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Phospholipase in Medical News

Newer Blood Tests May Not Improve Heart Risk Assessment

...markers be routinely measured." The six biomarkers surveyed in the study were CRP, an indicator of inflammation; cystatin C; lipoprotein-associated phospholipase 2; midregional proadrenomedullin; midregional proatrial natriuretic peptide; and N-terminal pro-B type natriuretic peptide. Five of the biomarkers ...

AUA Foundation names the 2009 Astellas Rising Stars in Urology award winners

...J. Brian Fowlkes, PhD and Charles Cain, PhD. Edward Schaeffer, MD, was named an Astellas Rising Stars in Urology for his project titled, "Roles for phospholipase A2 Signaling in Prostate Development." His mentors at Johns Hopkins Medicine are David Berman, MD, PhD, and William Isaacs, PhD. "These projects ar...

Inflammation Markers May Help Predict Stroke Risk

...high risk or low risk, they can provide you with more information." The markers in question are C-reactive protein (CRP) and lipoprotein-associated phospholipase A2 (Lp-PLA2). Both are indicators of inflammation, and both -- especially CRP -- have been well studied as potential predictors of cardiovascular cond...

Identification of genetic markers for ulcerative colitis could lead to treatment

...y genes implicated as possibly playing a role in ulcerative colitis include the ring finger protein 186 (RNF186), OTU domain containing 3 (OTUD3), and phospholipase A2, group IIE (PLA2G2E) genes on chromosome 1p36, and the interferon, gamma (IFNG), interleukin 26 (IL26), and interleukin 22 (IL22) genes on chromos...

Biomarkers improve ischemic stroke prediction

...earchers at Baylor College of Medicine in Houston in a report that appears online in the journal Stroke . The biomarkers -- lipoprotein-associated phospholipase A2 (Lp-PLA2) and high-sensitivity C-reactive protein (hs-CRP) -- are known to be associated with an increased risk of the kind of stroke that occurs w...

Exciting discovery could 'stop cancer from killing people'

...Now, a team of researchers lead by Professor Marco Falasca at Barts and The London School of Medicine and Dentistry has shown not only that the enzyme phospholipase Cγ1 (PLCγ1) plays a crucial role in metastasis formation, but that down regulation of PLCγ1 expression is able to revert metastasis pro...

Presence of gum disease may help dentists and physicians identify risk for cardiovascular disease

...bnormal cholesterol levels), inflammatory markers associated with disease risk (high-sensitivity c-reactive protein (hsCRP) and lipoprotein-associated phospholipase A2 (Lp-PLA2)). They were also asked standardized questions about their oral health status, including whether they had ever been diagnosed with periodo...

Morria Biopharmaceuticals Plc Announces Preliminary Results Regarding Inflammatory Markers From its Phase II Study in Allergic Rhinitis

...atory drugs (MFAIDs). This class of drugs uniquely combines two promising approaches to preventing and reversing inflammation: first, they control the phospholipase A2 (PLA2) enzyme family, a known, but previously elusive anti-inflammatory drug target. At the same time, they also protect cells and tissues against ...

Gladstone scientists identify role of fatty acids in Alzheimer's disease

...said Rene Sanchez-Mejia, M.D., lead author of the study. In the brain arachidonic acid is released from phospholipids by an enzyme called group IVA phospholipase A2 (or PLA2). The scientists lowered PLA2 levels in the Alzheimer mice by genetic engineering. Removal or even partial reduction of PLA2 prevented...

June 2008 highlights

...arried by sperm into the egg is crucial for promoting the oscillations in free calcium necessary to bring about a cascade of egg activation processes. phospholipase C zeta (PLCZ1) is a strong candidate for oscillin. Eventually PLCZ1 undergoes nuclear translocation to the zygotes pronuclei where its ability to prom...
Phospholipase in Medical Technology

Anthera's Varespladib Meets Primary Endpoint in Phase 2 FRANCIS Trial for the Treatment of Acute Coronary Syndrome

...t and highly selective oral inhibitor of secretory phospholipase A2 (sPLA2), an inflammatory enzyme implicated in A...potent and highly selective inhibitor of secretory phospholipase A2 (sPLA2), has demonstrated marked improvements i...t inhibit the enzymatic activity of members of the phospholipase (PLA2) family - a group of enzymes responsible fo...

