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Phospholipids in Medical News

The Link Between Oxidized Phospholipids And Coronary Artery Disease

According to a recent study published for the first time, researchers have made the first causal connection between concentrations of oxidized phospholipids and the risk of coronary artery disease (CAD).// As levels were also closely related to those of Lp(a) lipoprotein, the researchers sugge...

Peregrine Pharmaceuticals Completes Planned Patient Enrollment in Bavituximab Phase I Cancer Trial

...phosphatidylserine (PS) on the surface of tumor blood vessels. Since these phospholipids are typically not exposed on the surface of normal tissues, they represent ...nts. Bavituximab is a monoclonal antibody that binds specifically to these phospholipids exposed on the surface of the cells lining tumor blood vessels. Once bound,...

ASCO Research Foundation Grant Will Support Study of Peregrine's Bavituximab in Lung Cancer

...phosphatidylserine (PS) on the surface of tumor blood vessels. Since these phospholipids are typically not exposed on the surface of normal tissues, they represent ...ents. Bavituximab is a monoclonal antibody that binds specifically to these phospholipids exposed on the surface of the cells lining tumor blood vessels. Once bound...

Gladstone scientists identify role of fatty acids in Alzheimer's disease

...early and severely by Alzheimer's disease," said Rene Sanchez-Mejia, M.D., lead author of the study. In the brain arachidonic acid is released from phospholipids by an enzyme called group IVA phospholipase A2 (or PLA2). The scientists lowered PLA2 levels in the Alzheimer mice by genetic engineering. Removal ...

Interleukin Genetics Reports Fourth Quarter and Year End 2007 Financial Results

... reported at the American College of Cardiology (ACC) annual meeting that associations between coronary artery disease (CAD) and both oxidized phospholipids (OxPL) and Lp(a) levels appear to be dependent on pro-inflammatory variants of the interleukin-1 (IL-1) genes. The results were statistically ...

Research Reveals How Cells Store Fat

...sizing fat within cells, he noted. The new discovery describes the genes that package that fat into liquid droplets within a layer of molecules called phospholipids and proteins. Both genes produce proteins that consist of more than 200 subunits called amino acids, and the two genes are 50 percent similar to on...

Radiation and drug combo helps boost efficacy of lung cancer treatment

...ls that feed tumors. The reaction causes membrane components called anionic phospholipids to flip inside out, exposing them. In normal blood vessels, they face the i...y of mice, the researchers found that radiation increased the percentage of phospholipids that flip inside out from 4 percent to 26 percent. Treating the mice with b...

Genetic Mutation That Makes Common Cancers Resistant to Drugs Identified

... ovarian cancer. The mutation alters the electrostatics of binding pocket in the pleckstrin homology domain, the portion of the enzyme that docks with phospholipids on the cell membrane," said Dr. Kerry L. Blanchard, Executive Director, Discovery Biology Research, Eli Lilly and Company. During the study,...

Heart Disease In Women Can Be Reduced By Eating Grapes

...that is, in the grape powder group plasma triglycerides were 39 per cent lower, very low density lipoprotein (VLDL) cholesterol was 50 per cent lower, phospholipids were 30 per cent lower and concentrations of cholesterol in the aorta were 33 per cent lower. However blood levels of LDL cholesterol concentrations d...

Experimental Blood Test May Spot Heart Attack Risk, Study Says

... Oxidized phospholipids can be tested in blood to indicate the possibility... Medicine indicates that blood levels of Oxidized phospholipids may indicate the amount of fatty build- up patien... of invasive tests like angiograms. Oxidized phospholipids is similar to cholesterol. Researcher Tsimikas sai...
Phospholipids in Medical Technology

Omega 3 Fatty Acids Bound to Phospholipids has Potential Benefit for Attention-Deficit Hyperactivity Disorder (ADHD)

GREEN BAY, Wis., May 15 /PRNewswire/ -- Omega 3 fatty acids bound to phospholipids deserves to be further considered as a credible natural alternative and may have beneficial effect on impulsivity in ADHD patients, recent in vivo French study reveals. While several studies have reported benefi...

