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Polymerase in Medical News

Biologist finds plant polymerases IV and V are really variants of Polymerase II

It's a little like finding out that Superman is actually Clark Kent. A team of biologists at Washington University in St. Louis has discovered that two vital cellular components, nuclear RNA Polymerases IV and V (Pol IV and V), found only in plants, are actually specialized forms ...

New test for safer biomedical research results

...ailable commercial mycoplasma tests. McCT results are reproducible to 99.6 percent. The method is based on multiplication of specific DNA sequences by polymerase chain reaction and subsequent detection of the multiplied DNA regions. A special advantage of the new test is that it can be carried out on a high-thr...

Urine Test for Chlamydia Shown Effective in Men

...dia infection is diagnosed by nucleic acid amplification tests, such as the polymerase chain reaction. But these tests are expensive, technically complex and can ... fast and accurate results in women. The new study compared the test to the polymerase chain reaction test using urine samples from more than 1,200 men, ages 16 t...

Abbott Reports Strong Second Quarter Results; Confirms Double-Digit Earnings Growth Outlook for 2009

... Abbott's broad-based hepatitis C program includes our partnership with Enanta Pharmaceuticals to develop protease inhibitors, as well as our internal polymerase inhibitor program. Our compounds in development have the potential to shorten treatment duration, improve tolerability and increase cure rates. Abbott...

New Report Just Published: World Hepatitis C Virus And Therapeutics Market Report

...r and Boceprevir II-7 Telaprevir and Boceprevir - A Comparison II-8 polymerase Inhibitors (PLIs) - Adding More Teeth to HCV Pipeline II-8 Viral Polymerases II-8 polymerase Inhibitor Drugs in Pipeline by Company, Category, and Development Stage...

Pharmasset Nominates PSI-938 as a New Nucleotide Analog Inhibitor of Hepatitis C for Preclinical Development

...candidate from two series of purine analogs for the treatment of chronic hepatitis C virus (HCV) infection. PSI-938 is a proprietary nucleotide analog polymerase inhibitor of HCV that is being advanced into studies required for submission of an Investigational New Drug (IND) application with the FDA or equivale...
Polymerase in Medical Technology

Roche and Pharmasset Initiate Phase IIb Clinical Trial of R7128, Most Advanced Nucleoside Polymerase Inhibitor in Development for Chronic Hepatitis C

Start of trial triggers $10 million milestone payment to Pharmasset PRINCETON, N.J., April 24 /PRNewswire-FirstCall/ -- Pharmasset, Inc. (Nasdaq: VRUS ) and Roche (Roche SWX: RO, ROG; Pink Sheets: RHHBY) today announced that the first patient has been dosed in a Phase IIb study of R7128, th...

Roche's Investigational Polymerase Inhibitor, Combined with PEGASYS(R) and COPEGUS(TM), Shows Potent Antiviral Activity in Treatment of Chronic Hepatitis C at Four Weeks

- Roche progresses R1626 into phase IIb study, called POLI 1 - BOSTON, Nov. 2 /PRNewswire/ -- R1626, one of Roche's new investigational drugs for chronic hepatitis C virus (HCV) infection, has shown promising antiviral activity when given in combination with PEGASYS(R) (peginterferon alfa...

Genelabs Technologies Announces Presentation of Data on Non-Nucleoside HCV Polymerase Inhibitor at 20th International Conference on Antiviral Research Meeting

REDWOOD CITY, Calif., May 02, 2007 /PRNewswire-FirstCall/ -- Genelabs Technologies, Inc. announced today that a presentation was made today at the 20th International Conference on Antiviral Research being held in Palm Springs, California, on a non-nucleoside hepatitis C virus (HCV) polymerase inhi...

Pharmasset Reports Positive Preliminary Antiviral Data With PSI-7851 for the Treatment of Hepatitis C

... (HCV). PSI-7851 is a second generation nucleotide polymerase inhibitor of HCV. PSI-7851 Phase 1 Multip...tent than Pharmasset's first generation nucleoside polymerase inhibitor, RG7128 (formerly known as R7128). In v... which act as alternative substrates for the viral polymerase thus inhibiting viral replication. We currently ha...

Idenix Pharmaceuticals Successfully Completes Proof-of-Concept Study of IDX184 for the Treatment of Hepatitis C Virus (HCV)

...hich support the potential for IDX184 to be a best-in-class nucleoside/tide polymerase inhibitor with demonstrated antiviral activity and tolerability, coupled wi...gational new drug applications in the coming months from our non-nucleoside polymerase inhibitor and protease inhibitor programs, we are closer to achieving our u...

