Proteinuria

Questcor and Child Neurology Foundation Announce Creation of Infantile Spasms Awareness Week

...an inflammatory component, including the treatment of exacerbations associated with multiple sclerosis (MS) and to induce a diuresis or a remission of proteinuria in the nephrotic syndrome without uremia of the idiopathic type or that due to lupus erythamatosus. Acthar is not approved for, but is used in treatin...

Novel DNA vaccine leads to kidney damage prevention in systemic lupus erythematosus models

...igen-specific and successfully targeting particular antibodies. Significant proteinuria (a urinary condition which can indicate kidney damage) (>1.5+) was less com... levels. Serum autoantibodies were tested by immunoprecipitation and ELISA. proteinuria (excessive protein in the urine) was assessed monthly using Multistix. Kidn...

BioMarin and La Jolla Pharmaceutical Sign Worldwide (Excluding Asia Pacific) Development and Commercialization Agreement for Riquent

... is being evaluated in the international Phase 3 ASPEN trial designed to demonstrate that Riquent treatment delays the time to renal flare and reduces proteinuria in patients with lupus renal disease. The Riquent Phase 3 program is the subject of a special protocol assessment and has fast track designation from ...

Exjade(R) Benefits Chronically Transfused Patients by Significantly Reducing Toxic Iron That Can Damage Key Organs, According to Landmark Trial

...einitiated at a lower dose followed by gradual dose escalation, if the clinical benefit is expected to outweigh potential risks. Intermittent proteinuria (urine protein/creatinine ratio >0.6 mg/mg) occurred in 18.6% of EXJADE-treated patients, compared to 7.2% of deferoxamine-treated patients in Stud...

Halpin Foundation and the ASN announce recipient of Halpin Foundation-ASN research grant

...ic Syndrome and Other Mendelian Syndromes" will take place on Thursday, November 6 from 4:00 p.m. 6:00 p.m., and "New Insights into the Mechanisms of proteinuria and the Nephrotic Syndrome: Beyond the Slit Diaphragm" will occur on Friday, November 7 from 1:30 p.m. 3:30 p.m.. ...

Research May Help Predict Preeclampsia

...nosis tricky. A woman may have a single blood pressure reading that is higher than normal before her pressure slips down again, or she may not exhibit proteinuria until later in her pregnancy. "Sometimes women present with this kind of vague feeling that they're just not feeling well," said Dr. B. Denise Ray...

MultiVu Video Feed: Study in the New England Journal of Medicine Shows High Blood Pressure Drug Tekturna(R) Reduces Key Marker of Kidney Disease

...se of end-stage renal disease in developed countries, affecting more than 1.5 million people worldwide. In the AVOID (Aliskiren in the EValuation of proteinuria In Diabetes) study, Tekturna, when added to the maximum dose of losartan, reduced proteinuria by 20% compared to losartan alone in patients diagnosed ...

Study Showed ALIMTA(R) (pemetrexed for injection) Improved Survival in Certain Types of Non-Small Cell Lung Cancer

...vs 15, 64); nausea and vomiting (64 vs 58, 71); neutropenia (62 vs 18, 61); thrombocytopenia (47 vs 15, 36); pain (10 vs 7, 42); fever (30 vs 16, 38); proteinuria (10 vs 2, 32); constipation (10 vs 11, 31); diarrhea (24 vs 31, 30); rash (24 vs 13, 28); and bilirubin elevation (16 vs 25, 26). See complete Warni...

Abbott to Present Data on Novel Cancer Treatments at American Society of Clinical Oncology Annual Meeting

...hanges in serum biomarkers are consistent with anti-angiogenic activity. However, these serum biomarkers had limited value in predicting safety, i.e., proteinuria or hypertension. The utility of tumor flow and permeability changes on DCE-MRI in predicting proteinuria should be further examined. Updated informati...

Doctors See How Cancer Drug Can Damage Kidneys

...of blood vessels. One side effect of Avastin is proteinuria -- excess protein in the urine, an indicator of ki...iovascular problems. Various studies have found proteinuria in anywhere from 21 percent to 64 percent of peopl... of kidney damage," Quaggin said. "It is true that proteinuria is a very common finding, but it doesn't necessari...