ALP Life Sciences, LLC Announces Nanoveson(TM) Patent Filing and Whitepaper Availability on Proposed Therapy for Non-Alcoholic Fatty Liver Disease (NAFLD) and Comorbid Diseases

...f self-organizing lipid membranes. Nanoveson(TM) therapy utilizes only natural compounds. The therapy triggers liver triglyceride remodeling into bile phospholipids and lipid membrane fusion and aggregation in the intestines. Molecular compounds including biliary phospholipids, arachidonic acid metabolites, choles...

Peregrine Pharmaceuticals Highlights Promising Early Data From Its Three Phase II Bavituximab Cancer Trials

...phosphatidylserine (PS) on the surface of tumor blood vessels. Since these phospholipids are typically not exposed on the surface of normal tissues, they represent ...ents. Bavituximab is a monoclonal antibody that binds specifically to these phospholipids exposed on the surface of the cells lining tumor blood vessels. Once bound...

96-Well Filtration Plate From Varian, Inc. Improves Sensitivity and Precision for Trace Bio-Analysis by LC/MS

...ed today its new filtration plate for sample preparation. Captiva(TM) NDLipids is a simple to use, non-drip 96-well plate specially designed to remove phospholipids including lysophosphatidylcholines, from biofluids. It is intended for use by analytical chemists in the pharmaceutical and life science industries ...

ACC Presentation Indicates Interleukin-1 Gene Variants Determine Increased Risk for Coronary Artery Disease from Oxidized Phospholipids

...en coronary artery disease (CAD) and both oxidized phospholipids (OxPL) and Lp(a) levels appear to be dependent on ...tors, including C-reactive protein. "Oxidized phospholipids play a critical role in the initiation and progres...ween pro-inflammatory IL-1 genotypes, oxidation of phospholipids and predisposition to CAD in younger individuals,"...

Peregrine Pharmaceuticals Highlights Significant Advances in the Company's Clinical and Preclinical Cancer Programs Presented This Week at the AACR Annual Meeting

...nti-PS antibodies as the targeting agent for immunocytokine fusion proteins based on Peregrine's VTA platform. Their ability to target phospholipids primarily expressed on the surface of tumor blood vessels enables bavituximab-like antibodies to also serve as targeting agents for Pe...
Phospholipids in Medical Dictionary

Tissue

...ction of soft tissue sarcoma arising in the limb. ... Lipidomics is the new frontier in biomolecular structural studies. ... Altered levels of phospholipids in tissue are associated with Farber disease, ... Community Tissue Services ethically provides procurement, processing and ... who have been t...

Surfactant

...ty ... Surfactant is made by the cells in the airways and consists of phospholipids and ... Surfactant is found in amniotic fluid between 28 and 32 weeks. ...y surfactant , a developmentally regulated ... suggested that surfactant phospholipids secreted into ... Information about surfactant in the free online Eng...

Hydrophobia

...he Open Directory Project ... hydrophobia n. An abnormal fear of water. Rabies. ... Hydrophobia , a Hungarian disk magazine (1996–1997) ... A phospholipids is usually hydrophobic or hydrophobia ? ... More about Rabies: Causes and symptoms Diagnosis Treatment Prognosis Prevention Resources Rabies Defi...
Phospholipids in Biological News

Nanotechnology holds promise for STD drug delivery

...nd knockdown of gene activity lasted up to 14 days. While past work has focused on delivery of siRNAs with liposomes, bubble-like carriers made of phospholipids similar to those found in cell membranes, liposomes are potentially more toxic to the mucosal tissues and are unable to provide sustained release. In ...

A new view of oceanic phytoplankton

...urrounded by membranes containing molecules called phospholipids oily compounds that contain phosphorus, as well a...asic elements including carbon and nitrogen. These phospholipids are fundamental to the structure and function of t...thought to be an indispensable component of life. phospholipids are one of several classes of molecules that conta...

