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Promoter in Medical News

Researchers Have Identified Cancer Promoter Genes

Researchers at the University at Buffalo have identified particular genes that are most prone to become cancer promoters when exposed to a process called DNA promoter hypermethylation. Hypermethylation is a process that causes genes, which support normal cell development, to generate prote...

Fourth Annual Capitol Classic Bike Race for Autism Awareness

...gistration fees, prizes and donations visit www.bikeforautism.org . Interviews: Fraser autism experts Jay Dworsky, Event promoter and father of a son with autism Diane S. Cross, Fraser president and CEO Where: The streets surrounding Minnesota's State Capit...

Promising biomarker and candidate tumor suppressor gene identified for colorectal cancer

...r and biomarker. The researchers analyzed NDRG4 promoter methylation and expression in human colorectal can...olymerase chain reaction was used to examine NDRG4 promoter methylation as a biomarker in fecal DNA from 75 co...trol subjects. The researchers found that NDRG4 promoter methylation was more prevalent in colorectal cance...

A breakthrough in gastric carcinogenesis

...r (CHFR) is a mitotic stress checkpoint gene whose promoter is frequently methylated in various kinds of cancer. In gastric cancer, CHFR promoter hypermethylation has been reported to lead to chro... University examined the methylation status of the promoter region of CHFR and microsatellite instability (MIN...

Farnesoid X receptor regulates cystathionase

...stance. In the present study the analysis of the human Cystathionase gene promoter demonstrates the presence of an inverted repeat sequence. Administration of...ing four copies of this putative IR1 resulted in transactivation of the CSE promoter in presence of an FXR ligand, while the mutation of the IR1 binding site ab...

p90RSK: A new therapeutic target for liver fibrosis?

...transfected with RNAi targeted to p90RSK, the expression of collagen type I was down regulated according with that of p90RSK. However, collagen type I promoter activity was not alternated with up-regulation or down-regulation of p90RSK expression. Otherwise, p90RSK RNAi inhibited the proliferation of HSC sign...
Promoter in Medical Technology

Video: The Journal, Human Genetics, Publishes Results Supporting Interleukin Genetics' Heart Health Test

...of the results of clinical studies that support the company's Heart Health Genetic Test to assess cardiovascular risk. The article, titled, "IL1B Gene promoter Haplotype Pairs Predict Clinical Levels of Interleukin-1beta and C-reactive Protein," was published in the journal Human Genetics (123:387-398; May 20...

Celldex Therapeutics Receives Fast-Track Designation for CDX-110, a Novel EGFRvIII Vaccine for Glioblastoma

...orm of primary brain cancer and carries a very poor prognosis with current therapy. CDX-110 is an immunotherapy that targets the tumor-specific growth promoter EGFRvIII that can be expressed by GBM. In the ACTIVATE Phase 2a study, GBM patients treated with CDX-110 showed a median survival time of 30 months,...

Celldex Therapeutics Announces Orphan Drug Designation for CDX-110, a Novel EGFRvIII Vaccine for Glioblastoma Multiforme

...stoma Multiforme (GBM). GBM is the most common and aggressive form of brain cancer. CDX-110 is an immunotherapy that targets the tumor-specific growth promoter EGFRvIII. Celldex Therapeutics announced a definitive merger agreement with AVANT Immunotherapeutics, Inc. (Nasdaq: AVAN ) in October 2007. In the ...

Lpath Demonstrates Preclinical Efficacy of Lpathomab(TM) and Initiates Humanization Process

...on, England, to humanize Lpathomab to create a lead antibody for pre- clinical development. LPA is a bioactive lipid long recognized as a significant promoter of cancer-cell growth and metastasis in a broad range of tumor types, as well as a significant contributor to neuropathic pain. "Humanizing our Lpath...

