Scripps Florida scientists devise accelerated method to determine infectious prion strains
JUPITER, FL, May 28, 2009 Current tests to identify specific strains of infectious prions, which cause a range of transmissible diseases (such as mad cow) in animals and humans, can take anywhere from six months to a year to yield results a time-lag that may put human populations at risk.
Malaria Drug Doesn't Boost Survival Odds With Prion Diseases
Oral quinacrine showed no benefit for brain-wasting disorders such as Creutzfeldt-Jakob
WEDNESDAY, March 11 (HealthDay News) -- The drug quinacrine doesn't prolong survival of patients with brain-wasting prion
diseases such as Creutzfeldt-Jakob disease (CJD), British researchers say. ...
Mutant proteins result in infectious prion disease in mice
A worldwide group of scientists has created an infectious prion
disease in a mouse model, in a step that may help unravel the mystery of this progressive disease that affects the nervous system in humans and animals. The research team, including Christina J. Sigurdson, D.V.M., Ph.D., assistant pr...
New prion protein discovered by Canadian scientists may offer insight into mad cow disease
Scientists have discovered a new protein that may offer fresh insights into brain function in mad cow disease. Our team has defined a second prion
protein called Shadoo, that exists in addition to the well-known prion
protein called PrP said Professor David Westaway, director of the Centre for P...
New Insights into Prion Propogation
Prions -- infectious, oddly-folded proteins that are the main suspects in fatal neurodegenerative diseases such as Cruetzfeldt-Jakob and bovine spongiform encephalopathy , or "mad cow" -- remain mostly a mystery to scientists. Very few prions have been fully described. How they infect and propagate...
Significant Advances in VCJD Prion Detection
Scientists have made significant advances towards the development of a technique that could be used to confirm whether someone is infected with variant CJD .
The technique, which has so far been used mainly in animal models, works by mimicking and accelerating the replication of prions - abnor...
Vaccine Prevents Prion Disease in Mice
An oral vaccine can prevent mice from developing a brain disease similar to mad cow disease, according to research that will be presented at the American Academy of Neurology's 59th Annual Meeting in Boston, April 28 May 5, 2007. Prion
diseases, which include scrapie, mad cow disease, and chronic...
Vaccine Prevents Prion Disease in Mice
An oral vaccine can prevent mice from developing a brain disease similar to mad cow disease, according to research that will be presented at the American// Academy of Neurology's 59th Annual Meeting in Boston, April 28 – May 5, 2007. Prion
diseases, which include scrapie, mad cow disease, and chron...
Study Finds Prion Proteins in Milk
A study has identified the presence of normal prion
proteins in milk from humans, cows, sheep//, and goats.
"Prion Protein in Milk" appeared in the December issue of PLoS One, an online journal from the Public Library of Science, available at www.plosone.org.
Role of Hsp 104 in the Spread of Prion Diseases
Protein’s role in the spread of the lethal Prion
diseases has been brought to light by researchers from Brown University//. This was published in an online edition of PLoS Biology.
Researchers under Tricia Serio have revealed that the protein Hsp 104 is responsible for the spread and multiplic...
Prion in Medical Technology
Mayo Clinic Study Identifies Potential Causes of Young-Onset Dementia
...6. In one-third of patients, the dementia was caused by a
neurodegenerative disorder such as frontotemporal dementia, Huntington's
disease or familial prion
disease. However, Alzheimer's disease was an
uncommon cause. In 20 percent of patients, young-onset dementia was caused
by autoimmune or inflammatory ...
First High-Res 3-D Structures of Mammalian HSP90 Protein Solved, Key to Better Targets for AIDS, Sepsis, Cancer Drugs
... cancer to sepsis, and
drugs that stimulate HSP90 action may be appropriate therapies for diseases
involving protein folding, such as cystic fibrosis, prion
Alzheimer's Disease. Since 2001, Gewirth and his lab have been using the technique of X-ray
diffraction to solve the first high-resolut...
