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Polymerization in Medical News

UGA researchers achieve breakthrough in effort to develop tiny biological fuel cells

...h, the scientists laid down a single layer of thiophene as the film's initial coating, then built up chains of thiophene or benzene using a controlled polymerization technique. Their research, funded by the Petroleum Research Foundation, was published in the June issue of the journal, Chemical Communications . ...

The Scientific Business of Thomson Reuters Predicts Nobel Laureates

...or of Natural Sciences, Department of Chemistry, Carnegie Mellon University, Pittsburgh, Pa., USA -- For his development of atom transfer radical polymerization (ATRP) and other methods of "living" polymerization. Roger Y. Tsien Professor of Pharmacology and Professor of Chemistry and Biochemistry, Uni...

Black and White in ‘Shades of Grey

...elanin can be decreased due to various factors, like oxidative stress or exposure to light. A decrease in the molecular weight or an impairment in the polymerization of the melanin molecule results in the conversion of the normally anti-oxidant polymer, into a pro-oxidant one. These pro- oxidant melanin molecules a...
Polymerization in Medical Technology

Kosan Initiates Phase 2 Trial of Epothilone KOS-1584 in Non-Small Cell Lung Cancer

... potential pharmaceutical collaborators." KOS-1584 is a member of a class of cytotoxic macrolides (epothilones) capable of causing mitotic arrest by polymerization of cellular microtubules. Since microtubules are essential for mitosis, motility, secretion and proliferation, the observed antitumor effects of epoth...

EntreMed Presents Multi-Mechanism Antitumor Data for ENMD-1420 in Preclinical Models

...of ENMD- 1420 at maximally tolerated doses led to the disruption of established blood vessels. Previous studies showed that ENMD-1420 inhibits tubulin polymerization and TNF-alpha production, contributing to its antiproliferative activity through apoptosis. Collectively, these data suggest that both ENMD- 1420 and ...
Polymerization in Medical Products

Sonoclot Coagulation & Platelet Function Analyzer

Features:...e graph, known as the Sonoclot Signature, and quantitative results on the clot formation time (Activated Clotting Time - Onset) and the rate of fibrin polymerization (Clot RATE)....
Company:Sienco, Inc.

CEMEX System

Features:...oses the surgeon, O.R. staff and patient to 33% less monomer than traditional 2:1 bone cement systems. LESS HEAT: The amount of heat released during polymerization (setting) is directly proportional to the amount of monomer used. Cemex's reduced monomer results in less heat, minimizing the potential for thermal n...
Company:Exactech, Inc.

CEMEX Genta

Features:...poses the patient and medical professionals to less monomer than traditional 2:1 bone cement systems. Less Heat - The amount of heat released during polymerization (setting) is directly proportional to the amount of monomer used. Cemex's reduced monomer results in less heat, minimizing the potential for thermal n...
Company:Exactech, Inc.

CEMEX Fast Set

Features:...poses the patient and medical professionals to less monomer than traditional 2:1 bone cement systems. Less Heat - The amount of heat released during polymerization (setting) is directly proportional to the amount of monomer used. Cemex's reduced monomer results in less heat, minimizing the potential for thermal n...
Company:Exactech, Inc.
Polymerization in Biological News

Building memories with actin

...mplicates signaling cascades headed by GTPases, such as the RhoA-ROCK and Rac-PAK pathways. The researchers showed that a ROCK inhibitor stalled actin polymerization and resulted in a short-lived LTP. A Rac-blocking compound had no effect. That doesn't mean the Rac-PAK pathway isn't involved in LTP, however. The...

Carnegie Mellon's Kris Matyjaszewski recieves EPA's Presidential Green Chemistry Challenge Award

... development of an environmentally low-impact form of Atom Transfer Radical polymerization (ATRP), a widely used method for preparation of functional polymers. T...ong the most effective and most commonly used methods of controlled radical polymerization (CRP). It allows scientists to easily form polymers by piecing together the...

Plant Min protein sits tight and rescues E. coli

...MinC, D and E). MinE oscillates from the middle of the cell to one pole or another, driving the MinCD complex with it. The MinCD complex prevents FtsZ polymerization at the poles but not at the mid-line of the cell, where FtsZ ring formation leads to cell division. A team of Beijing-based scientists expressed th...