Data Show SuperGen's Multi-Targeted Tyrosine Kinase Inhibitor Suppresses Critical Double-Stranded DNA Repair Protein, Rad51

...ule inhibitors of DNA methyltransferase (DNMT). DNMT1 is considered to be the DNA methyltransferase enzyme mainly responsible for maintaining abnormal promoter methylation in various cancer types. Zebrafish embryos are a viable model for cancer drug research because of their close similarity to humans and the...

Telomerase Presentations at the AACR 2007 Annual Meeting

...e of telomere loss prior to telomerase activation in various tumor types, the role of telomere dysfunction in tumorigenesis, and use of the telomerase promoter to drive tumor cell death. "The data presented at AACR contribute to the growing body of evidence regarding the importance of telomerase targeted th...
Promoter in Medical Definition

Neuropsychiatry

..., Remick, R.A. & Keck, P.E, McElroy, S L, Alexander, L., Shaw, S.H., & Kelsoe, J. (2003) Evidence that a single nucleotide polymorphism in the promoter of the G protein receptor kinase 3 gene is associated with bipolar disorder. Molecular Psychiatry, 8, 546−557. Baughman, F.A., & Hovey, J. (2006...
Promoter in Medical Dictionary

Smooth muscle

...ons in ... ERK1/2-Dependent Contractile Protein Expression in Vascular Smooth Muscle Cells ... The 2.3 kb smooth muscle myosin heavy chain promoter directs gene expression ... Smooth muscle contraction is initiated by Ca2+-calmodulin activation of myosin ... Thus, Ca2+ plays a key role...

Epididymis

... in each testis; carries sperm to vas deferens ... of the epididymis are? Read answer... What is in the epididymis secretion? ... Multiple promoter and splicing mRNA variants of the epididymis -specific gene EP2. ... a family of androgen-dependent, epididymis -specific secretory proteins. ... ...
Promoter in Biological News

Whole genome promoter mapping - Human Genome Project v2.0?

Investigators from the University California, San Diego (UCSD) Branch of the Ludwig Institute for Cancer Research (LICR) and NimbleGen Systems have developed an efficient method to identify thousands of regulatory sequences in the human genome, according to a study published today in Nature. Gene...

Fox Chase researchers uncover one force behind the MYC oncogene in many cancers

... laboratory, used a luciferase assay developed from the luciferase enzyme fireflies use to make light to see exactly where DLX5 protein binds to the promoter region of the MYC gene. They found that there were two sites where DLX5 could bind to the MYC promoter, which is a section of DNA where certain protei...

Children's Hospital of Pittsburgh of UPMC scientists identify enzyme important in aging

...f spontaneous tumors than typical mice. PAPPA controls the availability in tissues of a hormone known as insulin-like growth factor (IGF) that is a promoter of cell division. Hence, IGF is required for normal embryonic and postnatal growth. But IGF also is associated with tumor growth, inflammation and car...

Scientists shed light on inner workings of human embryonic stem cells

...e concentrations of transcription factors rise. They also show that the control between miR-145 and the "reprogramming factors" goes both ways. The promoter for miR-145 is bound and repressed by a transcription factor known as OCT4, they found. "It's a beautiful double negative feedback loop," Kosik sai...

Using combinatorial libraries to engineer genetic circuits advances synthetic biology

...r, computer simulation, on its own, was unable to predict the behavior of this timing circuit. They then built a representative genetic timer using a promoter from each of their libraries and, over time, tracked its behavior. Based on information from one network, the research team was able to calibrate thei...

New nucleotide could revolutionize epigenetics

...DNA methyltransferase affixes a methyl group to cytosine, creating a different but stable nucleotide called 5-methylcytosine. This modification in the promoter region of a gene results in gene silencing. Some regional DNA methylation occurs in the earliest stages of life, influencing differentiation of emb...
Promoter in Biological Technology

Debiopharm Group and Moffitt Cancer Center Sign Development and Commercialisation Agreement for Small Molecule Debio 0928 in Early Preclinical Development for Treatment of Solid Tumours

...in many types of cancer, could open the door to more effective oncology treatments in the future." "The disruption of the binding of the tumour promoter Raf-1 to the tumour suppressor Rb with Debio 0928 is a novel, first-in-class therapeutic strategy that has the potential for targeting a wide spectrum...

