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Pooled in Medical News

Data from Pooled Analyses Demonstrates Welchol, Combined with Metformin- or Sulfonylurea-Based Therapy, Significantly Lowers Blood Glucose in Adults with Type 2 Diabetes

First and Only Therapy Approved to Treat Both Type 2 Diabetes and High LDL- Cholesterol Welchol Recently Added to ACE/AACE Road Maps PARSIPPANY, N.J., May 16 /PRNewswire/ -- Daiichi Sankyo, Inc. (DSI) announced today that data from two pooled analyses fu...

Errors in diagnosis of depression lead to over and under diagnosis in primary care

...ncet , written by Dr Alex Mitchell of University of Leicester together with Dr Amol Vaze, and Dr Sanajay Rao of Leicester Partnership Trust. The study pooled 41 trials from nine countries that used robust outcome standard of a semi-structured interview to assess depression. The researchers found that GPs w...

Gene linked to increasingly common type of blood cancer

...ndividuals who were HIV negative. Dr. Brown said future studies could include HIV-positive individuals, if enough samples were made available. This pooled genome-wide association study used by the UC Berkeley-TGen investigators allowed them to screen more than 500,000 SNPs. The nearly 90 most significant...

96-Week Safety and Efficacy Findings Presented for INTELENCE(TM) (etravirine) As Part of HIV Combination Therapy

...R, N.J., July 20 /PRNewswire/ -- Ninety-six week pooled results from two Phase 3 studies (DUET-1 and DUET-... 2009) in Cape Town, South Africa. In the pooled analysis of the DUET studies at 96 weeks, 57 perce...T-1 and -2: 96-Week Efficacy Data The 96-week pooled analysis of the DUET studies showed the following ...

Analysis of Four Large Post-Marketing Surveillance Studies Describe Clinical Effects of Sucrose-Formulated Recombinant Factor VIII

... BOSTON, July 13 /PRNewswire/ -- New data pooled from four large, "real world" post-marketing surve...or formation was observed in this analysis of data pooled from post-marketing surveillance studies. Inhibito...t factor VIII in patients with hemophilia A. pooled results from four open-label, post-marketing studi...

URAC and CARF International Announce New Survey Tool for Health Care Case Management Studies

... from key stakeholders and assist organizations in improving organizational well-being and performance improvement. It is a national and international pooled data system, featuring questionnaires with a core set of universal items for benchmark comparisons, an optional set of standardized items, and the abi...

New research identifies more effective tools for detection of colorectal cancer

...d international gastroenterology meetings from 2005 to 2007. Seventeen studies, consisting of 274,265 colonoscopies, met the inclusion criteria. pooled perforation rate in therapeutic colonoscopies was found to be 0.066 percent or approximately 1 in 1500 and in diagnostic colonoscopies was found to be...

PRA International Opens Additional Drug Safety Center in Sao Paulo, Brazil

...,000 Expedited Safety Reports to regulatory authorities 250 Cumulative Safety Reports to regulatory authorities 5 data integration and pooled analysis projects Hosted 21 client pharmacovigilance audits Contributed to 3 FDA Approvals About PRA Internation...

Perforomist Inhalation Solution data to be presented today at American Thoracic Society conference

...pleased that patients can benefit from our treatments." Studies Find Improvements in Pulmonary Function, Dyspnea, and Rescue Medication Use A pooled analysis of two similar studies evaluated the efficacy and safety of adding Perforomist Inhalation Solution to maintenance tiotropium in patients with...

Perforomist(R) Inhalation Solution Data in Patients With Moderate to Severe COPD to Be Presented at the International Conference of the American Thoracic Society

...pleased that patients can benefit from our treatments." Studies Find Improvements in Pulmonary Function, Dyspnea, and Rescue Medication Use A pooled analysis of two similar studies evaluated the efficacy and safety of adding Perforomist Inhalation Solution to maintenance tiotropium in patients with...
Pooled in Medical Technology

NicOx' Naproxcinod Shows Robust Blood Pressure Results in Phase 3 Pooled Analysis

SOPHIA ANTIPOLIS, France, December 17 /PRNewswire-FirstCall/ -- NicOx S.A. (NYSE Euronext Paris: COX) today announced positive results of a pre-specified pooled analysis of 2,734 patients with osteoarthritis (OA) from the 301, 302 and 303 pivotal phase 3 studies for naproxcinod. Both doses of ...

