Eliminating polio requires global, coordinated effort -- Health Affairs article highlights risks, rewards of eradication

...cause weakened live virus strains in the oral vaccine can occasionally mutate and circulate as vaccine-derived poliovirus; Securing stocks of wild poliovirus stored in laboratories all over the world; Promoting effective surveillance and reporting of polio outbreaks; and Making sure countries are pr...

Complete Genomes of All Known Human Rhinoviruses are Published

...which could help to better understand the infection mechanism. Specifically, nearly all the HRVs displayed a hypervariable region in the 5'UTR. In the poliovirus a similar region is found which determines the virulence of that virus, suggesting that this genomic region could determine the pathogenicity of indiv...

Oscar Nominated Films Raise Polio Awareness

...sh, India. And while not addressing polio directly, best picture nominee Slumdog Millionaire graphically depicts the conditions that allow the poliovirus to circulate in India's slums, including poor sanitation, contaminated water, and overcrowding. " The Final Inch shows us why it's critical to w...

The Rotary Foundation's First African Trustee Chair Takes Office

...kistan, Afghanistan, and particularly Nigeria, where a new outbreak of wild poliovirus threatens to spread to neighboring countries. According to WHO Director-General Margaret Chan, 80 percent of children paralyzed by type 1 poliovirus are in Nigeria. "In some parts of the country, more than a quarter of the...

Federal Advisory Committee Votes to Include Newly Licensed Pentacel(R) Vaccine in Vaccines for Children Program

...oids and Acellular Pertussis Adsorbed, Inactivated poliovirus and Haemophilus b Conjugate (Tetanus Toxoid Conjug...on vaccine licensed in the U.S. that includes both poliovirus and Hib vaccine antigens. Pentacel vaccine is appr... Adsorbed. (b) The true name for IPOL vaccine is: poliovirus Vaccine Inactivated. (c) The true name for ActHIB...

FDA Approves KINRIX(TM) - New Combination Vaccine for Children

...t the U.S. Food and Drug Administration (FDA) has approved KINRIX(TM) [Diphtheria and Tetanus Toxoids and Acellular Pertussis Adsorbed and Inactivated poliovirus Vaccine], the first combination vaccine to offer protection against diphtheria, tetanus, pertussis and polio diseases in one shot. "Children 4 to 6 ...

US FDA licenses Sanofi Pasteur's new pediatric combination vaccine, pentacel

...iphtheria and Tetanus Toxoids and Acellular Pertussis Adsorbed, Inactivated poliovirus and Haemophilus b Conjugate (Tetanus Toxoid Conjugate) Vaccine. Pentacel&re...accine for use in infants and young children in the U.S. that includes both poliovirus and Hib antigens. Pentacel® vaccine is approved for administration as...

U.S. FDA Licenses Sanofi Pasteur's New Pediatric Combination Vaccine, Pentacel(R)

...oids and Acellular Pertussis Adsorbed, Inactivated poliovirus and Haemophilus b Conjugate (Tetanus Toxoid Conjug... and young children in the U.S. that includes both poliovirus and Hib antigens. Pentacel(R) vaccine is approve... Adsorbed. (c) The true name for IPOL vaccine is: poliovirus Vaccine Inactivated. (d) The true name for ActHIB...

Rotary International and Gates Foundation Together Commit $200 Million to Eradicate Polio

...p up to meet the challenge." Most of the initial $100 million will be spent in support of mass immunization campaigns in polio-affected countries, poliovirus surveillance activities and community education and outreach. The grant will also support an expanded research agenda on ways to halt the spread of th...

India Records Substantial Decline in Polio Cases

... last six months - the longest period so far. 'Though the type 3 polio virus cases are up slightly, they remain restricted to the region. The poliovirus transmission has also been low in Bihar,' Ramadoss told IANS last week. The minister said frequent immunisation rounds using a monovalent pol...

