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Polycythemia in Medical News

New drug for children with high-risk leukemia

...n of the JAK2 in Down syndrome and leukemia causes polycythemia Vera, a disease common in adults that leads to the...wo completely different disorders, one that causes polycythemia in adults and the other that causes leukemia in ch...f JAK2," he says. "And because of the existence of polycythemia in adults, there are already drugs to fight...

Cytopia Lodges IND for JAK2 Inhibitor CYT387

...mplicated in a variety of haematological conditions known as the myeloproliferative disorders (MPDs). This suite of conditions includes myelofibrosis, polycythemia vera and essential thrombocythemia. Cytopia has demonstrated that CYT387 inhibits the overactive JAK2 enzyme in an invivo preclinical model and in cel...

Onyx Pharmaceuticals Acquires Option to License Novel Highly Specific JAK2 Inhibitors From S*BIO

...conditions characterized by an overproduction of blood cells in the bone marrow. The MPD conditions where JAK2 mutations are most commonly found are: polycythemia vera (PV), essential thrombocytopenia (ET), and primary myelofibrosis (MF). The JAK2 signaling pathway is also known to play a critical role in the p...

Experimental Drug Fights Bone Marrow Cancers

...mas Bumm said in a university news release. There are no U.S. Food and Drug Administration-approved targeted treatments for the "big three" MPDs -- polycythemia vera, essential thrombocythemia and primary myelofibrosis. "Based on the efficacy we demonstrated in the mouse model, there is a good chance that C...

Stem cell research leads to potential new therapy for rare blood disorder

...first author on a paper published in PNAS, outlining the discovery that a mutation in the JAK2 signaling pathway in patients with a type of MPD called polycythemia vera (PV) allows cells to bypass the process which would normally regulate the production of red blood cells. As a result of this defect, the bone mar...

OHSU Cancer Institute researcher discovers what fuels certain cancer mutation

...a to grow and cause a red blood cell cancer called polycythemia vera, said principal investigator Thomas Bumm, M.D...g in Atlanta on Monday, Dec. 10, at 3:30 p.m. polycythemia vera is a disease in which there are too many red ... At this point, there is no specific treatment for polycythemia vera cancer patients. Maybe we opened a new door t...

Top Scientists to Receive Prestigious Awards From the American Society of Hematology

...ells in the bone marrow. He was the first to find that a single mutation of the JAK2 gene commonly occurred in patients with three distinct disorders: polycythemia vera, idiopathic myelofibrosis, and essential thrombocythemia, a discovery which has profound implications for potential therapies. Dr. Vainchenker is...

JCI table of contents: Nov. 8, 2007

...new insight into the mechanisms underlying Chuvash polycythemia and should provide a useful tool to assess the eff...uction of red blood cells and that this causes the polycythemia in VhlR/R mice. TITLE: von HippelLindau mutation in mice recapitulates Chuvash polycythemia via hypoxia-inducible factor-2-alpha signaling and...

Abnormality in the Red Blood Count Cell Poses High Risks

...erpret hematocrit test results to improve patient outcomes." Wu and his colleagues set out to evaluate the prevalence of pre-operative anemia and polycythemia and their effects on 30-day post-operative outcomes for veterans. Wu and his team mined data from the Veterans Affairs National Surgical Quality Impro...

Delayed Cutting of Umbilical Cord Has Benefits

...ion that the evidence showed statistically significant lowering of anemia rates in babies who were clamped late, but no real increased risk of serious polycythemia (the opposite of anemia when blood becomes too thick and does not flow well) in those same babies. “The iron stores were increased out to six mont...
Polycythemia in Medical Technology

Cytopia Scientific Presentations on JAK2 Inhibitor Program

...ange of JAK2 related patents. The main focus of the JAK2 program is developing orally available JAK2 inhibitors to treat MPDs including myelofibrosis, polycythemia vera (PV) and essential thrombocythemia (ET). CYT387 is a specific JAK2 inhibitor with excellent potential for safe and efficacious chronic human dosi...

Cytopia Nominates JAK2 Clinical Candidate for Myeloproliferative Disorders

...tration of activity in an in-vivo model of myeloproliferative disease. Myeloproliferative disorders are a group of diseases including myelofibrosis, polycythemia vera (PV) and essential thrombocythemia (ET) that affect over 150,000 patients in the USA and more than twice that worldwide. Over 95% of PV cases and...

TargeGen Announces Initiation of Clinical Trial of JAK2 Inhibitor TG101348 in Myeloproliferative Disease Patients

.../cgi-bin/prnh/20030430/TARGEGENLOGO ) The V617F mutation of JAK2 is implicated in the pathogenesis of certain myeloproliferative diseases, including polycythemia vera (PV), essential thrombocytopenia (ET) and primary myelofibrosis (PMF). In preclinical models of myeloproliferative diseases, TG101348, administer...

