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Prothrombin in Medical News

No Benefit in Testing for Genes Linked to Leg Clots

...angerous blood clots called deep vein thrombosis, a new U.S. government report shows. The presence of two gene mutations called Factor V Leiden and prothrombin G20210A can signal continued risk of blood clots, according to background information in the study. But Agency for Healthcare Research and Quality ...

AstraZeneca Studies Show Relief of Nighttime Heartburn and Reduction in GERD-Related Sleep Disturbances

...f which NEXIUM is an enantiomer. As with all PPIs, patients treated concomitantly with warfarin may need to be monitored for increases in INR and prothrombin time. Like other proton pump inhibitors, esomeprazole may interfere with the absorption of drugs where gastric pH is an important determinant of bioav...

FDA Approves New Indication for Wyeth's TYGACIL (tigecycline) for the Treatment of Adult Patients with Community-Acquired Bacterial Pneumonia

...n of the teeth. TYGACIL should not be used during tooth development unless other drugs are not likely to be effective or are contraindicated prothrombin time or other suitable anticoagulant test should be monitored if TYGACIL is administered with warfarin Monotherapy should be used with caution...

KAPIDEX(TM) (dexlansoprazole) delayed release capsules Now Available for the Treatment of GERD

...xin, iron salts, ketoconazole). Patients taking concomitant warfarin may require monitoring for increases in international normalized ratio (INR) and prothrombin time. Please see the complete prescribing information and visit the KAPIDEX Web site at www.kapidex.com . Takeda Pharmaceuticals North Ame...

Twenty New Abstracts on Oral Xeloda(R) (capecitabine) Featured at the 31st San Antonio Breast Cancer Symposium

...a and warfarin has been demonstrated; altered coagulation parameters and/or bleeding and death have been reported. Clinically significant increases in prothrombin time (PT) and INR have been observed within days to months after starting Xeloda, and infrequently within one month of stopping Xeloda. For patients ...

Report Confirms Source of Contaminated Heparin

...That letter reported successful identification of OSCS contamination in heparin by use of one of the most common tests in medical practice --measuring prothrombin time, the time required for blood to clot, or coagulate. Studies show that coagulation time goes down as the amount of OSCS in a blood sample goes up,...

New Study Data: JANUVIA™ (sitagliptin) Significantly Reduced Blood Sugar Levels and Was Not Associated with Hypoglycemia in Elderly Patients with Type 2 Diabetes

...gfully alter the pharmacokinetics, as assessed by measurement of S(-) or R(+) warfarin enantiomers, or pharmacodynamics (as assessed by measurement of prothrombin INR) of a single dose of warfarin. Because S(-) warfarin is primarily metabolized by CYP2C9, these data also support the conclusion that sitagliptin i...

FDA Approves NOVO NORDISK's NovoSeven(R) RT (Coagulation Factor VIIa [Recombinant] Room Temperature Stable) for Hemophilia Patients With Inhibitors

...may be given bypassing agents, such as recombinant Factor VIIa or activated prothrombin complex concentrates (aPCCs), to resolve bleeds. Patients with lower respon...immobile objects. Also, people taking aPCCs/PCCs (activated or nonactivated prothrombin complex concentrates) at the same time that they're taking NovoSeven(R) may...

Xeloda(R), Taxotere(R) and Herceptin(R) Combination Study Suggests Clinical Benefit in Invasive Breast Cancer with Shortened Treatment Cycle

...a and warfarin has been demonstrated; altered coagulation parameters and/or bleeding and death have been reported. Clinically significant increases in prothrombin time (PT) and INR have been observed within days to months after starting Xeloda, and infrequently within one month of stopping Xeloda. For patients r...

Blood Markers Might Predict Clotting Risk With HRT

... blood increased the risk of thrombosis events. Elevated levels of D-dimer predicted a 2.8-fold increased risk of thrombosis, while elevated levels of prothrombin fragment 1.2 predicted a 1.9-fold increased risk. On the flip side, lower levels of anti-coagulant proteins, or proteins which are natural blood t...
Prothrombin in Medical Technology

Value of Genetic Testing for Preventing Blood Clots Unproven, According to New AHRQ Study

...wo mutations -- known as Factor V Leiden (FVL) and prothrombin G20210A -- as well as a history of deep-vein throm... validity and utility of genetic tests for FVL and prothrombin G20210A. This report, titled Outcomes of Genetic ...f the testing methods used to identify the FVL and prothrombin G20210A mutations, which can signal continued risk...

