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Protease in Medical News

Surveyed Physicians Will Treat Over 50 Percent of Hepatitis C Genotype 1-Infected Patients With the Protease Inhibitor Telaprevir

WALTHAM, Mass., Aug. 4 /PRNewswire/ -- Decision Resources, one of the world's leading research and advisory firms for pharmaceutical and healthcare issues, finds that, based on profiles provided to them of emerging protease inhibitors, surveyed physicians indicate that they will prescr...

Catalyst Biosciences Announces Agreement With MedImmune to Discover and Develop Engineered Protease Therapeutics

SOUTH SAN FRANCISCO, Calif., July 7 /PRNewswire/ -- Catalyst Biosciences, Inc. today announced the signing of an exclusive worldwide research and license agreement with MedImmune, the global biologics unit of AstraZeneca plc, to develop novel engineered proteases that specifically degrade or modul...

Mylan's Matrix Receives Tentative FDA Approval Under PEPFAR for First Generic, Heat-Stable Version of HIV Protease Inhibitor

Provides first affordable protease inhibitor for patients in developing countries Complements recent WHO approval earned for the same product PITTSBURGH, March 12 /PRNewswire-FirstCall/ -- Mylan Inc. (Nasdaq: MYL ) today announced that Matrix Laboratories Limited, its India-based subsidiary...

Mylan's Matrix Receives WHO Approval for First Generic, Heat-Stable Version of HIV Protease Inhibitor

Provides first affordable protease inhibitor for patients in developing countries PITTSBURGH, Feb. 25 /PRNewswire-FirstCall/ -- Mylan Inc. (Nasdaq: MYL ) today announced that Matrix Laboratories Limited, its India-based subsidiary in which it holds a 71.5% controlling interest, received th...

Reducing the Risk of Protease Inhibitor-Related Atherosclerosis

Physiologists may have found a way to decrease the risk of hardening of the arteries that accompanies the long-term use of protease inhibitors//, a class of drugs that has emerged as the most effective treatment against HIV and AIDS. Writing in the American Journal of Physiology–Cell Physiolog...

HIV integrase inhibitor effective for patients beginning antiretroviral treatment

...o be approved by the FDA. Other types of antiretroviral drugs inhibit HIV's protease or reverse transcriptase enzymes. Guidelines from the U.S. Department of Health and Human Services currently recommend efavirenz or a protease inhibitor, in combination with tenofovir and emtricitabine, as a preferred ...
Protease in Medical Technology

New Results From ARTEN Study of Nevirapine Plus Tenofovir and Emtricitabine (TDF/FTC) Versus Boosted Protease Inhibitor Regimen of Atazanavir/Ritonavir Plus TDF/FTC Revealed

CAPE TOWN, South Africa , July 20 /PRNewswire/ -- New data became available today at the 5(th) International AIDS Society Conference from ARTEN ( A tazanavir/ R itonavir on a background of T enofovir and E mtricitabine [Truvada(R)] versus N evirapine). ARTEN is an open-label, multi-c...

Abbott and Enanta Initiate Phase 1 Clinical Trial on ABT-450 HCV Protease Inhibitor

ABBOTT PARK, Ill., and WATERTOWN, Mass., Feb. 18 /PRNewswire-FirstCall/ -- Abbott ( NYSE: ABT ) and Enanta Pharmaceuticals announced today the advancement of their Hepatitis C (HCV) collaboration with a first-in-human study evaluating ABT-450, an oral protease inhibitor for the treatment of ...

Schering-Plough Provides Update on Boceprevir Clinical Development and Introduces Potent Next-Generation Oral HCV Protease Inhibitor for Treating Patients With Chronic Hepatitis C

Company reaffirms its innovation leadership and long-term commitment to hepatitis research KENILWORTH, N.J., Nov. 24 /PRNewswire-FirstCall/ -- Schering-Plough Corporation (NYSE: SGP ) today provided a clinical update on boceprevir, its lead investigational oral hepatitis C protease inhi...

Sequoia Pharmaceuticals Presents In Vitro and First-in-Human Data Supporting Further Development of SPI-256, a Novel Investigational Protease Inhibitor

WASHINGTON, Oct. 26 /PRNewswire/ -- Sequoia Pharmaceuticals presented positive results today from two studies on SPI-256, a novel investigational HIV protease inhibitor (PI). One study based on an in vitro analysis demonstrates that the mode of interaction of SPI-256 with HIV protease provides...

Schering-Plough To Initiate Phase III Studies With HCV Protease Inhibitor Boceprevir in Previously Untreated Hepatitis C Patients and Those Who Failed Prior Treatment

KENILWORTH, N.J., May 21 /PRNewswire-FirstCall/ -- Schering-Plough Corporation (NYSE: SGP ), a leader in hepatitis research, today announced that it is initiating two large Phase III studies of boceprevir, its investigational oral hepatitis C protease inhibitor, in patients chronically infect...

