Proliferating

NuVasive Reports Second Quarter 2009 Financial Results

... driving revenue growth and increased profitability. We are determined to become the #4 global spine company by developing innovative products and by proliferating a corporate culture of speed that generates results." Updated 2009 Financial Guidance NuVasive is updating its full year 2009 financial...

Leukemia cells evade immune system by mimicking normal cells, Stanford studies show

... by the leukemia stem cells as part of their leukemic progression," said Weissman. Jaiswal and his colleagues went on to show that although rapidly proliferating myeloid leukemia cells in human patients expressed about twice as much CD47 as their normal counterparts, CD47 levels were also temporarily elevated i...

Study in Nature: MicroRNAs hold promise for treating diseases in blood vessels

...t (bone, nerve, blood, skin, muscle, etc.). To serve specific roles in the body, some stem cells also switch back and forth between primitive, rapidly proliferating precursors and their mature, functioning, non-proliferating counterparts, a quality called "plasticity." Among the most "plastic" of cells are vasc...

Trimming the fat boosts blood recovery after marrow transplant

...g fat cells, were quicker to build up their bone marrow after it was depleted by irradiation. In particular, they were quicker to build up the rapidly proliferating blood cell progenitors that are known in mice as well as humans to be the most important in surviving the immediate post-transplant period. Sever...

Penn study demonstrates new way to boost immune memory

...so saw that T cells burn more fatty acids when given metformin. T cells proliferating to form an army of effector cells burn glucose for their energy. Non-prolif...implied that there's a switch in metabolism somewhere along the way between proliferating and non-proliferating T cell populations." Perhaps at the peak of the proli...

Process controlling T cell growth and production identified

...LF4, which signals cell cycle arrest in nave CD8 T cells," Lacorazza said. "This inhibitory process is important to T cells because it stops them from proliferating out of control." Cell cycle arrest means the cells do not go through the normal events of their life cycles: growth, replication and division. The des...

Mayo Clinic researchers formulate treatment combination lethal to pancreatic cancer cells

...ay, which is involved in growth and angiogenesis. "Overall, these results indicate that rapamycin and panobinostat disrupts essential survival and proliferating pathways in pancreatic cancer cells, and this is a good start toward a novel treatment of this cancer," Dr. Gupta says. ...

Innovation and Strategic Alliances Come to the Rescue of Participants in Mature Brazilian Market for Food Emulsifiers, Finds Frost & Sullivan

...ucers to remain alert to these trends and adapt their production models effectively to maintain market competitiveness. Dietary food options have been proliferating across all market segments, particularly in the bakery, confectionary, and dairy sectors. Advances in research have made available new knowledge to ci...

A new method for bone-marrow-derived liver stem cells isolation and proliferation

... easy method to separate stem cells, by avoiding complicated immunological manipulation. The successful passage of the stem cells further verifies the proliferating ability of the cells, although the passage is limited, and further research will provide more experience. In this study, the authors used their ori...

Scientists Identify Key Gene That Protects Against Leukemia

...ative disease, which can evolve to leukemia. The finding indicated that the proliferating JunB-deficient HSCs causes leukemia.     Like traffic lig...hicles and prevent accidents, JunB curtails both the rate at which HSCs are proliferating and the rate of differentiation toward the myeloid lineage that ultimately ...

Proliferating in Medical Technology

Lab Automation Networks Proliferating

Although it may still seem radically innovative in the context of many clinical laboratories, automated production in the manufacturing sector had been the norm for many years. In automobile assembly, for example, automated lines fabricate sub-assemblies and entire vehicles with only occasional hu...

Study Shows Cancer Vaccines Led to Long-Term Survival for Patients with Metastatic Melanoma and to Long Periods of Disease Control After Completion of Therapy

..."Phase II Trial of Dendritic Cells Loaded with Antigens from Self-Renewing, proliferating Autologous Tumor Cells as Patient-Specific Anti-Tumor Vaccines in Patients ...culture of the patient's own melanoma cells that had been self-renewing and proliferating in the laboratory. The patient-specific vaccine is designed to stimulate th...

Sunesis Pharmaceuticals Initiates Phase 2 Clinical Trial of Voreloxin (SNS-595) in Acute Myeloid Leukemia

...ble G2 arrest and rapid apoptosis. The topoisomerase II-associated DNA intercalation and DNA damage produced by voreloxin show greater selectivity for proliferating cells. In nonclinical evaluations, voreloxin demonstrates broad and potent activity in tumor biopsies and in xenograft, syngeneic and drug-resistant...

