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Platelets in Medical News

Children's National Research Links Platelets to Sepsis-Related Organ Failure

Conventionally thought to be the bloodstream's "innocent bystanders," platelets may actually play a more sinister role in organ failure caused by severe sepsis Washington, DC (Vocus) March 11, 2009 -- Scientists at Children's National Medical Center have ide...

GenPrime Initiates External Clinical Trials of its Bacterial Contamination Test for Rapid Detection of Bacteria in Platelets

SPOKANE, Wash., Oct. 17 /PRNewswire/ -- GenPrime, Inc. a leading provider of rapid microbial analysis technologies, has initiated multi-site clinical trials of its Bacterial Contamination Test for Platelets(TM). The test is a rapid QC device for detecting the presence of aerobic and anaerobic ...

Gel Made of Patients Own Platelets may Speed Up Wound Healing

A preliminary study has suggested that topical application of a gel made from platelets in healthy individuals own blood may help wounds heal more quickly and completely . Recent innovations have led to devices that can process blood into a concentrated plasma rich in platelets (particles i...

Quality Platelets and Improved Blood Availability No Longer a Pipe Dream

Canada: There is good news for patients afflicted by cancer, open heart surgeries, and victims of disaster, bone marrow donees and several others who are in need of blood platelet transfusions. A device, invented by a researcher // at the University of British Columbia's Centre for Blood Research ...

Effient(TM) is Now Available in Pharmacies

...to have multiple options for treating heart disease given how pervasive and costly this condition is in our society." Effient helps keep blood platelets from clumping together and developing a blockage in an artery. Taking Effient along with aspirin after PCI has been shown to reduce the chances of hav...

Next-Generation Hemostatic Dressing Available for Military Emergencies

...the dressing, offering a local hemostatic solution. The chitosan in ChitoGauze, without the addition of pro-clotting agents, binds red blood cells and platelets on the dressing's surface which provides localized clotting, independently from the normal clotting cascade. Localized clotting mitigates risk of embo...
Platelets in Medical Technology

Portola Announces Data Showing Its Anti-Platelet Drug Inhibits Platelets in Clopidogrel (Plavix(R)) Non-Responders

- Direct-Acting PRT060128 Provides Reversible, High-level Platelet Inhibition with Immediate Onset of Action - NEW ORLEANS and SOUTH SAN FRANCISCO, Calif., Nov. 12 /PRNewswire/ -- Portola Pharmaceuticals, a biopharmaceutical company developing innovative drugs that provide sign...

Cephalon Provides Clinical Update on Lestaurtinib in Relapsed Acute Myelogenous Leukemia

...nduces cell death (apoptosis). In myeloproliferative disorders, mutations in JAK2 may play a role in allowing large numbers of abnormal blood cells or platelets to grow and spread in the bone marrow and the rest of the body. Based on its potential to inhibit this activity, lestaurtinib is in ongoing studies fo...

Trius Announces Positive Results From Phase 2 Clinical Trial of Torezolid in Patients With Complicated Skin and Skin Structure Infections

...cebo while the labeled dose of linezolid produced the expected depletion of platelets and other cell lines. It is also encouraging that the efficacy of the 200 m...icant shifts from baseline in hematology or chemistry parameters, including platelets or liver enzymes. "The efficacy and safety of torezolid in this trial...

Video: Data on More Than 15 Novartis Oncology Compounds at ASCO Highlight Progress Toward Targeted Therapies for Diverse Tumor Types

...tolerated dose and pharmacokinetics of everolimus(3). The Grade 3 and 4 adverse events reported in the study included elevated bilirubin, drop in platelets count, diarrhea, bleeding, cardiac ischemia, elevated liver function tests and infection. Reactivation of Hepatitis B virus was observed in four patie...

New Analysis Evaluated Impact of Genetic Variation on Response to Prasugrel

... activation and subsequent aggregation by blocking the P2Y12 adenosine diphosphate (ADP) receptor on the platelet surface. Antiplatelet agents prevent platelets from clumping or sticking together, which can result in clogged arteries and may lead to heart attack or stroke. About Daiichi Sankyo A gl...