Following Encouraging Results Anthera to Continue IMPACTS Trial for the Prevention of Acute Chest Syndrome in Patients With Sickle Cell Disease

... and elevated serum level of the enzyme (secretory phospholipase or sPLA2). Acute chest syndrome is a life-threaten...t A-001 A-001 is a potent inhibitor of secretory phospholipase A2(sPLA2) activity¿ including groups IIA¿ V¿ and X...2 (varespladib) is a potent inhibitor of secretory phospholipase A2(sPLA2) activity, which in two previously comple...

Anthera Completes Special Protocol Assessment With FDA and Receives EMEA Scientific Advice on Development Path Toward Varespladib Approval

...of their selective Lp-PLA2 (lipoprotein-associated phospholipase A2) inhibitor, darapladib, on a secondary biologic...potent and highly selective inhibitor of secretory phospholipase A2 (sPLA2), has demonstrated marked improvements i...t inhibit the enzymatic activity of members of the phospholipase (PLA2) family -- a group of enzymes responsible fo...

Anthera Pharmaceuticals Advances Global Development Strategy for Varespladib in Patients With Acute Coronary Syndrome With the Initiation of FRANCIS Trial

...nued progress of our varespladib cardiovascular program targeting secretory phospholipase A2," said Paul Truex, President and Chief Executive Officer of Anthera Phar...re-clinical compounds that inhibit the enzymatic activity of members of the phospholipase (PLA2) family -- a group of enzymes responsible for the release of arachido...

Morria Biopharmaceuticals Plc Announces the Initiation of a Phase II Clinical Multi-dose Study of MRX-4 in Allergic Rhinitis

...atory drugs (MFAIDs). This class of drugs uniquely combines two promising approaches to preventing and reversing inflammation: first, they control the phospholipase A2 (PLA2) enzyme family, a known, but previously elusive anti-inflammatory drug target. At the same time, they also protect cells and tissues against ...

Morria Biopharmaceuticals Plc Announces Regulatory Approval to Commence Phase II Clinical Study of MRX-4 in Allergic Rhinitis

...atory drugs (MFAIDs). This class of drugs uniquely combines two promising approaches to preventing and reversing inflammation: first, they control the phospholipase A2 (PLA2) enzyme family, a known, but previously elusive anti-inflammatory drug target. At the same time, they also protect cells and tissues against ...

Human Genome Sciences Reports Progress With Late-Stage Products and New Initiatives

...nts with coronary heart disease (CHD). The study showed that darapladib produced sustained, dose-dependent inhibition of plasma lipoprotein-associated phospholipase A2 (Lp-PLA2) activity in patients receiving intensive atorvastatin (cholesterol-lowering) therapy. Lp-PLA2 is an enzyme associated with the formation ...

DSMB Supports Continuation of Anthera Phase II Impacts Trial for the Prevention of Acute Chest Syndrome in Patients With Sickle Cell Disease

...sessment process." About A-001 A-001 is a potent inhibitor of secretory phospholipase A2(sPLA2) activity, including groups IIA, V, and X. The U.S. Food and Drug ...re-clinical compounds that inhibit the enzymatic activity of members of the phospholipase (PLA2) family - a group of enzymes responsible for the release of arachidon...

Anthera Enters Into Manufacturing Agreements for Varespladib in Preparation for Pivotal Phase III Trials

...& Co. Ltd. worldwide rights (excluding Japan) to a series of clinical and pre-clinical compounds that inhibit the enzymatic activity of members of the phospholipase A2 (PLA2) family -- a group of enzymes responsible for the release of arachidonic acid and subsequent production of leukotrienes prostacyclins and oth...

Morria Biopharmaceuticals Plc Announces Preliminary Safety and Tolerability Results From Its Phase I Clinical Study of MRX-4 in Allergic Rhinitis Patients

...atory drugs (MFAIDs). This class of drugs uniquely combines two promising approaches to preventing and reversing inflammation: first, they control the phospholipase A2 (PLA2) enzyme family, a known, but previously elusive anti-inflammatory drug target. At the same time, they also protect cells and tissues against ...
Phospholipase in Medical Products

Lipoprotein-Associated Phospholipase A2(PLACTest)

Description: ARUP Laboratories is a national reference laboratory and a worldwide leader in innovative laboratory research and development. ARUP offers an extensive test menu of highly complex and unique medical tests in clinical and anatomic pathology. Owned by the University of Utah, ARUP Laboratories' client...
Company:ARUP Laboratories
Phospholipase in Medical Dictionary

Aldolase

...eases increase the aldolase level found in a person's ... Aldolase A edit Aldolase A, fructose-bisphosphate PDB rendering based on 4ALD. ... phospholipase D2 directly interacts with aldolase via Its PH domain" ... aldolase ( ) n. An enzyme present in certain living tissues, including skeletal ...
Phospholipase in Biological News

La Jolla Institute discovers novel tumor suppressor

...ng to some types of leukemia." The findings are being published online today in the journal Cancer Cell in a paper entitled "Tumor Suppression by phospholipase C- 3 via SHP-1-Mediated Dephosphorylation of STAT5." Researchers from UC San Diego Cancer Center, University of Alabama and the University of Western...