AviaraDx Confirms That Combination of Two Molecular Biomarkers Improves Prediction of Disease Recurrence in Early Stage Breast Cancer Patients

...tumors have high MGI values, it is important to measure H/I in order to determine likely benefit from endocrine therapy within the setting of a highly proliferating tumor." The authors conclude that these two markers together should enable oncologists to identify a large subgroup of women with low risk of recurr...

Preclinical Studies Show Promise for Novel Antibody Therapy to Treat Acute Myeloid Leukemia (AML)

...how that 7G3 is able to target LSC's to prevent them from moving around and proliferating in the mice, while at the same time having little effect on normal blood ce... specifically target the LSC, rather than simply attacking the cancer cells proliferating in the blood and bone marrow. Hopefully this means that it can fight leukem...

Siemens Showcases Its Most Comprehensive and Advanced Breast Care Portfolio

...s high quality images of 18F-FDG tracer, which shows a high sensitivity for the localization of distant metastases due to the high glucose affinity of proliferating tumor cells. This has made PET.CT a standard of care for breast cancer staging. Molecular imaging technologies can assist physicians in making more ac...

Sunesis Pharmaceuticals Commences Clinical Trials of SNS-595 and SNS-314

...l trials and a Phase 2 ovarian cancer clinical trial. SNS-595 is a replication- dependent DNA damaging agent that causes irreversible growth arrest of proliferating cells and rapid apoptosis. In clinical trials conducted to date, SNS-595 has been well tolerated and has shown promising signs of clinical activity in...

Sunesis Pharmaceuticals Presents SNS-314 Aurora Kinase Inhibitor Data Showing Broad Anti-Tumor Activity, Dosing Flexibility

... to have sustained exposure in tumor tissue, further supporting the compound's potential to differentiate its anti-tumor effects from effects on other proliferating tissues. Discovered by Sunesis, SNS-314 is targeted to inhibit Aurora kinases thus halting cell division at the mitotic phase of the cell cycle and ...

New Positive Pre-clinical Data for Active Biotech's RA Project I-3D

... The I-3D compound is a novel small molecule inhibitor of human dihydroorotate dehydrogenase (DHODH). Inflammatory diseases such as RA involve rapidly proliferating T cells with an exceptional requirement for de novo pyrimidine biosynthesis. DHODH inhibition results in inhibition of de novo pyrimidine synthesis an...

Proliferating in Medical Dictionary

Seborrheic keratoses

...s their waxy, ... Seborrheic keratoses have a variety of clinical appearances, and they develop ... In pigmented seborrheic keratoses , the proliferating keratinocytes trigger the ... Seborrheic keratosis is noncancerous (benign) wart-like growths on the surface of the skin. ... Seborrheic ke...

Proliferating in Biological News

Study shows cancer vaccines led to long-term survival for patients with metastatic melanoma

..."Phase II Trial of Dendritic Cells Loaded with Antigens from Self-Renewing, proliferating Autologous Tumor Cells as Patient-Specific Anti-Tumor Vaccines in Patients ...culture of the patient's own melanoma cells that had been self-renewing and proliferating in the laboratory. The patient-specific vaccine is designed to stimulate th...

Activated stem cells in damaged lungs could be first step toward cancer

...nticipate would stimulate these stem cells. Our findings demonstrate that, with severe injury, the resulting repair response leads to large numbers of proliferating cells that are derived from these rare stem cells." Stripp said this finding could be related to the increased incidence of lung cancer in people w...

Scientists identify key gene that protects against leukemia

...ative disease, which can evolve to leukemia. The finding indicated that the proliferating JunB-deficient HSCs causes leukemia. Like traffic lights, which limit sp...hicles and prevent accidents, JunB curtails both the rate at which HSCs are proliferating and the rate of differentiation toward the myeloid lineage that ultimately ...

At WPI, some students are learning it's OK to peek

... procedures, the interpretation, and hypothesizing, which are important parts of what we're trying to teach." Clickers as classroom tools have been proliferating at schools and universities in the United States for several years. Typically, they are used to take attendance or to permit students to respond to mu...