BASF Sues DuPont for Patent Infringement

... patented technology that confers tolerance to a key class of herbicides. Specifically, DuPont's Optimum GAT corn product incorporates BASF's patented promoter which is an important genetic component that enables successful tolerance toward an herbicide class known as AHAS or ALS inhibitors. BASF Plant S...

Tigris Pharmaceuticals Presents Results of Breast Cancer Research at AACR Annual Meeting

...gulator of CYP1A1) from the cytoplasm to the nucleus, and its subsequent interaction with the xenobiotic-response element (XRE) sequence on the CYP1A1 promoter region, causing induction of CYP1A1 transcription. This enzyme expression converts AF to metabolites that are covalently bound to DNA. This results ...

DNA2.0 Introduces Freedom of Expression With a New Family of Bacterial Expression Vect:ors

...o ensure optimal repression prior to induction. These vectors are available with either the T7 or T5 promoter. DNA2.0's research has shown that the T5 promoter routinely expresses proteins at higher levels comparable to T7 pET vectors and works in any E. coli host. Cloning into the pJexpress series is free of...

Sigma-Aldrich Introduces MISSION(R) LentiPlex(TM) Pooled shRNA Libraries to Enable Rapid Whole Genome Screening in Primary Cells, Stem Cells or Tumor Cells

...hat are typically resistant to standard siRNA transfection or other viral delivery systems. In addition, Sigma-Aldrich's shRNA libraries include a U6 promoter for shRNA expression in a wide variety of cell lines including embryonic stem cells. These characteristics mean researchers can now conduct high qual...

New Collaboration Aims To Expand Seed-Based Technologies, Benefit Farmers

...ng computational approaches, to identify promoter candidates. Once specific promoter sequences are identified, the information can be further used to design nov...ve Padgette, vice president of biotechnology for Monsanto. "A robust promoter toolbox can further leverage Monsanto's extensive gene library and lead to ...
Promoter in Biological Products

Goat Anti-BRF2 Polyclonal Antibody, Unconjugated from GeneTex

Description:...ound Information BRF2 is one of the multiple subunits of the RNA polymerase III transcription factor complex required for transcription of genes with promoter elements upstream of the initiation site. BRF2 is directly recruited to the TATA-box of polymerase III small nuclear RNA gene promoters through its in...
Company:GeneTex

APAgene Genome Walking Kit from Bio S&T

Description:...e. All necessary ingredients are provided in each kit. The Genome Walking Kit can be used for gap filling, localized cloning of genomic DNA, isolating promoter and regulatory sequences corresponding to cloned cDNAs, 5 and 3 RACE of first-strand cDNAs, identifying intron/exon junctions....
Company:Bio S&T

ChIP-PCR for NFkb from Aviva Systems Biology

Description:...matin solution can be first reverse crosslinked and purified by phenol extraction. Then, PCR reactions using specific primers to amplify certain known promoter regions can be performed to check whether the chromatin immunoprecipitation is successful....
Company:Aviva Systems Biology

pAcAB4 Baculovirus Transfer Vector from BD Biosciences Pharmingen

Description:...r that contains two copies of the AcNPV polyhedrin promoter and two AcNPV p10 promoters. Downstream of the fir...equences. Upstream of this, an inverted polyhedrin promoter has been inserted containing Xba I and Stu I as si...equence. Additionally, there is another polyhedrin promoter and BamH I cloning site downstream of the first p1...
Company:BD Biosciences Pharmingen