Poliovirus in Medical Technology

ViroDefense Inc Announces Selection of Poliovirus Antiviral Preclinical Candidate

Compound Emerged from Technology Licensed from Schering-Plough Research Institute ROCKVILLE, Md., June 3 /PRNewswire-FirstCall/ -- ViroDefense Inc today announced that it has chosen to advance a compound licensed to ViroDefense Inc by Schering-Plough Corporation i...

Researchers Use Poliovirus to Destroy Neuroblastoma Tumors in Mice

PHILADELPHIA, March 15, 2007-- The cause of one notorious childhood disease, poliovirus, could be used to treat the ongoing threat of another childhood disease, neuroblastoma. In the March 15 issue of Cancer Research, researchers from Stony Brook University report that an attenuated -- or non-viru...

New Data Show That GlaxoSmithKline's Rotarix(R) Could Be Given With Other Routine Infant Vaccines in the U.S.

...e doses of the currently recommended infant vaccines, Pediarix(R) (Diphtheria and Tetanus Toxoids and Acellular Pertussis, Hepatitis B and Inactivated poliovirus Vaccine), Prevnar(R) (Pneumococcal 7-valent Conjugate Vaccine) and ActHIB(R) (Haemophilus b Conjugate Vaccine), at two, four, and six months of age wi...

Costs of Eradicating Poliomyelitis Now Are Much Lower Than Trying to Control It Later

... dynamic modelling technique based on current wild poliovirus endemic areas of India. The results show the impor...tudy of the efficacy of the monovalent oral type 1 poliovirus vaccine (moPV1). This vaccine was developed in 2005 to tackle persistent poliovirus transmission in the last remaining infected countr...

GlaxoSmithKline’s Hib-MenCY-TT Combination Vaccine Meets Phase II Study Endpoints of Immunogenicity and Safety Compared to Licensed Vaccines

...ntly with DTaP-Hep B-IPV (Pediarix ® Diphtheria and Tetanus Toxoids and Acellular Pertussis Adsorbed, Hepatitis B (Recombinant) and Inactivated poliovirus Vaccine Combined ) and pneumococcal 7-valent conjugate vaccine (Prevnar ® Pneumococcal 7-valent Conjugate Vaccine Diphtheria CRM Protein ). A se...

Poliovirus in Medical Dictionary

Polio

...irtually ... At the height of the polio epidemic in 1952, nearly 60,000 cases with more than ... In the remaining polio endemic countries, poliovirus is mainly passed through ... Such individuals will not develop polio , but can carry the virus in their ... The polio virus enters the body...

Poliomyelitis

...y in the United States when a ... More on poliomyelitis from Fact Monster: ... Poliomyelitis or polio is an infection of the nerves by the poliovirus resulting ... Poliomyelitis is a disorder caused by a viral infection. ... ...

Poliovirus in Biological News

Scripps research team solves structure of 'beneficial' virus

...th it is arranged in a round mesh rather like a whiffleball. "It is not at all like other known picornaviruses that we are familiar with, including poliovirus and rhinoviruses, which cause the common cold," says the study's senior author, Associate Professor Vijay S. Reddy, Ph.D., of The Scripps Research Ins...

Discovery may help defang viruses

... research associates, have identified a key amino acid in the polymerase of poliovirus that controls the speed and accuracy with which the virus is able to multip... is optimized; there is a delicate balance. We have defined the optima for poliovirus but where that balance is going to be for different viruses, we do not yet ...

Tips from the Journals of the American Society for Microbiology

...Animal Model Developed for Oral Infection of Human poliovirus For the first time researchers have developed an animal model for oral poliovirus infection. They report their findings in the August 2007 issue of the Journal of Virology. poliovirus causes acute disease in the central nervous system...

Billions of dollars saved in US by polio vaccination

...ings to society." Although the last case of paralytic polio from wild poliovirus occurred in the U.S. in 1979, poliovirus outbreaks currently still occur around the world and American children cont...

