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Polypeptide in Medical News

New Study Data: JANUVIA™ (sitagliptin) Significantly Reduced Blood Sugar Levels and Was Not Associated with Hypoglycemia in Elderly Patients with Type 2 Diabetes

...reasing and prolonging the action of these hormones. Incretin hormones, including glucagon-like peptide-1 (GLP-1) and glucose-dependent insulinotropic polypeptide (GIP), are released by the intestine throughout the day, and levels are increased in response to a meal. These hormones are rapidly inactivated by the...

Eliminate Varicose Veins with Invisible Veins, a Product of Pharmaco LLC

...a manufacturer and sales organization of the natural, efficacious and unique Anti-Aging Immupure ® Skin Perfecting System. Our proprietary natural polypeptide and growth factor complex provides unmatched results in wrinkle reduction and skin improvements. Clinical results are available on our web site. Ph...

Targeted Anticancer Drugs - In Vitro Assessment and Non-Invasive Imaging of Patient and Tumor Status Will Determine Clinical and Commercial Success

...-activated protein kinase (p38 MAPK); p53; P-glycoprotein (P-gp); phosphatidylinositol 3`kinase (PI3K); phosphatidyserine (PS); PI3K, catalytic, delta polypeptide (PI3KCD); PIK3C2A; plasminogen activator, urokinase (PLAU); polo-like kinase 1 (Plk1); poly (ADP- ribose) polymerase (PARP); programmed cell death-1 (...

Study raises questions about prostate cancer therapies targeting IGF-1

...tumor suppressor gene p53 is already compromised, according to new research by investigators at Fred Hutchinson Cancer Research Center. IGF-1 is a polypeptide hormone that can influence growth, differentiation and survival of cells expressing the type 1 receptor (IGF-1R). Past clinical, epidemiological and e...

Trubion Pharmaceuticals Announces Dates for Fourth-Quarter and Year-End 2007 Earnings Conference Call

...safety, efficacy, and convenience that it believes may offer improved patient experiences. Trubion's current product candidates are novel single-chain polypeptide protein, or SMIP(TM), therapeutics, and are designed using its custom drug assembly technology. Trubion's lead product candidate, TRU-015, has complet...

Trubion Announces Presentations at Upcoming Investor Conferences

...safety, efficacy, and convenience that it believes may offer improved patient experiences. Trubion's current product candidates are novel single-chain polypeptide protein, or SMIPtm, therapeutics, and are designed using its custom drug assembly technology. Trubion's lead product candidate, TRU-015, has completed...
Polypeptide in Medical Technology

Oramed Pharmaceuticals Launches GLP1-Analog Program, Based on its Proprietary Drug Delivery Platform

...ks the next strategic milestone for our company as we demonstrate the effectiveness of our oral delivery technology in yet another important family of polypeptide drugs for diabetes, that are until now only available in injection form," said Oramed CEO Nadav Kidron. We plan to conduct the ORMD 0901 trials at H...

Arisaph Pharmaceuticals Announces Results of its Potent Smart DPP-4 Inhibitor, ARI-2243, at the ADA

...-4: DPP-4 or dipeptidylpeptidase type 4 is a naturally occurring, proteolytic enzyme that rapidly degrades the incretin hormones, gastric inhibitory polypeptide (GIP) and glucagon-like protein (GLP-1). GLP-1 has a favorable anti-diabetic role because it stimulates glucose dependent insulin secretion from the p...

Late Breaking Data Released at ADA Showed that the Investigational Use of Januvia and Metformin as Initial Combination Therapy Provided Significant Glucose Lowering Efficacy over 54 Weeks in Patients with Type 2 Diabetes

...asing and prolonging the action of these hormones. Incretin hormones, including glucagon-like peptide-1 (GLP-1) and glucose-dependent insulinotropic polypeptide (GIP), are released by the intestine throughout the day, and levels are increased in response to a meal. These hormones are rapidly inactivated by t...

