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Progenitors in Medical News

Comprehensive Look at Rare Leukemia Finds Relatively Few Genetic Changes Launch Disease

...ocesses may need to be altered in hematopoietic stem cells, multi-potential progenitors or committed myeloid progenitors to convert them from a normal cell to AML," the authors noted, referring to...

Trimming the fat boosts blood recovery after marrow transplant

...many blood-forming stem cells and up to three times fewer specialized blood progenitors than did the leaner thoracic vertebrae. In cell culture, the mere prese...ticular, they were quicker to build up the rapidly proliferating blood cell progenitors that are known in mice as well as humans to be the most important in surv...

Cell microenvironments hold key to future stem cell therapies

...ions with other cells and those resulting from cell interactions with the ECM or other signaling molecules. Both immortalized and primary human breast progenitors were analyzed with the MEArrays and the results were used in conjunction with physiologically relevant 3-D human breast cultures. This approach enable...

Scientists uncover indicator that warns leukemia is progressing to more dangerous form

...R-ABL to the blast crisis stage. This stage is characterized by the over-production of beta-catenin in white blood cells called granulocyte macrophage progenitors (GMP) in effect, leukemia stem cells. According to Jamieson, a major roadblock in predicting and stopping the conversion of chronic CML to blast c...

Genetics of aging and cancer resistance

...ists showed that p16(Ink4a) and Arf contribute to the age-related decline in B-cell lymphopoiesis, and that inhibition of p16(Ink4a) and Arf in B-cell progenitors rejuvenates their growth potential and facilitates the development of acute lymphoblastic leukemia. This newly established role for p16(Ink4a) and ...

Anti-angiogenic drugs impede chemotherapy-stimulated tumor recovery

...ment with a type of cytotoxic-like agent known as a vascular disrupting agent (VDA) induces rapid mobilization of cells called circulating endothelial progenitors (CEPs) from the bone marrow compartment that helps the tumor to regrow blood vessels and thereby recover from treatment. The researchers built on ...

Researchers Hunt Normal Cells That Give Rise to Cancer

... Identifying these progenitors may provide context for tumor formation, new treatments MONDAY, Aug. 11 (HealthDay News) -- Learning more about normal cells that give ...

Brain Stem Cells Reverse Myelin Deficiency in Mice

...ve transmission along remyelinated axons. They observed velocities on par with those of normal mice. "That is proof in principle that putting glial progenitors in a brain like this will at least partially remyelinate the brain, and do so functionally," said James Goldman. Though this study involved a conge...

World-Renowned Scientists to Lead Immunology Course

..., Fourth Floor, Boston Marriott Copley Place Thematic Symposia: Pulmonary CXCR2 Regulates VCam-I Dependent, Antigen-induced Recruitment of Mast Cell progenitors to Lung, presented by K. Frank Austen, MD, Brigham & Women's Hospital Saturday, June 7 2:00 pm to 2:30 pm Salon F, Fourth Floor, Boston Marriott...

Heart's Stem Cells Not Created Equally

...ed muscle, in hope of creating healthy tissue. The theory supposes that all progenitors are the same. "What we have found is that this belief simply isn't true...other genes in addition to CASTOR to determine how many types of heart cell progenitors exist. He hopes to verify his findings other animal models before searching...
Progenitors in Medical Technology

St. Jude Finds Signaling System That Halts the Growth of a Childhood Brain Cancer

...author. Several research teams are seeking to decipher the intricate signaling mechanisms that govern the proliferation of cells called granule neuron progenitors (GNPs). These cells go on to develop into neurons in the cerebellum during the first year of life. But the disruption of this differentiation process ...

Research Indicates Geron's Human Embryonic Stem Cell-Based Therapeutic for Spinal Cord Injury Evades Direct Attack by the Human Immune System

...era from the remaining two individuals induced only 10% GRNOPC1 cell lysis. GRNOPC1 is an allogeneic population of cells containing oligodendroglial progenitors that is intended for transplantation into the lesion site of patients with spinal cord injury to induce tissue repair. Geron's development plan for th...