University of Michigan Study Shows SEQUENOM's MassARRAY Technology Identifies HPV Infections Missed by Standard Hybridization Test

...ely licensed by SEQUENOM and known as the AttoSense(TM) HPV assay). Utilizing SEQUENOM's proprietary MassARRAY((R)) system that couples standard polymerase chain reaction (PCR) techniques with mass spectrometry (PCR-MS), study samples were simultaneously screened, genotyped and quantified for each of 13 H...
Polymerase in Medical Products

COBAS TaqMan Analyzer

Description:... Next-generation real-time polymerase chain reaction (PCR) testing for clinical laboratories. The COBAS TaqMan 48 Analyzer allows automated real-time amplification and detection of ...
Company:Roche Diagnostics

HLA SSP Trays

Description:...amplification. It is based on the principle that only primers whose sequence is completely complementary to a target sequence will be converted by the polymerase into PCR products. In contrast, non-complementary primers produce no amplification product. Using the Biotest SSP Kit Systems, reliable typing results...
Company:Biotest

HLA SSP Kits

Description:...amplification. It is based on the principle that only primers whose sequence is completely complementary to a target sequence will be converted by the polymerase into PCR products. In contrast, non-complementary primers produce no amplification product. Using the Biotest SSP Kit Systems, reliable typing results...
Company:Biotest

TaqScreen West Nile Virus Test

Description:... Roches patented polymerase chain reaction (PCR) technology, the worlds leading nucleic acid amplification technology, is an essential component of Roches blood screening assays ...
Company:Roche Molecular Systems, Inc.

HSV Non-Typing ASR

Description:... The HSV Non-Typing ASR contains primers and a FAM-labeled probe that is designed to detect a 92 bp region of the HSV Type 1 and Type 2 polymerase gene. This ASR requires an instrument that can detect a FAM reporter dye like the Cepheid SmartCycler System. The Cepheid Analyte Specific Reagent* (...
Company:Cepheid

Applied Biosystems 2720 Thermal Cycler

Description:...nywhere. And because its cooling vents are in the back, you can safely place it in tight spaces to save valuable bench space. Practice of the patented polymerase chain reaction (PCR) process requires a license. The Applied Biosystems 2720 Thermal Cycler is an Authorized Thermal Cycler for PCR and may be used wi...
Company:Applied Biosystems
Polymerase in Biological News

New RNA polymerase discovered in plants

Biologists at Washington University in St. Louis have discovered an entirely new cellular "machine" in plants that plays a significant role in plant flowering and DNA methylation, a key chemical process essential for an organism's development. A team headed by Craig Pikaard, Ph, D., Washington U...

Faster, more cost-effective DNA test for crime scenes, disease diagnosis

... Scientists in Japan are reporting development of a faster, less expensive version of the fabled polymerase chain reaction (PCR) a DNA test widely used in criminal investigations, disease diagnosis, biological research and other applications. The new method ...

Molecular typesetting -- proofreading without a proofreader

...ular machines called RNA polymerases. "The RNA polymerase acts like an old fashioned newsprint typesetter, c...y assembling letters one at a time. Similarly, RNA polymerase constructs RNA by reading the DNA and adding new l... explains Dr Cohen. There's no way for the RNA polymerase to ensure that the correct letter is always incorp...

DNA template could explain evolutionary shifts

...g the hydrogen bonds between the A T and G C base pairs. The two separating strands become the replication fork. On one strand, an enzyme called DNA polymerase reads the genetic material in the strand as a template and makes a strand of complementary DNA to pair to it. Again, the code is A to T and C to G. Th...

New piece found in the puzzle of epigenetics

...the fine regulation of the cell nucleus enzyme RNA polymerase II. This transcribes the genetic information of th... basis for protein synthesis. At the same time RNA polymerase II is also responsible for the production of other...gues had observed that a certain region of the RNA polymerase II enzyme the carboxy-terminal domain is involve...

TRAPping proteins that work together inside living cells

...A polymerase, a well-studied machine in cells. The polymerase is made up of many proteins that cooperate to translate DNA. One of the polymerase proteins has a tail that is known to touch the DNA and some helper proteins just before the polymerase starts translating. No one knew if this tail -- al...
Polymerase in Biological Technology

Real-Time Quantification of Genomic DNA Using DyNAzyme II DNA Polymerase and SYBR Green I Dye

Mimi Amutan and David Batey, Ph.D. Abstract Real-time quantification was performed for lambda and human genomic DNA on the DNA Engine Opticon system (MJ Research). DyNAzyme II DNA polymerase* was used for amplification, and SYBR Green I fluoresc...

