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Phosphorylation in Medical News

Pharmasset Nominates PSI-938 as a New Nucleotide Analog Inhibitor of Hepatitis C for Preclinical Development

...s a complementary resistance profile and is metabolized through a different phosphorylation pathway," stated Michael Otto, PhD, Pharmasset's Chief Scientific Officer. ...gs, and are metabolized to the active triphosphate form through a different phosphorylation pathway than the pyrimidines. Given these characteristics, purine and pyrim...

Stanford researchers harness nanoparticles to track cancer-cell changes

...y, one common way for proteins to get activated is through a process called phosphorylation that slightly changes a protein's shape, in effect turning it on. Two in... of cancer. The Stanford team was able to simultaneously monitor changes in phosphorylation levels of both proteins in lab-cultured myeloid leukemia cells. The changes...

New alternative to biopsy detects subtle changes in cancer cells, Stanford study shows

...mas from others. Finally, they were able to detect subtle differences in phosphorylation in several other cancer-associated proteins. "Some of these proteins can ex...s research in the Felsher lab, the lipid-lowering drug atorvastatin reduces phosphorylation of yet another cancer-associated protein. "This is the first time we've bee...

Protein-Folding Problem May Help Spur Alzheimer's

...urs at an early stage of neurofibrillary degeneration and ... that the prolonged activation of the [unfolded protein response] is involved in both tau phosphorylation and neurodegeneration in [Alzheimer's disease] pathogenesis ... Future studies will address the therapeutic opportunities of this pathway for the trea...

Scientists uncover secrets of potential bioterror virus

... Rift Valley fever virus from using cellular protein synthesis machinery to make the proteins it needs to replicate itself. But since NSs prevents the phosphorylation of eIF2-alpha by taking out PKR, the virus is free to copy itself within host cells without interference. "It's amazing that the virus evolved to ...

Oncogene inhibits tumor suppressor to promote cancer: Study links B-RAF and LKB1

...ignaling activated AMPK. The researchers went on to show that LKB1 was phosphorylated by two kinases that are downstream of B-RAF, ERK and Rsk. The phosphorylation of LKB1 interfered with the ability of LKB1 to bind and activate AMPK. Importantly, expression of mutant LKB1 that could not be phosphorylated resulte...
Phosphorylation in Medical Technology

Cylene to Present Advances in its Oral Inhibitor of CK2 at AACR Annual Meeting

...peutics 34, Abstract 4660 Tuesday, April 21, 2009: 2:00 PM CX -4945, a potent and selective inhibitor of CK2, modulates PI3K/AKT signaling and phosphorylation of p21 in vitro and in vivo: Implications for biomarker development - Experimental and Molecular Therapeutics 37, Minisymposium, Abstract 4768 ...

Nerviano Medical Sciences Invited by EORTC-NCI-AACR to Present the State-of-the-Art of Aurora

...lly highlighted in experimental tumour models and was recently confirmed by findings obtained from patient biopsies", explains Laffranchi. A decreased phosphorylation of Histone H3 in patients treated with PHA 739358 supports this hypothesis whereby the anti-cancer activity exerted by the compound is mediated throug...

SuperGen's JAK2 Inhibitor, SGI-1252, Inhibits in Vivo Tumor Cell Proliferation

... presented data indicating that SGI-1252 selectively inhibits wildtype and mutant JAK2 activity in cancer cell lines, resulting in inhibition of STAT5 phosphorylation as well as a reduction in Bcl-XL expression. SGI-1252 was also shown to prevent tumor growth in mouse xenograft models. Pharmacokinetic studies indica...

Keryx Biopharmaceuticals, Inc. Announces Poster Presentation Highlighting Observed Clinical Activity of KRX-0401 (Perifosine) at the American Society of Clinical Oncology Meeting in Chicago, Illinois

...inical rationale for combination targeted therapy in advanced clear cell renal cell carcinoma (RCC): Abrogation of rapamycin-mediated induction of AKT phosphorylation by perifosine. Investigators: W. S. Holland, P. C. Mack, D. R. Gandara, P. N. Lara KRX-0401 (Perifosine) Mechanism of Action and Profile KRX-040...