Phytoplankton cell membranes challenge fundamentals of biochemistry

...completely unexpected way of building their cells. Until now, it was thought that all cells are surrounded by membranes containing molecules called phospholipids oily compounds that contain phosphorus, as well as other basic biochemical nutrients including nitrogen. However, Van Mooy and his colleagues from WH...

New scientific knowledge on juvenile diabetes

...o developed diabetes had reduced serum levels of succinic acid and phosphatidylcholine at birth, reduced levels of triglycerides and antioxidant ether phospholipids throughout the follow-up and increased levels of proinflammatory lysophosphatidylcholines several months prior to autoimmunity to pancreatic beta cell...

Dominant cholesterol-metabolism ideas challenged by new research

...fter the PS is expressed on the cell surface, the phospholipids and excess cholesterol can be loaded onto a circu...the enzyme, scramblase, which causes PS and other phospholipids to redistribute until there are equal amounts ins...the cell membrane, making it possible to load the phospholipids and cholesterol onto apoA1. During programmed...

Batten down the hatches against HIV

...es in at the same time. The researchers attached phospholipids—molecules from which cell membranes are also made—to chains of polyethylene glycol. The phospholipids nestle securely onto the outer wall of the carbon nanotubes while the polyethylene glycol chains protrude into the surrounding solution. The required ...

Cornell researcher helping develop quick, cheap HIV/AIDS test

...st for CD4+ T-lymphocytes in the blood that can be likened to a pregnancy test using biosensor nanovesicles (microscopic, fluid-filled pouches made of phospholipids that can deliver drugs -- also known as liposomes) to enhance the signal. Several other consortium organizations also are working on the similar produ...

Nano-particles effective in killing cancer with one-two punch of chemotherapeutics

...ipids, a polymersome is comprised of two layers of synthetic polymers. The individual polymers are degradable and considerably larger than individual phospholipids but have many of the same chemical features. This results in a structure that looks like a very small cell or virus. Discher and his colleagues t...

Virginia Tech scientists develop process for creating biocompatible fibers

... The researchers used a commercial product, lecithin, a natural mixture of phospholipids and neutral lipids. The materials will spontaneously organize into cylindri...understand the association of small molecules, then he determined that once phospholipids form an entangled network they can be treated similarly to higher weight mo...

Newly Discovered Role for Heart Response Enzyme May Yield Better Heart Failure Therapy

...esearchers' experiments revealed that PI(3)K plays multiple roles as an enzyme that affect heart responses. It manufactures signaling molecules called phospholipids in the cell. And it activates other molecules, among them one called "non-muscle tropomyosin," which plays an important role in maintaining cell struc...
Phospholipids in Biological Technology

Neptune Technologies patent granted for novel phospholipids in multiple diseases and pharmaceutical applications

- Composition of Matter Patent Granted and Enforceable in 24 European Countries - Competitors Precluded from Immediate Commercialization of Competitive Products LAVAL, QC, March 27 /PRNewswire-FirstCall/ - Neptune Technologies & B...

Peregrine Pharmaceuticals Presents Promising Data From Its Phase II Bavituximab Breast Cancer Trial at 2009 ASCO Annual Meeting

...phosphatidylserine (PS) on the surface of tumor blood vessels. Since these phospholipids are typically not exposed on the surface of normal tissues, they represent ...ents. Bavituximab is a monoclonal antibody that binds specifically to these phospholipids exposed on the surface of the cells lining tumor blood vessels. Once bound...

Clinical Data on Peregrine's Bavituximab Cancer Program to Be Discussed in Two Presentations at 2009 ASCO Annual Meeting

...phosphatidylserine (PS) on the surface of tumor blood vessels. Since these phospholipids are typically not exposed on the surface of normal tissues, they represent ... target for anti-cancer treatments. Bavituximab binds specifically to these phospholipids exposed on the surface of the cells lining tumor blood vessels. Once bound...