Challenge the Performance of Your Hot-Start PCRs with FastStart Taq DNA Polymerase and the Novel FastStart High Fidelity PCR System

The FastStart Taq DNA Polymerase FastStart Taq DNA Polymerase, a chemically modified version of Taq DNA Polymerase for hot start PCR, was introduced in 2000. Based on the feedback f...

C. therm. Polymerase for Reverse Transcription in Two-Step RT-PCR

Polymerase for two-step RT-PCR amplification of up to 4 kb targets Cat. No. 2 016 311 300 units Description C. therm. Polymerase provided by Roche Applied Science is the recombinant form ...

C. therm. Polymerase One-Step RT-PCR System

for one-step RT-PCR amplification of up to 3 kb RNA targets Cat. No. 2 016 338 50 reactions Cat. No. 2 016 346 250 reactions Description The system contains a unique enzyme blend of C. therm....

The Use of MasterTaq Polymerase for PCR with Humic Material-Contaminated DNA

Katrin Ravenschlag Max-Planck-Institute for Marine Microbiology, Celsiusstr.1, 28359 Germany Phone: ++49-421-2028-936, Fax: ++49-421-2028-580, email: kravensc@mpi-bremen.de Introduction Direct extracti...

Unique Enhanced DNA Polymerase Delivers High Fidelity and Great PCR Performance

Improve reliability of PCR reactions with Herculase enhanced DNA polymerase Michael Borns Holly Hogrefe Stratagene Stratagene recently released Herculase enhanced DNA polymerase,* , a novel enzyme formulation that provides superior performance in both routine and...

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Polymerase in Biological Products

Mouse Anti-Bacteria RNA polymerase sigma 70 Monoclonal Antibody, Unconjugated, Clone 2G10 from ABR-Affinity BioReagents

Description: RNA polymerase sigma 70 Immunogen: Recombinant, full length protein. Storage: -20 C, Avoid Freeze/Thaw Cycles...
Company:ABR-Affinity BioReagents

T7 RNA Polymerase from New England Biolabs

Description: Request Info...
Company:New England Biolabs

GoTaq Flexi DNA Polymerase from Promega

Description: ...
Company:Promega

Taq DNA Polymerase from QIAGEN

Description: ...
Company:QIAGEN

Chicken Anti-Human DNA-directed RNA Polymerase II 7.6 Kd Polypeptide (POLR2L) Polyclonal Antibody, Unconjugated from Lifespan Biosciences

Description: Chicken Anti-Human DNA-directed RNA Polymerase II 7.6 Kd Polypeptide (POLR2L Polyclonal AntibodyOther Sub-Family: not assigned-Other Applications: ELISA, Western Blot...
Company:Lifespan Biosciences

NovaTaq DNA Polymerase from Novagen

Description: NovaTaq DNA Polymerase is a premium quality recombinant form of Thermus aquaticus DNA polymerase. This thermostable enzyme is suitable for a wide range of PCR applications. To ensure the highest purity and reproducible performance, each preparation is extensively tested in a variety of quality cont...
Company:Novagen

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Polymerase in Biological Definition

Cloning

...eticists at the Australian Museum announced that they had replicated DNA of the Thylacine (Tasmanian Tiger), extinct about 65 years previous, using polymerase chain reaction (PCR) [3] . However, on February 15 2005 the museum announced that it was stopping the project after tests showed the specimens' ...

DNA

...n be easily separated by enzymes . Enzymes known as helicases unwind the strands to facilitate the advance of sequence-reading enzymes such as DNA polymerase . The unwinding requires that helicases chemically cleave the phosphate backbone of one of the strands so that it can swivel around the other. The str...

Enzyme

...th the word ending in "-ase". Examples are alcohol dehydrogenase and DNA polymerase . Kinases are enzymes that transfer phosphate groups. The Internationa...imilar compounds Phenylalanine hydroxylase (PAH): Phospholipase polymerase : builds long chains of nucleic acid polymers from their constituents ...

Genetic fingerprinting

...omparing individual samples of DNA. One of the most modern and widely accepted methods for producing DNA fingerprints in criminal cases, is that of polymerase chain reaction (PCR). PCR involves the amplification of specific regions of DNA that are known to be highly variable from one individual to another. ...

