP) Inhibitor is a Novel, Potent Orally Active A...

Alfacell's ONCONASE(R) and R-Amphinase Show Anti-Tumor Activity in Chronic Lymphocytic Leukemia and Acute Myeloblastic Leukemia Cells

...4-72 hours with either ONCONASE or R-Amph alone and in combination with the purine analogues cladribine (2-CdA) and fludarabine (FA), as well as with doxorubi...gistic activity was seen in the combination of the endonuclease plus either purine analogue. The combination of doxorubicin with ONCONASE or R-Amph demonstrat...

BioCryst to Present Three Posters During the 50th American Society of Hematology Annual Meeting and Exposition

...8. Forodesine HCl and BCX-4208 are clinical-stage purine nucleoside phosphorylase (PNP) inhibitors. ...H is as follows: BCX-4208 (RO5092888), a purine Nucleoside Phosphorylase ( PNP ) Inhibitor is a ...fic Time; Hall A A Phase II Study of the purine Nucleoside Phosphorylase (PNP) Inhibitor RO5092888...

BioCryst Reports Third Quarter 2008 Financial Results and Provides Corporate Update

...s with moderate to severe plaque psoriasis were consistent with interim findings. BCX-4208, a potent, rationally designed, orally available purine nucleoside phosphorylase inhibitor, met its primary endpoint of safety and tolerability and displayed dose-dependant reductions in periphera...

Cephalon Submits New Drug Application for TREANDA for the Treatment of Patients with Relapsed Indolent Non-Hodgkin's Lymphoma

... About TREANDA TREANDA is a novel chemotherapeutic agent, a hybrid of a purine analog and an alkylator. Preclinical data demonstrate that TREANDA acts in ...catastrophe (a disruption of normal cell division). The contribution of the purine analog to the antitumor effect of TREANDA is under investigation but has no...

Cephalon Submits New Drug Application for TREANDA for the Treatment of Chronic Lymphocytic Leukemia

...DA for CLL, the company will make a $15 million milestone payment to former shareholders of Salmedix. About TREANDA TREANDA is a rationally designed purine analog/alkylator hybrid. Preclinical data demonstrate that TREANDA induces rapid, sustained single- and double-strand DNA damage, which results in apo...

FDA Grants Orphan Drug Designation to TREANDA, an Investigational Treatment for Chronic Lymphocytic Leukemia

...TRISENOX(R) (arsenic trioxide) injection and CEP-701 (lestaurtinib), which is in development. About TREANDA TREANDA is the first rationally designed purine analog / alkylator hybrid, combining the moieties of an antimetabolite and an alkylator. Preclinical data show that TREANDA induces rapid, sustained s...
Purine in Biological Products

Chicken Anti-DCTD (dCMP deaminase) Polyclonal Antibody, Unconjugated from GenWay Biotech, Inc.

Description:...quamous Cell Car Protein Functions: Protein Byiosynthesis; Phosphotransferases; Pyrimidine Metabolism; One-Carbon Group Transferases; Dna Polymerase; purine Metabolism; Nucleotide Sugars Metabolism; Esterases; Glycosyltransferases; Cell Division; Ligases; Acid Anhydride Hydrolases; Nitrogen Tissues: Intra...
Company:GenWay Biotech, Inc.

Pyrophosphate Fluorometric (Blue) Assay Kit, EnzChek® from Molecular Probes (Invitrogen)

Description:...bb.2 In the presence of inorganic phosphate (Pi ), the substrate 2-amino-6-mercapto-7-methylpurine ribonucleoside (MESG) is converted enzymatically by purine nucleoside phosphorylase (PNP) to ribose 1-phosphate and 2-amino-6-mercapto-7-methylpurine (Figure 1). Enzymatic conversion of MESG results in a shift...
Company:Molecular Probes (Invitrogen)
Purine in Biological Definition

Purine

Purine Chemical name Purine Chemical formula C 5 H 4 N 4 Molecular mass 120.11 g/mol Melting point 214 C CAS number 120-73-0 SMILES C1(NC=N2)=C2C=NC=N1 Purine is a heterocyclic aromatic organic compound , consisting of a pyrim...