Exelixis Reports Positive Clinical Pharmacodynamics Data for PI3K/mTOR Inhibitor XL765 at ASCO

...chondrosarcoma at the 60 mg twice-a-day (BID) dose level. Reductions in the phosphorylation of these pathway components were also observed at this dose level in surrog...lbs, skin, and peripheral blood cells. The pattern of inhibition of protein phosphorylation observed in these tissues is consistent with observations from preclinical ...

Intra-Cellular Therapies Initiates Phase 2 Clinical Trial for Sleep Maintenance Insomnia

... ITI-007, ITI's first-in-class 5-HT2A antagonist/ dopamine receptor protein phosphorylation modulator (DPPM), presently in clinical trials for the treatment of schizop...'s first-in-class dual 5-HT2A receptor antagonist/dopamine receptor protein phosphorylation modulator (DPPM) for the treatment of schizophrenia. ITI-007 has dual prope...
Phosphorylation in Medical Products

IGFBP-1, Total IRMA Test

Description:...[5,6] IGF bioactivity. These paradoxical reports may be due to differential phosphorylation of IGFBP-1 which may significantly alter its affinity for IGFs and, therefo...sponsiveness. As many as five IGFBP-1 variants, differing in their state of phosphorylation and relative expression in serum, amniotic fluid, decidua and cell culture ...
Company:Diagnostic Systems Laboratories, Inc.

IGFBP-1, Total ELISA Test

Description:...[5,6] IGF bioactivity. These paradoxical reports may be due to differential phosphorylation of IGFBP-1 which may significantly alter its affinity for IGFs and, therefo...sponsiveness. As many as five IGFBP-1 variants, differing in their state of phosphorylation and relative expression in serum, amniotic fluid, decidua and cell culture ...
Company:Diagnostic Systems Laboratories, Inc.
Phosphorylation in Medical Dictionary

Antibody

...n ... Signalway Antibody (SAB) develops rabbit polyclonal phospho-specific antibodies ,rabbit monoclonal,mouse monoclonal for studying protein phosphorylation in cell ... Antibody molecules are constructed from two light chains (kappa or lambda) and ... The isotype of the antibody is defined by the...
Phosphorylation in Biological News

SEX4, starch and phosphorylation

Energy from the sun and carbon dioxide fuel photosynthesis in plants and algae, making life on earth possible. Carbon that is fixed by plants is converted to starch and sucrose, which are utilized by plants for energy and to build biomass. Human evolution and society have been intimately tied t...

Grant supports LSUHSC research on how like cell receptor systems determine very different functions

... personnel needed to identify and characterize ERK phosphorylation targets proteins to which phosphate groups can be...protein function specified by the scaffold. These phosphorylation targets are involved in the development of disease...ion activity of growth factor receptors as a novel phosphorylation target. Understanding this novel mechanism might b...

Building memories with actin

...ex et al. tackled the question by dosing slices of rat hippocampus with adenosine, a naturally occurring signal that squelches LTP. Adenosine prevents phosphorylation and inactivation of cofilin, an inhibitor of actin filament assembly, the team found. Cofilin's involvement, in turn, implicates signaling cascades he...

Protein can help cells or cause cancer, Purdue researcher finds

...rs. Topors binds itself to p53 molecules during the ubiquitination process. phosphorylation is basically an instruction from Plk1 to increase its ubiquitination activi...he research is to test different Plk1 inhibitors to see how they affect the phosphorylation process. ...

New piece found in the puzzle of epigenetics

...be produced, but not any snRNA. The reason for that is presumably that this phosphorylation enables the interaction with a protein complex the so-called integrator co...k Eick showed that the enzyme TFIIH kinase is responsible for the selective phosphorylation of RNA polymerase II. "With these findings another building block has been ...

