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Prostaglandin in Medical News

QLT announces interim data from a Phase II clinical trial and a device study for the Punctal Plug Drug Delivery System

...nvestigate the safety and preliminary efficacy of L-PPDS containing either 44-(micro)g (first cohort) or 81-(micro)g (second cohort) of latanoprost, a prostaglandin analogue, with a punctal plug delivery system, in patients with OAG or OH over a six-week period. Sixty patients diagnosed with OAG/OH with a mean age...

Potential lung disease biomarkers yield clues to COX-2 inhibitor side effects

...ing-related lung disease. The researchers had hypothesized that early-stage lung injury could "turn on" the COX-2 gene, increasing levels of the major prostaglandin metabolite PGE-M in the urine. In addition to determining PGE-M levels, the investigators also looked at levels of the biomarker leukotriene E4 (LT...

New target for maintaining healthy blood pressure discovered

...d that mice that lack the receptor for one type of prostaglandin have lower blood pressure and less atherosclerosis...ults indicate that the normal role for the type of prostaglandin studied, PG F2-alphais to increase... National Academy of Sciences . "Blocking this prostaglandin receptor may provide a strategy for controlling bl...

Licorice compound offers new cancer prevention strategy

...rhizic acid, the main sweet-tasting component of licorice, and by silencing the gene for 11βHSD2. Both treatments inhibited the production of prostaglandin E2 (an inflammatory molecule produced by the COX-2 enzyme) and prevented the development of polyps (adenomas) and tumor growth and metastasis. Bec...

ROXRO Announces FDA Accepts for Review NDA for ROX-888 for the Management of Acute Moderate to Severe Pain

...avenously for the short-term treatment of moderate to severe pain. The analgesic efficacy of ketorolac is primarily associated with the inhibition of prostaglandin synthesis via non-selective inhibition of COX-1/COX-2 enzymes. Based on clinical studies conducted to date, ROX-888 is expected to allow patients to ...

Equateq Delivers Pharma-Grade DGLA for Skin Health

...e raw material in the creation of potent anti-inflammatory compounds called prostaglandin E1 and 15-HETrE. In other recent research showing that DGLA countered the role of inflammatory prostaglandin E2 in animal models, the authors concluded that DGLA administration in huma...

Researchers detail how aging undermines bone healing

...hen they were able to reverse the process with a drug known to encourage the COX-2 signaling effect. COX-2 catalyzes the conversion of a fatty acid to prostaglandin E2 (PGE2), a hormone with many functions in the animal body depending on the type of cell they interact with, from blood vessel dilation to embryo imp...

Amira Announces the Successful Completion of GLP Toxicity Studies for a Novel DP2 Antagonist.

...receptor DP2 (also known as CRTH2 or chemoattractant receptor-homologous molecule expressed on Th2 lymphocytes). DP2 is a high affinity receptor for prostaglandin (PG) D2 and, in humans, is implicated in Th2-dependent allergic inflammation. Recent studies have shown that a DP2 antagonist has the potential to be...

What is the pathogenesis of C. jejuni-related disease?

...ol, and ultrastructural disruption of tight junctions, with rounding and lifting of cells off the filter membrane. Synthesis of interleukin (IL)-8 and prostaglandin E2 was increased with strains that invaded the monolayer but not with those that did not. Their results indicated that two distinct patterns of int...

Abortion drug's off-label use may have led to deaths

...term births are a growing problem. Misoprostol is actually a synthetic version of one of the body's own suppressors of the immune response, called prostaglandin E2 (PGE2). Natural suppressors help keep a fine balance between an active or overactive immune response. PGE2 and other prostaglandins, bountiful ...
Prostaglandin in Medical Products

BioTears Oral GelCaps

Features:...de nutrients that are suggested to appropriately inhibit the essential fatty acid arachidonic acid production of the COX2 enzyme, the pro-inflammatory prostaglandin PGE2, and Interleukin Il-6. BioTears Oral GelCaps include nutrients that are suggested to modulate goblet cell/mucin production in both the stimulat...
Company:Biosyntrx, Inc.
Prostaglandin in Biological News

Disabling enzyme allows mice to gorge without becoming obese, new study finds

...spholipase A2 (AdPLA), is found in abundance only in fat tissue. AdPLA sets off a chain of events that increases levels of a signaling molecule called prostaglandin E2 (PGE2), which suppresses the breakdown of fat. Mice that have no AdPLA have lower PGE2 levels and a higher rate of fat metabolism. "When levels ...

The quest for specific anti-inflammatory treatment

... Moreover, it causes cell inflammation, i.e. when the cells detect the presence of this molecule, they secrete molecules that generate inflammation - prostaglandin and cytokine cells, for example. But this process does not occur with all types of cells. Although apparently contradictory, in some cells this sam...