Research Documents Scalable Production, Survival Following Engraftment and Positive Impact on Cardiac Function in Infarcted Rats for Geron's Human Embryonic Stem Cell-Based Therapeutic for Heart Failure

...e model is for Geron to provide cell-based therapies as off-the-shelf products for the treatment of chronic degenerative diseases." Oligodendroglial progenitors for the Treatment of Spinal Cord Injury The properties and functions of GRNOPC1, Geron's lead hESC product for the treatment of spinal cord injury, ...
Progenitors in Medical Definition

Thymocyte

... ultimately derived from bone marrow hematopoietic progenitors cells [see hematopoietic stem cell , hematopoies...ymus through the circulation. [2] The number of progenitors that enter the thymus each day is thought to be extremely small. Therefore which progenitors colonize the thymus is unknown. Currently Early Ly...
Progenitors in Medical Dictionary

Granulocyte

... Original Article from The New England Journal of Medicine -- Granulocyte -Macrophage progenitors as Candidate Leukemic Stem Cells in Blast-Crisis CML Original Article from The New England Journal of Medicine -- Mutations in the Gene for the G...

Germ

... of its progenitors. The Germ ... Germ (mathematics), an object in a topological space that captures local properties ... Germ cells are progenitors of the gametes. These singled-out cells move through the gut to the developing gonads and undergo mitotic proliferation followed by meiosis and diff...
Progenitors in Biological News

Comprehensive look at rare leukemia finds relatively few genetic changes launch disease

...ocesses may need to be altered in hematopoietic stem cells, multi-potential progenitors or committed myeloid progenitors to convert them from a normal cell to AML," the authors noted, referring to...

Domestication of Capsicum annuum chile pepper provides insights into crop origin and evolution

...f patterns in the sequence data, Dr. Kim et al. hypothesize that chiles were independently domesticated several times from geographically distant wild progenitors by different prehistoric cultures in Mexico, in contrast to maize and beans which appear to have been domesticated only once. Geographical separat...

Google Earth aids discovery of early African mammal fossils

...m el Raqaba area," Gunnell said. Were the tiny bats, rats and other creatures whose fossils the researchers found among those very first migrants, the progenitors of today's iconic African wildlife? "The record isn't good enough to pin that down yet," Gunnell said. "But when these animals are studied in detai...

Creating ideal neural cells for clinical use

...the cortex and olfactory bulb. The transplanted cells did not generate tumor outgrowth. "The uniform conversion of embryonic stem cells into neural progenitors is the first step in the development of cell-based therapies for neurodegenerative disorders or spinal injuries," said Dr. Terskikh. "Many of the met...

Amniotic fluid may provide new source of stem cells for future therapies

...ecific genes known to be involved in hematopoietic development. The overall gene expression profile of the AFKL cells was found to resemble blood cell progenitors from known hematopoiesis sites such as the aorta-gonadmesonephros region, placenta, and the umbilical/vitelline arteries. ...

Brain building: Study shows brain growth tied to cell division in mouse embryos

... fate asymmetry is thought to depend on the orientation of cell division, and the authors observed an increase in the number of symmetrically dividing progenitors in the brains of Vangl2-lacking mouse embryos. Also, Vangl2-lacking cells in culture showed symmetrical distribution of a spindle-orienting factor tha...

UCLA stem cells scientists make electrically active motor neurons from iPS cells

...rom the brain and spinal cord and regulate muscle contraction. The study demonstrates the feasibility of using iPS-derived motor neurons and their progenitors to replace damaged or dead motor neurons in patients with certain disorders. It also opens the possibility of studying motor neuron-related diseases i...

Researchers generate functional neurons from somatic cells

...tina Wiedau-Pazos of the University of California Los Angeles, researchers compared the ability of different human cell lines to generate motor neuron progenitors and fully differentiated motor neurons. "These findings support the possibility that reprogrammed somatic cells might prove to be a viable alternative...

Fat-regenerating 'stem cells' found in mice

...on known as lipodystrophy. Those animals are unable to produce fat normally and they also have diabetes. Injection with the newly discovered fat cell progenitors reversed the animals' diabetes and restored their fat levels within two weeks, they report. Rodeheffer said that there are likely to be analogous c...

