Advanced targeted therapies effective as first-line treatment for lung cancer
...ased doublet chemotherapy. Researchers evaluated molecular markers including EGFR protein and EGFR gene copy number, EGFR- and KRAS-mutations and EGFR polymorphism
in order to potentially identify predictive markers for erlotinib therapy.
Both arms of the trial were well represented in patient and disease cha...
Gene linked to increasingly common type of blood cancer
In the first genome-wide association study of non-Hodgkin lymphoma, scientists at UC Berkeley and TGen identified a SNP a single nucleotide polymorphism
that could determine susceptibility to follicular lymphoma. The SNP, a DNA variant within the more than 3-billion base pairs in the human genome, was...
Gene Studies Reveal Cancer's Secrets
...and UGT2B28 genes were between 3.4 percent and 19.9, this did not increase the risk for prostate cancer.
"We did not see any association between polymorphism
of UGT2B17 and UGT2B28 with cancer," Setlur said during Tuesday's teleconference.
For more about cancer, visit the American...
Scientists Identify More Breast Cancer Genes
The newly identified genetic variations are located on chromosomes 1 and 14. The region on chromosome 1 contained the rs11249433 single nucleotide polymorphism
(SNP). SNPs, the most common type of genetic variation, affect just a single building block of DNA.
The function of the rs11249433 SNP is unknown,...
Are vitamin supplements effective in celiac disease patients?
...le against the effect of villous atrophy on homocysteine levels, irrespective to the genetic susceptibility status as manifested by carrying the C677T polymorphism
of 5,10-methylenetetrahydrofolate reductase.
Exploring Genetic Link Between Migraines, Cardiovascular Trouble
"Their issue is that maybe an angiotensin-converting enzyme polymorphism
may account for some of the association between migraine and cardiov...isease," Lipton said. "They ruled out one [polymorphism], but it's a single polymorphism
in a gene and there could be a dozen that play in that gene, and if you loo...
Blocking protein leads to fewer, smaller skin cancer tumors
...sal cell carcinoma to see if these patients have a polymorphism
on the MIF gene that would suggest a genetic predi...e cancer.
"If we find a correlation, a MIF-gene polymorphism
could become a biomarker to predict skin cancer. That would mean people who have a polymorphism
that makes them high MIF producers would be more l...
Genetic Markers Identified for Alcohol Response in UCSF Gallo Study
...effects of alcohol and thus how prone they are to alcohol abuse.
The researchers found that a DNA sequence variation, known as a single nucleotide polymorphism
(SNP), on chromosome 15 is significantly associated with the level of response to alcohol and could signal the genetic factors that affect alcohol abu...
Genetic disease treatments and pharmacogenetics: From scientific discovery to medical delivery
...tic makeup, thereby reducing the risk of adverse events caused by inappropriate dosing.
McGinnis' research team were among the first to show that a polymorphism
in the warfarin drug target VKORC1 accounts for a major portion (~30%) of the variance in RD, and they have recently evaluated 1,523 Swedish patients ...
Presentations at AHA expand on clinical utility of deCODE's DNA-based tests
...tudy." Presenter: C.M. Ballantyne, Baylor College of Medicine
10:45-11:00am, Room 265-266, presentation number 4403, "Significant single nucleotide polymorphism
associated with atrial fibrillation located on chromosome 4q25 in a whole genome association study and association with left atrial gene expression." ...
Polymorphism in Medical Technology
University of Michigan Study Shows SEQUENOM's MassARRAY Technology Identifies HPV Infections Missed by Standard Hybridization Test
...ccurate, and cost efficient manner. SEQUENOM's MassARRAY system facilitates a number of nucleic acid analysis applications including single nucleotide polymorphism
(SNP) genotyping and allelotyping, copy number variation analysis, quantitative gene expression analysis, quantitative methylation marker analysis, co...