APAgene Genome Walking Kit from Bio S&T

Description:...e. All necessary ingredients are provided in each kit. The Genome Walking Kit can be used for gap filling, localized cloning of genomic DNA, isolating promoter and regulatory sequences corresponding to cloned cDNAs, 5 and 3 RACE of first-strand cDNAs, identifying intron/exon junctions.TRIAL 6-WALK FORMAT OFFE...
Company:Bio S&T

loxP flanked Ampicillin Selection Cassette (loxP-amp-loxP) from Gene Bridges GmbH

Description:... The loxP-amp-loxP cassette is designed to allow ampicillin selection in prokaryotic cells. The prokaryotic promoter gb2 driving the gene for ampicillin resistance is a slightly modified version of the Em7 promoter. It mediates higher transcription efficiency than th...
Company:Gene Bridges GmbH
Promoter in Biological Definition

Promoter

for disambiguation of the term promoter, see the promoter Wiktionary article In genetics , a promoter is a DNA sequence that enables a gene to be transcribed . The promoter is recognized by RNA polymerase , which then initiates transcription. In RNA synthesis, promoters are a means...

Bioinformatics

... to that expression data to determine which genes are co-expressed. Further analysis could take a variety of directions: one 2004 study analyzed the promoter sequences of co-expressed (clustered together) genes to find common regulatory elements and used machine learning techniques to predict the promot...

Bioinformatics

... to that expression data to determine which genes are co-expressed. Further analysis could take a variety of directions: one 2004 study analyzed the promoter sequences of co-expressed (clustered together) genes to find common regulatory elements and used machine learning techniques to predict the promot...

Enhancer

... article in Science , where researchers Wedel, et. al., made two linked circles of DNA, one circle with the enhancer sequence and the other with its promoter . An abstract can be found here .) An enhancer does not need to bind close to the transcription initiation site to affect its transcription, as ...

Gene

...he DNA strand is expressed into a trait only if it is transcribed to RNA . Because the transcription starts from a specific base-pair sequence (a promoter ) and stops at another (a terminator ), our DNA strand needs to be correctly placed between the two. If not, it is considered as junk DNA , and is ...

Homeobox

...ty of a single homeodomain protein is usually not enough to recognize only its desired target genes. Most of the time, homeodomain proteins act in the promoter region of their target genes as complexes with other transcription factors, often also homeodomain proteins. Such complexes have a much higher target ...
Promoter in Biological Dictionary

Promoter

In genetics, a promoter is a region of DNA that facilitates the transcription of a particular gene. Promoters are typically located near the genes they regulate, on the same strand and upstream . An entertainment promoter is a person or company in the business of marketing and promotin...

Uracil

... ... uracil DNA N-glycosylase activity. • protein binding ... Structure of the gene for human uracil -DNA glycosylase and analysis of the promoter function. ... Uracil pairs with adenine through hydrogen bonding. Uracil is the hydrogen bond acceptor and can form two hydrogen bonds. U...

Transversion

...sversion event in rat neuroblastomas. ... The promoter sequence having this transversion has a higher promoter activity ... Nuclear dbpA expression and the T-to-G transversion in the promoter region of dbpA ... it is a beautiful clutch pu...

Transcription start site

...e . The basal promoter. An Analogy ... a transcription start site . a promoter ... Transcription start site . This is where a molecule of ... H...s ... Redistribution of transcription start sites within the FMR1 promoter region with ... The transcription start sites of the human FMR1 g...

Terminator region

...he. DNA. Initiation. • Genes on the DNA begin with a ... A terminator probe vector was constructed by cloning the M. tuberculosis hsp60 ... promoter Regions (Genetics) Terminator Regions (Genetics) Transcription, Genetic ... Not on Region 2. Horror And Gore. Unrated. Clearance. Used Blu-...

TATA box

... The TATA box is a DNA sequence found in the promoter region of most genes in eukaryotes and Archaea. The TATA binding p...ite protein in the assembly ... The GTFs that recognize the TATA - Box promoter for Pol II (TFIID, TFIIB, TFIIF, ... TATA , box ,biological,biology di...
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