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Pioglitazone in Medical News

Diabetic drug Pioglitazone found to reduce heart risk

Patients with type-2 diabetes are at high risk of fatal and non-fatal myocardial infarction and stroke, these events are the main reason for their decreased life expectancy//. There is indirect evidence that agonists of peroxisome proliferator-activated receptor-? (PPAR-?) could reduce macrovascula...

Roche to Commence Phase III Trials with Innovative Treatment Designed to Lower Cardiovascular Risk in Diabetes Patients with Recent Heart Attack

...50 microgram aleglitazar dose (currently in clinical trials) demonstrated numerically comparable reductions from baseline HbA1c to those observed with pioglitazone (-0.85%, 95% CI: -0.50 to -1.20, P<0.0001 vs.-0.71%, 95% CI: -0.36 to -1.06, P<0.0001). The study's secondary clinical endpoints were chang...

New Diabetes Drug Shows Promise in Trial

...fat. In the 16-week trial, 332 patients with type 2 diabetes received either once-daily doses of aleglitazar (at varying doses), the diabetes drug pioglitazone (Actos), or a placebo. At lower doses, aleglitazar appeared safe and effective, with less incidence of heart failure or edema than either Actos or ...

Amylin Pharmaceuticals to Present Compelling Efficacy and Safety Data From Diabetes Programs at ADA 2009

... Poster Late Breaker: "DURATION-2: Exenatide Once Weekly Demonstrated Superior Glycemic Control and Weight Reduction Compared to Sitagliptin or pioglitazone after 26 Weeks of Treatment" will be presented by Richard Bergenstal, M.D., during a poster session on Saturday, June 6 from 11:30 AM - 1:30 PM CT (12...

Diabetes drug shows promise against multiple sclerosis

...remitting multiple sclerosis were assigned to take pioglitazone (a drug commercially known as Actos used to treat ...onths and again after one year. Patients taking pioglitazone showed significantly less loss of gray matter over...1 patients who finished the study, patients taking pioglitazone had no adverse reactions and, further, found takin...

Halting Avandia Use Hikes Blood Sugar Levels

...ice , which published the study. This study reaffirms that patients who discontinue use of rosiglitazone and another thiazolidinedione (TZD) called pioglitazone (Actos) are at increased risk for higher fasting blood glucose and hemoglobin A1c levels, which may increase their cardiovascular risk, cardiologists ...

Certain Diabetes Drugs May Pose Eye Risk

...(DME), which features swelling and fluid accumulation in the retina. Glitazones are a newer class of diabetes drugs that includes medicines such as pioglitazone (Actos) and rosiglitazone (Avandia). The U.S. study of 996 DME patients found that those who took glitazones were 2.6 times more likely to develop ...

Diabetes drug class linked to vision-threatening complication

..., including heart failure. Fluid retention from heart failure or other diseases can worsen DME. Most of the glitazone users in the study were taking pioglitazone (Actos). Other studies have linked rosiglitazone (Avandia)the only other approved glitazone drugto a possible increase in the risk of myocardial infa...

Glitazones have not yet been sufficiently investigated

...d metformin failed to achieve the desired success. pioglitazone can also be used in combination with insulin. ...o assess the benefit of the long-term treatment of pioglitazone and rosiglitazone versus placebo, or versus other ...sus each other. A total of 7 eligible studies on pioglitazone and 16 eligible studies on rosiglitazone were iden...

Prime Pharmacists Recognized by the Journal of Managed Care Pharmacy

...(JMCP) Award of Excellence for their manuscript assessing rosiglitazone and pioglitazone utilization trends and associated medical and pharmacy claims data indicati...esearch and formulary teams began an in-depth analysis of rosiglitazone and pioglitazone utilization based on this publication. The medical and pharmacy claims inte...
Pioglitazone in Medical Technology

Exenatide Once Weekly Provided Superior Glucose Control With Weight Loss Compared to Sitagliptin or Pioglitazone in Head-to-Head DURATION-2 Study

SAN DIEGO, INDIANAPOLIS and CAMBRIDGE, Mass., March 31 /PRNewswire-FirstCall/ -- Amylin Pharmaceuticals, Inc. (Nasdaq: AMLN ), Eli Lilly and Company (NYSE: LLY ) and Alkermes, Inc. (Nasdaq: ALKS ) today announced positive results from DURATION-2, the second in a series of studies designed to...

Cleveland Clinic Study Shows the Diabetes Drug Pioglitazone Reduces Risk of Death, Heart Attack and Stroke, but Increases Risk of Heart Failure

Results Appear in the Sept. 12 Issue of the Journal of the American Medical Association CLEVELAND, Sept. 11 /PRNewswire/ -- A drug widely used to treat type 2 diabetes has been found to reduce the risk of death, heart attack (myocardial infarction) or stroke when use...

Research: Popular Diabetes Medications Associated with Increase in Bone Fractures

...king TZDs. TZDs -- a class of drugs used to control blood sugar -- are used by as many as 4 million Americans. The study examined the effects of pioglitazone (Actos(R)) and rosiglitazone (Avandia(R)), the two drugs that make up the TZD class, and found that both medications equally increase the risk of bone...