ALP Life Sciences, LLC Announces Nanoveson(TM) Patent Filing and Whitepaper Availability on Proposed Therapy for Non-Alcoholic Fatty Liver Disease (NAFLD) and Comorbid Diseases
...r diseases and comorbid diseases utilizing the principles of Applied Lipid polymorphism
, which includes a revolutionary application of nanobiotechnology in the ar...ics and diagnostics based on the new and emerging science of Applied Lipid polymorphism
. ALP Life Sciences, LLC is currently evaluating strategic relationships in...
Interleukin Genetics Presents Research Linking Vertebral Fractures to Gene Variations in Asian Women With Osteoporosis
...orean women in the study were seventy percent more likely to get vertebral fracture if they carried a genetic variation, also called single nucleotide polymorphism
(SNP), in the IL-10 gene, while those who carried a SNP in the IL1-RN gene were fifty percent more predisposed to vertebral fracture. The study result...
Karmanos Researchers Study the Impact of Galectin-3 on Breast Cancer Disparity in Caucasian and Asian Women
... H64 allele, of which
5% were homozygous and 25% were heterozygous and the remaining 70% were
homozygous for P64.
The analysis distribution of the polymorphism
of galectin-3 in
Caucasian and Asian breast cancer patients showed that about 70% and 90% of
the tumor samples from Caucasians and Asians, respectivel...
ARCA Discovery Announces Data Demonstrating Potential for Bucindolol as Targeted Therapy in Heart Failure, Atrial Fibrillation, and Ventricular Arrhythmia
Determined by the Beta-1 389 Arg/Gly Receptor polymorphism
Data from a
sub-study analysis of the BEST cohort"...cluded that genetic targeting of the
beta-1 AR 389 polymorphism
may improve the clinical responses to bucindolol
f...ed both the beta-1 389
Arg/Arg adrenergic receptor polymorphism
and the alpha-2c wild type gene
variant are positi...
Versatility of 454 Sequencing(TM) Demonstrated in Three Publications in Science Last Week
...luding paired reads, characteristic of
454 Sequencing. Previous studies of human genomic variation tended to look at changes
called single nucleotide polymorphism
(SNP), variations that involve just
one nucleotide. However, the study, "Paired-End Mapping Reveals Extensive
Genomic Structural Variation in Humans,"...
The Past, Present and Future of HLA Typing
... HLA polymorphisms. In this technique, primers can be constructed specifically to complement HLA polymorphisms; if the primers bind the complementary polymorphism
and amplify the gene segment, then the PCR product can be detected by standard techniques. If the primer is not complementary to the polymorphism, th...
Polymorphism in Medical Definition
....L., Sadovnick, A.D., Remick, R.A. & Keck, P.E, McElroy, S L, Alexander, L., Shaw, S.H., & Kelsoe, J. (2003) Evidence that a single nucleotide polymorphism
in the promoter of the G protein receptor kinase 3 gene is associated with bipolar disorder. Molecular Psychiatry, 8, 546−557.
Baughman, F.A., &...
Polymorphism in Medical Dictionary
... become macrophages ... The IL1A gene is also known by other names, listed below. ... macrophage ; monocyte ; nucleotide ; osteomyelitis ; polymorphism
; protein ; ... Online Medical Dictionary and glossary with medical definitions ... ( In other words, a monocyte is thus a mononuclear phagoc...
Polymorphism in Biological News
NMR researchers unlock hydrogen's secrets to spot polymorphism in pharmaceuticals
Researchers at the University of Warwick and Astra Zeneca have found a new way to use solid-state NMR equipment to crack the secrets of hydrogen atoms and thus spot unwanted polymorphs in pharmaceuticals.
Pharmaceuticals companies are constantly battling the problem of polymorphism
in which an ...
DNA template could explain evolutionary shifts
...ng reasons for genetic mutations or changes looked at molecular "typos" in this process, tiny changes in the As, Ts, Cs or Gs called single nucleotide polymorphism
(SNPs). They changed the message of the gene. However, in the early 1990s, Lupski was one of the early champions of a newly discovered mechanism in wh...
