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Phosphorylase in Medical News

BioCryst Reports Second Quarter 2009 Financial Results And Provides Corporate Update

... diseases. BioCryst has two product candidates in pivotal clinical trials; peramivir, an anti-viral for influenza, and forodesine, a purine nucleoside phosphorylase (PNP) inhibitor for cutaneous T-cell lymphoma (CTCL). Utilizing crystallography and structure-based drug design, BioCryst continues to expand its po...

New strategy in tumor treatment

...tively kill tumors while protecting healthy cells. In previous studies, researchers discovered that a specific enzyme known as methylthioadenosine phosphorylase (MTAP) is missing in 35 to 70 percent of lung, pancreatic and biliary tract cancer, melanoma, glioblastoma, osteosarcoma, soft-tissue sarcoma, mesoth...

BioCryst Pharmaceuticals Announces Presentation of Forodesine Data at the 45th Annual Meeting of the American Society of Clinical Oncology

...of Clinical Oncology (ASCO) being held in Orlando, Florida from May 29-June 2. Forodesine is a transition-state analog inhibitor of purine nucleoside phosphorylase (PNP), a purine salvage pathway enzyme that is essential for the proliferation of T-cells and B-cells. The poster entitled "Long-Term Treatment o...
Phosphorylase in Medical Technology

BioCryst Initiates Enrollment in Pivotal Trial of Forodesine HCL in Patients with Cutaneous T-Cell Lymphoma (CTCL)

...ouse, President and Chief Executive Officer of BioCryst. Forodesine HCL is a transition-state analog inhibitor of the target enzyme purine nucleoside phosphorylase (PNP). In addition to CTCL, the drug is currently being studied in clinical trials for indications including T and B- cell leukemia (T-ALL, B-ALL), an...
Phosphorylase in Biological Technology

BioCryst Pharmaceuticals to Announce Second Quarter 2009 Financial Results on July 30, 2009

... diseases. BioCryst has two product candidates in pivotal clinical trials; peramivir, an anti-viral for influenza, and forodesine, a purine nucleoside phosphorylase (PNP) inhibitor for cutaneous T-cell lymphoma (CTCL). Utilizing crystallography and structure-based drug design, BioCryst continues to expand its po...

Catalyst Biosciences Expands Scientific Advisory Board With Leading Experts in Protease Therapeutic Discovery and Development

...ng a total of approximately three hundred scientific papers, he has published 50 manuscripts on protease structure and function. His work on glycogen phosphorylase revealed the first mechanism of phosphorylation control of protein function. Professor Fletterick's laboratory solved the first structure of a nuclea...

BioCryst Reports Fourth Quarter and Year End 2008 Financial Results and Provides Corporate Update

... A poster entitled, "A Phase 2 Study of the Purine Nucleoside phosphorylase (PNP) Inhibitor RO5092888 (BCX-4208) in Patients with Moderate to Severe Ch...sented a poster at ASH entitled, "BCX-4208 (RO5092888), a Purine Nucleoside phosphorylase (PNP) Inhibitor is a Novel, Potent Orally Active Anti T- and B-Cell Agent."...

BioCryst to Present Three Posters During the 50th American Society of Hematology Annual Meeting and Exposition

... and BCX-4208 are clinical-stage purine nucleoside phosphorylase (PNP) inhibitors. The schedule for BioCry... BCX-4208 (RO5092888), a Purine Nucleoside phosphorylase ( PNP ) Inhibitor is a Novel, Potent Orally Acti... A Phase II Study of the Purine Nucleoside phosphorylase (PNP) Inhibitor RO5092888 (BCX-4208) in Patients ...

BioCryst Reports Third Quarter 2008 Financial Results and Provides Corporate Update

... severe plaque psoriasis were consistent with interim findings. BCX-4208, a potent, rationally designed, orally available purine nucleoside phosphorylase inhibitor, met its primary endpoint of safety and tolerability and displayed dose-dependant reductions in peripheral blood lymphocyte counts...

The Bio-Rad Silver Stain, Rev E

...Proc Natl Acad Sci USA 82, 41374141 (1985) 33. Khan ZA and Fraenkel-Conrat H, Purification and characterization of polynucleotide phosphorylase from cucumber, Proc Natl Acad Sci USA 82, 13111315 (1985) 34. King SM et al., Characterization of monoclonal antibodies against ...
Phosphorylase in Biological Products

Chicken Anti-Human Uridine Phosphorylase 1 Polyclonal Antibody, Unconjugated from Abcam

Description: Chicken polyclonal to Uridine Phosphorylase 1 ( Abpromise for all tested applications). Antigen: Synthetic peptide: MAATGANAEK AESHNDCPVR LLNPNIAKMK EDILYHFNLT TSRHNFPALF GDVKFVCVGG SPSRMKAFIR CVGAELGLDC PGRDYPNICA GTDRYAMYK, corresponding to amino acids 1-99 of Human Uridine Phosphorylase 1 ...
Company:Abcam

PPase-2A from Promega

Description:...m human red blood cells. It is isolated as the heterodimer of 60kDa (A) and 36kDa (C) subunits. It has the ability to dephosphorylate the a-subunit of phosphorylase kinase. With its 3638kDa catalytic subunit, PPase-2A has broad substrate specificity and may play a regulatory role in DNA replication, transcription,...
Company:Promega
Phosphorylase in Biological Definition

Signal transduction

...h a protein is the regulation of calmodulin by Ca 2+ . Calmodulin itself can regulate other proteins, or be part of a larger protein (for example, phosphorylase kinase ). The Ca 2+ /calmodulin complex plays an important role in proliferation, mitosis and neural signal transduction. Lipophilic seco...
Phosphorylase in Biological Dictionary

Pyrimidine

...tionary and ... Pyrimidine rings are also components of several larger compounds, such as ... Information on EC 2.4.2.2 - pyrimidine -nucleoside phosphorylase ... Use of 4-thiouridine and 4-thiothymidine in studies on pyrimidine nucleoside phosphorylases ... Definition and other additional information...

Nucleoside

...eic acid metabolic process. • DNA modification ... Purine nucleoside phosphorylase deficiency. ... Definition of nucleoside from the Merriam-Webster Onli...ntiretroviral agents ... Information on EC 2.4.2.1 - purine- nucleoside phosphorylase ... ordered bi-bi mechanism with nucleoside being the first substrate t...

Glycogen

... storage in animals and occurs primarily in the liver and Glycogen phosphorylase This article needs additional citations for verification. ... Glycogen is...mance. ... replenish muscle glycogen while fructose ... Glycogen phosphorylase catalyzes the rate limiting step in the degradation of ... Glycogen is le...
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