Proteinuria in Medical Technology

Exelixis Reports Top-Line Results of the Phase 2 Trial of XL784 in Patients With Proteinuria Associated With Diabetic Nephropathy

- Data to be presented November 2 at the American Society of Nephrology Meeting - SOUTH SAN FRANCISCO, Calif., Oct. 16 /PRNewswire-FirstCall/ -- Exelixis, Inc. (Nasdaq: EXEL ) announced that a recently completed phase 2 trial of XL784 did not meet its primary end...

Human Genome Sciences and GlaxoSmithKline Announce Positive Phase 3 Study Results for BENLYSTA(TM) in Systemic Lupus Erythematosus

...nalysis for the primary endpoint is based on intention-to-treat (ITT) and adjusted for baseline stratification factors, including SELENA SLEDAI score, proteinuria and race. In each of the two Phase 3 trials, patients were randomized to one of three treatment groups: 10 mg/kg belimumab (BLISS-52, n=290)...

More Than 200 Abstracts at ASH and SABCS Reveal Potential Compelling Patient Benefits From Novartis Oncology Current and Pipeline Therapies

...einitiated at a lower dose followed by gradual dose escalation, if the clinical benefit is expected to outweigh potential risks. Intermittent proteinuria (urine protein/creatinine ratio >0.6 mg/mg) occurred in 18.6% of Exjade-treated patients, compared to 7.2% of deferoxamine-treated patients in Stud...

Rigel's R788 Slows Progression of Murine Lupus in Preclinical Studies

...tion of the study, only 2 of the 29 mice in the 40 mg/kg group had elevated proteinuria compared to 21 of the 30 mice in the control group. All 29 (100%) of the mi...hat the majority of the animals (~95%) given the 40 mg/kg dose had elevated proteinuria levels that decreased following the onset drug treatment. Systemic Lupus ...

Keryx Biopharmaceuticals Announces Termination of SUN-MACRO Phase 4 Trial

...ollowing which the Company would make a decision regarding whether the trial ought to be continued or terminated. Based on a review of the available proteinuria data, Sulonex did not appear to be different than placebo. The study was not terminated by the DSMC for a safety problem or safety signal. About Ker...

Powerful New Efficacy Data in Moderate and Severe Hypertensive Patients Supports FDA Approval of AVALIDE(R) (Irbesartan-Hydrochlorothiazide) as the First Combination Therapy for Initial Use in Patients Likely to Need Multiple Drugs to Achieve Their Blood

...bination with other antihypertensive agents. AVAPRO is also indicated for the treatment of diabetic nephropathy with an elevated serum creatinine and proteinuria (>300 mg/day) in patients with type 2 diabetes and hypertension. In this population, AVAPRO reduces the rate of progression of nephropathy as measured...

Lilly Files for European Approval of ALIMTA(R) (pemetrexed for injection) for First-Line Treatment of Non-Small Cell Lung Cancer

...t 20% of patients and is rarely dose-limiting. Common: Diarrhoea, oral toxicity (mainly soreness and erythema), and constipation. Renal: Very common: proteinuria and haematuria, rarely clinically significant. Rare: Haemolytic uraemic syndrome and renal failure of unknown aetiology. GEMZAR should be withdrawn if...

SIGA Passes First Hurdle with Lassa Fever Antiviral ST-193

...r, retrosternal pain (pain behind the chest wall), sore throat, back pain, cough, abdominal pain, vomiting, diarrhea, conjunctivitis, facial swelling, proteinuria (protein in the urine), and mucosal bleeding. Neurological problems have also been described, including hearing loss, tremors, and encephalitis. The...

New Study Shows That telmisartan has Greater Renoprotective Potential Thanlosartan in Hypertensive Patients With Type 2 Diabetes

...rtension, Milan. The results from this study show that telmisartan reduces proteinuria to a significantly greater extent than losartan.(1) Commenting on...umber of adverse events was observed between the two treatments groups(1). proteinuria (high levels of protein in the urine) is a very important signal for disea...