Immune cells reveal fancy footwork

...se their podosomes very quickly during maturation but she also identified the substances that are responsible for their disappearance. The presence of prostaglandin E2 is indispensable for this disassembly. In addition, it appears that dendritic cells lose their podosomes after interaction with certain bacteria. W...

Story ideas from the Journal of Lipid Research

...ntent/abstract/48/9/1985 ">Sphingosylphosphorylcholine acts in an anti-inflammatory manner in renal mesangial cells by reducing interleukin-1b-induced prostaglandin E2 formation , by Cuiyan Xin, Shuyu Ren, Wolfgang Eberhardt, Josef Pfeilschifter, and Andrea Huwiler. MEDIA CONTACT: Andrea Huwiler, University of ...

JCI table of contents: Aug. 16, 2007

...al Investigation, Matthew Breyer and colleagues show that inhibitors of the prostaglandin E2 receptor EP1 reduce hypertension in rats. Consistent with this, mice lac...h to treating hypertension. TITLE: Antihypertensive effects of selective prostaglandin E2 receptor subtype 1 targeting AUTHOR CONTACT: Matthew D. Breyer Vander...

Scripps research team discovers a chemical pathway that causes mice to overeat and gain weight

...th the receptors. The EP3 receptor is one of four types of receptors for prostaglandin E2 (PGE2), the most important inflammatory mediator that controls a variety... treatments like ibuprofen are aimed at reducing PGE2 signaling at all four prostaglandin receptors. The absence of EP3 receptors has long been known to prevent...

Chemicals in brown algae may protect against skin cancer

...genase-2 (COX-2) and of the hormone-like substance prostaglandin E2, both of which are strong indicators of inflamm...ed with BAPs showed lower levels of both COX-2 and prostaglandin E2. The researchers found that the dietary B...e oral and topical BAP treatment reduced COX-2 and prostaglandin E2 cell proliferation levels in the skin," Stoner ...

New understanding of COX-1 and COX-2 enzymes could revise classification of pain meds

...the genetically modified mice created in this study. The JCI study found a drug target that might substitute for COX-2: an enzyme called microsomal prostaglandin E synthase (mPGES)-1. The researchers showed that this drug did not predispose the animals to thrombosis or elevate blood pressure. ...

Study fishes out new role for prostaglandins

...velopment. Mice lacking an enzyme that synthesizes prostaglandin had numerous developmental defects, but the true e...ins on the embryo were likely obscured by maternal prostaglandin production. Because they develop outside the mo...said Solnica-Krezel, "is that…if you just put some prostaglandin back in the culture medium, you rescue the phenoty...

Therapeutic prospects beyond Vioxx

...first place." A surprising finding came when the investigators turned to a drug target that might substitute for COX-2 ?an enzyme called microsomal prostaglandin E synthase (mPGES)-1. Other investigators had shown previously that deletion of this enzyme seemed as effective as treatment with NSAIDs in models of ...
Prostaglandin in Biological Technology

Amira Initiates Phase I Clinical Trial of Novel DP2 Antagonist

...es." DP2 is also known as CRTH2 or chemoattractant receptor-homologous molecule expressed on Th2 lymphocytes. DP2 is a high affinity receptor for prostaglandin D2 and, in humans, is implicated in Th2-dependent allergic inflammation. "The start of the AM211 clinical studies marks another impressive mile...

Video: Allergan Announces U.S. Food and Drug Administration (FDA) Approval of Latisse(TM) -- First and Only Treatment Approved by the FDA for Hypotrichosis of Eyelashes

...the formulation of LATISSE(TM) and is a structural prostaglandin analog, a lipid compound derived from fatty acids designed to bind to prostaglandin (PG) receptors. PG receptors are present in hair,...he use of bimatoprost and other prostaglandins and prostaglandin analogs as a treatment to stimulate eyelash growth...

Celadrin(R) Research Unveiled at Nutrigenomics 2008 Meeting in Paris, France

...o inhibit the thromboxane synthase enzyme using prostaglandin G2 (PGG2) and prostaglandin H2 (PGH2) as substrates. Thromboxane is a very strong facilitator of inflam... production or receptor inhibition suggests that Celadrin(R) influences the prostaglandin cascade and resulting inflammation," stated Dr. Hesslink. "It is this cellu...