Polio vaccination strategies assessed as eradication nears

...ne systems were weakened by HIV would re-introduce poliovirus into the community. The other study looks at the ...r the use of OPV, however, because vaccine-derived poliovirus (VDPV) can occasionally cause another form of poli...ut of a total of 419 adults with HIV infection, no poliovirus was isolated from any of the specimens. Because o...

New Vaccine To Be Used For First Time In Polio Outbreak Response

...w vaccine enables a precisely tailored immunological response to the type 1 poliovirus that is causing the outbreak. Compared to the commonly-used trivalent OPV, ... types of wild poliovirus, mOPV1 provides a greater immunity to type 1 wild poliovirus with fewer doses. Use of mOPV1 is expected during a nationwide immunization...

UN pours polio vaccine into Yemen amid outbreak

... As Yemen geared up for an end-of-month nationwide campaign to immunize all children under 5 against a fast-moving paralytic poliovirus outbreak, the United Nations Children's Fund (UNICEF) said it was shipping in 6 million doses of polio vaccine. In addition, 10 experts from the Wo...

Poliovirus in Biological Technology

Sanofi Pasteur Responds to Nation's Need for Hib Vaccine With Increased Supply

...ination through the use of its two Hib-containing vaccines: Pentacel(R) (Diphtheria and Tetanus Toxoids and Acellular Pertussis Adsorbed, Inactivated poliovirus and Haemophilus b Conjugate [Tetanus Toxoid Conjugate] Vaccine) and ActHIB(R) (Haemophilus b Conjugate Vaccine [Tetanus Toxoid Conjugate]). "Sano...

Tips from the journals of the American Society for Microbiology

...hen compared with a benchmark alcohol-based hand sanitizer, results showed higher levels of reduced infectivity of human rotavirus, adenovirus type 5, poliovirus type 1, and norovirus, as well as feline calicivirus and murine norovirus type 1 from the new ethanol-based sanitizer. "Based on these results...

Tips from the journals of the American Society for Microbiology

...hen compared with a benchmark alcohol-based hand sanitizer, results showed higher levels of reduced infectivity of human rotavirus, adenovirus type 5, poliovirus type 1, and norovirus, as well as feline calicivirus and murine norovirus type 1 from the new ethanol-based sanitizer. "Based on these results...

Tips from the journals of the American Society for Microbiology

...hen compared with a benchmark alcohol-based hand sanitizer, results showed higher levels of reduced infectivity of human rotavirus, adenovirus type 5, poliovirus type 1, and norovirus, as well as feline calicivirus and murine norovirus type 1 from the new ethanol-based sanitizer. "Based on these results...

CDC Immunization Advisory Committee Recommends Two New Pediatric Vaccines from GlaxoSmithKline

...s and Acellular Pertussis Adsorbed and Inactivated poliovirus Vaccine] recommended for vaccination of children t...s and Acellular Pertussis Adsorbed and Inactivated poliovirus Vaccine], in the childhood immunization program. R...ertussis (DTaP) and the fourth dose of Inactivated poliovirus (IPV). KINRIX is the first approved combination ...

Tips from the Journals of the American Society for Microbiology

...Animal Model Developed for Oral Infection of Human poliovirus For the first time researchers have developed an animal model for oral poliovirus infection. They report their findings in the August 2007 issue of the Journal of Virology. poliovirus causes acute disease in the central nervous system...

Efficient Cloning and Electro-transformation of Large Eukaryotic DNA Fragments

... 6. Sedivy, J. M., Capone, J. P., RajBhandary, U. L., and Sharp, P. A., An inducible mammalian amber suppressor: propagation of a poliovirus mutant, Cell, 50 , 379389 (1987). 7. Yanisch-Perron, C., Vieira, J., and Messing, J., Improved M13 phage cloning vect...

Poliovirus in Biological Definition

Virus classification

... Luteoviridae Family Marnaviridae Family Narnaviridae - naked RNA viruses Family Nodaviridae Family Picornaviridae - e.g. poliovirus , Rhinovirus , Hepatitis A virus Family Potyviridae Family Sequiviridae Family Tetraviridae Family Togaviridae - e.g. ...