K-State Researchers Bringing Expertise to Kansas City Symposium on Disease and National Security
...ff the symposium at 8:30 a.m. with "BSE Prions and
Flu Viruses: Two Distinct Zoonotic Agents." This presentation will provide
a basic understanding of prion
diseases, especially bovine spongiform
encephalopathy, or mad cow disease. He'll discuss the molecular features of
typical and atypical cases of mad c...
Adlyfe Study on the Detection of Misfolded Proteins Published in the Journal Transfusion
...seases, announced today the publication of a study, "Detection of
protein in blood with conformationally sensitive peptides,"
in the August 2...fe's MPD assay is a
sensitive and specific test for the detection misfolded prion
may be useful in both preclinical and clinical diagnosis tran...
Prion in Medical Definition
Artificial induction of immunity
...system is developing.
Synthetic ( recombinant or cell-clone) human immunoglobulins can now be made, and for several reasons (including the risk of prion
contamination of biological materials) are likely to be used more and more often. However, they are expensive to produce and are not in large-scale p...
...such infectious (or transmissible) proteopathy is prion
disease , which can be transmitted by exposure of a host organism to purified prion
protein in a disease-causing conformation.  ... (Aβ) (senile plaques), Tau protein (fibers)
Prion in Medical Dictionary
The concept of prion
was initially greeted with skepticism by the scientific ... Some cases of prion
-related disease seem to be caused neither by inheritance nor ... International Bio pharmaceutical Association Medical Terms ... Prusiner coined the word " prion
" as a name for the infecti...
Diseases (TSEs) Classification and external resources ... All known prion
diseases affect the structure of the brain o... prions, though some other data suggest an... prion
diseases ( ′Prī′än di′zēzəz ) ( medicine ) A gr...
Mad Cow Disease
...athy or BSE), scrapie, Creutzfeldt-Jakob Disease (CJD and ... BSE (Bovine Spongiform Encephalopathy, or Mad Cow Disease ) ... Scrapie is a prion
disease of sheep. ... It was in an adult Holstein cow from Washington State. ... new worries about mad cow disease , Creutzfeldt-Jacob ...
Prion in Biological News
Iron is involved in prion disease-associated neuronal demise
Imbalance of iron homeostasis is a common feature of prion
disease-affected human, mouse, and hamster brains, according to a new study by Dr. Neena Singh and colleagues at Case Western Reserve University School of Medicine, alongside collaborators from Creighton University. These findings, publish...
Scripps scientists develop new tests that identify lethal prion strains quickly and accurately
One of the new in vitro tests, called the Standard Scrapie Cell Assay, measures prion
infectivity levels in a highly accurate and extremely rapid way, producing results in less than two weeks. The second test, called the Cell Panel Assay, allows researchers to quickly distinguish between several p...
Lymph nodes can be key in spreading prion infectivity
Lymph nodes can be crucial for spreading low doses of infective prion
agents -the pathogens responsible for conditions such as scrapie and Creutzfeldt-Jakob disease - into the nervous system, according to new research published in the online open access journal BMC Veterinary Research. While we ca...
NIH awards researcher $1.5 million 'new innovator' grant for fruit-fly studies of prion proteins
GALVESTON, Texas -- The National Institutes of Health has selected University of Texas Medical Branch at Galveston (UTMB) Assistant Professor of Neurology Pedro Fernandez-Funez to receive a five-year, $1.5 million NIH Directors New Innovator Award.
NIH Director Dr. Elias Zerhouni will officiall...
Redefining what it means to be a prion
CAMBRIDGE, Mass. (April 2, 2009) Whitehead Institute researchers have quintupled the number of identifiable prion
proteins in yeast and have further clarified the role prions play in the inheritance of both beneficial and detrimental traits.
"The big debate in the field is are the prions funct...
Common soil mineral degrades the nearly indestructible prion
MADISON In the rogues' gallery of microscopic infectious agents, the prion
is the toughest hombre in town.