Two new studies on circadian rhythms

...ting the 24-hour cycle. Both studies looked at phosphorylation of the frequency (FRQ) clock protein, a central fe...k. "The Cell paper describes how the cell uses phosphorylation of a clock protein to keep the period length of th... We used mass spectrometry to follow the degree of phosphorylation of over 75 sites on the FRQ clock protein across t...
Phosphorylation in Biological Technology

Detection and Identification of Phosphorylation Sites in Proteins Using LC/MS/MS with Neutral Fragment Loss Mapping

Michaela Scigelova, Gary Woffendin; Thermo Finnigan, Hemel Hempstead, UK. Malcolm Ward, Helen Byers; Proteome Sciences, London, UK. Diane Hanger; Institute of Psychiatry KCL, London, UK. ...

New MedPredict Report Reveals Top Alzheimer's Experts' Insights on Diagnostics and Treatments in Development Pipeline

...ntibodies that are targeting amyloid and plaques, offering their opinions on gamma-secretase inhibitors and modulators, beta-secretase inhibitors, Tau phosphorylation inhibitors, cardiovascular agents, anti-amyloids and aggregation inhibitors, histone deacetylases (HDACs), SIRT-1, metal chelators and drugs like Dime...

Scotland Highlights New Partnerships and Cutting-Edge Drug Discovery Research

...nternational Scottish Enterprise Scottish Stem Cell Network TalentScotland Tissue Solutions Ltd University of Dundee - MRC Protein phosphorylation Unit University of Dundee - Research and Innovation Service University of Edinburgh - College for Medicine and Veterinary Medicine Univers...

Sigma-Aldrich Introduces Precisio(TM) Kinases for High-Throughput Screening and Kinase Profiling

....com/precisiokinases ), a new collection of high quality active kinases that is expected to enable scientists to achieve greater insight into protein phosphorylation and cell signaling. Optimized for high-throughput kinase screening and profiling, Precisio Kinases allow for the characterization of cellular process...

Tigris Pharmaceuticals Presents Results of Breast Cancer Research at AACR Annual Meeting

...gion, causing induction of CYP1A1 transcription. This enzyme expression converts AF to metabolites that are covalently bound to DNA. This results in phosphorylation of p53 with induction of the p53 downstream target p21Waf1/Cip1 and apotosis. About Tigris Pharmaceuticals, Inc. Tigris Pharmaceuticals, Inc....

Telik Reports Preclinical Results at AACR Annual Meeting

... Drug inhibition of aurora kinase and VEGFR activity in tumor samples of treated animals was established by analysis of markers, such as histone H3 phosphorylation and CD31. Anti-Tumor Efficacy and Molecular Mechanism of TLK58747; Abstract # 4515 Telik researchers identified a novel alkyl...
Phosphorylation in Biological Products

Protein Phosphorylation from Promega

Description: Protein Phosphorylation...
Company:Promega

H2A.X Phosphorylation Assay Kit (Flow Cytometry) from Upstate

Description: Assay Kit formatted for flow cytometric detection of levels of phosphorylated histone H2A.X....
Company:Upstate

H2A.X Phosphorylation Assay Kit (Chemiluminescence Detection) from Upstate

Description: Request Info...
Company:Upstate

Rabbit Anti-ATF4, phospho (Ser245) Polyclonal Antibody, Unconjugated from Abcam

Description:... polyclonal to ATF4 (phospho S245) ( Abpromise for all tested applications). Antigen: Synthetic phosphopeptide derived from human ATF4 around the phosphorylation site of Serine 245. Entrez GeneID: 468 SWISS Protein ID: P18848...
Company:Abcam

Rabbit Anti-MKK6, phospho (Ser207) Polyclonal Antibody, Unconjugated from Abcam

Description:... polyclonal to MKK6 (phospho S207) ( Abpromise for all tested applications). Antigen: Synthetic phosphopeptide derived from human MKK6 around the phosphorylation site of Serine 207 (V-D-S P -V-A). Entrez Gene ID: 5608 Swiss Protein ID: P52564...
Company:Abcam