Blue light used to harden tooth fillings stunts tumor growth

...hardening," says Alpesh Patel, a rising MCG School of Dentistry junior. "The light waves produce free radicals that activate the catalyst and speed up polymerization of the composite resin. In oral cancer cells, though, those radicals cause damage that decreases cell growth and increases cell death." Mr. Patel, ...

Carnegie Mellon scientists develop nanogels that enable controlled delivery of carbohydrate drugs

...ased drugs. The scientists created the nanogels using atom transfer radical polymerization (ATRP), which will ultimately enable the nanogels to deliver more drug dire... American Chemical Society in Boston. ATRP, a controlled living radical polymerization process, allows chemists to precisely regulate the composition and architec...

NHGRI aims to make DNA sequencing faster, more cost effective

... apply force spectroscopy, a technique used to understand the mechanical properties of polymer molecules or chemical bonds, to DNA undergoing arrested polymerization to initially demonstrate one-molecule-at-a-time analysis of changes in molecular mechanics at a resolution of a single base. Using optical, near-field...

Carnegie Mellon scientists use 'green' approach to transform plastics manufacturing

...ics for applications ranging from targeted drug delivery systems to resilient paint coatings. The revolutionary improvement in atom transfer radical polymerization (ATRP) now enables large-scale production of many specialty plastics, according to the scientists, whose work appears in a special issue of the Procee...

New insight into machinery of immune cells' 'tentacles'

...ns that include the Wave family of proteins, might regulate actin polymerization. The Abi/Wave complex had already been shown to be involved in actin polymerization in other cells, said Pendergast. Using tracer molecules to tag the proteins in T cells, the researchers found that both Abi and Wave homed in on si...

Wrinkled membranes create novel drug-delivery system

...id bilayer membranes. Some of the lipids are then "sewn together" through a polymerization process. Cooling the capsules by 10 degrees Celsius causes the capsules to ...logy. "And the amount of wrinkling is dependent upon the degree of membrane polymerization that took place." One problem that remains is how to cool the capsules w...

The making and breaking of microtubules

...ntly elongate and retreat in a thrashing frenzy of polymerization and depolymerization, like the writhing snakes of ... proteins, dubbed the alpha and beta forms. During polymerization the dimers stack end to end to make a protofilamen... on beta tubulin (the E-site or exchangeable site) polymerization occurs: tubulin dimers pile onto the protofilament...
Polymerization in Biological Technology

Acrylamide Polymerization A Practical Approach

Paul Menter, Bio-Rad Laboratories, 2000 Alfred Nobel Drive, Hercules, CA 94547 USA Introduction The unparalleled resolution and flexibility possible with polyacrylamide gel electrophoresis (PAGE) has led to its widespread use for the s...

Nereus Pharmaceuticals Initiates ADVANCE, a Randomized Phase 2 Clinical Trial of NPI-2358 in Non-Small Cell Lung Cancer

...mor effects in combination with docetaxel and other oncology therapies, as well as single-agent efficacy in a number of models. NPI-2358 prevents the polymerization of tubulin monomers without altering the dynamic function of formed microtubules. As demonstrated in preclinical testing, this results in a highly sp...

MacroChem Acquires Virium Pharmaceuticals

...e compounds that are in the class known as tubulin binding agents. One compound, VP601, has initially exhibited strong broad-spectrum in vitro tubulin polymerization inhibitory activity and cytotoxicity against numerous cancer cell lines tested thus far, including cervical, ovarian, breast, prostate, leukemia, and ...

Nereus Pharmaceuticals Initiates Clinical Trial of NPI-2358 in Non-Small Cell Lung Cancer Following Encouraging Phase 1 Data

...r oncology therapies, as well as single-agent efficacy in a number of orthotopic models. NPI-2358 interacts with soluble beta-tubulin and prevents the polymerization of tubulin without altering dynamic microtubule function of formed microtubules. As demonstrated in preclinical testing, this target profile results i...

AEterna Zentaris to Further Develop Three Follow-up Multi-targeted Cytotoxic Candidates to AEZS-112 as Potential Novel Cancer Treatment

...tled, "Highly Potent Cytotoxic Compounds with Inhibitory Effects on Tubulin polymerization and Topoisomerase II", reviewed results of a pharmacological characterizati...n exerting cytotoxic activity in tumor cell lines and inhibiting tubulin polymerization than AEZS-112, whereas induction of cell cycle arrest and apoptosis was ...