An Investigational Study Released at ADA Showed that Initial Combination Therapy with Januvia (sitagliptin) and Metformin Led to Improvement in Markers of Beta Cell Function in Patients with Type 2 Diabetes

...asing and prolonging the action of these hormones. Incretin hormones, including glucagon-like peptide-1 (GLP-1) and glucose-dependent insulinotropic polypeptide (GIP), are released by the intestine throughout the day, and levels are increased in response to a meal. These hormones are rapidly inactivated by t...
Polypeptide in Medical Products

Pancreatic Polypeptide

Description: ARUP Laboratories is a national reference laboratory and a worldwide leader in innovative laboratory research and development. ARUP offers an extensive test menu of highly complex and unique medical tests in clinical and anatomic pathology. Owned by the University of Utah, ARUP Laboratories' client...
Company:ARUP Laboratories

Gastric Inhibitory Polypeptide

Description: ARUP Laboratories is a national reference laboratory and a worldwide leader in innovative laboratory research and development. ARUP offers an extensive test menu of highly complex and unique medical tests in clinical and anatomic pathology. Owned by the University of Utah, ARUP Laboratories' client...
Company:ARUP Laboratories

PYY, Total ELISA Test

Description:...crease in the cumulative 24-hour caloric intake in both obese and lean subjects. The same group of investigators has recently reported that pancreatic polypeptide has similar effects on energy homeostasis. These results are certainly of great interest and warrant further investigation. Tatemoto K & Mutt V Na...
Company:Diagnostic Systems Laboratories, Inc.

Free Activin AB ELISA Test

Description:... Activins are polypeptide hormones which belong to the transforming growth factor- (TGF-) superfamily. The TGF- superfamily is a large group of extra-cellular growth factors wh...
Company:Diagnostic Systems Laboratories, Inc.

Free Activin A ELISA Test

Description:... Activins are polypeptide hormones which belong to the transforming growth factor- (TGF-) superfamily. The TGF- superfamily is a large group of extra-cellular growth factors wh...
Company:Diagnostic Systems Laboratories, Inc.

Free Activin B ELISA Test

Description:... Activins are polypeptide hormones which belong to the transforming growth factor- (TGF-) superfamily. The TGF- superfamily is a large group of extra-cellular growth factors wh...
Company:Diagnostic Systems Laboratories, Inc.
Polypeptide in Medical Definition

Proteopathy

...earance, and can become pathogenic. Because of the common structure of the polypeptide backbone, all proteins have the potential to misfold under some conditions...ary) amyloidosis Amyloid A protein Type II diabetes Islet amyloid polypeptide (IAPP; amylin) Aortic medial amyloidosis Medin (lactadherin) ...
Polypeptide in Medical Dictionary

PTH

... Parathyroid hormone ( PTH ), or parathormone, is secreted by the parathyroid glands as a polypeptide containing 84 amino acids. It acts to increase the concentration of calcium (Ca2+) in the blood, whereas calcitonin of the... Port Huron (Amtr...

Oxytocin

...s a mammalian hormone that also acts as a ... One international unit (IU) of oxytocin is the equivalent of about 2 ... oxytocin n. A short polypeptide hormone, C 43 H 66 N 12 O 12 S 2 , released from the posterior lobe of the pituitary gland, that stimulates the Oxytocin reduces cravings. ....

Monocyte

... Warren Strober, M.D. ... MONOCYTE , GRANULOCYTE, CALPROTECTIN, CLONE: 27E10, MAB ANTI-HUMAN, RHESUS MONKEY ... ENDOTHELIAL- MONOCYTE ACTIVATING polypeptide II (EMAP II), 20KD, CLONE: 546-2, ... Currently, monocyte -derived DCs are the most widely used, because they can be ... Efficiency of monocyte ...

Growth hormone

...e hormone . It stimulates growth and cell reproduction and regeneration in humans and other animals. It is a 191-amino acid, single-chain Protein polypeptide hormone that is... Growth hormone (GH) is a protein hormone secreted by the pituitary gland that stimulates growth and cell reprod...

Glucagon

...ne dictionary ... Glucagon Information. Find Free Reference & Encyclopedia Articles Quickly. ... Glucagon for Injection (rDNA origin) is a polypeptide hormone identical to human ... Glucagon is ... altered by the addition of the gene for glucagon . ... IOH Diabetes: How and when to inject ...

Calcitonin

... Calcitonin is a 32-amino acid linear polypeptide hormone that is produced in humans primarily by the parafollicular cells of the thyroid, and in many other animals in the ultimobranchial body. It a...
Polypeptide in Biological News

Study shows more genes are controlled by biological clocks

... "But perhaps the most important role we've seen so far is the clock's role in ribosome biogenesis." Ribosomes assemble individual amino acids into polypeptide chains by binding a messenger RNA and then using this as a template to connect the correct sequence of amino acids. Ribosome biogenesis is the process...

Seeing Alzheimer's amyloids

...ime but stubbornly refuses elucidation. Researchers using x-ray crystallography have so far been unable to obtain crystals from fibrils of full-length polypeptide chains. Structural models based on NMR data have also come up short. Scientists have made do with studying fragments of the A-beta peptide. The major ...

