LOH analysis on 4q in sporadic colorectal carcinoma
... Thirteen fluorescent labeled polymorphic
microsatellite markers were analyzed in 83 cases of colorectal carcinoma and matched normal tissue DNA by polymerase chain reaction (PCR). PCR product...
The American College of Cardiology, American Heart Association and the Heart Rhythm Society Release Updated Cardiac Device-Based Therapy Guidelines
...g heart failure, congenital heart disease and sudden cardiac
arrest. Guidelines also address treatment for genetic disorders such as
VT, Brugada syndrome, arrhythmogenic right
ventricular cardiomyopathy and short QT syndrome.
Revised ICD indications reflect the new developments an...
American Chemical Society's Weekly PressPac -- Feb. 13, 2008
...tal formation, thereby preventing fat bloom. MTS
ARTICLE #1 FOR IMMEDIATE RELEASE Effect of Antibloom Fat Migration from a Nut Oil Filling on the polymorphic
Transformation of Cocoa Butter
DOWNLOAD FULL TEXT ARTICLE
Kevin W. Smith, Ph.D.
Unilever R&D ...
Childhood Abuse Increases the Risk of Alcoholism
...i, M.D., a visiting fellow in NIAAAs Laboratory of Neurogenetics in Bethesda, Maryland. DNA variations occur within a regulatory area the MAOA-linked polymorphic
region (MAOA-LPR) -- of the MAOA gene.
Two such MAOA-LPR variants occur most frequently and result in high or low MAOA enzyme activity. In a r...
Young People Who Died Suddenly, Inexplicably Had Genetic Heart Defects
...s spelling errors in the genetic code. The defects produced one of two abnormal heart rhythm conditions: Long QT syndrome (LQTS) and catecholaminergic polymorphic
ventricular tachycardia (CPVT). Both syndromes can declare their presence silently and catastrophically with a sudden death episode as the first sympt...
Alcohol Dehydrogenase Gene may Protect from Developing Alcoholism
... Alcohol dehydrogenase (ADH) is one of the major enzymes involved in alcohol metabolism. The genes for ADH are polymorphic
at two loci, ADH1B and ADH1C.//
The three alleles at the ADH1B locus have previously been linked with protection from alcohol dependence, a new ...
Does Aspirin Crystallize?
... one polymorph or the other.
Aspirin is the first case in which two different “polymorphic” structures exist in one single crystal. So is aspirin polymorphic
or not? Should the definition of polymorphism be updated? Such questions are not just philosophical in nature, but could have tangible implications in...
Allergies can prevent brain cancer
...oblastoma multiforme (GBM) might be prevented by the same genetic factors that cause allergies.
Researchers had found that the different kinds of polymorphic
forms of two genes are responsible for people being susceptible to allergic conditions and having a minor risk of GBM.
The current study include...
Risk for Diabetes type II may be in the genes
...allas, Texas and 858 Caucasians living in Dallas, Texas. While 25% of the people in Chennai belonging to the non-diabetic group were carrying the gene polymorphic
ENPP1 121Q allele, 34% of the diabetics in Chennai had the same gene. For the subjects in Dallas, the prevalence of the gene in the non-diabetic group...
Polymorphic in Biological News
New research reveals why chili peppers are hot
...lleagues were able to arrive at these conclusions because at least three of the approximately 15 species of chilies that grow in the Bolivian wild are polymorphic
for pungency, which means that some individuals of those species produce pungent fruit and others produce non-pungent fruit. This provided the researc...
Tomato stands firm in face of fungus
...e evolutionary change in plant diseases is to make use of the innate immune system of plants. Growers can cross into targeted plant varieties certain polymorphic
resistance genes that occur in related plants, thereby naturally boosting the plants immune system.
In this study, Dr. Martijn Rep and his team e...
Researchers link two more genes to sudden infant death syndrome
... CAV3 as a novel LQTS-causing gene. RyR2 was targeted because of its involvement in a distinct genetic heart rhythm disease known as catecholaminergic polymorphic
ventricular tachycardia (CPVT).