PhosphoSafe Extraction Buffer from Novagen

Description:... PhosphoSafe Extraction Reagent extracts cytosolic proteins from mammalian and insect cells while preserving their phosphorylation state. The reagent, an enhancement of the CytoBuster Protein Extraction reagent, includes four phophatase inhibitors. PhosphoSafe is compatible with W...
Company:Novagen
Phosphorylation in Biological Definition

Phosphorylation

Phosphorylation is the addition of a phosphate (PO 4 ) group to a protein or a small molecule. Its prominent role in biochemistry is the subject of a very large body of research (the Medline database returns over 100,000 articles on the subject, largely on protein phosphorylation). ...

Oxidative phosphorylation

Oxidative phosphorylation is a biochemical process in cells . It is the final metabolic pathway of cellular respiration , after glycolysis and the citric acid cycle . The process takes place at a biological membrane . In prokaryotes this is the plasma membrane , and in eukaryot...

Adenosine triphosphate

...furanosyladenine-5'-triphosphate. Synthesis ATP can be produced by various cellular processes, most typically in mitochondria by oxidative phosphorylation under the catalytic influence of ATP synthase or in the case of plants in chloroplasts by photosynthesis . The main fuels for ATP synthesis are ...

ATP synthase

...ve force created by the electron transport chain as a source of energy. The overall process of creating energy in this fashion is termed oxidative phosphorylation . Same process takes place in mitochondria , were ATP synthase is located in the inner mitochondrial membrane (so that F 1 -part sticks into mitocho...

Carbohydrate

...the blood. Catabolism There are three metabolic pathways of carbohydrate catabolism : glycolysis citric acid cycle oxidative phosphorylation See also Biochemistry Macromolecules Glycolysis Gluconeogenesis Pentose phosphate pathway External links IU...

Citric acid cycle

...citric acid cycle is always followed by oxidative phosphorylation . This process extracts the energy from NADH and F...id cycle itself does not use oxygen, but oxidative phosphorylation does. The total energy gained from the complete ...y glycolysis, the citric acid cycle and oxidative phosphorylation equals about 38 ATP molecules. The citric acid cy...
Phosphorylation in Biological Dictionary

Phosphorylation

Phosphorylation is the addition of a phosphate (PO4) group to a protein or other organic molecule. Phosphorylation turns many protein enzymes on and off, causing or preventing the mechanisms of diseases such as cancer and... Oxidative phosphorylation is a metabolic pathway that use...

Sarcoplasmic reticulum

...ticulum ? What is the ... sarcoplasmic reticulum ? ... Sarcoplasmic reticulum calcium release in frog skeletal muscle fibres estimated ... phosphorylation of heavy sarcoplasmic reticulum vesicles: identification and ... Surface particles of sarcoplasmic reticulum membranes. ... Lipid compositi...

Photophosphorylation

...use it produces ... Photophosphorylation ... photophosphorylation n. phosphorylation induced by radiant energy in photosynthesis. ... How does phosphorylation and photophosphorylation differ? ... Photophosphorylation refers to...

Nuclear lamina

...ntermediate filament-type network underlying the inner nuclear membrane. ... In vitro disassembly of the nuclear lamina and M phase-specific phosphorylation ... Nuclear Envelope Breakdown Proceeds by Microtubule-Induced Tearing of the Lamina ... One cannot watch cells crawling, dividing, segrega...

Motif

... of free enterprise. Origin: ... What is motif -x designed to do? What is the central character parameter? ... Can motif -x predict potential phosphorylation sites in my protein? ... Find Motif in Little Falls, MN (Minnesota) and search our online directory for more at DexKnows.com. Dex Knows the inte...

Kinase

...t modifies other proteins by chemically adding phosphate groups to them . phosphorylation usually results in a functional change of the target protein (substrate) ... provides reagents and protocols for the rapid analysis of p70 S6 kinase phosphorylation at ... Find the kinase kit you need using kit comparison tables and t...
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