New Study Suggests Rx Estrogen Delivery Through the Skin May Show Safety Benefits as Opposed to Oral Delivery

...trogen therapy and whether to take it orally or through the skin." The research team studied platelet activity in the study participants' blood. platelets serve a central role in forming pathological arterial thrombosis that causes myocardial infarction and stroke. The study's authors further concluded ...
Platelets in Medical Products

BloodSTOP Hemostatic Gauze

Description:...final treatment or temporary control, BloodSTOP safely and quickly stops bleeding. When BloodSTOP comes in contact with blood, it interacts with blood platelets and fibrin to form a hemostatic matrix - a gelatinous clear shield that seals the wound and stops bleeding quickly and safely. In situations requirin...
Company:LifesciencePlus

PFA-100 System

Description:...n the rapid, detection of platelet dysfunction. It is the first commercially available in vitro system that uniquely simulates the in vivo function of platelets in primary hemostasis. The system measures platelet function under high shear conditions similar to the environment of a partially occluded blood vess...
Company:Dade Behring, Inc.

ADVIA 2120 Hematology System

Description:...ase states, including those associated with anemia. Two dimensional optical platelets analyze both extra-cellular and intracellular properties, ensuring that large platelets are included in your counts, and known interferences are not. Flexible samp...
Company:Siemens Medical Solutions Diagnostics

VerifyNow IIb/IIIa Assay

Description:...telet function based upon the ability of activated platelets to bind to fibrinogen coated beads. The detection ... receptors. The GP IIb/IIIa receptors on activated platelets will bind to the fibrinogen-coated microbeads and ...icrobeads resulting in a clearing of the beads and platelets within the detection well. The instrument uses lig...
Company:Accumetrics

VerifyNow System

Description:... stroke, and other vascular events by causing platelet dysfunction, so that platelets will not aggregate. Over 20 million people in the U.S. alone take aspirin daily to prevent platelets from clotting. Clinical data shows that not all patients receive the full b...
Company:Accumetrics

INSTAT Collagen Absorbable Hemostat

Description:...protein. The helical structure of native collagen is preserved during the manufacture of INSTAT Hemostat. When collagen comes into contact with blood, platelets aggregate on the collagen and release coagulation factors which, together with plasma factors result in the formation of fibrin, and finally in the fo...
Company:Ethicon, Inc.
Platelets in Medical Definition

Hematopathology

...xysmal nocturnal hemoglobinuria ) • Aplastic anemia : ( Acquired pure red cell aplasia , Fanconi anemia ) • Hemochromatosis Coagulation / platelets DIC • Hemophilia ( A , B , C ) • Von Willebrand disease • Purpura ( Henoch-Schönlein , ITP , TTP ) other Methemoglobinemia - ...

Pathology

...xysmal nocturnal hemoglobinuria ) • Aplastic anemia : ( Acquired pure red cell aplasia , Fanconi anemia ) • Hemochromatosis Coagulation / platelets DIC • Hemophilia ( A , B , C ) • Von Willebrand disease • Purpura ( Henoch-Schönlein , ITP , TTP ) other Methemoglobinemia - ...
Platelets in Medical Dictionary

Thrombosis

...t (thrombus) inside a blood vessel, obstructing the flow of blood through the circulatory system. When a blood vessel is injured, the body uses platelets and fibrin to form a blood clot, because the first step in repairing it... ... answers to questions about the causes and symptoms of deep v...

Thrombocyte

... erythrocyte, reticulocyte, thrombocyte , platelet, leukocyte, ... blood platelets ( thrombocytes ) : see lab section on erythrocytes ... Zoology informat... Platelet count - Risks, A platelet count is a test to measure how many platelets ... Thrombocyte count. What the risks are: There is very little risk invo...

Thrombocytopenia

...as a low number of blood cell fragments called platelets (PLATE-lets) The condition can be inherited (p...rn about thrombocytopenia , a decreased number of platelets in the blood. ... Platelet counts less than 150,00.... Thrombocytopenia is an abnormally low level of platelets in the blood. ... thrombocytopenia . thromboc...

Platelet

...s a Brief and Straightforward Guide: What are platelets ? ... What is a Blood Platelet Count? What Shoul...g a Bone Marrow Test? ... How to Increase Low platelets . Low platelets , or thrombocytopenia, can cause excessive bleedi...