AstraZeneca Submits NDA for Low Dose Aspirin/Esomeprazole Combination Product

...f which NEXIUM is an enantiomer. As with all PPIs, patients treated concomitantly with warfarin may need to be monitored for increases in INR and prothrombin time. Like other proton pump inhibitors, esomeprazole may interfere with the absorption of drugs where gastric pH is an important determinant of bioav...

New Overall Survival Study Results Confirm Oral Xeloda(R) plus Oxaliplatin (XELOX) is Comparable to FOLFOX-4 for the First-Line Treatment of Advanced Colorectal Cancer

...a and warfarin has been demonstrated; altered coagulation parameters and/or bleeding and death have been reported. Clinically significant increases in prothrombin time (PT) and INR have been observed within days to months after starting Xeloda, and infrequently within one month of stopping Xeloda. For patients ...

Nuvelo Announces Positive Phase 1b Proof-of-Concept Data With Anticoagulant NU172

...s of NU172 for four hours. In all four cohorts, NU172 produced dose-dependent increases in anticoagulation, measured by activated clotting time (ACT), prothrombin time (PT) and activated partial thromboplastin time (aPTT). The highest infusion dose rate tested, 6.0 mg/kg/hr, resulted in an average ACT per subjec...

AstraZeneca Submits sNDA for NEXIUM(R) I.V. for Peptic Ulcer Bleed Indication

..., of which NEXIUM is an enantiomer. As with all PPIs, patients treated concomitantly with warfarin may need to be monitored for increases in INR and prothrombin time. Like other proton pump inhibitors, esomeprazole may interfere with the absorption of drugs where gastric pH is an important determinant of bioav...

Wyeth Receives Approvable Letter from FDA for TYGACIL for the Treatment of Patients with Community-Acquired Pneumonia

...of the teeth. TYGACIL should not be used during tooth development unless other drugs are not likely to be effective or are contraindicated -- prothrombin time or other suitable anticoagulant test should be monitored if TYGACIL is administered with warfarin -- Monotherapy should be used with caution...

Nearly 60 New Studies of Oral Xeloda(R) (capecitabine) Featured at the 44th American Society of Clinical Oncology Annual Meeting

...a and warfarin has been demonstrated; altered coagulation parameters and/or bleeding and death have been reported. Clinically significant increases in prothrombin time (PT) and INR have been observed within days to months after starting Xeloda, and infrequently within one month of stopping Xeloda. For patients r...

More Clinical Data Required to Support European Approval of CAP Indication for TYGACIL

...of the teeth. TYGACIL should not be used during tooth development unless other drugs are not likely to be effective or are contraindicated -- prothrombin time or other suitable anticoagulant test should be monitored if TYGACIL is administered with warfarin -- Monotherapy should be used with caution...

Novel Xeloda(R) Dosing Schedule May Offer Well-Tolerated Alternative for Treatment of Advanced Breast Cancer

...a and warfarin has been demonstrated; altered coagulation parameters and/or bleeding and death have been reported. Clinically significant increases in prothrombin time (PT) and INR have been observed within days to months after starting Xeloda, and infrequently within one month of stopping Xeloda. For patients r...

Medicare Announces Expanded Coverage for Anticoagulation Patients, Opening the Door for More Patients to Test PT/INR at Home

... Diagnostics Corporation; 2006. (5) Giles TD, Roffidal L. Results of the prothrombin Office-Testing Benefit Evaluation (PROBE). CVR&R. 2002;23:27-28, 30, 3...tistical and clinical evaluation of fingerstick and routine laboratory prothrombin time measurements. Pharmacotherapy. 1997;17(5): 861-866. (7) Kaatz SS...
Prothrombin in Medical Products

Factor V/Prothrombin ASRs*

Description:...r the detection of two genetic mutations associated with thrombosis: the G1691A mutation on the Factor V (Leiden) gene and the G20210A mutation on the prothrombin gene. Laboratories may use the reagents to create homebrew tests. *Analyte Specific Reagents. Analytical and performance characteristics ar...
Company:Nanogen, Inc.