Exelixis Presents Encouraging Phase 1 Data For XL019, A Novel Selective Inhibitor of JAK2

...at drive blood cell expansion, including erythropoietin and thrombopoietin. Mutational activation of JAK2 is observed in the majority of patients with polycythemia vera, essential thrombocythemia and myelofibrosis, and is thought to drive the inappropriate expansion of blood cells observed in these conditions. Ot...

TargeGen Announces Planned Initiation of Clinical Trial of JAK2 Inhibitor TG101348 in Myeloproliferative Disease Patients, and Presentations at ASH

...on of JAK2 Driven Erythroid Differentiation of polycythemia Vera -- Animesh Pardanani & Ayalew Tefferi -- Pri...eatment of a Murine Model of JAK2V617F-Induced polycythemia Vera, Session Type -- Betty Tam -- TG101348: A Du... of certain myeloproliferative diseases, including polycythemia vera (PV), essential thrombocytopenia (ET) and pri...

S*BIO to Develop New JAK-2 Inhibitor for Treatment of Myeloproliferative Disorders and Hematological Malignancies

...cies in which the bone marrow develops and functions abnormally. MPD is characterised by an excess of blood cells and the three main disorders include polycythemia vera (excess red blood cell mass), essential thrombocythemia (excess blood platelets) and myelofibrosis. S*BIO is a privately-held biotech company foc...
Polycythemia in Medical Definition

Hematopathology

...Myeloma ( Multiple myeloma , Extramedullary plasmacytoma ) Myeloid : Myeloid leukemia ( AML , CML ) • MPD Ph- ( Essential thrombocytosis , polycythemia vera , Myelofibrosis ) • MDS • Neutropenia Red blood cells / anemia / hemoglobinopathy Nutritional anemia: ( Iron deficiency anemia ,...

Pathology

...Myeloma ( Multiple myeloma , Extramedullary plasmacytoma ) Myeloid : Myeloid leukemia ( AML , CML ) • MPD Ph- ( Essential thrombocytosis , polycythemia vera , Myelofibrosis ) • MDS • Neutropenia Red blood cells / anemia / hemoglobinopathy Nutritional anemia: ( Iron deficiency anemia ,...
Polycythemia in Medical Dictionary

Polycythemia

Polycythemia is a condition in which there is an increase in the proportion of blood volume that is occupied by red blood cells, which is measured as hematocrit level. Comprehensive overview including signs, symptoms, diagnosis, and treatment of this blood disorder, polycythemia v...

Polycythemia vera

... polycythemia vera is a blood disorder in which the bone marrow makes too many red blood cells. polycythemia vera may also result in the overproduction of whi...lets. Most of the health concerns associated with polycythemia vera are caused by a... Fact sheet about ...

Myeloproliferative Disorders

...e three main myeloproliferative disorders are polycythemia vera, essential ... Blood Disorders . Subjec... Three major myeloproliferative disorders are polycythemia vera, myelofibrosis, ... Myeloproliferative ... disorders include chronic myeloid leukemia, polycythemia vera, ... © 2004-2008, The Myeloproliferative ...

Marfan syndrome

... the connective tissue in the body to be weaker than it should be. ... Marfan syndrome can affect both men and women. ... Print All Page for polycythemia Vera Topic ... DCI Home: Heart & Vascular Diseases: Marfan Syndrome : Printer Friendly Summary Page ... Marfan syndrome information inc...

Hyperviscosity

... with plasma cell dyscrasias ... ... with polycythemia is related to hyperviscosity and its associated... ... Introduction· Perinatal Anemia·Perinatal polycythemia and Hyperviscosity Syndrome ... The terms polycythemia and hyperviscosity are often used interchangeab...

Endemic

..., Jentink's duiker (Cephalophus jentinki) and zebra ... Other species considered endemic include chestnut owlet (Glaucidium castaneum) ... This polycythemia is endemic in Chuvashia, whereas its worldwide frequency is very low. ... VHL gene mutation is endemic on Ischia ... Weeds should be rega...
Polycythemia in Biological News

Mutation in blood stem cells provides clues to cancer development

... A mutation in blood stem cells occurs in patients with a blood disorder called polycythemia vera (PV), scientists at the Moores Cancer Center at the University of California, San Diego (UCSD) and the Institute for Stem Cell Biology and Regene...
Polycythemia in Biological Technology

Cytopia Scientific Presentation on JAK2 Inhibitor Program at American Chemical Society Conference

...ge of JAK2 related patents. The main focus of the JAK2 program is developing orally available JAK2 inhibitors to treat MPDs including myelofibrosis, polycythemia vera and essential thrombocythemia. CYT387 is a specific JAK2 inhibitor with excellent potential for safe and efficacious chronic human dosing. I...
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