Weizmann Institute scientists show extra copies of a gene carry extra risk

...mice were a bit smaller than average. On closer inspection, they discovered a range of subtle changes in cell polarity and movement: Nuclei within the proliferating zone tended to move faster, but with less control; rates of cell death were higher; and various factors in the cell became more disordered. Reiner...

The gold standard: Biodesign Institute researchers use nanoparticles to make 3-D DNA nanotubes

...ructures may soon find their way into a new generation of ultra-tiny electronic and biomedical innovations. Yan and Liu are working in the rapidly proliferating field of structural DNA nanotechnology. By copying a page from nature's guidebook, they capitalize on the DNA molecule's remarkable properties of self...

Tips from the American Journal of Pathology

...-irradiation and had decreased adipocyte size and a reduced number of mature adipocytes. Poglio et al also observed severe decreases in the number of proliferating cells and increases in the number of dying cells. Taken together, the data from Dr. Cousin's group suggest that "in terms of therapeutics, these ...

Mammals can be stimulated to regrow damaged inner retina nerve cells

...1 and insulin, they were able to stimulate the Mller glia cells to re-start their dividing engines and begin to proliferate across the retina. The proliferating Mller glia cells first transformed into unspecialized cells. The researchers were able to detect this transformation by checking for chemical markers ...

Researchers identify Achilles heel of common childhood tumor

... have discovered a mechanism for the rapid growth seen in infantile hemangioma, the most common childhood tumor. The tumors, which are made up of proliferating blood vessels, affect up to 10 percent of children of European descent, with girls more frequently afflicted than boys. The growths appear within day...

Cholesterol-lowering drugs and the effect on muscle repair and regeneration

... in the viability of the satellite cells at 1.0, 10 and 100M concentrations of simvastatin. At approximately 5.0 M concentration the viability of the proliferating cells was reduced by 50% (equivalent to the availability of simvastatin in circulation from a 40 milligram dose per day used in some patients). Specif...

Proliferating in Biological Technology

Yaupon Therapeutics Completes Patient Enrollment for Pivotal Phase 2 Study of Clearazide for Treatment of Cutaneous T-cell Lymphoma

...rm of nitrogen mustard, an alkylating agent that works by inhibiting DNA replication. Nitrogen mustard has also demonstrated activity in other T-cell proliferating diseases such as psoriasis and alopecia areata and has a rich history of use in dermatology dating back to the 1950s. To date, topical nitrogen musta...

Patent for Making Combination Chemotherapy Work Better

...cols achieve only a fraction of the potential inherent in the combination of the underlying drugs. Novel synergistic protocols are provided. All proliferating cells progress through 4 distinct phases, in sequence, G1, S, G2, and M. "S-Phase cytotoxics, such as Pfizer's irinotecan or Eli Lilly's gemcitabine,...

BioNeutral's Ygiene(TM) New Hospital Grade Disinfectant Will Save Lives and Billions of Dollars Annually at Health Care Facilities Around the World

...he more difficult organisms, work too slowly or have other draw backs which limit their usefulness to protect and prevent powerful microorganisms from proliferating in health care facilities. This regretfully places patients, staff and visitors at severely added risk." Stephen J. Browand, Managing Director, said...

GeoPharma Adds India, Nepal, Bangladesh, Sri Lanka and South Korea as New Distribution Channels for Mucotrol(TM)

...afer, which had received FDA approval as a medical device. The recent extension of the primary agreement allows for additional partners to be secured, proliferating the acceptance of Mucotrol(TM) in other regions of the world previously unexplored. The new aspect of the agreement embraces two new regional partners...

Worldwide Center for Adult Stem Cell Education LLC Changes Name to 'The Repair Stem Cell Institute LLC'

...g diseases such as diabetes, Alzheimer's, Parkinson's, ALS (Lou Gehrig's Disease), and even Autism! Repair stem cells are unlike embryonics, which are proliferating stem cells, so they cannot be moved off that goal of rapid expansion no matter how brilliant the research team. For that reason they are unstable and ...

Anavex 7-1037 reduces rate of cancer tumor growth 69% in pre-clinical studies, compared to currently marketed drug Dacarbazine showing no measurable activity

...d lung. Interestingly, sigma receptors are more highly expressed in rapidly proliferating cells and are down-regulated when cells become inactive. Their high density in various tumor cell types, and particularly in proliferating cells, makes sigma receptors a potential target for diagnostic imaging as w...