Platelet count

...A platelet count is a test to measure how many platelets you have in your blood. ... Drugs that can lower ...is a diagnostic test that determines the number of platelets in ... Platelet Count Health Article. Save Ema...is a diagnostic test that determines the number of platelets in ... The primary functions of a platelet co...

Monocyte

...s plaques. J. Clin. Invest. ... Britannica online encyclopedia article on monocyte (biology), ...from the lungs and deliver it to the tissues; platelets participate in forming blood clots; ... These monocyte -derived cells then acquire the characteristics of mature DC, ... The monocyte -derived...
Platelets in Biological News

Children's National research links platelets to sepsis-related organ failure

WASHINGTON, DCScientists at Children's National Medical Center have identified a previously unknown contributor to organ failure in patients suffering from sepsis: platelets. The finding, published in the American Journal of Respiratory and Critical Care Medicine , is the first time doctors...

Researchers tap into a new and potentially better source of platelets for transfusion

Clot-forming blood cells, or platelets, can drop to dangerously low levels in diseases such as anemia and in patients undergoing chemotherapy. To replace these critical cells, doctors filter platelets from donated blood, but this approach can increase the risk of transmitting blood infections and ...

Researchers explore new driver of transplant rejection: Platelets

Platelets, tiny and relatively uncharted tenants of the bloodstream known mostly for their role in blood clotting, turn out to also rally sustained immune system inflammatory responses that play a critical role in organ transplant rejection, according to a new report from Johns Hopkins scientists....

How cancer spreads by aggregating platelets

BETHESDA, Md. Scientists have provided new details about how cancer cells spread by surrounding themselves with platelets the blood cells needed for blood clotting. Katsue Suzuki-Inoue, Associate Professor of Medicine at the University of Yamanashi, Japan, and colleagues have identified for the ...

American Chemical Society's weekly PressPac -- May 27, 2009

...cribe development and lab testing of silver nanoparticles that seem to keep platelets in an inactive state. Low levels of the nanosilver, injected into mice, reduced the ability of platelets to clump together by as much as 40 percent with no apparent harmful side ef...

Genetic factors may predict depression in heart disease patients

...rs to have a significant association. vWF is a protein produced by the endothelium that is critical to the initial stages of blood clotting by helping platelets stick to damaged blood vessels. When elevated in concentration, VWF is a strong predictor of endothelial dysfunction and a risk factor for atheroscler...
Platelets in Biological Technology

Improving Transfusion Safety: Fenwal, Verax Biomedical Sign Agreement for Rapid, Point-of-Care Bacteria Test

...platelet doses are transfused annually worldwide. platelets are tiny cells in blood that help blood clot. They are transfused when platelets levels are low - as, for example, a result of illn...ria, and up to 50 percent of bacteria-contaminated platelets may escape detection by conventional culture testi...

Former Secretary of Veterans Affairs James Peake to Join the Cellphire Board of Directors

...ective in stopping uncontrollable bleeding on the battlefield or in trauma. platelets can only be stored for 5 days and cannot be provided to combat zones, altho...arkets. Current efforts and product development are aimed toward stabilized platelets for advanced wound care, transfusion, and reagent products for clinical and...

Multiple Types of Heart Attacks Reduced by Prasugrel in TRITON-TIMI 38 Trial

... activation and subsequent aggregation by blocking the P2Y12 adenosine diphosphate (ADP) receptor on the platelet surface. Antiplatelet agents prevent platelets from clumping or sticking together, which can result in clogged arteries and may lead to heart attack or stroke. About Daiichi Sankyo A glob...

Dozens of New Clean Technology and Nanotech Products Unveiled at TechConnect World Expo in Houston, Texas, May 5-6

... Nanotech '09 News Announcements: Angstron Materials (booth 1506): is announcing the development of new nano graphene platelets (NGPs), which are cost effective, high performance alternatives to carbon nanotubes (CNTs). Angstron is the first company to isolate single-layer and...

European Commission Approves EFIENT(R) (prasugrel) for Patients with Acute Coronary Syndrome Undergoing PCI

...lotting, from sticking or clumping together. By blocking a specific receptor (P2Y12 adenosine diphosphate) on the platelet surface, prasugrel prevents platelets from clumping, which can result in clogged arteries and may lead to heart attack. "The approval of Efient helps to meet an important medical nee...