STA NEOPLASTINE CI + 10 (ISI ~ 1.3)

Description:... Determination of prothrombin Time (PT) by STA Analyzers (ISI~1.3).Freeze-dried rabbit brain thromboplastin with heparin inhibitor....
Company:Diagnostica Stago, Inc.

STA NEOPLASTINE CI + 5 (ISI ~ 1.3)

Description:... Determination of prothrombin Time (PT) by STA Analyzers (ISI~1.3).Freeze-dried rabbit brain thromboplastin with heparin inhibitor....
Company:Diagnostica Stago, Inc.

STA NEOPLASTINE CI 10 (ISI ~ 1.8)

Description:... Determination of prothrombin Time (PT)by STA Analyzers (ISI~1.8).Freeze-dried rabbit brain thromboplastin with heparin inhibitor....
Company:Diagnostica Stago, Inc.

STA NEOPLASTINE CI 5 (ISI ~ 1.8)

Description:... Determination of prothrombin Time (PT)by STA Analyzers (ISI~1.8).Freeze-dried rabbit brain thromboplastin with heparin inhibitor....
Company:Diagnostica Stago, Inc.

Immedia PT System

Description:... The Immedia PT System is an in vitro diagnostic device that provides quantitative prothrombin time (PT) results, expressed in seconds and INR units. The System uses fresh capillary whole blood. It is intended for use by health care professional...
Company:Farallon Medical, Inc.

Pefakit APC-R Factor V Leiden

Description:... commercially available methods, Pefakit APC-R FVL shows no interference from protein C or S, Lupus Anticoagulants, Elevated FVIII levels, Heparins or prothrombin G20210A. Everything you need is included in a simple, easy-to-use kit which is adaptable to any instrument capable of detecting a fibrin clot. Unprece...
Company:Centerchem, Inc.

INRatio

Description:... The INRatio meter is a diagnostic Point Of Care system that provides prothrombin Time (PT) and International Normalized Ratio (INR) results using one drop of fresh capillary whole blood from a fingerstick....
Company:HemoSense Inc.

CoaguChek S

Features:... The prothrombin time is determined by taking just one single drop of capillary whole blood from the finger tip Large, easy to read display with clear, simple instr...
Company:Roche Diagnostics

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Prothrombin in Medical Dictionary

Vitamin K

..... Vitamin K is integrally involved in the clotting mechanism of blood. A deficiency of vitamin K results in decreased blood levels of prothrombin and ... Vitamin K deficiency is manifest as a tendency to bleed excessively. ... Without vitamin K , the carboxylation does not occur and...

Thrombophlebitis

...tis involves inflammation of a vein caused by a blood clot inside. ... Superficial thrombophlebitis may be associated with Factor V Leiden, prothrombin ... The following increase your chances for thrombophlebitis : ... There are two main types of thrombophlebitis : ... to prevent thrombophlebit...

Nose bleeds

...your nose ! Read this article to find out what ... nose may break and bleed , causing ... Acquired Aplastic Anemia - nose bleeds . Acquired prothrombin deficiency - nosebleeds ... Acute promyelocytic leukemia - nose bleeds . more causes... Reviews often overlooked causes of nose bleeds...