"For a parent whose infant died suddenly and mysteriously even five years ago, we were essentially unable to provid...
Swiss researchers develop all-in-one remote control gene expression tool
...factor can now be turned off when the desired effect is achieved, thus preventing unharnessed growth ?otherwise known as cancer.
"It's an extremely polymorphic
tool, useful in testing therapies and in preclinical studies," says Trono. "Using it we can control the gene expression in vivo in an extraordinary an...
Polymorphic in Biological Technology
Detection of Variation in Highly Polymorphic Mhc Genes by Denaturing Gradient Gel Electrophoresis Using the DCode System
Kristi M. Miller, Tobi J. Ming and Ruth E. Withler, Pacific Biological Station,
Department of Fisheries and Oceans, Nanaimo, B.C. V9R 5K6, Canada
We describe a rapid and sensitive method for the detection of nucleotide
BioNanomatrix Awarded New NIH Grant for Development of Nanoscale Platform for Single-Molecule DNA Mapping and Haplotype Applications
... designed to accommodate massively parallel analyses of
individual DNA molecules to permit standardized, high-throughput mapping of
sequence motifs or polymorphic
sites along the DNA. Such capabilities could
transform biological analyses, permitting highly sensitive detection of
genetic information for genome-wi...
ARCA biopharma Appoints James Carr as Vice President of Marketing
... at Buffalo School of Pharmacy. He earned a Doctor of
Pharmacy degree from the University of Minnesota and conducted
post-graduate work in the area of polymorphic
drug metabolism of
beta-blockers, also at the University of Minnesota.
About ARCA biopharma
ARCA biopharma, Inc. is a privately held company focus...
Synvista Therapeutics Increases Commercial Focus by Appointing David C. Tantillo Senior Director of Marketing and Sales
...ceived MPH and MBA degrees from Illinois Benedictine
College, and a BS in Mechanical Engineering from Iowa State University.
haptoglobin (Hp) protein is derived from two alleles, 1
and 2, existing at the Hp genetic locus. Three phenotypes linked to the
three genotypes, Hp 1-...
Synvista Therapeutics Highlights Newly Published Data Demonstrating the Value of Haptoglobin Genotype Testing In People with Diabetes
in cardiovascular events in patients with Hp 2-2 taking Vitamin E, as the
primary endpoints had been met.
About Haptoglobin 2-2
The Hp protein is polymorphic
in humans, occurring with two alleles, 1
and 2, existing at the Hp genetic locus. Three phenotypes linked to the
three genotypes, Hp 1-1, Hp 1-2 and H...
Interleukin Genetics Enters into New Clinical Research Collaboration with Alticor
...rleukin Genetics will be conducting various clinical studies, which
shall be fully funded by Alticor. Studies will look to correlate single
(SNPs) gene variations to the risk of osteoporosis
or cardiovascular disease in Asian populations. Other studies will seek to
identify genetic factors...
Glossary for The BioPharm Guide to Fermentation and Cell Culture
teristics of life.
DNA fingerprinting Sequences of nucleic acids in specific areas (loci) on a
DNA molecule are polymorphic
, meaning that the genes in those locations
may differ from person to person. DNA fragments can be cut from those
sequences using ...
Endotoxins and their Relevance in R&D ApplicationsLPS Detection & Removal Methods
shock. LPS causes a very strong stimulation of different cells of the
immune system, such as monocytes, macrophages, B cells, polymorphic
and endothelial vascular cells.
LPS is biologically effective even in lowest concentrations (lower pg/ml
Practical Applications of HyperDSC in a Pharmaceutical Laboratory
...he pharmaceutical analysis. As demonstrated HyperDSC increases the sensitivity of DSC analysis, separates transitions and allows better evaluation of polymorphic
materials. The analysis time is very short and permits you to increase your sample throughput or to use this technique as a screening tool for new mat...