Initial Results of Phase II Study with HCV Protease Inhibitor Boceprevir in Treatment-Naive Hepatitis C Patients Show a High Rate of Early Virologic Response

Top Line Results of Phase II Study in Previous Nonresponders also Reported KENILWORTH, N.J., Oct. 18 /PRNewswire-FirstCall/ -- Schering-Plough Corporation (NYSE: SGP ) today provided an update on the clinical development program for boceprevir, its investigational oral hepatitis C protease inh...
Protease in Medical Products

Serine Protease 3 Antibody

Description: ARUP Laboratories is a national reference laboratory and a worldwide leader in innovative laboratory research and development. ARUP offers an extensive test menu of highly complex and unique medical tests in clinical and anatomic pathology. Owned by the University of Utah, ARUP Laboratories' client...
Company:ARUP Laboratories

Renin IRMA Test

Description:... Renin, a protease secreted by the kidney, plays a vital role in the renin-angiotensin system. The renin-angiotensin system regulates blood pressure, and controls water ...
Company:Diagnostic Systems Laboratories, Inc.

IGFBP-4 ELISA Test

Description:...to be inhibitory to IGF action by binding the IGFs and preventing their interaction with the IGF receptors [1]. This inhibitory function of IGFBP-4 is protease dependent [2]. The regulatory mechanisms that control IGFBP-4 expression are still poorly understood, however in bone IGFBP-4 appears to be regulated ...
Company:Diagnostic Systems Laboratories, Inc.

Prostate Specific Antigen (PSA) - Rapid Test

Description:... Prostate specific antigen (PSA) is a serine protease that is found only in the prostate within the epithelial cells of the acini and ducts. Normal PSA concentration in whole blood or serum is 0.1-2.6 ng/...
Company:Bio-Quant, Inc.

OneStep PSA InstaTest

Description:... Prostate specific antigen (PSA) is a serine protease that is found only in the prostate within the epithelial cells of the acini and ducts. Normal PSA concentration in whole blood or serum is 0.1-2...
Company:Bio-Quant, Inc.

AccuGENE LB Broth

Description:...liable - Manufactured according to strict quality control standards to ensure lot-to-lot consistency. High Quality - No detectable DNase, RNase, or protease activities unless otherwise noted. Efficient - Ready-made solutions eliminate experiment preparation time. Flexible - Customized solutions are a...
Company:Cambrex
Protease in Medical Definition

Sexual orientation and medicine

.... 1993 Dr. Dean Hamer publishes a paper suggesting a genetic component to sexual orientation. [3] 1995 Saquinavir , the first protease inhibitor is approved for public use by the FDA . HAART radically changes the prognosis of HIV/AIDS . 1996 The US Department of Defense ...
Protease in Medical Dictionary

Protein C

...nticoagulant. It is a vitamin K-dependent serine protease enzyme (EC 3.4.21.69) that is activated by throm... or ... Protein C is a Vitamin K-dependent protease that functions as an anticoagulant ... This was ex...VIIIa. ... Activated Protein C is a serine protease which functions to inactivate Factors Va and VIIIa...

Factor XII

...Hageman factor is a plasma protein also known as factor XII . It is the zymogen form of factor XIIa, an enzyme (EC 3.4.21.38) of the serine protease class. In humans, factor XII is encoded by the F12 gene. factor XII ( ′faktər ′twelv ) ( biochemistry ) A blood clotting factor effectiv...

Complement

...ing on all items. Complement refers to a family of immune system chemicals that are activated ... Once activated, complement proteins become protease enzymes. ... Buy.com is the best online site for books: new ~ used ~ paperbacks ~ NYTBS. Buy The Complement System for $129.00 now & save. ...
Protease in Biological News

HIV-1 protease inhibitor induced oxidative stress in pancreatic B-cells: thymoquinone protection

Researchers at the Tulane University School of Medicine, New Orleans, Louisiana have discovered that the HIV-1 protease inhibitors (PIs), such as nelfinavir included in highly active antiretroviral therapy (HAART) regimen for the treatment of HIV-1 patients, induce deleterious effects on insulin s...

Researchers describe protease inhibitor that may aid in diabetic retinopathy treatment

NEW YORK, Jan. 21, 2009 Researchers from Joslin Diabetes Center, Boston, and ActiveSite Pharmaceuticals, Inc., San Francisco, announced today that they have demonstrated that a specific inhibitor of the protease plasma kallikrein, ASP-440, developed by ActiveSite Pharmaceuticals, may provide a ne...