Cascades Technologies, Inc. Chosen to Deliver IT Support on a DoD Blast Injury Research Program

...simulation of blast-induced brain injuries to improve the design of personal protective equipment, development of a prototype agent using freeze-dried platelets that improves clotting time and clot strength to facilitate wound-healing, procedures and products that may lengthen amputated fingers and restore fun...
Platelets in Biological Products

Mouse Anti-Human Integrin alpha 2b / beta 3 Monoclonal Antibody, Unconjugated, Clone CRC64 from Abcam

Description:... Mouse monoclonal [CRC64] to Integrin alpha 2b + beta 3 ( Abpromise for all tested applications). Antigen: Human platelets Entrez Gene ID: 23295 Swiss Protein ID: P05106...
Company:Abcam

Human / Mouse / Rat Blood Vessels (CD31 / Von Willebrand Factor (vWF)) IHC staining Kit from CHEMICON

Description:...von Willebrand Factor (Factor VIII Related Antigen) and CD31 (PECAM-1). von Willebrand Factor is synthesized by endothelial cells, causing adhesion of platelets to injured vessel walls and functions as a carrier and stabilizer for coagulation of Factor VIII. CHEMICONs von Willebrand Factor antibody reacts spec...
Company:CHEMICON
Platelets in Biological Definition

Blood

...sed of fluid plasma and cells ( red blood cells , white blood cells , platelets ). Medical terms related to blood often begin in hemo- or hemato- ( BE ...3.0%), are part of the immune system ; they destroy infectious agents. platelets or thrombocytes (1.0%) are responsible for blood clotting or coagulation...

Full blood count

...3 Results from a blood count 3.1 Red cells 3.2 White cells 3.3 platelets Automated blood count Blood for a FBC is usually taken into ...in peripheral blood, but may be released in certain disease processes. platelets Platelet numbers are given, as well as information about their size a...

Nephron

... the capillaries squeezes liquid into the Bowman's capsule . This process is known as ultra-filtration. The solids, including the blood cells , platelets , and large proteins , stay behind. The liquid, known as glomerular filtrate , contains water , glucose , salt , amino acids , and urea . ...
Platelets in Biological Dictionary

Platelets

Platelets , or thrombocytes, are small, irregularly-shaped anuclear cells, 2-4 µm in diameter, which are derived from fragmentation of precursor megakaryocytes.  The average lifespan of a platelet is between 8 and 12 days. ... A 250 ml bag of newly collected platelets . ... Each unit of pl...

Thrombocytes

... for all of the latest information on leukemia ... platelets (also called thrombocytes ) help form blood clots...ura (ITP) is a bleeding condition in which the ... platelets also are called thrombocytes (THROM-bo-sites) ..... to run some blood work ... cells), the number of platelets ( thrombocytes ), the hemoglobin level, and the...

Sarcoplasmic reticulum

... smooth and striated muscle. ... The sarcoplasmic reticulum contains large stores of calcium, ... sarcoplasmic reticulum and human blood platelets using a monoclonal antibody, FIIlb5. ... The 190 kDa platelet and sarcoplasmic reticulum proteins were ... The sarcoplasmic reticulum ...

Red blood cells

... cells . ... Each unit of packed red blood cells administered to an adult is expected to ... red blood cells (RBCs) or erythrocytes. platelets or thrombocytes ... Red blood cells have surface antigens that differ between people and that create ... The capitalized term Red Blo...

Phagocytes

...rimarily ... SEARCH: Advanced. Phagocytes . Citations 1-10 of 972 total displayed. ... Phagocytes . Phagocytes , Granulocytes, and Myelopoiesis. platelets and Thrombopoiesis ... Phagocytosis Greek -phagos, one that eats; kytos, cell, process of ingestion of matter by cells known, in this context, as...

Oxygenated blood

... in the body to help fight diseases and help stabilize body temperature and pH to... blood n. The fluid consisting of plasma, blood cells, and platelets that is ... oxygenated blood in the arterial side of the circulation between the cardiac ... ... of blood to the brain Understanding how the...
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