Genetic code

...ous nucleotide bases grouped into 2 categories, purine and pyrimidine . The purine bases adenine ( A ) and guanine ( G ) are lar...rd position. Since transition mutations (purine to purine or pyrimidine to pyrimidine mutations) are more li...

Genetic code

...ous nucleotide bases grouped into 2 categories, purine and pyrimidine . The purine bases adenine ( A ) and guanine ( G ) are lar...rd position. Since transition mutations (purine to purine or pyrimidine to pyrimidine mutations) are more li...

Pyrimidine

... these bases form hydrogen bonds with their complementary purines . purine pyrimidine A T G C In RNA , the complement of A is U instead of T: purine pyrimidine A U G C Thymine ...
Purine in Biological Dictionary

Purine

Purine (1) is a heterocyclic aromatic organic compound, consisting of a pyrimidine ring fused to an imidazole ring. Purines, including substituted purines and their tautomers, are the most widely distributed kind of nitrogen-containing heterocycle in nature. purine ( ) n. A double-ringed, ...

Z-DNA

.... Fratini & M. L. Kopka (1982) The anatomy of A-, B-, and Z-DNA . ... Left-handed Z-DNA can be formed by sequences containing alternating purine ... Under physiological conditions, Z-DNA formation is a dynamic process, largely ... Twenty years after visualizing a surprising left-handed fo...

Wobble base pair

...vitch wobble , the change in the axial tilt, axial precession and orbital ... base pair n. The pair of nitrogenous bases, consisting of a purine linked ... bonds, does occur fairly often in RNA (see wobble base pair ) but rarely in DNA. ... wobble hypothesis Proposed by Francis Cri...

Uric acid

...ound, C 5 H 4 N 4 O 3 , that is a nitrogenous end product of protein and purine metabolism and is the chief nitrogenous High uric acid level — Ov...nd side effects uric acid diet ... Uric acid is the end product of purine degradation. ... High uric acid is a subtype of autism that respond...

Transversion

... transversion refers to the substitution of a purine for a pyrimidine or vice versa . It can only be... transversion n. A point mutation in which a purine is replaced by a pyrimidine, or a pyrimidine .....ology, ... transversion A mutation in which a purine is replaced by a ... transversion ... Trans...

Thymine

...DNA damage... Thymine , also known as 5-methyluracil, is one of the five main ... Nucleobases: Adenine - Thymine - Uracil - Guanine - Cytosine - purine - Pyrimidine ... Encyclopedia article about thymine . Information about thymine in the Columbia Encyclopedia, Computer Desktop Encyclopedia, com...

Sense strand

...virus: Also known as a sense - strand RNA virus, a virus whose ... ... sense strand differs from the 2'-sugar modification of any of the purine ... molecule of claim 1, wherein the sense strand includes a terminal cap moiety at ... ( A) Base pair homology comparison of 736 siRNA s...

Ribonucleotides

... A ribonucleotide is a nucleotide in which a purine or pyrimidine base is linked to a ribose molecule. The base may be ...(ribonucleic acid) is a polymer of ribonucleotides ... Surprisingly, the purine ribonucleotides are formed as such de novo, and the ... Dietary ribo...

Pyrimidine

...biosynthesis. v • d • e ... Nucleotide metabolism: purine metabolism · Nucleotide salvage · Pyrimidine .... Pyrimidine Catabolism. De novo Synthesis of purine Nucleotides ... The purine and pyrimidine bases released are either degr...

Nucleoside

...pedia.org /wiki/ Nucleoside " ... nucleobase, nucleoside , nucleotide and nucleic acid metabolic process. • DNA modification ... purine nucleoside phosphorylase deficiency. ... Definition of nucleoside from the Merriam-Webster Online Dictionary with audio pronunciations, thesa...
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