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Presenilin in Medical News

American Health Assistance Foundation & Asbury Methodist Village to Host Special Community Screening and Discussion of the HBO Series, The Alzheimer's Project

...breaking, involving research into the relationship between a protein called presenilin and the brain's way of regulating calcium concentrations. Dr. Foskett has shown that presenilin disrupts the regulated calcium in cells causing a cascade of events includi...

American Health Assistance Foundation & Asbury Methodist Village to Host Special Community Screenings and Discussion of HBO Series The Alzheimer's Project

...breaking, involving research into the relationship between a protein called presenilin and the brain's way of regulating calcium concentrations. Dr. Foskett has shown that presenilin disrupts the regulated calcium in cells causing a cascade of events includi...

Novel role of protein in generating amyloid-beta peptide

...toxic protein Aβ is derived when the amyloid precursor protein (APP) is "cut" by two enzymes, β-secretase (or BACE) and γ-secretase (or presenilin complex.) However, inhibiting these enzymes in order to stop the amyloid cascade has many negative side effects, as these enzymes also have various b...

Study Recruiting From Alzheimer's-Prone Families

... images. "While three mutated genes -- amyloid precursor protein (APP), presenilin 1 and presenilin 2 -- are known causes of inherited early-onset Alzheimer's, DIAN researcher...

Bart De Strooper receives prestigious $200,000 Alzheimer Prize

...g pioneering research on Alzheimers disease. He has discovered important mechanisms that lead to this disorder and has uncovered the central role that presenilin plays in the onset of the disease. This finding was the impetus for the global search for remedies. Since then, Bart De Strooper and his research team...

Effectiveness of mouse breeds that mimic Alzheimer's disease symptoms questioned

...eta peptides. Mouse breeds that carry both APP and presenilin mutations develop symptoms earlier and the disease...ore reliable than the ones that carry both APP and presenilin mutations, because they cause less aggressive symp...s also propose creating a mouse breed in which the presenilin mutation does not affect both members of the pair ...
Presenilin in Biological News

New insight into Alzheimer's disease pathology

...s hope that by studying the function of the protein, they will glean insights into the pathology of the more common non-inherited form of the disease. presenilin is known to form part of an enzyme complex called gamma secretase, which sits in nerve cell membranes and chops up other proteins. Inoue et al have fo...

Moss protein plays role in Alzheimer's disease

...ch Kopan toward that goal. Heres how. The gene presenilin in mammals provides the catalytic activity for an ...se. Another common site for mutations is found in presenilin (PS) proteins. The enzyme gamma secretase contain... PS. However, Notch is absent in plant cells, and presenilin function in plants remained mysterious until Quatr...

WUSTL researchers spearhead key genome initiative

... of Raphael Kopan, Ph.D., in the Department of Molecular Biology and Pharmacology, recently published a paper on the function of a gene in moss called presenilin that is very similar to a gene in humans that has been implicated in Alzheimer's disease. Quatrano's interest in the moss genome focuses on genes t...

Novel pathway regulates timing of brain cell development

...strocyte formation," explains S. Pablo Sardi, PhD, a postdoctoral fellow at Children's and the study's first author. Previous studies have found presenilin activity to be altered in Alzheimer's disease, and that erbB4 is abundant around the plaques found in Alzheimer's patients' brains. Taken together, th...

Scientists identify protein with a crucial role in cell death

...t to interact with Presenilin, one of the major players in Alzheimer's disease. Previous research had already indicated that the link between PARL and presenilin is negligible. It was understood that PARL is important to the cell's mitochondria, but the protein's particular function has remained unknown for a l...
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