HIV Patients May Be at Risk of Heart Problems When Taking Protease Inhibitor Drugs

A widely-used class of drugs that keep the HIV-virus infection from progressing to AIDS may cause serious and potentially lethal heart rhythm disturbances in some patients. The finding of a Mayo Clinic-led investigation appears in the current edition of The Lancet. In collaboration with colleag...

UCSF researchers identify new drug target for Kaposi's sarcoma

...the possibility of using the class of drugs called protease inhibitors against the full herpes family of virus...ttain. The new drug target, which is known as a protease dimer, could serve as a model for developing new t... be activated, according to the paper. The HIV protease was successfully targeted for drug development in ...

Enzyme involved in inflammatory bowel disease discovered at Penn State College of Medicine

...ferred to as IBD. The enzyme, coded for by the MEP1A gene, is a zinc-containing metalloprotease called meprin, and is abundant in the intestine. A protease is an enzyme that breaks down proteins in the body. Researchers at Penn State College of Medicine studied the role of meprin in IBD using geneticall...

Locking parasites in host cell could be new way to fight malaria

...parum parasites, the team infected human red blood cells, using pharmacological and biochemical evidence to discover that parasites activate the host protease calpain-1. Blocking or removing calpain-1, a calcium regulated protease, left parasites trapped inside the host cell. By adding calpain-1 back into th...
Protease in Biological Technology

Catalyst Biosciences Expands Scientific Advisory Board With Leading Experts in Protease Therapeutic Discovery and Development

SOUTH SAN FRANCISCO, Calif., March 24 /PRNewswire/ -- Catalyst Biosciences, Inc., a pioneer in the discovery and development of engineered proteases known as Alterase(TM) therapeutics, has appointed four new members to the company's Scientific Advisory Board (SAB). Robert J. Fletterick, Ph.D., Da...

InterMune to Present Abstracts on HCV Protease Inhibitor ITMN-191 and HCV Development Program at the EASL Meeting

BRISBANE, Calif., March 18 /PRNewswire-FirstCall/ -- InterMune, Inc. (Nasdaq: ITMN ) today announced that five abstracts from clinical and in-vitro studies of ITMN-191 (R7227) and the company's research programs related to the hepatitis C virus (HCV) have been accepted for presentation at the 44...

LI-COR Introduces Three IRDye(R) Near-Infrared Fluorescence Resonance Energy Transfer (NIR-FRET) Protease Substrates

LINCOLN, Neb., Nov. 12 /PRNewswire/ -- Protease substrates provide a sensitive method to detect protease activity, measure potency of inhibitors and screen compound collections for discovery of drug candidates. LI-COR Biosciences now offers three different IRDye NIR-FRET Protease Substrates: I...

InterMune to Present Four Abstracts on HCV Protease Inhibitor ITMN-191 at the AASLD Meeting

- Results of Phase 1 clinical studies support advancement to Phase 2 - - Results of in-vitro study of ITMN-191 with Roche polymerase inhibitors - BRISBANE, Calif., Sept. 24 /PRNewswire-FirstCall/ -- InterMune, Inc. (Nasdaq: ITMN ) today announced that four abstracts from clinical and in-vit...

InterMune Earns Development Milestone in HCV Protease Inhibitor Collaboration With Roche

- $15 million development milestone payment to InterMune - - Roche to lead ITMN-191 program in Phase 2 - BRISBANE, Calif., Sept. 2 /PRNewswire-FirstCall/ -- InterMune, Inc. (Nasdaq: ITMN ) today announced that InterMune has earned a $15 million development milestone under i...

Fluorometric Protease Assays in the SpectraMax Gemini Microplate Spectrofluorometer: Example Using Caspase3 (MaxLine Application Note #35)

Evelyn McGown, Ph.D. and Anna Lam, B.S. Molecular Devices Corporation, 8/99 INTRODUCTION Modern assays for proteolytic activity typically use synthetic chromogenic or flu-orogenic peptide substrates. Enzyme selectivity is obtained by choosing a peptide...
Protease in Biological Products

AcTEV Protease from Invitrogen

Description: AcTEV Protease is an enhanced form of Tobacco Etch Virus (TEV) protease that is highly site-specific, highly active, and significantly more stable than native TEV protease, resulting in long-term activity. AcTEV Protease specifically recognizes a seven amino acid (Glu-Asn-Leu-Tyr-Phe-Gln-Gly, cleav...
Company:Invitrogen

HRV 3C Protease from Novagen

Description: Recombinant type 14 3C protease from human rhinovirus (HRV 3C) is the newest addition to the Novagen brand line of restriction grade proteases. The recombinant protease is a highly purified recombinant 6XHis-fusion protein, which recognizes the same cleavage site as the native enzyme: LeuGluValLeuP...
Company:Novagen