Human hormone blocker found to help prevent obesity and diabetes: study

...he body is capable of promoting weight loss, improving insulin resistance and reversing diabetes in an animal model. The hormone is gastric inhibitory polypeptide (GIP) receptor blockade. Background GIP is a peptide hormone that is secreted in response to food. It inhibits the secretion of acids stimulat...

Clearance of hepatitis C viral infection after liver transplantation

...e treatment before liver transplantation. PEGylation is a chemical modification incurring higher water-solubility and higher stability to the modified polypeptide medicine. Five weeks after the PEG-IFN treatment, HCV antigen was no longer detectable from the patient serum, but HCV-RNA persisted. Even after the l...

Microbes at work cleaning up the environment

...stern Wisconsin. The team found that organic nitrogen was highly concentrated in all of the zinc-sulfide aggregates, indicating a high protein or polypeptide content relative to inorganic zinc-sulfide minerals. In combination with the other techniques and experiments, the team concluded that the protein cau...

Mechanisms involved with tumor relapse identified

..." said lead investigator, Masoud H. Manjili, D.V.M., Ph.D., a member scientist with the Massey Cancer Center. "Ultimately, we hope to offer a new polypeptide vaccine approach that induces tumor killing without causing HER-2/neu loss. Loss of HER-2/neu is a mechanism that tumors utilize to escape the immune-...
Polypeptide in Biological Technology

Psylin Neurosciences Commences Development of Compound for Depression

...eatment of depression. (Logo: http://www.newscom.com/cgi-bin/prnh/20090420/LA01157LOGO ) PSN0041, a peptide from Amylin's proprietary polypeptide hormone library, PHORMOL, was identified as having utility in depression after screening it in PsychoGenics' proprietary, drug discovery technologies....

Kun Run Biotechnology, Inc. Year-End Revenues Increase 56% to $11.6 million

...y, Inc., together with its subsidiaries, engages in manufacture and sale of polypeptide medicines. It uses solid phase peptide synthesis (SPPS) and advanced purifying technology to produce various therapeutic polypeptide drugs, of which is "TP-5" most known for efficiently regulating humans' imm...

Could Database Software Help Cure Alzheimer's and Save the Earth?

...one of the fundamental unsolved problems in molecular bioengineering: the mechanism by which proteins fold themselves from essentially two-dimensional polypeptide chains into precise, three-dimensional structures. Experts believe that incorrectly folded proteins may be responsible for some of the most menacing d...

New Study Raises Questions About Prostate Cancer Therapies Targeting Insulin-Like Growth Factor Receptor

...r suppressor gene -- p53 -- is already compromised, according to new research by investigators at Fred Hutchinson Cancer Research Center. IGF-1 is a polypeptide hormone that can influence growth, differentiation and survival of cells expressing the type 1 receptor (IGF-1R). Past clinical, epidemiological and e...

Nastech Assigns Intellectual Property Related to the Development of RNA-Based Therapeutics to its Subsidiary, MDRNA, Inc.

...elated to RNA-based therapeutics and diagnostics include the following published patent applications: -- Compositions and Methods for Lipid and polypeptide Based siRNA Intracellular Delivery -- Compositions and Methods for Complexes of Nucleic Acids and Organic Cations -- Cationic Peptides f...

Clinical Data Acquires Epidauros Biotechnologie AG, Significantly Enhancing Proprietary Genetic Biomarker Portfolio

...g Cassette, Subfamily C, Member 1 (4) Cytochrome P450, Subfamily IIB, polypeptide 6 (5) Cytochrome P450, Subfamily IID, polypeptide 6 ...
Polypeptide in Biological Products

Chicken Anti-Polymerase (RNA) II (DNA directed) polypeptide L Antibody, Unconjugated from CHEMICON

Description: Polymerase (RNA) II (DNA directed) polypeptide L...
Company:CHEMICON

Chicken Anti-Human DNA-directed RNA Polymerase II 7.6 Kd Polypeptide (POLR2L) Polyclonal Antibody, Unconjugated from Lifespan Biosciences

Description: Chicken Anti-Human DNA-directed RNA Polymerase II 7.6 Kd Polypeptide (POLR2L Polyclonal AntibodyOther Sub-Family: not assigned-Other Applications: ELISA, Western Blot...
Company:Lifespan Biosciences

Rabbit Anti-Human DDX5 Polyclonal Antibody, Unconjugated from Proteintech Group, Inc.

Description:... DEAD (Asp-Glu-Ala-Asp) box polypeptide 5...
Company:Proteintech Group, Inc.

