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Plasmids in Medical News

Therapeutic vaccines

...e Fraunhofer Institute for Cell Therapy and Immunology IZI in Leipzig have developed the DNA vaccine. "In this type of vaccine, DNA molecules known as plasmids extracted from the pathogen are used for inoculation, instead of the whole virus. They contain the genetic code for the antigens that stimulate the bo...

How to select anti-hepatitis B virus agents for drug-resistance patients?

...erted into an universal HBV expression vector respectively. The recombinant plasmids containing 1.1 copies of HBV genome were transient transfected into Huh7 ce...mivudine-resistance were cloned into HBV expression vector, and recombinant plasmids were transcient transfected into Huh7 cells. The results indicated that HB...

Vical to Present Phase 1 Data for Vaxfectin(R)-Formulated Pandemic Influenza DNA Vaccines

...esponses against the H5 protein, but could elicit T-cell responses against H5 as well. Vical's trivalent vaccine contains the H5 plasmid plus separate plasmids encoding consensus sequences of two highly-conserved influenza virus proteins: nucleoprotein (NP) and ion channel protein (M2). The trivalent vaccine ...

What is the more suitable for early detection of low abundant lamivudine-resistant mutants?

...Gastroenterology (volume 14, issue 1) addresses this question. It compared LDR and real-time PCR for detection of low abundant YMDD mutations in mixed plasmids and serum samples from 52 lamivudine treated patients. Time required and reagent cost for both assays were evaluated. The research was conducted caref...

Researchers solve first structure of a key to intact DNA inheritance

...asmids, they represent wonderful drug targets." plasmids are additional strips or circles of DNA found in b...se - in this case, protection against antibiotics. plasmids can be transferred from one type of bacteria to another through a number of mechanisms. plasmids are also a great model for understanding cell divi...

Vical Expands Clinical Testing of DNA Vaccine Against H5N1 Pandemic Influenza

...vaccines for the prevention of pandemic influenza, and in pursuing potential future vaccine applications." Vical's vaccine contains three individual plasmids encoding consensus sequences of two highly-conserved influenza virus proteins -- nucleoprotein (NP) and ion channel protein (M2) -- and a hemagglutini...
Plasmids in Medical Technology

Vical Pandemic Influenza Vaccines Achieve T-Cell Responses and Cross-Clade Reactivity in Humans

...responses against the H5 protein but could elicit T-cell responses against H5 as well. Vical's trivalent vaccine contains the H5 plasmid plus separate plasmids encoding consensus sequences of two highly conserved influenza virus proteins: nucleoprotein (NP) and ion channel protein (M2). The trivalent vaccine...

Vical Announces Breakthrough for Pandemic Influenza DNA Vaccines With Preliminary Human Data

...responses against the H5 protein but could elicit T-cell responses against H5 as well. Vical's trivalent vaccine contains the H5 plasmid plus separate plasmids encoding consensus sequences of two highly conserved influenza virus proteins: nucleoprotein (NP) and ion channel protein (M2). The trivalent vaccine ...

Senesco Chooses VGXI to Produce Factor 5A Plasmid

...l data has shown, should cause cancer cells to enter apoptosis, or programmed cell death. "VGXI's manufacturing and technical expertise in producing plasmids for Senesco's planned toxicology study and ultimately our clinical trial led us to choose them. We are pleased to be working with a company that has s...

Bad News to Bad Bugs: Northern Antibiotics Develops Novel Polymyxins With Reduced Toxicity

...bapenems, aminoglycosides and fluoroquinolones has been reported in K. pneumoniae. One does not need to be very smart to guess what follows when these plasmids become more common and the resulting extremely multidrug-resistant strains start to spread." About Northern Antibiotics Ltd. Founded in 2003 and h...

Vical Begins Phase 1 Trial of DNA Vaccine Against H5N1 Pandemic Influenza

...ant, which has potential applications with both pDNA vaccines and conventional protein-based vaccines." Vical's vaccine contains three individual DNA plasmids encoding consensus sequences of two highly-conserved influenza virus proteins -- nucleoprotein (NP) and ion channel protein (M2) -- plus a hemagglutin...

Inovio Biomedical's Partners to Present New Data from Two Cancer Immunotherapy Clinical Trials

...s. DNA plasmids are designed to express antigens that can induce an immune response specific to a cancer or infectious disease-causing organism. These plasmids are created synthetically and readily manufactured using well-established bacterial fermentation and purification technology. After a plasmid is deliv...
Plasmids in Medical Dictionary

Enterotoxin

...n it; or. Breathing it in. Staphylococcal enterotoxin B as a weapon: It can be released into the air and ... Molecular analysis of enterotoxin plasmids of enterotoxigenic Escherichia coli ... Vascular permeability activity in Escherichia coli heat-stable enterotoxin . ... What is enterotoxin ? M...
Plasmids in Biological News

Evolutionary origin of bacterial chromosomes revealed

...rial species to allow the inference of a general model for bacterial genome evolution. It appears that the transfer of genes from chromosomes to large plasmids mediates second chromosome formation." "Examination of different genome sequences within the Rhizobiales family has revealed that gene migration is...