TAXUS(R) Stent Demonstrates Similar Outcomes in Diabetic Patients Compared to Non-diabetics in Pooled Analysis of TAXUS IV and V Trials

NATICK, Mass. and CHICAGO, April 1, 2008 /PRNewswire-FirstCall/ -- Boston Scientific Corporation (NYSE: BSX ) today announced results from a pooled analysis of patients from its TAXUS IV and TAXUS V randomized clinical trials. The analysis compared the safety and efficacy of the TAXUS(R) Expr...

Schering-Plough Expands Vicriviroc Phase II Study in Treatment-Naive Patients With HIV

...roc clinical studies, please visit www.clinicaltrials.gov , search term: vicriviroc. Key Safety Findings with Vicriviroc A pooled data analysis was conducted for two vicriviroc Phase II studies involving 205 treatment-experienced HIV-infected patients who continued on vicriviroc ...

New Data Supports Significant Economic and Clinical Value of MENOPUR(R) in IVF

...les involving frozen embryo transfers using a simulation model. The economic evaluation compared HP-hMG and rFSH using individual patient data (n=986) pooled from two large, randomised, multi- national, non-inferiority trials (EISG[3] and MERiT[4])[5]. The simulation model used both live-birth data f...

Data Demonstrates Long-Term Reduction In Seizure Frequency With Novel Once Daily Anti-Epileptic Zebinix(R)

...rtial-onset seizures, with or without secondary generalisation(3,4). pooled data from more than 1,000 patients enrolled in the three pivotal phase III ...rated a favourable safety profile(5). This has been further reinforced by a pooled analysis indicating that most adverse events begin within the first weeks o...

Meta-Analysis of Clinical Data Showed No Increased Risk of Cardiovascular Events Associated With Exenatide Use: Data Presented at ADA 2009

... BYETTA(R) (exenatide) injection use compared to a pooled comparator group treated with either placebo or in...tegrated analysis, 2,316 BYETTA subjects and 1,629 pooled comparator subjects were treated for a total of 1,...ent was 2.0 percent for BYETTA and 2.6 percent for pooled comparator; the relative risk between BYETTA and...

Merz Pharmaceuticals Announces Results of Clinical Trials with NT-201(Botulinum neurotoxin type A free from complexing proteins) at Annual Movement Disorders Society Meeting

...ee from complexing proteins) authored by R. Benecke, S. Grafe, I. Sassin, and G. Comes. Method Efficacy in focal dystonia was analyzed on the pooled data from 2 pivotal clinical trials in blepharospasm and cervical dystonia (343 NT 201 patients; 340 BTXCo* patients) and 1 post-stroke spasticity tri...

Results of Two Phase 3 CAPACITY Studies of Pirfenidone in IPF Presented at American Thoracic Society (ATS)

...was not met (p=0.501). An exploratory analysis of pooled primary endpoint data from both studies using the ...a worse outcome on any endpoints. Analyses of pooled data for the pre-specified secondary endpoints of ...Six-Minute Walk Test distance (p=0.001). Although pooled analyses of secondary endpoints were pre-specified...

Video: Partnership Unites UCB with Consumer Product Innovator OXO(R)

...ignancies including lymphoma. The most commonly occurring adverse events were upper respiratory tract infections, rash and urinary tract infections. A pooled analysis of the safety data show there was a low incidence of injection site pain (<2%) and a low level of discontinuations due to adverse events (...

RAPAFLO(TM) (silodosin) Provides Rapid and Sustained Benign Prostatic Hyperplasia (BPH) Symptom Relief in as Little as Three Days

... generic and specialty branded pharmaceuticals. In an analysis of data pooled from two Phase 3 studies, patients taking RAPAFLO(TM) demonstrated statisti...rination and nocturia. Clinical Trial Results The new paper is a pooled analysis of two, 12-week, randomized, placebo-controlled, double-blind mult...
Pooled in Medical Products