Amplified Fragment Length Polymorphism (AFLP) Analysis on Applied Biosystems Capillary Electrophoresis Systems
...hat can rapidly and accurately identify common and polymorphic
peaks among large numbers of samples. Genotyping q... in GeneMapper software for easy identification of polymorphic
peaks (red arrow) and common peaks (black arrow). For example, in the data shown in Figure 4, a polymorphic
peak can be easily identified in the P1 sample (re...
Polymorphic in Biological Definition
...n cause reduced fitness and an increased chance of extinction .
When many alleles exist for a given gene or locus , a population is said to be polymorphic
with respect to that gene or locus. When no variation exists, it is labelled monomorphic .
small population ...
Major histocompatibility complex
...membrane polypeptide chain (the α-chain) and a β 2 microglobulin (which is encoded elsewhere, not in the MHC). The α chain has two polymorphic
domains, α 1 , α 2 , which present peptides derived from cytosolic proteins to the immune system. The peptides are short, consisting of...
...ite locus, one would expect to see a sequence of "TAGTAGTAGTAGTAGTAGTAG..."
The number of repeats at a particular locus is hypervariable (highly polymorphic
) between individuals of the same species. It is for this reason that microsatellite sequences can be used for genetic fingerprinting and paternity...
Polymorphic in Biological Dictionary
Single locus probe
...ning ... ... Restriction Fragment From Human Genome for Developing Single Locus Probe ... For developing a single locus probe , a highly polymorphic
human Bkm positive ... ... reflected in the shift from Multi Locus Probe . systems (MLP) to Single Locus Probe (SLP) approaches. ... obt...
Simple Sequence Repeat
... ... Microsatellites, or Simple Sequence Repeats (SSRs), are polymorphic
loci present ... ISSR (for inter- simple sequence repeat ) is ... 1991) ... Microsatellites, or Simple Sequence Repeats (SSRs), are polymorphic
loci present ... ISSR (for inter- simple sequence repeat ) is a gener...
...Phylogenetics, Instruction. Sequence analyses ... DnaSP: estimates several measures of DNA sequence ... 1 Types of polymorphism . 2 Assembling polymorphic
genomes. 2.1 Getting started ... If sequence is present in one allele but missing in the other, this can prevent ... A Single Nucleotide Polym...
... RAPD stands for Random Amplification of polymorphic
DNA. It is a type of PCR reaction, but the segment...r change your subscription ... Random amplified polymorphic
DNA ( RAPD ) variation in Fagopyrum tataricum Ga...equences using ... The RAPD (random amplified polymorphic
DNA) technique (10, 12) has been widely ... RAPD ...
... Comparison of agarose type (non- polymorphic
loci ) ... These primers amplify polymorphic
loci , and alleles of different sizes can be observed. ... Many polymorphic
loci have been identified, and scientists have ...
...dual or ... In this book a panel of expert international mycologists critically review the ... The heterozygosity far exceeds that found in other polymorphic
genomes such as ... Free radical articles relating to ' heterozygosity ' ... Association of presenile cataracts with heterozygosity for galactosa...
...n The Spot e-News. Points to Consider. Presentations ... Diagnostic Services > SignatureChip® Clone List. Clone List ... ... of an EST(s) or polymorphic
marker(s) within a genomic clone , PCR primers, ... To map the genomic clone to chromosomal location, unfertilized eggs were used to ... CYP...
...tion through hydrogen bonding and ... Agarose gels can be run at various voltages, depending on the separation desired ... Agarose gels and polymorphic
loci. As depicted also in Fig. 7, agarose ... Agarose gels separate DNA fragments differing by a hundred or more base pairs, ... dishes, kn...
...bridization-based fingerprinting and ... (See AFLP Procedure Diagram) It is based ... back to AFLP Analysis. back home ... tion Fragment Length polymorphic
( AFLP ) DNA ... example, in a comparative study of AFLP , RFLP, and ... (1996) reported that AFLP gave a number of discrimi ... posted to cruen...