Factor Xa Protease from QIAGEN

Description: For cleavage of 6xHis tags from proteins containing a Factor Xa Protease recognition site Efficient 6xHis tag cleavage (greater than 90%) ...
Company:QIAGEN

Mouse Anti-Presenilin 2 Monoclonal Antibody, Unconjugated, Clone APS 26 from GeneTex

Description:...resenilins are involved in the cleavage of the Notch receptor, such that that they either directly regulate gamma-secretase activity or themselves are protease enzymes. Two alternative transcripts of PSEN2 have been identified. Immunogen: Synthetic peptide: CLPYDPEMEEDSYDSFGEP, corresponding to amino acids...
Company:GeneTex

Mouse Serpin A1 from R&D Systems

Description:... Recombinant Mouse Serpin A1/alpha-1-Antitrypsin, CF Protein Family: Coagulation, Serine protease Regulators...
Company:R&D Systems

Goat Anti-Human TFPI Polyclonal Antibody, Unconjugated from R&D Systems

Description:... Human TFPI Affinity Purified Polyclonal Ab Protein Family: Coagulation, Inflammation, Serine protease Regulators...
Company:R&D Systems
Protease in Biological Definition

Apoptosis

... in human cells, and succeeded in cloning the DNA sequence of this cysteine protease [19] , [20] . That same year, graduate student Shai Shaham working in Hor...Southwestern Medical Center at Dallas), which they called Apaf-1 (apoptotic protease activating factor). The team published their results in an article titled "...

Citric acid cycle

... into the mitochondria . It is converted into acetyl-CoA and enters the citric acid cycle. In protein catabolism , proteins are broken down by protease enzymes into their constituent amino acids. These amino acids are brought into the cells and can be a source of energy by being funnelled into th...

Cytotoxic T cell

...a membrane ; this causes ions and water to flow into the target cell, making it expand and eventually lyse . T C also release granzyme , a serine protease , that can enter target cells via the perforin-formed pore and induce apoptosis (cell death). Most T C cells have present on the cell surface the...

Enzyme

...active; for instance, chymotrypsin , a digestive protease , is produced in inactive form as chymotrypsinoge...ucleic acid polymers from their constituents protease (peptidase): those enzymes which cut peptide bon...enzymes that begin with a preparation containing a protease will often result in loss of the enzyme being puri...

Citric acid cycle

... into the mitochondria . It is converted into acetyl-CoA and enters the citric acid cycle. In protein catabolism , proteins are broken down by protease enzymes into their constituent amino acids. These amino acids are brought into the cells and can be a source of energy by being funnelled into th...

Lipase

...Brzozowski, Z. S. Derewenda, E. Dodson, G. Dodson, S. Tolley, J. P. Turkenburg, L. Christiansen, B. Huge-Jensen, L. Norskov, and et al. 1990. A serine protease triad forms the catalytic centre of a triacylglycerol lipase. Nature 343:767-70. Carriere, F., C. Withers-Martinez, H. van Tilbeurgh, A. Roussel, C....
Protease in Biological Dictionary

Thylakoids

... ... experimental system composed of thylakoids isolated from senescing leaves ... acid pretreatment of the thylakoids and it is inferred that the protease ... ... peripheral proteins in the thylakoids of pea were systematically ... Thylakoids /metabolism. Substances: Photosynthetic Reaction Cen...

Proteolysis

... Proteolysis is the directed degradation (digestion) of proteins by cellular enzymes called proteases or by intramolecular digestion. A protease is any enzyme that conducts proteolysis , that is, begins protein catabolism by hydrolysis of the peptide bonds that link amino acids tog...

Proteasome

...ore Particle (CP) ... The drug blocks the proteolytic action of the proteasome . ... Proteasome Complex ... Many inhibitors of proteasome protease activity are known, some of which are ... Several subunits of the proteasome are glycosylated with GlcNAc (N ... Ubiquitons and Zomes (Ubiquitin ...

Polyprotein

...y, Chicken ... ... RNA genome which encodes a protease as part of a large precursor polyprotein . ... cleavage products surrounding the protease region of the viral polyprotein were ... To a...... Polyprotein processing activity of the NS3 protease is required for NS4A ... ... at the N terminus ...

Nuclease

... Articles > Nuclease Protections Assays ... One of the biggest frustrations of working with RNA is the ubiquitous nature of ... Nuclease and protease tests are also performed with the test component at a ... Micrococcal Nuclease (S7 Nuclease ) is a relatively nonspecific ... nuclease -free .....

Klenow Fragment

... The Klenow fragment is a large protein fragment produced when DNA polymerase I from E. coli is enzymatically cleaved by the protease subtilisin. First reported in 1970, it retains the 5’ → 3’ polymerase activity and the 3’ →... The large or Klenow fragment of DNA polymeras...
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