Luteinizing Hormone, Pooled

Description: ARUP Laboratories is a national reference laboratory and a worldwide leader in innovative laboratory research and development. ARUP offers an extensive test menu of highly complex and unique medical tests in clinical and anatomic pathology. Owned by the University of Utah, ARUP Laboratories' client...
Company:ARUP Laboratories

Liquichek Seroconversion Panels

Features:... Drawn from a unique donor over various periods of time Panels are native, naturally occurring, undiluted single donor plasma Panels are neither pooled patient samples nor prepared from viral inactivated cell lines Sufficient numbers of vials in each kit to detect a slow rise in titer Panels are...
Company:Bio-Rad Laboratories

Liquichek Antigen Panels

Features:... Panels are native, naturally occurring, undiluted donor samples Panels are neither pooled patient samples nor prepared from viral inactivated cell lines Panels are at clinically significant levels appropriate for assay evaluation comparis...
Company:Bio-Rad Laboratories
Pooled in Medical Dictionary

Lead levels

...tly Accepted Levels , American Public Health ... Low- Level Environmental Lead Exposure and Children's Intellectual Function: An International pooled Analysis, Location: Main Section of EHP Online Lead Levels - Blood (Blood Lead Levels ) information center covers description, preparation,...

Hemorrhagic stroke

... This is a hemorrhagic stroke . ... Hemorrhagic stroke . Arteriovenous ... For hemorrhagic stroke , surgery is often required to remove pooled blood from ... Hemorrhagic stroke involves bleeding within the brain, which damages nearby brain tissue. ... Most often, hemorrhagic st...

Fecal culture

...includes culturing for Salmonella, ... paratuberculosis was detected by pooled fecal culture on 93% of 27 infected ... pooled fecal culture was compared with serologic examination for submissions ....
Pooled in Biological News

Humans related to orangutans, not chimps, says new Pitt, Buffalo Museum of Science study

...ilarities, Schwartz and Grehan write. Chimpanzees and gorillas were found to share only those features found in all great apes. Schwartz and Grehan pooled humans, orangutans, and the fossil apes into a new group called "dental hominoids," named for their similarly thick-enameled teeth. They labeled chimp...

Technology guide: Principles -- applications -- trends

...sciplines. New possibilities often emerge at the interfaces between specialist disciplines and fields of expertise, particularly wherever knowledge is pooled in an unusual way." The discourse on technology and how to handle it creatively concerns us all, for the technical options available largely determ...

Results of national nursery survey unveiled

...st given the recent emphasis on producing plants in an environmentally sustainable manner. Eight geographic regions were identified for analysis of pooled data, including: Appalachia, Great Plains, Midwest, Mountain, Northeast, Pacific, South Central, and Southeast. The regions represented agroclimatic z...

Largest study of its kind implicates gene abnormalities in bipolar disorder

... searching for the genomic hot spots in bipolar disorder, these researchers pooled their data for maximal statistical power and unearthed surprising results,"...gnals of illness association. To boost their odds, Sklar and colleagues pooled data from the latter two previously published and one new study of their ow...

American Chemical Society's Weekly PressPac -- July 9, 2008

...e two regions. They also found distinct differences in proteins collected from newborns and adult snakes. The study "highlights the necessity of using pooled venoms as a statistically representative venom for antivenom production" for human snakebite victims, the report states. MTS ARTICLE #4 FOR IMMEDI...

Great Ape Trust's Wich lead author of Oryx paper on continuing orangutan population declines

...ponsible for environmental stewardship cannot hide indecisively behind purported scientific uncertainty. "Second, those answers are the results of pooled knowledge of nearly two dozen high-profile investigators who set aside their own professional reputations and agendas to collect data in a standardize...

AMNH scientists grace Science & Nature covers

...encourage other tropical countries to try similar approaches that pool data to develop more effective conservation solutions. Wheeler and colleagues pooled data of a different sortsamples from a diverse array of animalsto look at evolutionary relationships from sponges to humans. Genetic sampling allows r...

Paving the way for green roads

...nable materials and socially sensitive designs that protect air, water, land, and human resources. Funded by the Federal Highway Administration and pooled state highway funds, as well as Environmental Protection Agency (EPA) grants for specific research projects, Gardner established the new Recycled Mate...