Sticky mussels inspire biomedical engineer yet again

...lute -- only two milligrams of dopamine per one milliliter of water.) At marine pH, there are chemical changes in the dopamine molecule that result in polymerization of the molecules together to form a polymer, polydopamine, which coats the object. The polymer is fairly similar to what is found in the mussel adhesi...

A DELFIA Assay for Inhibition of PARP

...the response to DNA damage, where it catalyzes the polymerization of nicotinamide adenine diphsophate (NAD) into chains of poly(ADPribose) polymers 1 . The polymerization occurs on a number of nuclear proteins, as well as... METHODS The DNA used in the polymerization reaction was fragmented by hydrodynamic shearing. ...

Extended data analysis using DeCyder EDA

...he images showed that both spot maps from the duplicate patient were of very low quality. Both gels were from the same casting batch and showed severe polymerization problems, as well as dust particles and air bubbles.

Conclusions The purpose of this application note...

Preparative Nondenaturing Gel Electrophoresis to Purify NADP-Specific Glutamate Dehydrogenase From Chlorella, Rev B

...oflavin-5-phosphate (Bio-Rad) and 0.365 l/ml TEMED. Stacking gel polymerization was achieved by exposure to two 5 W fluorescent lights for 45 mi...led as per the Model 491 prep cell instruction manual during the polymerization process. All acrylamide stock solutions were pretreated with AG ...

Detection of Platinum Species in Plant Material by Preparative Isotachophoresis Using the Model 491 Prep Cell, Rev A

... was cast on the separating gel to a height of 1 cm. The stacking gel was overlayed with water-saturated 2-butanol. After polymerization the butanol was removed and the gel surface was rinsed with water. The gel was used for running after about 15 h in order to obtai...
Polymerization in Biological Products

Taq DNA Polymerase -Klein Taq from AppliChem GmbH

Description:... Repeated exposure to 98 C does not diminish the enzyme activity. Significant activity remains even after exposure to 99 C. The mutation rate during polymerization is twofold lower for Klein Taq as compared to the full-length Taq DNA polymerase. Klein Taq has a very low 'background' ability to extend a mismatched...
Company:AppliChem GmbH

AMV Reverse Transcriptase from Promega

Description:... Avian Myeloblastosis Virus Reverse Transcriptase (AMV RT) catalyzes the polymerization of DNA using template DNA, RNA or RNA:DNA hybrids (1). It requires a primer (DNA primers are more efficient than RNA primers) as well as Mg2+ or Mn2+....
Company:Promega

M-MLV Reverse Transcriptase from USB Corp.

Description:... Source: E. coli strain containing an overproducing clone of M-MLV Reverse Transcriptase. M-MLV Reverse Transcriptase catalyzes the polymerization of DNA using template DNA, RNA or RNA:DNA hybrids(1). Full-length copies of large mRNAs, >10 kb, may be synthesized. M-MLV Reverse Transcriptase has a...
Company:USB Corp.

DNA Polymerase I from Promega

Description:... DNA Polymerase I catalyzes the template-directed polymerization of nucleotides into duplex DNA in a 5?3 direction. DNA Polymerase I possesses a 3?5 exonuclease activity or "proofreading" function, which lowers the ...
Company:Promega

DNA Polymerase I Large (Klenow) Fragment from New England Biolabs

Description:...agment is a proteolytic product of E. coli DNA Polymerase I which retains polymerization and 3 -> 5 exonuclease activity, but has lost 5 ->3 exonuclease activity. Klenow retains the polymerization fidelity of the holoenzyme without degrading 5 termini....
Company:New England Biolabs
Polymerization in Biological Definition

Actin

...microtubules , actin filaments are polar, with the plus (+) end elongating approximately 10 times faster than the minus (-) end. The process of actin polymerization , nucleation, starts with the association of three G-actin monomers into a trimer. ATP-actin then binds the plus (+) end, and the ATP is subsequently ...