New insights into a leading poultry disease and its risks to human health

...egies that bacteria use to trade genetic material. plasmids are able to acquire more virulence genes or turn b...ellata and her team have discovered a new way that plasmids use to move from one bacteria to another. This sys...f hijacking the transfer machinery of other helper plasmids present in the same bacteria. To create a vaccin...

NYU scientists discover dangerous new method for bacterial toxin transfer

...me major public health concerns after gaining antibiotic resistance through plasmids transferred from other species. The startling new finding, published in th... along, and the scientists showed in another experiment that staphylococcal plasmids containing antibiotic resistance genes could also be transferred to Listeri...

Photonic crystal biosensors detect protein-DNA interactions

...n-antitoxin system MazEF, which binds to DNA in a sequence-specific manner and is thought to be responsible for the maintenance of resistance-encoding plasmids in certain infectious bacteria. The second was the human apoptosis-inducing factor (AIF), a protein that binds to chromosomal DNA in a DNA-sequence-in...

DOE JGI extends the capabilities of the Integrated Microbial Genome System

...llection. IMG 2.6 contains a total of 4,207 genomes consisting of 1078 bacterial, 56 archaeal, 40 eukaryotic genomes, 2,230 bacterial phages, and 803 plasmids that did not come from a specific microbial genome sequencing project. Among these genomes, 3,737 are finished and 470 are draft genomes. IMG 2.6 cont...

New paradigm for cell-specific gene delivery

...nd Texas A & M University have discovered a new way to limit gene transfer and expression to specific tissues in animals. In studies to determine how plasmids enter the nuclei of non-dividing cells, the group previously identified a region of a smooth muscle cell-specific promoter that was able to mediate nu...
Plasmids in Biological Technology

New Fusion Trans-Activator Plasmids for Studying Signal Transduction Pathways

Study the signal transduction pathway of your choice Li Xu Chao-Feng Zheng Stratagene Cloning Systems, Inc. The PathDetect in vivo signal transduction pathway reporting systems are designed for assessing the in vivo activation of signal transduction pathways. The PathDetect t...

New Reporter Plasmids for Studying Interferon-Stimulated Signal Transduction Pathways

Monitor activation status of interferon-stimulated signaling pathways Li Xu Tim Sanchez Mary Buchanan Chao-Feng Zheng Stratagene Stratagenes family of PathDetect cis-reporting systems now includes the GAS and ISRE reporting systems, to better study the activation of ...

ImmunoVaccine Technologies Partners with FIT Biotech to advance a therapeutic HIV vaccine

...sponse that slows the progression of HIV in infected individuals. IVT's pre-clinical research demonstrates that DepoVax(TM) effectively delivers DNA plasmids into draining lymph nodes with as little as one dose. The DepoVax(TM) platform uses liposomes to encapsulate a target antigen, like GTU(R) MultiHIV, a...

On the trail of rogue genetically modified pathogens

...uish between artificial vector sequences and natural DNA sequences. Natural plasmids and artificial vector sequences have much in common, but these new tools sh...le sequenced artificial vectors with available natural sequences, including plasmids and chromosomes, from bacteria and viruses. The tool clusters the artificia...

Supreme Court limits foreign reach of U.S. patents

... cells to produce the patented protein. Under the Microsoft decision, Company B arguably does not infringe Company A's protein patent because the plasmids actually used to make the protein were not supplied from the United States. Rather, they are foreign made copies of the supplied plasmid. Consequen...

Glossary for The BioPharm Guide to Fermentation and Cell Culture

... in scaling up processes from the laboratory to commercial production. plasmid Hereditary material that is not part of a chromosome. plasmids are circular and self-replicating and found in the cytoplasm of cells (naturally in bacteria and some yeasts). They can be used as...
Plasmids in Biological Products

DNA Sequencing Service from Yorkshire Bioscience Ltd

Description:... DNA sequencing - plasmids or PCR fragments, 3-7 working days service....
Company:Yorkshire Bioscience Ltd

X-GAL (5-Bromo-4-Chloro-3-Indolyl-Beta-D-Galactopyranoside), = 99.0% from AMRESCO, Inc.

Description:... Ultra Pure Grade. Used in conjunction with IPTG to identify bacterial colonies that contain recombinant plasmids by blue/white selection. X-Gal forms an intense blue precipitate in the presence of beta-Galactosidase. Other sizes available....
Company:AMRESCO, Inc.