Neptune Product and Distribution Update

...ns containing its proprietary marine omega-3 phospholipids enhanced with validated bioactive ingredient...sents the first and only clinically proven omega-3 phospholipids exhibiting unmatched safety, purity and stability. NKO(R) omega-3 marine phospholipids set a new standard of omega-3 excellence supported...

Neptune Technologies to expect Record Revenues; Fiscal 2009 Third Quarter and Year-End Results

...e Krill Oil NKO(R) represents the first and only, clinically proven omega-3 phospholipids exhibiting unmatched safety, purity and stability. NKO(R) omega-3 marine phospholipids set a new standard of omega-3 excellence supported by a strong intellectual...

HybridSPE(TM)-Precipitation Technology Wins SelectScience.net 2009 Scientists' Choice Award for Best New Separations Product in 2008

...the selectivity of SPE for the targeted removal of phospholipids and proteins from biological samples prior to LC-M... ion-suppression in bioanalysis is the presence of phospholipids during LC-MS or LC-MS-MS analysis in the positive ion electrospray mode (+ESI). phospholipids are the second largest lipid component in biologic...

Human clinical study demonstrates superior Neptune Krill Oil NKO(R) pharmacokinetic profile

... - Marine omega-3 phospholipids in NKO(R) outperform established nutrac...an of 120 days. The positive effect of Neptune phospholipids on the EPA/ arachidonic acid index and the omega-3... compositions, which form the basis of our omega-3 phospholipids nutraceutical and pharmaceutical pipeline," said D...

Acasti Pharma completes offer to exchange outstanding Neptune Technologies dividend notes

... portfolio of proprietary novel long-chain omega-3 phospholipids are sourced from sustainable abundant marine biomass including Antarctic krill (Euphausia superba). phospholipids are the major component of cell membranes and are ...lesterol efflux. Acasti Pharma's proprietary novel phospholipids carry and functionalize the polyunsaturated omega-...

Neptune Technologies successfully completes $2.75 million private placement with 10% management participation

...olio includes proprietary novel long-chain omega-3 phospholipids sourced from sustainable abundant marine biomass including Antarctic krill (Euphausia superba). phospholipids are the major component of cell membranes and are ...lesterol efflux. Acasti Pharma's proprietary novel phospholipids carry and functionalize the polyunsaturated omega-...

Neptune Technologies and Marine Life Sciences enter worldwide distribution alliance with Weider Global Nutrition

...new standard in the premium nutraceutical market. The omega-3 fatty acids EPA (eicosapentaenoic acid) and DHA (docosahexaenoic acid) functionalized on phospholipids combined with potent antioxidants and minerals work in synergy offering significant health and athletic performance benefits. "We are very excited t...
Phospholipids in Biological Products

9(S)-HODE-d4, Deuterium Conjugated/Tagged from Cayman Chemical

Description:...he lipoxygenation of linoleic acid in both plants and animals. It has been detected in atherosclerotic plaques, as an esterified component of membrane phospholipids and in oxidized LDL particles....
Company:Cayman Chemical

9(S)-HODE-d4, Deuterium Conjugated/Tagged from Cayman Chemical

Description:...he lipoxygenation of linoleic acid in both plants and animals. It has been detected in atherosclerotic plaques, as an esterified component of membrane phospholipids and in oxidized LDL particles....
Company:Cayman Chemical
Phospholipids in Biological Definition

Biological membrane

...ch acts as a barrier within or around a cell . It is a lipid bilayer , being composed of a double layer of lipid -class molecules , specifically phospholipids , with occasional proteins intertwined, some of which function as channels . Such membranes typically define enclosed spaces or compartments ...

Cell metabolism

...secured in ATP . Fat catabolism Main article: Fat catabolism Fat catabolism, also known as lipid catabolism, is the process of lipids or phospholipids being broken down by lipases . The opposite of fat catabolism is fat anabolism , involving the storage of energy, and the building of membranes. ...