Takeda to Revise Timing of Alogliptin and Alogliptin/ACTOS MAA Filings in Europe

...lopment strategy for the Marketing Authorization Applications (MAAs) for its investigational compounds, alogliptin and alogliptin/ACTOS (generic name: pioglitazone HCl), in Europe, and accordingly, has initiated an additional long-term clinical study for alogliptin. The additional two-year study is to evalua...

InteKrin Therapeutics to Present at the 2009 American Diabetes Association Annual Meeting

... efficacy of PPAR gamma activation, while mitigating or eliminating the well recognized side effects of TZD full PPAR gamma agonists rosiglitazone and pioglitazone (Avandia(R) and Actos(R) respectively). About InteKrin ( www.InteKrin.com ) InteKrin Therapeutics is a privately-held clinical-stage drug dev...

Diabetes drug supported by Mexican Diabetes Federation

...zone drugs. The first glitazone, troglitazone was approved in 1998 but was withdrawn shortly thereafter. Two additional glitazones - rosiglitazone and pioglitazone - have recently been targeted with a "black box" warning by the U.S. FDA due to concerns related to cardiac risk when taking these drugs (see

MEDIA ADVISORY: Subsets of Landmark Diabetes Trials Investigating MacroVascular Outcomes Presented at the American Diabetes Association 67th Scientific Sessions

...risk type 2 diabetes patients treated with pioglitazone for 3 years: results from PROactive; Poste....m. and 6:00- 7:15 p.m. -- Effects of pioglitazone in patients with type 2 diabetes and reduced ...5 p.m. -- Effects of long-term treatment with pioglitazone on lipid levels in patients receiving stat...

Late Breaking Data Released at ADA Showed that the Investigational Use of Januvia and Metformin as Initial Combination Therapy Provided Significant Glucose Lowering Efficacy over 54 Weeks in Patients with Type 2 Diabetes

...00 mg daily as monotherapy or in combination with pioglitazone and more commonly than in patients treated with p...-------------------------------- Combination with pioglitazone JANUVIA 100 mg + Placebo + pioglitazone Pioglitazone ---------------------------------...

An Investigational Study Released at ADA Showed that Initial Combination Therapy with Januvia (sitagliptin) and Metformin Led to Improvement in Markers of Beta Cell Function in Patients with Type 2 Diabetes

...00 mg daily as monotherapy or in combination with pioglitazone and more commonly than in patients treated with p...-------------------------------- Combination with pioglitazone JANUVIA 100 mg + Placebo + pioglitazone Pioglitazone ---------------------------------...
Pioglitazone in Biological News

Long-term use of diabetes drugs by women significantly increases risk of fractures

...igures show there are around 4 million users of these drugs in the US, while in the UK there were around 2 million prescriptions for rosiglitazone and pioglitazone last year. "Women with type 2 diabetes are already at an increased risk of fractures - with a near doubling in the risk of hip fractures - so any ...
Pioglitazone in Biological Technology

Cardiovascular Side Effects of Pioglitazone and Rosiglitazone Linked to Vascular and Energy Pathways by Genomas Clinical Study

Basis Established for DNA-Guided Decision Support in Diabetes Drug Therapy HARTFORD, Conn., Jan. 21 /PRNewswire/ -- Research by Genomas has shown statistically significant associations of certain genes in vascular and energy pathways to body mass index (BMI) and edema (fluid retention) in pat...

Mindset BioPharmaceuticals (USA) Inc Obtains Notice of Allowance for European Patent Related to Use of Insulin Sensitizers in Senile Dementia, Dementia and Memory Loss

... and treatment of memory loss. Drugs of this type include Rosiglitazone and pioglitazone which have been approved for the treatment of type II diabetes mellitus. G...o the action of insulin. Insulin sensitizer drugs such as Rosiglitazone and pioglitazone help brain cells properly use glucose in individuals whose ability to use i...

New Data Published in Circulation Showed an Increase in HDL Cholesterol Levels with ACTOS(R) (pioglitazone HCl)

...ibuted to the reduction of atherosclerosis progression as measured by CIMT at 72 weeks. These results suggest that suppression of atherosclerosis with pioglitazone therapy is linked to its effect to raise HDL cholesterol. An increase in CIMT, the thickness of the inner lining of a patient's carotid, is an indicat...

GlaxoSmithKline Responds to JAMA Article on the ICES Thiazolidinediones and Cardiovascular Outcomes in Older Patients with Diabetes

...ilar increased risk of CHF. Yet, in this analysis, pioglitazone is not associated with an increased risk of CHF (A...nic diseases compared with those prescribed pioglitazone alone; therefore they were sicker patients....ered to detect adverse effects associated with pioglitazone because of the relatively small number of pers...
Pioglitazone in Biological Products

PPARGamma-Competitor Assay Kit Green from Invitrogen

Description:...ipid metabolism. Agonists include the (TZD) class of anti-diabetic agents called thiazolidinediones (TZD) or "glitazones." Rosiglitazone (Avandia) and pioglitazone (Actos) are two PPAR agonists currently marketed for treatment of type 2 diabetes. PPAR agonists may also be therapeutically important in the treatmen...
Company:Invitrogen
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