New Benefactors Show Support for CDA4CDT:

...teroperable specifications for common types of clinical notes makes good business sense to us." Imagetek, Inc. joined the CDA4CDT initiative because proliferating the adoption of interoperable electronic documents makes it easier to support patient-centric records management for the healthcare sector of their co...

A 'Must Read' for Breast Cancer Patients

...asses of chemotherapeutics to function synergistically. The protocols are designed to provide a way of holding the cancer in check indefinitely. All proliferating cells progress through 4 distinct phases termed G1, S, G2, and M. "S-Phase cytotoxics, such as Pfizer's Camptosar(R) or Eli Lilly's Gemzar(R), are cap...

On the road to a new cancer therapy -- starving the tumor

...ded. However, this is not the case with cancer cells: cancer cells know how to circumvent the control system and go on multiplying out of control. The proliferating cells spread to surrounding tissue or are carried to other tissues and organs via the blood or the lymph system. This seriously disrupts our bodys vit...

GE Medical Systems Signs Clinical Trial with National Cancer Institute

... FLT is a PET radiopharmaceutical used to image DNA synthesis, showing high contrast in the presence of cellular proliferation in tumors and other proliferating tissues. FLT has shown preliminary promise for the in-vivo imaging of cellular proliferation. The monitoring of the anti-proliferative effects of ...

Proliferating in Biological Products

Rabbit Anti-Ki67 Polyclonal Antibody, Unconjugated from GeneTex

Description:... Rabbit polyclonal to Ki67 - Proliferation Marker, prediluted Ki67 antigen is the prototypic cell cycle related nuclear protein, expressed by proliferating cells in all phases of the active cell cycle (G1, S, G2 and M phase). It is absent in resting (G0) cells. Ki67 antibodies are useful in establishing t...
Company:GeneTex

Mouse Anti-Cytokeratin 5, 6 Monoclonal Antibody, Unconjugated, Clone D5/16 B4 from GeneTex

Description:...omplex epithelia and in mesothelial cells and mesothelioma. Cytokeratin 6 (56 kD) is also a high molecular weight, basic type cytokeratin expressed by proliferating squamous epithelium often paired with cytokeratin 16. Immunogen: BALB/C mice were injected with cytokeratin 5....
Company:GeneTex

Proliferating in Biological Definition

Helper T cell

...eins or peptides that stimulate other lymphocytes ; the most common is interleukin-2 (IL-2), which is a potent T cell growth factor. Activated, proliferating T H cells can differentiate into two major subtypes of cells, Th1 and Th2 cells. These subtypes are defined on the basis of specific cytokines prod...

Proliferating in Biological Dictionary

Topoisomerase

..... Eukaryotic type II topoisomerase cannot introduce supercoils; it ... In cancers, the topoisomerase IIalpha is highly expressed in highly proliferating cells. ... Inhibition of Human Topoisomerase II in Vitro by Bioactive Benzene Metabolites, ... Topoisomerase -interactive agents make up one rec...

Primary oocyte

...e . ... ... of follicular assembly and the primordial to primary follicle transition... Primary follicles, an oocyte surrounded by a layer of proliferating granulosa, ... ...

Optic lobes

...ic lobes of the brain, which develop during metamorphosis. from the eye discs and the optic lobe anlagen ... Optic lobes were scored as not proliferating ... Find dictionary definitions, audio pronunciations, and spellings for optic lobe in the free online American Heritage Dictionary on Yahoo! E...

Forebrain

...l, Credit Card Required. Online Shopping at DirectTextBook.com - Save up to 80%, buy or rent. New and used books like Distribution and Phenotype of proliferating Cells in the Forebrain of... A basal ganglia- forebrain circuit in the songbird biases motor output to avoid ... GABAergic and cholinergic basal...

Carboxyl Terminus

...... A novel apoptosis pathway activated by the carboxyl terminus of p21 ... dependent kinases, while the carboxyl terminus interacts with proliferating cell ... To date, the carboxyl terminus of hLHß appears to end at either position Gln114 ... To investigate the carboxyl terminus polymo...

Blastema

...Online.org dictionary. ... Dictionary " B " Blastema . Blastema . Blastema ... ... in the formation of a blastema (a mass of dedifferentiated proliferating cells). As the blastema forms, pattern formation genes – such as Hox A and HoxD – are ... Pronunciation of blastema . blastema synonyms. blas...