Warped pathogens that lack both DNA and RNA, prions are believed to cause such fatal brain ailments as chronic wasting disease (CWD) in deer and moose, mad cow disease in cattle, scrapie in...
Vaccine prevents prion disease in mice
An oral vaccine can prevent mice from developing a brain disease similar to mad cow disease, according to research that will be presented at the American Academy of Neurology's 59th Annual Meeting in Boston, April 28 ?May 5, 2007. Prion
diseases, which include scrapie, mad cow disease, and chronic ...
Scripps research study reveals structural dynamics of single prion molecules
The new findings, which are being published the week of February 12 in an online edition of the Proceedings of the National Academy of Sciences, offer significant insights into normal folding mechanisms as well as those that lead to abnormal amyloid fibril conversion. The new insights may lead to t...
Brown team finds crucial protein role in deadly prion spread
A single protein plays a major role in deadly prion
diseases by smashing up clusters of these infectious proteins, creating the "seeds" that allow fatal brain illnesses to quickly spread, new Brown University research shows.
The findings are exciting, researchers say, because they might reveal a ...
New evidence questions the simple link between prion proteins and madcow disease
While newly published research confirms that under laboratory circumstances prion-protein can be absorbed across the gut, it also shows that this is unlikely to occur in real life. In addition, the results show that the places in the gut that do take up these disease-associated proteins are differe...
Prion in Biological Technology
ProMetic Further Confirms Performance of Prion Capture Resin at the Recovery of Biological Products Conference
MONTREAL, June 25 /PRNewswire-FirstCall/ - ProMetic Life Sciences Inc.
(TSX:PLI) ("ProMetic") announced today that it has further confirmed the
efficacy of the prion
capture resins developed by Pathogen Removal and
Diagnostic Technologies Inc. ("PRDT")' in the removal of prions from
ProMetic announces Octapharma publication of PRDT'S prion removal resin in Octaplas(R) manufacturing process at 30th International Congress of the International Society for Blood Transfusion meeting in Macao SAR, China
- First publication on utility of PRDT's prion
reduction technology to
further reduce risk of variant Creutzfeldt-Jakob Disease ("vCJD") from Octaplas(R)
- Octapharma sponsoring lunchtime Symposium at meeting to discuss prion
removal capacity, technical pe...
ProMetic announces scale-up of prion removal resin in plasma product for biopharmaceutical use
- First phase of development of product to reduce risk of variant Creutzfeldt-Jakob Disease from plasma product completed on schedule - Scale-up phase worth $ 1 M to ProMetic
- Multi-million dollar long-term agreement to supply prion
removal affinity resin following regul...
ProMetic and MacoPharma announce successful completion of P-Capt(R) prion reduction filter clinical studies
- Irish and UK Blood services continue pre-adoption clinical evaluation of filter
- Recent case of vCJD now means that all the population is susceptible to the disease
- Increased concerns over "second wave" of vCJD in individuals wi...
HemoGenix(R), Inc Announces Implementation of ORF Genetics Human Growth Factors and Cytokines in All Human HALO(R) Assay Kits and Contract Research Services
...al research, cellular
therapy, regenerative medicine, cosmetics and biopharma. ORF Genetics products
are free of contaminants for bacterial, viral and prion
pyrogenic; endotoxin-free; and perfectly safe according to FDA guidelines.
Through close collaboration, HemoGenix(R) has tes...
Prometic provides information for its Annual and Special Meeting of Shareholders
... the Meeting's agenda as per the Management Information Circular - Corporate Presentations
- MacoPharma presents update on launch of P-Capt(R) prion
capture filter - Protein Technologies business update - Anemia drugs program update - PBI-1402 and analogues - Corporate strategy to bui...
ProMetic to obtain controlling stake in Pathogen Removal and Diagnostic Technologies Inc.