Genetic roots of bipolar disorder revealed by first genome-wide study of illness

... scan the entire group at a small fraction of the cost of scanning each person's material individually. The genetic material of the healthy group was pooled and scanned separately, again at a fraction of the cost of individual scans. The researchers then zeroed in on the gene variations that occurred more...

Sleep quantity affects morning testosterone levels in older men

...ted by Plamen Penev, MD, PhD, of the University of Chicago, focused on 12 healthy men between the ages of 64 and 74. Three morning blood samples were pooled for the measurement of total and free testosterone. In addition to overnight laboratory polysomnography, wrist activity monitoring for six-to-nine da...
Pooled in Biological Technology

Sigma-Aldrich Introduces MISSION(R) esiRNA for Low Cost, High Specificity Pooled RNAi Screening

ST. LOUIS, April 28 /PRNewswire-FirstCall/ -- Sigma-Aldrich (Nasdaq: SIAL ) today announced the global release of MISSION(R) esiRNA, a pool of gene-specific siRNA that provides a novel and powerful approach to RNAi screening in mammalian cells. Unlike traditional synthetic RNAi, esiRNA ( htt...

Sigma-Aldrich Introduces MISSION(R) LentiPlex(TM) Pooled shRNA Libraries to Enable Rapid Whole Genome Screening in Primary Cells, Stem Cells or Tumor Cells

ST. LOUIS, March 3 /PRNewswire-FirstCall/ -- Sigma-Aldrich (Nasdaq: SIAL ) today announced the global release of the MISSION(R) LentiPlex(TM) Pooled Human and Murine shRNA Libraries ( http://www.sigma-aldrich.com/lentiplex ). Using the shRNA collections of The RNAi Consortium (TRC), the ...

SAPHRIS(R) (asenapine) Meets Primary Endpoint in Long-Term Extension Study in Patients With Predominant, Persistent Negative Symptoms of Schizophrenia

...symptoms after one year of treatment, but the difference between the two was not statistically significant.(1) Additionally, a preliminary pooled analysis of the combined data for these two identically designed studies showed a statistically significant treatment effect in favor of asenapine aft...

REMERON(R) Now Approved in Japan for the Treatment of Depression in Adult Patients

...essants may have a role in inducing worsening of depression and the emergence of suicidality in certain patients during the early phases of treatment. pooled analyses of short-term placebo-controlled trials of antidepressant drugs (SSRIs and others) showed that these drugs increase the risk of suicidal thin...

Clinical Pharmacology Study With AZILECT(R) (Rasagiline Tablets) Demonstrated It Does Not Increase Tyramine Sensitivity

...t geometric mean TSF of 17.32 +/- 12.76. Geometric mean TSF for rasagiline 1 mg once daily, the maximum approved dose, was 2.03 compared with 1.50 for pooled placebo and 2.47 for selegiline. About AZILECT(R) AZILECT(R) (rasagiline tablets) is indicated for the treatment of the signs and symptoms...

Polycystic Kidney Disease Assay at Cornell University Uses Transgenomic's Surveyor Nuclease & WAVE Technology

...utations. It identifies all base substitutions, insertions and deletions and can detect multiple mutations in a single fragment, in individual or even pooled PCR samples. By pre-screening with Surveyor Nuclease, the complexity, cost and time for analysis is significantly reduced. Additionally, information i...

MannKind Submits NDA for AFRESA for Treatment of Diabetes

... program included over 5,300 patients. More than 2,450 subjects with type 1 or type 2 diabetes were randomly assigned to treatment with AFRESA in the pooled controlled Phase 2/3 clinical studies. In addition, the clinical pharmacology program included more than 450 subjects exposed to AFRESA in single-dos...

Financial Results for Full Year 2008: NicOx in a Unique Position to Deliver Significant Shareholder Value

...prospectively designed statistical analysis of the pooled Office Blood Pressure Measurement (OBPM) dat...eline and at weeks 2, 6 and 13. This OBPM data was pooled and analyzed according to a prospectively designed... over weeks 2, 6 and 13. Further analyses on these pooled data are ongoing and NicOx plans to disclose more ...

InterMune Reports Results of Two Phase 3 CAPACITY Studies of Pirfenidone in IPF

...as not met (p= 0.501). An exploratory analysis of pooled primary endpoint data from both studies using the ...th a worse outcome on any endpoints. Although pooled analyses of secondary endpoints were pre-specified...endpoint of both studies was not met. Analyses of pooled data for the pre-specified secondary endpoints of ...