Genetics

...orking independently. Sanger's lab complete the entire genome of sequence of Bacteriophage Φ-X174; . 1983 Kary Banks Mullis discovers the polymerase chain reaction enabling the easy amplification of DNA 1989 The first human gene is sequenced by Francis Collins and Lap-Chee Tsui , it encodes...

Kary Mullis

... Kary Banks Mullis (born December 28 , 1944 ) is a biochemist . In the 1980s , he invented the polymerase chain reaction (PCR), a central technique in molecular biology which allows the amplification of specified DNA sequences. He was awarded the No...
Polymerase in Biological Dictionary

Polymerase

A polymerase is an enzyme whose central function is associated with polymers of nucleic acids such as RNA and DNA. The primary function of a polymerase is the polymerization of new DNA or RNA against an existing DNA or RNA template in the processes of replication and... RNA polymera...

Taq polymerase

Taq polymerase is a thermostable DNA polymerase named after the thermophilic bacterium Thermus aquaticus from which it was originally isolated by Thomas D. Brock in 1965 . It is often abbreviated to " Taq Pol", and is frequently used in polymerase chain reaction (PCR),... What...

T7 RNA Polymerase

T7 RNA Polymerase is an RNA polymerase that catalyzes the formation of RNA in the 5'→ 3' direction. T7 polymerase is extremely promoter-specific and only transcribes bacteriophage T7 DNA or DNA cloned downstream of a T7 promoter. The T7 polymerase also requires a DNA...

RNA polymerase

RNA polymerase is an enzyme that produces RNA . In cells, RNAP is needed for constructing RNA chains from DNA genes as templates, a process called transcription. RNA polymerase enzymes are essential to life and are found in... RNA polymerase II is an enzyme found in eukaryotic...

DNA polymerase

A DNA polymerase is an enzyme that catalyzes the polymerization of deoxyribonucleotides into a DNA strand. DNA polymerases are best-known for their role in DNA replication, in which the polymerase "reads" an intact DNA strand... DNA polymerase lambda, also known as ...

Transcription start site

...promoter region with ... The transcription start sites of the human FMR1 gene were determined using 5' ... transcription factors, RNA polymerase II in eukaryotes recognizes the start site ... TATA box and the transcription start site . This spacing is characteristic ... ... initi...
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(Date:10/2/2014)... HealthDay Reporter WEDNESDAY, Oct. 1, 2014 ... raise your risk for high blood pressure, a new study ... lived within 109 yards of a busy road had a ... women living at least half a mile away, researchers report. ... of our physical environment on our health and well-being," said ...
(Date:10/2/2014)... HealthDay Reporter WEDNESDAY, Oct. 1, 2014 (HealthDay News) -- ... may face an increased risk of dying in the next several ... older Americans, researchers found those who were unable to detect scents ... as likely to die in the next five years, versus those ... the inability to distinguish odors -- was a bigger predictor of ...
(Date:10/2/2014)... HealthDay Reporter WEDNESDAY, Oct. 1, 2014 (HealthDay ... have a total of 500 confirmed cases of Enterovirus D68, ... since the summer, U.S. health officials reported Wednesday. Four ... but it,s not clear what role -- if any -- ... officials are also trying to determine if the virus is ...
(Date:10/1/2014)... University of Adelaide have developed a model that could ... outcome from treatment - from their very first psychotic ... of factors, including clinical symptoms, cognitive abilities, MRI scans ... blood. , Speaking in the lead up to World ... Psychiatry , Professor Bernhard Baune , says ...
(Date:10/1/2014)... shown that more than 80 per cent of bowel ... study found that medicines called ,JAK inhibitors, halted tumour ... is present in more than 80 per cent of ... are in clinical trials, for diseases including rheumatoid arthritis, ... is the second-most common cancer in Australia with nearly ...
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(Date:9/30/2014)... the environmental effects of moorland burning is published today ... with the aim of relieving tensions on both sides ... EMBER (Effects of Moorland Burning on the Ecohydrology of ... moorland, which is practised predominantly to support red grouse ... peat hydrology, peat chemistry and physical properties, river water ...
(Date:9/30/2014)... The most comprehensive assessment conducted by the Ocean ... out of 100 in overall health. In addition, ... Antarctic and the 15 ocean regions beyond national ... maintaining a healthy climate, safeguarding biodiversity and providing ... update of the index, a partnership led by ...
(Date:9/30/2014)... Calif. The National Institutes of Health (NIH) ... today to develop an electrode array system that ... brain works through unprecedented resolution and scale. , ... to support President Obama,s BRAIN (Brain Research ... research effort to revolutionize our understanding of the ...
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