Endotoxins and their Relevance in R&D ApplicationsLPS Detection & Removal Methods

...ey trigger the release of tumor necrosis factor (TNF), Interleukins-1,6 and 8 and the production of Platelet-activating factors, prostaglandin E 2 , Thromboxane A 2 7 8 . LPS Detection Today the LAL (Limulus Amebocyte Lysate) assay is used for the ...
Prostaglandin in Biological Products

Anti-6-keto Prostaglandin F1 alpha (EIA Antiserum) Antibody, Unconjugated from Cayman Chemical

Description: 6-keto Prostaglandin F1α EIA Antiserum 6-keto-PGF1alpha EIAs prostaglandins antisera enzyme immunoassays reagents 6-keto-PGF1.alpha....
Company:Cayman Chemical

Rabbit Anti-13,14 dihydro 15 keto Prostaglandin E2 Polyclonal Antibody, Unconjugated from Abcam

Description: Rabbit polyclonal to 13,14 dihydro 15 keto Prostaglandin E2 ( Abpromise for all tested applications)....
Company:Abcam

6-keto Prostaglandin F1alpha-d4 from Cayman Chemical

Description: PGF1α-d4 contains 4 deuterium atoms at the 3, 3', 4, and 4' positions. It is intended for use as an internal standard for the quantification of PGF1α by GC- or LC-mass spectrometry....
Company:Cayman Chemical

8-iso-13,14-dihydro-15-keto Prostaglandin F2alpha from Cayman Chemical

Description: 8-iso-13,14-dihydro-15-keto Prostaglandin F2α (8-iso-13,14-dihydro-15-keto PGF2α) is a metabolite of the isoprostane, 8-isoprostane (8-iso PGF2α), in rabbits, monkeys and humans. 8-iso PGF2α is a PG-like product of non-specific lipid peroxidation. In both humans and monk...
Company:Cayman Chemical

8-iso Prostaglandin E2 from Cayman Chemical

Description: 8-iso PGE2 is one of several isoprostanes produced from arachidonic acid during lipid peroxidation. It is a potent renal vasoconstrictor in the rat. 8-iso PGE2 inhibits U-46619 or I-BOP-induced platelet aggregation with IC50 values of 0.5 and 5 µM, respectively. When infused into the renal a...
Company:Cayman Chemical

15(R)-17-phenyl trinor Prostaglandin F2alpha isopropyl ester from Cayman Chemical

Description: 15(R)-17-phenyl trinor Prostaglandin F2α isopropyl ester (15(R)-17-phenyl trinor PGF2α isopropyl ester) is the latanoprost-related isomer containing both a double bond at 13,14 and an inverted (β) hydroxyl group at C-15. Similar to 15(S)-latanoprost, 15(R)-17-phenyl trinor PGF2...
Company:Cayman Chemical

15(S)-15-methyl Prostaglandin F2alpha from Cayman Chemical

Description: 15(S)-15-methyl PGF2α is a metabolically stable analog of PGF2α. It is a potent uterine stimulant and abortifacient which can be administered intramuscularly to induce labor. It induces luteolysis and reduces serum progesterone concentrations when given as an intramuscular injection i...
Company:Cayman Chemical

Prostaglandin E2-d4 from Cayman Chemical

Description:... PGE2-d4 contains 4 deuterium atoms at the 3, 3', 4, and 4' positions. It is intended for use as an internal standard for the quantification of prostaglandin E2 (PGE2) by GC- or LC-mass spectrometry. PGE2 is one of the primary cyclooxygenase products of arachidonic acid and one of the most widely investigat...
Company:Cayman Chemical

Prostaglandin E2-d4 from Cayman Chemical

Description:... PGE2-d4 contains 4 deuterium atoms at the 3, 3', 4, and 4' positions. It is intended for use as an internal standard for the quantification of prostaglandin E2 (PGE2) by GC- or LC-mass spectrometry. PGE2 is one of the primary cyclooxygenase products of arachidonic acid and one of the most widely investigat...
Company:Cayman Chemical

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Prostaglandin in Biological Definition

Bone

...ewed as bone forming cells. They are located near to the surface of bone and their functions are to make osteoid and manufacture hormones such as prostaglandin which act on bone itself. Osteoblasts are mononucleate. Active osteoblasts are situated on the surface of osteoid seams* and communicate with each ot...

Semen

...etal and salt ions , sugars , lipids , steroid hormones , enzymes , prostaglandin hormones, amino acids and basic amines . The purpose of the seminal pla...erm cells to swim though, and preventing their diffusion out of the semen. prostaglandin hormones are involved in supressing an immune response by the female agains...

Signal transduction

...r prohormone , which can be brought to the cell through the bloodstream. a hormone that was completely synthesized within the cell, for example, prostaglandin . These receptors are located in the nucleus and are not accompanied by chaperone proteins . In the absence of hormone, they bind to their spe...
Prostaglandin in Biological Dictionary

Seminiferous tubules

... tubules of the testis provide a specialized ... seminiferous tubules . ... Contractility of rat testicular seminiferous tubules in vitro: prostaglandin f 1 ... Intracellular potentials in cells of the seminiferous tubules of rats. J Physiol. ... B. Rat Seminiferous Tubules (see online sum...

Prostaglandins

... actions and produced in virtually all tissues prostaglandin n. Any of a group of potent hormonelike substance...nd medicine, family of chemicals similar to ... prostaglandin - Wikipedia, the free encyclopedia ... Online ... Prostaglandins and Related Products Advances in prostaglandin Thromboxane and Leukotriene... Prostaglandins...
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