Endoplasmic reticulum

... The smooth ER has functions in several metabolic processes. It takes part in the synthesis of various lipids (e.g., for building membranes such as phospholipids ), fatty acids and steroids (e.g., hormones ), and also plays an important role in carbohydrate metabolism , detoxification of the cell (enzymes...

Glycolipid

...Their role is to provide energy and also serve as markers for cellular recognition. They occur where a carbohydrate chain is associated with phospholipids in the cell surface membrane . The carbohydrates are found on the outer surface of all eukaryotic cell membranes. They extend from the phosph...

Hormone

... Sterol hormones such as calcitriol are a homologous system. Lipid and phospholipid hormones are derived from lipids such as linoleic acid and phospholipids such as arachidonic acid . The main class is the eicosanoids , which includes the widely studied prostaglandins . Physiology of hormones Ev...

Life

...Plausible pre-biotic conditions result in the creation of the basic small molecules of life. This was demonstrated in the Urey-Miller experiment . phospholipids spontaneously form lipid bilayers , the basic structure of a cell membrane . Procedures for producing random RNA molecules can produce " ribozy...

Lipid

...ably larger and more polar, as described below. phospholipids or, more precisely, glycerophospholipids , are bu...y 14-24 carbon groups long. The head groups of the phospholipids found in biological_membranes are phosphatidylch...ition of one to three more phosphate groups. While phospholipids are the major component of biological membranes, o...

Mitochondrion

...o membranes, however, have very different properties. The outer mitochondrial membrane, which encloses the entire organelle, is composed of about 50% phospholipids by weight and contains a variety of enzymes involved in such diverse activities such as the oxidation of epinephrine (adrenaline), the degrada...

Mitochondrion

...o membranes, however, have very different properties. The outer mitochondrial membrane, which encloses the entire organelle, is composed of about 50% phospholipids by weight and contains a variety of enzymes involved in such diverse activities such as the oxidation of epinephrine (adrenaline), the degrada...

Origin of life

... the basic small molecules of life. This was demonstrated in the Urey-Miller experiment by Stanley L. Miller and Harold C. Urey in 1953 . phospholipids spontaneously form lipid bilayers , the basic structure of a cell membrane . Procedures for producing random RNA molecules can produce " riboz...
Phospholipids in Biological Dictionary

Signal transduction

...ses/Phosphatases ... The signal transduction page provides a brief discussion of various biological signaling molecules and pathways. ... and phospholipids in Signal Transduction ... ,biological,biology definition,biology terminology,biology terms,biology abbreviations ... 3.1.2 Signal transduct...

Plasma membrane

...r lies in the plasma membrane of nerve cells. ... Plasma membrane phospholipid bilayer. The plasma membrane consists of a combination of phospholipids ... The cell's plasma membrane does not simply form a "sack" in which to keep all ... The plasma membrane is a very important structure whi...

Phospholipid bilayer

...ganisms and many viruses is made... ... allow phospholipids to play an important role in the phospholipid bilayer . ... Lipid bilayer - phospholipids - Proteolipids - Sphingolipids - Sterols. v • d •...layer but to interactions: ... A bilayer of phospholipids forms a sphere in which water is trapped inside. ...

Phospholipid

... vesicles obtained by photon correlation ... phospholipids phospholipid ... The phospholipid composition...spholipid and no cholesterol was present. ... phospholipids , ... Individual phospholipid molecules are able...es into a bilayer in an ... Supplies GMP grade phospholipids for worldwide drug manufacturers and develops new...

Liposomes

...osome n. An artificial microscopic vesicle consisting of an aqueous core enclosed in one or more phospholipid layers, used to convey vaccines, phospholipids are the basic building block of every cell membrane in the human body. ... Liposomes are lipid bubbles and are the foundation of Liposomal ......

Lipids

...f Energy storage. Lipids contain a lot of ... Since Lipids are generally insoluble in polar substances such as water, they are ... - Lipids . phospholipids are Like Triglycerides with a Phosphate Group ... between the hydrophobic lipid molecules in the tails. More Membranes and Lipids ... Lipids ...