Big-brained animals evolve faster

...rapidly radiated in 13 species, each one adapted to use the food resources in a different way. This and other examples have led some to think that the progenitors of the major evolutionary radiations are those that happened to be in the right place and at the right time to take advantage of ecological opportunit...
Progenitors in Biological Technology

Amniotic Fluid May Provide New Source of Stem Cells for Future Therapies

...ecific genes known to be involved in hematopoietic development. The overall gene expression profile of the AFKL cells was found to resemble blood cell progenitors from known hematopoiesis sites such as the aorta-gonad-mesonephros region, placenta, and the umbilical/vitelline arteries. The American Societ...

Stemgent, CellDesign Sign Co-Exclusive Marketing Agreement on Stem Cell-Based Adipocyte Research Products

...CellDesign. Added Ian Ratcliffe, CEO, Stemgent, "We are extremely excited to be able to offer CellDesign's cutting-edge technology for adipogenic progenitors to the stem cell research community." Under the terms of the agreement, the kits will be sold under both companies' names. Kits will be shipped ...

Many paths, few destinations: How stem cells decide what they'll be

...researchers examined how blood stem cells decide to become white blood cell progenitors or red blood cell progenitors. They began by examining populations of s...lood stem cells with low levels of Sca-1 differentiated into red blood cell progenitors seven times more often than cells high in Sca-1 when exposed to erythropoie...

ReachBio Partners with Axiogenesis to Distribute Novel Cell-Based Products in North America

... in providing pre-qualified, standardized primary cells, as well as highly predictive assay services utilizing normal human bone marrow stem cells and progenitors for drug discovery and toxicity testing applications. Furthermore, their founders have years of experience in the sales, marketing and technical suppo...

Families of Spinal Muscular Atrophy; University of California, Irvine Stem Cell Scientist; and California Stem Cell Announce Collaboration for Safety Studies for Stem Cell Therapy in Spinal Muscular Atrophy

... in accordance with FDA regulations, will assess the safety of motor neuron progenitors derived from human stem cells after transplantation. SMA is a genetic d...s to produce and supply the large population of clinical-grade motor neuron progenitors required for these pivotal studies and future human clinical trials. "T...

UW-Madison rat experiment could lead to stem-cell treatment for ALS

... progenitor cells. The next problem was actually getting the cells into the right location of the ALS rat spinal cord. "Nobody had shown that human progenitors could be delivered right into the region of the dying motor neurons," Klein said in the release. Klein bored into the base of a rat's spine using a mi...

Wisconsin tries to woo another stem cell company

... The company has developed a method to derive neural progenitor cells from human embryonic stem cells, enabling it to produce kits containing neural progenitors and the reagents needed to both proliferate and differentiate them into cultures of neural cells. The cells and proliferation media are used by bi...

Wisconsin won't get Georgia biotech without a fight

...oundation , has developed a method to derive neural progenitor cells from human embryonic stem cells, enabling Aruna to produce kits containing neural progenitors and the reagents needed to both proliferate and differentiate them into cultures of neural cells. The cells and proliferation media are used by biomed...

RNArticles: RNA Amplification Used to Develop a New In Vitro HCMV Assay

..., Goodrum et al. (2) used microarray analyses to establish the role of infected primary CD34+ haemotopoeitic progenitors grown above a murine stromal AFT024 monolayer as a potential in vitro model system to study HCMV latency. Fo...
Progenitors in Biological Products

Pokeweed Mitogen Spleen Cell Conditioned Medium, 25 mL from StemCell Technologies, Inc.

Description:... Source of colony stimulating factors for assays of mouse hematopoietic progenitors from bone marrow, spleen, blood and fetal liver. Suitable for the growth of mouse BFU-E, CFU-M, CFU-G and CFU-GEMM when added to methylcellulose at a...
Company:StemCell Technologies, Inc.
Progenitors in Biological Dictionary

Sex cells

... Germ cells are progenitors of the gametes. These singled-out cells move through the gut to the developing gonads and undergo mitotic proliferation followed by meiosis and ...

Myotome

...tains a permanent record of original somite ... Although the contour of the myotome was complex at ages when vertebrae could be ... ... mitotic progenitors colonizes the myotome , initially stemming from the extreme ... is sufficient to promote myotome colonization, whereas its absence drives ... Th...
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