... commercialization of the P-Capt(R) filter and the prion
resin that was fully licenced to ProMeti...on reduction filter, in addition to the use of the prion
affinity resin for biopharmaceutical use, ...positioned to capitalize on the growing market
removal. Corporate control moving from ARC to ProM...
Prometic to present at the American Chemical Society
...e risks from blood-associated TSE
infectivity with prion
Dr. Gurgel's lecture titled "...to
the identification of a specific ligand for the prion
for the transmission of mad co...ase in humans. This ligand is being
used to remove prion
protein from blood products. Dr. Carbonell is the
ProMetic announces signature of definitive license agreement with Kedrion for two hyperimmune products
...first hyperimmune product - Kedrion has in-licensed ProMetic's yield improving technology
- Incorporation of ProMetic's prion
reduction technology in Kedrion's manufacturing process
MONTREAL, Feb. 26 /PRNewswire-FirstCall/ - ProMetic Life Sciences In...
ProMetic provides business update - Over $35 million worth of business secured in January
... - Shipment of prion
capture resin to MacoPharma in Q1 2008;
- MacoPh...P-Capt(R) filters sale in 2008;
- Use of affinity prion
adsorbent for plasma-derived products to generate ...holders," added Mr. Laurin.
- ProMetic to ship prion
capture resin in Q1 2008 for incorporation into ...
Prion in Biological Definition
For the bird called a "prion", see Prion
Prions — short for proteinaceous infectious particle — are infectious self-reproducing protein structures. Though their exact mechanisms of action and reproduction are still unknown, it is now commonly accepted that prions...
...he time, unknown class of organic compounds.
Protein structure prediction
Prion in Biological Dictionary
) is an infectious agent that is composed of protein. To date, all such agents that have been discovered propagate by transmitting a mis-folded protein state; the protein does not itself self-replicate and the process... Transmissible spongiform encephalopathies are a group of prog...
...® Xenopus tropicalis Genome Array contains ... It did not emerge from prion
research per se but rather a Xenopus genomic transcriptome project. ... Like doppels, xenopus prion
has post-signal region, here ... Xenopus tropicalis is a unique resou...
...rnary Structure . Complex ... Quaternary Structure ... Quaternary structure and amyloid. X-ray Diffraction of Scrapie Prion. Interactive prion
models ... Certainly, the quaternary structure has a modulating ... TUTORIAL ON PEPTIDE AND PROTEIN STRUCTURE . IV. QUATERNARY STRUCTURE ...
... or SNPs. A point mutation or SNP (Single Nucleotide Polymorphism), involves the ... Nonetheless, this type of mutation does occur and is ... prion
gallery: 3D blow-ups of point mutation environments. ... The combinatorics of 42 point mutations , 6 deletions, and 28 insertions give ... ...
... Answer the following multiple choice questions: 1. A single-celled microorganism ... A. photoautotroph . B. chemoautotroph. C. photoheterotroph. D. prion
... Genetic Manipulation of Carotenoid Biosynthesis in the Green Sulfur Bacterium ... bacterium Chlorobium tepidum is a strict anaerobe and an o...
...treat diabetic foot ulcers and venous leg ulcers... Organogenesis . Oxidative Medicine & Cellular Longevity. Plant Signaling & Behavior. prion
... Click here to begin receiving Organogenesis Table of Contents via email. ... The field of Organogenesis unites research in the clinical, ba...
...haper... Yeast chaperone protein and mad cow disease. Article highlights or off-site fulltexts 1, 2 ... Chaperone -supervised conversion of prion
protein to its protease ... The first protein to be called a chaperone assists the assembly of nucleosomes ... 2 Human chaperone proteins...
...n in ... Yeast chaperone protein and mad cow disease. Article highlights or off-site fulltexts 1, 2 ... Chaperone -supervised conversion of prion
protein to its protease ... Chaperone Proteins , a Brief Overview. Manipulating HSP Levels— Chaperone Proteins as ... Chaperone protein...