Fluid mosaic model

... ... of which abet consistent with, and add much detail to, the fluid mosaic model . ... fluid refers for the frequent lateral movement of phospholipids within the ... we may one day prove te fluid mosaic model wrong, but it has survived for a long ... Fluid - Mosaic Model Of Cell Membra...
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(Date:8/20/2014)... most persistent and deadliest infectious diseases in the world, ... Scientists who study tuberculosis have long debated its origins. ... in Africa to seals and sea lions that brought ... Native people there before Europeans landed on the continent. ... a Source of New World Human Tuberculosis," was published ...
(Date:8/20/2014)... (PRWEB) August 20, 2014 As concerns ... of power morcellators ( http://www.injurybeacon.com/power-morcellator/ ) in gynecological ... two U.S. Senators from New York are urging the ... recall of the devices. In a letter dated August ... also implored the agency to seriously consider the testimony ...
(Date:8/20/2014)... stimulates stress responses in adults, researchers at Yerkes ... that the amygdala has an inhibitory effect on ... primates. , The results are published this week ... amygdala is a region of the brain known ... and learning about threats. Alterations in the amygdala ...
(Date:8/20/2014)... HealthDay Reporter TUESDAY, Aug. 19, ... a baby,s immune system is twice as common as once ... says. This is the first evaluation of the effect ... as severe combined immunodeficiency (SCID), or "Bubble Boy" disease, the ... by the boy in the bubble, who was born without ...
(Date:8/20/2014)... CA (PRWEB) August 20, 2014 The main ... 12 per diode panel band perfect spectrum that encompasses the ... most likely to use during photosynthesis. A key point ... is that they almost exclusively reside between 440-480 on the ... the red side of the spectrum. The KIND LED K3 ...
Breaking Medicine News(10 mins):Health News:New research shows seals and sea lions likely spread tuberculosis to humans 2Health News:New research shows seals and sea lions likely spread tuberculosis to humans 3Health News:Power Morcellator News: Bernstein Liebhard LLP Notes Senators’ Letter Seeking FDA Morcellator Recall 2Health News:Power Morcellator News: Bernstein Liebhard LLP Notes Senators’ Letter Seeking FDA Morcellator Recall 3Health News:Power Morcellator News: Bernstein Liebhard LLP Notes Senators’ Letter Seeking FDA Morcellator Recall 4Health News:Maturing brain flips function of amygdala in regulating stress hormones 2Health News:Maturing brain flips function of amygdala in regulating stress hormones 3Health News:'Bubble Boy' Disease May Be More Common Than Thought 2Health News:'Bubble Boy' Disease May Be More Common Than Thought 3Health News:Cheap LED Grow Lights Are Quickly Being Replaced by Premium Grow Lights 2
(Date:8/19/2014)... Aug. 19, 2014 To improve students, chances ... grades, the University of Houston (UH) implemented a ... students at risk for failure. , Through ... Board (THECB), the Department of Biology and Biochemistry ... students taking "General Biology" for non-majors and "Introductory ...
(Date:8/19/2014)... of the world, leprosy and tuberculosis live side-by-side. ... leprosy per year, with nearly all of them ... century-old vaccine Bacille Calmette-Guerin, or BCG, provides only ... a more potent vaccine is needed to combat ... stronger weapon against both diseases., In a study ...
(Date:8/19/2014)... Aug. 19, 2014 ) -- Scientists at the Houston ... up and transfer single cells using a pipette -- ... describe this engineering feat and preliminary test results in ... American Chemical Society . , "Studying single cells and ... biomedical research," said nanomedicine department. faculty member Lidong Qin, ...
Breaking Biology News(10 mins):University of Houson program earns kudos for improving grades, retaining students 2University of Houson program earns kudos for improving grades, retaining students 3New vaccine shows promise as stronger weapon against both tuberculosis and leprosy 2Moving single cells around -- accurately and cheaply 2
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