Rabbit Anti-Human ADH5 Polyclonal Antibody, Unconjugated from Proteintech Group, Inc.

Description:... Homo sapiens alcohol dehydrogenase 5 (class III), chi polypeptide (ADH5), mRNA....
Company:Proteintech Group, Inc.

Puromycin, Dihydrochloride from Calbiochem

Description:...ine, 2HCl White to off-white solid. PROTECT FROM MOISTURE. Protein synthesis inhibitor. Inhibits translation by causing premature release of nascent polypeptide chains. Induces DNA fragmentation in thymocytes and in human HL-60 leukemia cells. Purity: ≥98% by TLC. Soluble in H 2 O. RTECS AU7355000, CAS 58...
Company:Calbiochem

Mouse Anti-Human UGT2B10 Monoclonal Antibody, Unconjugated, Clone 2D9 from Novus Biologicals

Description:... Mouse monoclonal antibody to UGT2B10 - UDP glucuronosyltransferase 2 family, polypeptide B10...
Company:Novus Biologicals
Polypeptide in Biological Definition

Alpha helix

... (n+4). Short polypeptides usually are not able to adopt the alpha helical structure, since the entropic cost associated with the folding of the polypeptide chain is too high. Some amino acids (called helix breakers ) like proline will disrupt the helical structure. Ordinarily, a helix has a buildup ...

Alternative splicing

...for genetics it means that the old idea of one DNA sequence coding for one polypeptide (the "one-gene-one-protein" hypothesis) is no longer correct. External information is needed in order to decide which polypeptide is produced, given a DNA sequence and pre-mRNA. (This does not necessarily ...

Amino acid

...ation of the nitrogen occurs, changing the properties of histidine and the polypeptide as a whole. It is used by many proteins as a regulatory mechanism, changing the conformation and behavior of the polypeptide in acidic regions such as the late endosome or lysosome . I ...

Antibody

...o additional chains. One of these is the J chain (from j oin), which is a polypeptide of molecular mass 1,5 kD, rich with cysteine and structurally completel...secreting cells. The dimeric form of IgA in the outer secretions has also a polypeptide of the same molecular mass (1,5 kD) that is called the secretory chain and ...

Genetic code

...translated , by mediation of a machinery consisting of ribosomes and a set of transfer RNAs and associated enzymes , into an amino acid chain ( polypeptide ), which will then be folded into a protein . The gene sequence inscribed in DNA, and in RNA, is composed of tri-nucleotide units called codons , ...

C-terminal end

... The C-terminal end refers to the extremity of a protein or polypeptide terminated by an amino acid with a free carboxyl group (COOH). See also N-terminal end . ...
Polypeptide in Biological Dictionary

Polypeptide

4.3 Pancreatic polypeptide -related peptides. 4.4 Opioid peptides. 4.5 Calcitonin peptides ... A polypeptide is a single linear chain of amino acids. ... Amylin, or Islet Amyloid Polypeptide (IAPP), is a 37-residue peptide hormone secreted by pancreatic β-cells at the same time as...

Zinc finger

.... The information for the 141 zinc finger plasmids is also available as a tab ... Typically three or more zinc fingers are combined in one polypeptide to make a ... What sequence in which DNA chain is contacted by zinc finger 3? answer ... C4 zinc finger : Its consensus sequence is CX2...

Western blot

... in a given sample of tissue homogenate or extract. It uses gel electrophoresis to separate native or denatured proteins by the length of the polypeptide or by the 3-D structure of the protein .... Information about the Western Blot technique. Learn the western blotting protocol and method...

Viral oncogene

... viral oncogene homolog isofrom 1. Category ... RELA - v-rel reticuloendotheliosis viral oncogene homolog A, nuclear factor of kappa light polypeptide gene enhancer in B-cells 3, p65 (avian) - Bioportfolio FOS - v-fos FBJ murine osteosarcoma viral oncogene homolog - Bioportfolio ... v-fos...

Transmembrane proteins

.... Classifying transmembrane proteins using predicted structural features. 12. Conclusions ... In others - the transmembrane proteins - the polypeptide chain actually ... The figure shows a transmembrane protein that passes just once through the ... statistical testing of general hypotheses co...

Transfer RNA

... RNA molecule that transfers a specific active amino acid to a growing polypeptide chain at the ribosomal site of protein synthesis during translation. I...cules that transport amino acids to ribosomes for incorporation into a polypeptide undergoing tRNA abbr. transfer RNA ... Also called transfer RNA ...
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