Researchers gain genome-wide insights into patterns of the world's human population structures
... see significant variations. The UW researchers applied this method to a data set of almost 650,000 SNPs (pronounced "snips").
A single nucleotide polymorphism
is a genetic variation in which the DNA code differs by only one "letter" in the same DNA sequence from two individuals of the same species. The data ...
New therapeutic strategy could target toxic protein in most patients with Huntington's disease
...of Huntingtin . "Then, as he was leaving my office, it occurred to me that you could," he recalled. The key was something called a single nucleotide polymorphism
A SNP is any place on the genetic code that varies by a single unit. The genetic code is written with four letters, A, C, T, and G, which s...
The genetics of fear: Study suggests specific genetic variations contribute to anxiety disorders
... to treat anxiety and depression, harbors a common polymorphism
in its gene. This polymorphism
can come in two different versions that differ in ...arning, motivation and seeking rewards. A specific polymorphism
in this gene results in higher levels of extracell...
Researchers identify 4 genetic hotspots associated with psoriasis
...e," Krueger said. "Second, it confirmed findings we reported in 2007 of polymorphisms (mutations) in the IL-12/23 pathways. Third, we now find a third polymorphism
in this same cluster, IL-23A. Fourth, a treatment that knocks down IL-12 and IL-23 recently has been shown to be a very effective treatment for psori...
Scientists uncover new genetic variations linked to psoriasis
...sity of Utah and colleagues in Canada and Europe, focused on sites within the genome where a single unit of DNA is changed, called a single nucleotide polymorphism
(SNP). The researchers scanned nearly 450,000 SNPs in each of the genomes of 1,409 psoriasis patients and compared the DNA variations to those in 1,43...
Human genomics in China
...tic diseases (such as deaf). Furthermore, substantial progresses were made in the
development of technologies for human genome genotyping and genetic polymorphism
detection, as well as for
expressed sequence tag (EST) and full-length cDNA cloning and sequencing. All these achievements greatly
strengthened the ...
Children's Hospital researchers identify genetic mutation that may predict organ rejection
... Pittsburgh of UPMC have identified a genetic mutation that identifies transplant recipients who experience rejection.
Known as a single nucleotide polymorphism
(SNP), the genetic mutation validates the effectiveness of the system the researchers developed to search the human genome, according to principal inv...
TGen investigators devise faster, cheaper way of analyzing the human genome
...nding on whether the objective is:
Discovering genetic variants for genotyping by a separate method such as custom SNP genotyping.
discovery and variant calling within one sequencing experiment.
Exhaustively resequencing for all common and rare variants.
The new method of ...
Polymorphism in Biological Technology
Amplified Fragment Length Polymorphism (AFLP) Analysis on Applied Biosystems Capillary Electrophoresis Systems
Amplified fragment length polymorphism
(AFLP) analysis is a genetic mapping technique that uses selective amplification of a subset of restriction enzyme-digested DNA fragments to generate a unique fingerprint for a particular genome. First developed ...
SEQUENOM Announces Launch of MassARRAY Compact 96 System
...to assays and biomarkers throughout the validation process.
MassARRAY technology supports key genomic applications, including single nucleotide polymorphism
(SNP) genotyping, quantitative gene expression, and copy number variation (CNV) analysis, providing a multi-faceted view of a researcher's biological ...
Evidence for a New Genetic Link to Therapeutic Efficacy for Alzheimer's Disease
...omic responses of AC-1202 in AD, the effects of APOE4 carriage status and a polymorphism
(IDE_7) in the insulin degrading enzyme gene (IDE) on ADAS-Cog scores were ...
In the population of patients who were both APOE4(-) and lacked the C/C polymorphism
in IDE 7, more pronounced improvements in ADAS-cog scores than those previo...
Vanda Pharmaceuticals to Present Data on Fanapt(TM) and Tasimelteon at the 162nd American Psychiatric Association Annual Meeting
...ies will be presented at scientific poster sessions on Wednesday, May 20 from 3:00 pm to 5:00 pm.