Amino acid

...ling organisms, such as cone snails . They are also abundant components of the cell walls of bacteria . Reactions Proteins are created by polymerization of amino acids by peptide bonds in a process called translation . Peptide bond formation 1. Amino acid; 2, zwitterion structure; 3...

Diffusion

...or Brownian motion Cell membrane Circulatory system Diffusion equation Effusion Electrochemical potential Emulsion polymerization Fick's law of diffusion Fokker-Planck equation Gel permeation chromatography Hydrothermal circulation Isotope separation ...

Actin

...microtubules , actin filaments are polar, with the plus (+) end elongating approximately 10 times faster than the minus (-) end. The process of actin polymerization , nucleation, starts with the association of three G-actin monomers into a trimer. ATP-actin then binds the plus (+) end, and the ATP is subsequently ...

Origin of life

...the amino acids or terminate the peptide chain. A possible answer to this polymerization conundrum was provided in 1980s by Gnter Wchtershuser , in his iron-sul...ary of some scientific critiques of origin theories) Origin of life: the polymerization problem Origin of life: the chirality problem Origin of Life: Insta...

Pseudopod

...First, the cell surface extends a membrane process, named lamellipodium . polymerization of actin takes place and form filaments at the leading edge, which subse...quently will blend into one another to form networks. We suppose that actin polymerization is at the origine of the force propelling the cell forwards. Function ...
Polymerization in Biological Dictionary

Tubulin

...jor constituent of microtubules. ... This tubulin does not have a C-terminal tyrosine. SIMILARITY: Belongs to the tubulin family. ... Tubulin polymerization with GTP/GMPCPP/Taxol. I. Solutions & Supplies ... GMPCPP is the best current GTP analog for tubulin polymerization. ... Zebrafish protein-co...

SDS-PAGE

... how SDS - PAGE can be used to determine the molecular mass of a protein ... In SDS - PAGE , the gel matrix is a thin porous slab formed by the polymerization ... SDS - PAGE . SDS - PAGE : gel electrophoresis of proteins ... 20% SDS 3 ml. Glycerol (100%) 3 ml. B-mercaptoethanol 1.6 ml ... SDS ...

Polymerase

... acids such as RNA and DNA. The primary function of a polymerase is the polymerization of new DNA or RNA against an existing DNA or RNA template in the processe...ng optimization. ... DNA polymerase is an enzyme which catalyzes the polymerization of Deoxyribonucleic acid (DNA) ... Polymerase Chain Reaction (PCR) is a l...

Polyacrylamide Gel

...er bed. ... Lecture 7 - Polyacrylamide Gel Electrophoresis (PAGE) on GOT -- Expt 4 ... gel ... acrylamide, to make the gel by free radical polymerization results ... SDS- Polyacrylamide Gel Electrophoresis (SDS-PAGE) is probably the worlds most ... 1964, Davis 1964, thus developing polyacrylamide...

Klenow Fragment

...abeled with ... DNA Polymerase I, Large ( Klenow ) Fragment is a proteolytic product of <I>E. coli </I>DNA Polymerase I which retains polymerization and 3'-> 5' exonuclease activity, ... Klenow Fragment (3'-> 5' exo- ) is an N-terminal truncation of DNA Polymerase I which retains po...

DNA polymerase

... A DNA polymerase is an enzyme that catalyzes the polymerization of deoxyribonucleotides into a DNA strand. DNA polymerases are best-known for their role in DNA replication, in which the polymerase "rea...

Capacitation

...quisition process, termed capacitation ' (Austin, 1952), occurred only ... ... in mammalian sperm capacitation and the acrosome reaction ... polymerization occurs during capacitation (Castellani-Ceresa et ... sperm capacitation . ... Current research into sperm capacitation : ... Capacitation ...

Actin

... skeletal muscle, actin compromises about 15% of the total protein. ... In skeletal muscle, actin comprises about 15% of the total protein. ... polymerization of actin in the presence of various ions. ... Actin is a 43 kDa protein that is very highly conserved between species. ... Importantly, diffe...

Acrylamide gels

...rs for the acrylamide to completely ... ... gels are formed from the polymerization of two compounds, acrylamide and ... While acrylamide gels have becom... in a multitude of sizes. ... acrylamide and bisacrylamide gels . The polymerization reaction is ... investigators prefer to run acrylamide gels in 0.5x TBE...
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