Origami(DE3) Glycerol Stock from Novagen

Description:...ls were similar (1). Origami hosts are compatible with ampicillin-resistant plasmids and are ideal for use with pET-32 vectors, since the thioredoxin fusion tag...cline, respectively; therefore, this strain is recommended for use with pET plasmids carrying the ampicillin resistance marker bla....
Company:Novagen

Origami(DE3)pLysS Glycerol Stock from Novagen

Description:...ls were similar (1). Origami hosts are compatible with ampicillin-resistant plasmids and are ideal for use with pET-32 vectors, since the thioredoxin fusion tag...cline, respectively; therefore, this strain is recommended for use with pET plasmids carrying the ampicillin resistance marker bla....
Company:Novagen

Site-directed DNA Mutagenesis Service from Yorkshire Bioscience Ltd

Description:... Deletions, insertions or substitutions. Mutations in plasmids of size up to 15 kb. Single or multiple mutations...
Company:Yorkshire Bioscience Ltd

Topoisomerase I (Vaccinia) from Molecular Cloning Laboratories (MCLAB)

Description:...iption in vitro Studying chromatin reconstitution in vitro Determining the degree of supercoiling of naturally occurring DNA Detecting mutant plasmids that differ in length by only one base-pair Increasing restriction endonuclease digestion of resistant DNA substrates by "unwinding" the DNA coils ...
Company:Molecular Cloning Laboratories (MCLAB)
Plasmids in Biological Definition

Bacterium

...a, having acquired DNA from any of these events, can then undergo fission and pass the recombined genome to new progeny cells. Many bacteria harbor plasmids that contain extrachromosomal DNA. Under favourable conditions, bacteria may form aggregates visible to the naked eye, such as bacterial mats . ...

Chromosome

...have one chromosome, while others have a few. Bacterial DNA also exists as plasmids . The distinction between plasmids and chromosomes is poorly defined, though size and necessity are generally ...

Cytoskeleton

...e proteins, and these proteins form a helical network beneath the cell membrane that guides the proteins involved in cell wall biosynthesis . Some plasmids encode a partitioning system that involves an actin-like protein ParM . Filaments of ParM exhibit dynamic instability , and may partition plasmid DNA...

Bacterium

...a, having acquired DNA from any of these events, can then undergo fission and pass the recombined genome to new progeny cells. Many bacteria harbor plasmids that contain extrachromosomal DNA. Under favourable conditions, bacteria may form aggregates visible to the naked eye, such as bacterial mats . ...

Microbiology

... Bacteria and simple eukaryotes contain small circular DNAs , called plasmids . plasmids can be genetically modified in vitro then inserted into bacteria that a...

Phage

...ir genetic material into the chromosomal DNA of the host bacterium (much like endogenous retroviruses in animals) or establishing themselves as plasmids . These endogenous phages, referred to as prophages , are then copied with every cell division together with the DNA of the host cell. They do not...
Plasmids in Biological Dictionary

Zinc finger

...ll target them. ... The Zinc Finger Consortium (www.zincfingers.org) was established to promote ... The information for the 141 zinc finger plasmids is also available as a tab ... Typically three or more zinc fingers are combined in one polypeptide to make a ... What sequence in which DN...

Transposon

... is to a lab dedicated to transposon tagging of genes. ... Britannica online encyclopedia article on transposon (genetics), ...Genes carried on plasmids can find their way onto the bacterial chromosome and become a stable ... DGI leads in applying the zebrafish model organism to determine gene f...

SiRNA

...earcher to specifically inhibit MEK1 expression using RNA interference, a method in which ... siRNA Products ... Chromosome DBase siRNA shRNA plasmids shRNA Lentiviral Transfected Lysates Flow ... Biotechnology now offers siRNA gene silencers targeted ... Small interfering RNA Mediating RNA i...

Recombinant clone

...e Softpedia™ logo are registered trademarks of ... ... Electrophoresis - plasmids - recombinant DNA - clone library - Examples ... a plasmid ( which ...nant plasmid ... 1.1 Cloning and relation to plasmids. 1.2 Chimeric plasmids ... The use of cloning is interrelated with Recombinant DNA in classica...

Plasmid

...rate from the chromosomal DNA which is capable of replicating independently of the chromosomal DNA. In many cases, it is circular and double-stranded. plasmids usually occur... The sequence starting with which the plasmid -DNA will be replicated in the recipient cell. ... F factor as a plasmid ind...

Phagemid

...loning vector developed as a hybrid of the filamentous phage M13 and plasmids to produce a vector that can grow as a plasmid, and also be packaged as s...loning vector developed as a hybrid of the filamentous phage M13 and plasmids to produce a vector that Definition and other additional information o...
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