Oncology Biomarker KRAS to be Discussed at FDA Panel Meeting

...n of KRAS status seen in the "408" trial, additional retrospective analyses of all other studies of Vectibix monotherapy in mCRC were performed. A pooled analysis, presented at the European Society of Medical Oncology in 2008 from over 700 patients (including subjects randomized to Vectibix in "408") wi...
Pooled in Biological Products

Normal Pooled Human Serum from Innovative Research

Description: Normal Pooled Human Serum • Human serum is obtained from normal human donors who are found to be negative by a test for Human Immunodeficiency Virus Antigen (s) (HIV-1Ag), Antibodies to Human Immunodeficiency Virus (Anti-HIV 1/2), Hepatitis C Virus (HCV), and Nonreactive for Hepatitis B Surfac...
Company:Innovative Research

Rat Complement from Pel-Freez Biologicals

Description:...ley, averaging 7-8 weeks of age, either sex) is collected at the time of slaughter and processed within 45 minutes. It is then filtered through gauze, pooled in an ice bath, bottled, and frozen at -70C....
Company:Pel-Freez Biologicals

Anti-Rheumatoid Factor Monoclonal Antibody, Unconjugated from QED Bioscience Inc.

Description:...-rheumatoid factor paraproteins from unrelated individuals. It does not cross-react with IgM, IgA, or IgG proteins lacking rheumatoid factor nor with pooled F(Ab)2 fragments. This antibody can be used in ELISA to detect rheumatoid factor. Product Category: Hormone and Serum Protein Antibodies...
Company:QED Bioscience Inc.

Mouse Complement from Pel-Freez Biologicals

Description:...d is collected from mice (Swiss Webster, 8-10 weeks old,either sex) and processed within 45 minutes of collection. The complement is then filtered and pooled on ice, bottled and stored at -70C....
Company:Pel-Freez Biologicals

Rapid-Screen Arrayed cDNA Library Panels Master Plates -Human Kidney from OriGene Technologies

Description:... the Master Plate (a process which may lose specific clones). Instead, the Sub-Plates were generated first and the wells from each Sub-Plate were then pooled to generate the Master Plate. To guarantee that clones from different wells in the Master Plate were each independently-derived, the Sub-Plates were g...
Company:OriGene Technologies

Rapid-Screen Arrayed cDNA Library Panels Master Plates -Human Peripheral blood leukocyte from OriGene Technologies

Description:... the Master Plate (a process which may lose specific clones). Instead, the Sub-Plates were generated first and the wells from each Sub-Plate were then pooled to generate the Master Plate. To guarantee that clones from different wells in the Master Plate were each independently-derived, the Sub-Plates were g...
Company:OriGene Technologies

Rapid-Screen Arrayed cDNA Library Panels Master Plates -Human Spleen from OriGene Technologies

Description:... the Master Plate (a process which may lose specific clones). Instead, the Sub-Plates were generated first and the wells from each Sub-Plate were then pooled to generate the Master Plate. To guarantee that clones from different wells in the Master Plate were each independently-derived, the Sub-Plates were g...
Company:OriGene Technologies

Rapid-Screen Arrayed cDNA Library Panels Master Plates -Human Colon from OriGene Technologies

Description:... the Master Plate (a process which may lose specific clones). Instead, the Sub-Plates were generated first and the wells from each Sub-Plate were then pooled to generate the Master Plate. To guarantee that clones from different wells in the Master Plate were each independently-derived, the Sub-Plates were g...
Company:OriGene Technologies

Rapid-Screen Arrayed cDNA Library Panels Master Plates -Human Lung from OriGene Technologies

Description:... the Master Plate (a process which may lose specific clones). Instead, the Sub-Plates were generated first and the wells from each Sub-Plate were then pooled to generate the Master Plate. To guarantee that clones from different wells in the Master Plate were each independently-derived, the Sub-Plates were g...
Company:OriGene Technologies

Rapid-Screen Arrayed cDNA Library Panels Master Plates -Human Brain (fetal) from OriGene Technologies