Factor II deficiency

...ficiency . Alternative Names: Hypoprothrombinemia; prothrombin deficiency . Treatment: ... Factor II de...eficiency , there is a lower than normal amount of prothrombin in ... Factor II deficiency is a rare, i...hould not be confused with a mutation of ... The prothrombin gene mutation is called Factor II mutation...
Prothrombin in Biological News

Nature study demonstrates that bacterial clotting depends on clustering

...t does not infect humans). It found that in the case of human blood, coagulation required the secretion of zinc metalloprotease InhA1, which activated prothrombin and factor X directlynot via factor XII or tissue-factor pathways. "We refer to this mechanism as 'quorum acting' to distinguish it from quorum sensi...
Prothrombin in Biological Technology

China Biologic Products Announces SFDA Approval for the Production of Cryoprecipitate and for the Clinical Trial of Human Prothrombin Complex

TAI'AN, Shandong, China, April 30 /Xinhua-PRNewswire-FirstCall/ -- China Biologic Products, Inc. (OTC Bulletin Board: CBPO) ("CBP," or "the Company"), one of the leading plasma-based pharmaceutical companies in the People's Republic of China ("PRC"), today announced that the Company received a...

FDA Approves KAPIDEX(TM) (Dexlansoprazole) delayed release capsules for the Treatment of GERD

...oxin, iron salts, ketoconazole). Patients taking concomitant warfarin may require monitoring for increases in international normalized ratio (INR) and prothrombin time. Please see the complete prescribing information and visit the KAPIDEX Web site at www.kapidex.com . About Takeda Pharmaceutical Comp...

China Biologic Products Reports Second Quarter 2008 Results

...e quarter, the Company achieved the following milestones: -- Received approval for the production of Cryoprecipitate and clinical trials of Human prothrombin Complex -- Began production and sales of Human Albumin 12.5g/vial (25%, 50 ml) -- Received approval to purchase excess clinical plasma -- Received ...

China Biologic Products Reports First Quarter 2008 Results

...f SFDA approval to Supply Cryoprecipitate in the second quarter of 2008. (3) The Company received approval SFDA for Clinical Trial of Human prothrombin Complex. Business Outlook In recent years, the biopharmaceutical industry and the plasma-based product market have outperformed the pharmaceutical ...

Roche Diagnostics Launches CoaguChek XS Plus System to Provide New PT/INR Point-of-Care Solution for Non-Waived Anticoagulation Services

...www.roche-diagnostics.us . All trademarks used or mentioned in this release are legally protected by law. (1) Giles TD and Rofidal L. Results of the prothrombin office testing benefit evaluation (PROBE), Cardiovascular Review and Reports. Vol XXIII, No. 1, January 2002. (2) Second Quarter 2007 total...

New 200 mg Vial for Eloxatin(R) (Oxaliplatin Injection) Offers Greater Convenience and Efficiency of Preparation

...ons, including necrosis. Injection site reaction, including redness, swelling and pain, has been reported -- There have been reports of prolonged prothrombin time and INR occasionally associated with hemorrhage in patients receiving Eloxatin(R) plus 5-FU/LV while on anticoagulants. Patients receivin...

Third Wave to seek FDA clearences after expanding pipeline

...s. Read more here. Third Wave expects to seek FDA clearance for in-vitro diagnostics for Factor V Leiden, a hereditary blood disease, and Factor II prothrombin deficiency, a form of hemophilia. The company said the products are already on the market, but FDA clearance would allow more direct marketing efforts...

The Gradient Feature: Use in Optimization of Allelic Discrimination Assays, Rev B

... hybridization, Nat Biotechnol 14, 303308 (1996) van den Bergh FA et al., Rapid single-tube genotyping of the factor V Leiden and prothrombin mutations by real-time PCR using dual-color detection, Clin Chem 46, 11911195 (2000) Wallace RB et al., Hybridization of synthetic...

Fluorescence-Based Single-Tube Assays to Rapidly Detect Human Gene Mutations

...the coagulation factor II (prothrombin) gene. The mutation, a G to A substitution at nucleotide position 20210, is associated with elevated plasma prothrombin levels and an increased risk of deep vein thrombosis. 5,6 The mutation is also being evaluated clinically as a risk factor for cardiovascular dis...
Prothrombin in Biological Dictionary

Dimer

...s. Explains how D-dimer is used; when D-dimer is used; what the results of D-dimer might mean ... Related Tests: Fibrin Degradation Products (FDP); prothrombin ... Why get the D-dimer test, which tests for thrombotic diseases and conditions; when to get D-dimer for thrombotic diseases and conditions The...
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