NR7-098 Effect of a Period 3 (PER3) polymorphism
Architecture in Phase Advanced Transient Insomnia.
NR7-100 Effect of Melatonin Agonist Tasimelteon on Sleep Parameters
Frost & Sullivan Lauds BioTrove for Providing Research-Enabling Life Sciences and Drug Discovery Technologies
... assist research efforts with the company's innovative technologies. These research endeavors ranged from lead compound discovery to single nucleotide polymorphism
(SNP) genotyping on the OpenArray(R) system to investigating novel therapeutic targets with the RF-MS system. Researchers often appreciate a company t...
California Grants SeqWright License to Operate as a Clinical Laboratory
...that it has been granted a California clinical laboratory license. This license enables SeqWright to utilize its DNA sequencing and Single Nucleotide polymorphism
(SNP) Genotyping expertise in order to provide genetic tests to California residents and represents a significant step forward in the shift towards pe...
Ortho Biotech Oncology Research & Development Unites Johnson & Johnson Biopharmaceutical Oncology R&D Assets
...obins H, Lutzker SG, Arva NC, Bargonetti
J, Bartel F, Taubert H, Wuerl P, Onel K, Yip L, Hwang SJ, Strong LC, Lozano
G, Levine AJ. A Single Nucleotide polymorphism
in the MDM2 Promoter
Attenuates the p53 Tumour Suppressor Pathway and Accelerates Tumour
Formation in Humans. Cell; 2004; 119: 591-602.
Third Wave Achieves Milestone, Delivers 200,000 SNP Assays to RIKEN In Japan
... MADISON, Wis. -- Third Wave Technologies Inc. (Nasdaq: TWTI) today announced it delivered a total of 200,000 single nucleotide polymorphism
(SNP) assays to RIKEN in Japan for use in various large scale genotyping projects.
Since the beginning of 2003, Third Wave has been supplying its I...
Glossary for The BioPharm Guide to Fermentation and Cell Culture
...amples can be
analyzed to determine whether they are from the same person. The technique
of analyzing restriction fragment length polymorphism
(RFLP) is called DNA
typing or DNA fingerprinting.
DNA vaccine A nucleic acid vaccine: Genes coding for specific antigenic
SNPs Powerful Tools for Association Studies
...sts build case for haplotype map of human genome, find new gene for Crohns disease.
Eureka Alert. October 3. Kan, Y.W. and Dozy, A.M. 1978. polymorphism
of DNA sequence adjacent to human beta-globin structural gene: relationship to sickle mutation. Proc Natl Acad Sci USA. 75(11):5631-5.
Polymorphism in Biological Products
Fingerprinting II Comparative Quantification and Polymorphism Analysis from Bio-Rad
Description: Fingerprinting II comparative quantification and polymorphism
analysis is an optional module that adds comparative quantification and polymorphism
analysis functions to the Fingerprinting II Basic software package....
Pre-Validated Kinase Polymorphism Assays from Agencourt Bioscience
Description: Agencourt offers pre-validated SNP sequencing services for over 1500 amplicons within 93 genes including oncogenes, serine/threonin kinases, and more than 80 tyrosine kinases. These assays were developed and validated with leading researchers at the Dana-Farber Cancer Insitute....
Complete SSCP Kit, 20 cm from Bio-Rad
Description:... The complete SSCP kit provides all the accessories necessary for casting gels for mutation detection by single-stranded conformation polymorphism
analysis (SSCP) with the DCode universal mutation detection system. The kit includes a cooling finger adaptor for use with an external chiller (not pr...
Freedom EVO 150 from Tecan
Description:...action (SPE), magnetic bead separation or centrifugation Sequencing reaction set-up PCR set-up PCR PCR clean-up Genotyping single nucleotide polymorphism
(SNP) scoring Spot array printing, hybridization, and DNA normalization Gene expression in situ hybridization (ISH), fluorescence in situ hybridi...