Description:... the Master Plate (a process which may lose specific clones). Instead, the Sub-Plates were generated first and the wells from each Sub-Plate were then pooled to generate the Master Plate. To guarantee that clones from different wells in the Master Plate were each independently-derived, the Sub-Plates were g...
Company:OriGene Technologies
Pooled in Biological Dictionary

Hepatocytes

...CYTES . INHIBITORY AGAINST ... Founded by Andrew Parkinson, XenoTech is the leading provider of quality in vitro drug metabolism ... CryoXTreme pooled Cryopreserved Human Hepatocytes ... Environmental Health Issues, food carcinogen, PhIP, 2-amino-1-methyl-6-phenylimida zo pyridine, hepatocytes ...

Genomic DNA

...ies and genomic libraries . DNA ... resequencing a large region of genomic DNA , usually of >100 kilobases (kb), from ... Genomic DNA , pooled isolates from individual patients or tissue samples ... AxyPrep™ Bacterial Genomic DNA Miniprep Kit ... AxyPrep™ Blood Genomic DNA Midipr...

Allele frequency

... ... Download format for Arlequin: Allele frequency tables available in Arlequin ... To measure a SNP allele frequency in a mixture of DNAs pooled from individual ... When the allele frequency is 50%, one expects that each of the two PCR ... We find that allele frequency restriction ...
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(Date:7/10/2014)... Emergency Medical Service (EMS) responders felt better prepared to ... tactical training according to a new study in the ... the first study to specifically examine the EMS provider ... a shooter has not yet been neutralized or working ... such as the Columbine High School shooting, the Virginia ...
(Date:7/10/2014)... beverages consumed, even for light-to-moderate drinkers, may improve ... heart disease, lower body mass index (BMI) and ... published in The BMJ and co-led ... University of Pennsylvania. The latest findings call into ... amounts of alcohol (0.6-0.8 fluid ounces/day) may have ...
(Date:7/10/2014)... The U.S. Department of Health and Human Services ... (UH) Case Medical Center Seidman Cancer Center totaling $4.7 ... improving care for patients with complex cancer. , ... unique model developed at UH to enhance care for ... demonstrated need for high health care utilization. ...
(Date:7/10/2014)... benefits of medical imaging far outweigh the risks when ... with The Right Radiation Dose. However, overuse and misuse ... is leading a collaborative effort to ensure a national ... in the Journal of Patient Safety , calls ... the Intersociety Accreditation Commission, and the Centers for Medicare ...
(Date:7/10/2014)... A research review identifying the clinical indicators most strongly ... the process of developing evidence-based guidelines for concussion diagnosis, ... by Neurosurgery , official journal of ... journal is published by Lippincott Williams & Wilkins ... . , Based on analysis of the best ...
Breaking Medicine News(10 mins):Health News:Active shooter training increases comfort level of emergency responders 2Health News:New study shows drinking alcohol provides no heart health benefit 2Health News:UH Case Medical Center awarded $4.7 million grant from HHS 2Health News:UH Case Medical Center awarded $4.7 million grant from HHS 3Health News:Mayo Clinic calls for standardization of safe imaging protocols for children 2Health News:What's a concussion? Review identifies four evidence-based indicators 2Health News:What's a concussion? Review identifies four evidence-based indicators 3
(Date:7/10/2014)... 10 July 2014 Amyloid diseases, such as ... spongiform encephalopathies, all share the common trait that ... plaques. Yet in vitro studies have found that ... themselves are very toxic. New evidence using two-dimensional ... structure during the amylin aggregation pathway that may ...
(Date:7/10/2014)... 10,2014 For children and teens living with a ... contribute to decreased quality of life, reports a study ... Behavioral Pediatrics , the official journal of the ... The journal is published by Lippincott Williams & ... . , "Self-competence may function as a protective factor ...
(Date:7/10/2014)... natural-color satellite image was collected by the Moderate Resolution ... 10, 2014. Each hot spot, which appears as a ... on the MODIS instrument recognized temperatures higher than background. ... image, such hot spots are diagnostic for fire. ... little danger coming directly from the fires, although the ...
Breaking Biology News(10 mins):New technology reveals insights into mechanisms underlying amyloid diseases 2For children with pacemakers, 'self-competence' affects quality of life 2
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