New Data Presented on Micardis (Telmisartan) Tablets in Hypertensive Patients With Type 2 Diabetes

...20% with losartan (p= 0.0284).(1) At baseline proteinuria was similar for both groups. The change from basel....77) vs. losartan 0.80 (95% CI; 0.74, 0.87)].(1) proteinuria (high levels of protein in the urine) is a very im...enal outcomes trials have shown that reductions in proteinuria of >30% at six months are strongly linked to slowe...

Proteinuria in Medical Products

Lyphochek Quantitative Urine Control

Description:...emistry, biogenic amines and hormones. It also contains hCG (for qualitative pregnancy tests) and microalbumin at levels suitable for monitoring early proteinuria and associated nephropathy....
Company:Bio-Rad Laboratories

Proteinuria in Medical Dictionary

Proteinuria

Proteinuria ʊəriə/, from protein and urine) means the presence of an excess of serum proteins in the urine. The protein in the urine often causes the urine to become foamy, although foamy urine may also be caused by bilirubin in the urine (bilirubinuria), retrograde... Protei...

Urine collection

... INTRODUCTION A split urine test is a method to determine whether the protein ... Patient information: Split urine collection for orthostatic proteinuria ... Urine collection is a method of getting a urine sample from an infant for testing purposes. ... Open a urine collection bag (a pl...

Kidney function tests

...diagnostic tests used to determine kidney function and describes ... proteinuria and should have additional tests to evaluate kidney function . ... ...ical Tests for Prostate Problems. Medical Tests of Kidney Function . proteinuria ... National Kidney and Urologic Diseases Information ... More about ...

Proteinuria in Biological News

Simple screening questionnaire for kidney disease outperforms current clinical practice guidelines

...ionnaire and a simple scoring system based on seven risk factors for CKD -- age, sex, hypertension, diabetes, cardiovascular disease (CVD), anemia and proteinuria (the presence of excessive protein in the urine). All risk factors for CKD are supported by scientific theory and have been validated by national surv...

Proteinuria in Biological Technology

PTC Therapeutics Initiates Phase 2 Clinical Trial of PTC299 in Patients with Neurofibromatosis Type 2

...ate in severity, did not require intervention, and were not clearly related to PTC299. In addition, adverse events such as bleeding, hypertension and proteinuria were not observed. The Phase 2 clinical trial of PTC299 is supported by a grant from the U.S. Department of Defense Neurofibromatosis Research ...

BioMarin Announces Fourth Quarter and Full Year 2008 Financial Results

...n C study -- 1Q09: Results from Phase 2 PAH trial -- 1Q09/2Q09: Initiation of Phase 1 trial for GALNS for MPS IVA -- 2Q09: Results from proteinuria in chronic kidney disease trial -- 2Q09: Results from PEG-PAL Phase 1 trial -- 2Q09: Initiation of PEG-PAL Phase 2 trial Upcoming Inve...

BioMarin Announces Third Quarter 2008 Financial Results

...no -- 1Q09: Results from Phase 2 PAD trial -- 1Q09: Results from BH4+Vitamin C study -- 1Q09: Results from Phase 2 PAH trial -- 1Q09: Results from proteinuria in chronic kidney disease trial -- 1Q09: Initiation of Phase 1 trial for GALNS for MPS IVA -- 1Q09/2Q09: Results from PEG-PAL Phase 1 trial -- 1Q09...

JCI table of contents: April 22, 2008

...csd.edu . View the PDF of this article at: https://www.the-jci.org/article.php?id=32691 ACCOMPANYING COMMENTARY TITLE: Linking adiponectin to proteinuria AUTHOR CONTACT: Rexford S. Ahima University of Pennsylvania School of Medicine, Philadelphia, Pennsylvania, USA. Phone: (215) 573-1872; Fax: (21...

Exelixis Announces Third Quarter 2007 Financial Results and Business Update

...pleted phase 2 trial of XL784 did not meet its primary endpoint of reducing proteinuria compared with placebo in patients with proteinuria associated with diabetic nephropathy. Various subgroup analyses suggest tha...

Proteinuria in Biological Definition

Ebola

...ress to vomiting , diarrhea , oropharyngeal lesions , conjunctivitis , organ damage (notably the kidney and liver ) by co-localized necrosis , proteinuria (the presence of proteins in urine), and bleeding both internal and external, commonly through the gastrointestinal tract . Death or recovery to c...