CEQ 8800 Genetic Analysis System from Beckman Coulter
Description:...cing, mutation analysis, allele identification, SNP (single nucleotide polymorphism) scoring, microsatellite instability and amplified fragment length polymorphism
fingerprinting. To ensure accurate sample tracking, CEQ 8800 sample set-up can be created at the initial sample preparation stage on the Biomek serie...
Polymorphism in Biological Definition
Restriction fragment length polymorphism
In molecular biology , the term restriction fragment length polymorphism
(or RFLP ) is used in two related contexts: as a characteristic of DNA molecules (arising from their differing nucleotide sequences) by which they may be distinguished, and as the laboratory technique which uses th...
... A common method is a buccal swab .
Next, restriction fragment length polymorphism
(RFLP) analysis is performed by using a restriction enzyme to cut the DN...ir 30-plus year sentences.
restriction fragment length polymorphism
Discussion of concer...
Polymerase chain reaction
...allele-specific PCR, one can easily determine which allele of a mutation or polymorphism
an individual has. Here, one of the two primers is common, and would anneal... of the alleles. If the mutation of interest is a T or C single nucleotide polymorphism
(T/C SNP), one would use two reactions, one containing a primer ending in ...
Polymorphism in Biological Dictionary
In computer science, polymorphism
is a programming language feature that allows values of different data types to be handled using a uniform interface. The concept of parametric polymorphism
applies to both data types and functions. A function that can evaluate to or be... Type polymorphism...
Sequence Polymorphism Polymorphism
in biology occurs when two or more clearly different phenotypes exist in the same population of a species — in other words, the occurrence of more than one form or morph. In order to be classified as such, morphs... In 1985, Sir Alec Jeffreys developed restriction fragme...
...e well known for their high mutation ... Some VNTR's , however, exhibit polymorphism
in their individual repeat sequences. ... Psychology research, informat...lection, strong LD in the ... The 2R VNTR downstream region contains a polymorphism
pattern identical to that ... http://www. vntr .net - site internet d...
...pathways supplement the linear concept of HSC activation to myofibroblasts, point to ... role of thrombocytes in liver ... see thrombocytes . polymorphism
... of the major blood cells--erythrocytes, leukocytes, and thrombocytes (platelets) ... thrombocytes ... megakaryocyte ( ) n. A large bone ma...
Tandem repeat sequence
...stematically cataloged all tandem repeats with periods ... of the consensus sequence (both strands) of the tandem repeat from ALL TRs ... polymorphism
of tandem repeats within protein-coding sequences is known to ... expect higher levels of tandem repeat sequence length variation in the...
Simple Sequence Repeat
...ts (SSRs or microsatellites') are short, hypervariable ... Simple sequence repeats (SSRs) or microsatellites are an important class of ... polymorphism
revealed by simple sequence repeats . Trends Plant Sci. 1, 215-222. ... phpSSRMiner: Simple Sequence Repeat Marker Miner (v0.9b) phpSSRM...
... Jeffreys developed restriction fragment length polymorphism
( RFLP ), which quickly became the standard techn...ragment varies ... restriction fragment length polymorphism
( ri¦strikshən ¦fragmənt ′leŋkth ... Analysis of ...hers in ... RFLP . Restriction Fragment Length polymorphism
( RFLP ) analysis. measures fragments ... RFLP t...
... Jeffreys developed restriction fragment length polymorphism
(RFLP), which quickly became the standard techniq... of genetic... restriction fragment length polymorphism
( ri¦strikshən ¦fragmənt ′leŋkth ′päli′mör′fizəm ... and is ... A restriction fragment length polymorphism
is defined by the existence of ... The length of ...
...heat ... These co-dominant RAPD markers were detected by size and were a result of ... RAPD requires minute quantities of DNA for detection of polymorphism
based on ... RAPD analysis showed that the Chilanshan population had higher genetic diversity ... RAPD markers are based on the amplifica...
is common in nature; it is related to ... blood t...isms . ... a range of polymorphisms . ... polymorphism
(biology), having multiple allele of a gene within a population, ... polymorphism
in object-oriented programming ... ...