Scientists uncork a potential secret of red wine's health benefits

...ch to stop inflammation in the mice by preventing the body from creating two different molecules known to trigger inflammation, sphingosine kinase and phospholipase D. This finding suggests that resveratrol may be harnessable as a treatment for inflammatory diseases and may also lead to entirely new resveratrol-ba...

2009 ASPB Summer Undergraduate Research Fellowship award announcement

...ings in Montreal at the annual ASPB meeting in 2010. David Seung, University of Sydney Mentor: Jan Marc The interaction of abscisic acid and phospholipase D mediated pathways in environmental stress signaling: The role of the cytoskeleton It is with great honor and excitement that I accept this award. ...

Lipid droplets lead a Spartin existence

...in Troyer patients, but author Paul Bieniasz points to precedents of defects in lipid turnover triggering neuronal disorders, such as mutations in the phospholipase NTE causing motor neuron disease. ...

New potential therapeutic target discovered for genetic disorder -- Barth syndrome

... failure in childhood. The new study entitled, "Role of calcium-independent phospholipase A2 in the pathogenesis of Barth syndrome", was recently published in the P...eficiency can be genetically suppressed by inactivating calcium-independent phospholipase A2, which prevents the degradation of cardiolipin. This method keeps cardio...

Compounds could be new class of cancer drugs

... of chemical compounds that could represent a new class of drugs for treating cancer. The compounds are the first selective inhibitors of the protein phospholipase D (PLD), an enzyme that has been implicated in multiple human cancers including breast, renal, gastric and colorectal. The new inhibitors, reported i...

Disabling enzyme allows mice to gorge without becoming obese, new study finds

... post-doctoral researcher; Maryam Ahmadian, graduate student; and Robin Duncan, post-doctoral fellow. The enzyme in the spotlight, adipose-specific phospholipase A2 (AdPLA), is found in abundance only in fat tissue. AdPLA sets off a chain of events that increases levels of a signaling molecule called prostaglan...

New genetic markers for ulcerative colitis identified, researchers report in Nature Genetics

...y genes implicated as possibly playing a role in ulcerative colitis include the ring finger protein 186 (RNF186), OTU domain containing 3 (OTUD3), and phospholipase A2, group IIE (PLA2G2E) genes on chromosome 1p36, and the interferon, gamma (IFNG), interleukin 26 (IL26), and interleukin 22 (IL22) genes on chromos...

Does the victim affect snake venom composition?

...esenting only the stretches of DNA that code for venom gland proteins, and studied two types of protein toxins. The three-finger toxins (3FTx) and the phospholipase A2 (PLA2) enzymes are the main components of sea snake venom. Although the sea snakes studied lived in very different aquatic environments, the tox...

Mutant gene causes severe kidney disease in infants

...overed a previously unknown cause for a severe, early-onset form of kidney disease and renal failure in children: recessive mutations in a gene called phospholipase C epsilon or PLCE1. Identifying the mutant gene is important to scientists because PLCE1 affects the development of podocytes ?specialized cells tha...
Phospholipase in Biological Technology

Anthera Completes Enrollment and Dosing of Varespladib Cardiovascular Trial

...spladib cardiovascular program targeting secretory phospholipase A2," said Paul Truex, President and Chief Executiv...potent and highly selective inhibitor of secretory phospholipase A2 (sPLA2), has demonstrated marked improvements i...t inhibit the enzymatic activity of members of the phospholipase (PLA2) family - a group of enzymes responsible for...

Anthera's Varespladib Demonstrates Significant Anti-Inflammatory Effect and LDL Reduction in Patients With Coronary Heart Disease

...tial reduction in the target enzyme and pro- inflammatory marker, secretory phospholipase A2 (84%, p<.0001) -- Varespladib resulted in a significant reduction in L...re-clinical compounds that inhibit the enzymatic activity of members of the phospholipase (PLA2) family -- a group of enzymes responsible for the release of arachido...

Morria Biopharmaceuticals Plc Announces Positive Clinical Results for MRX-4 in its Phase II Clinical Study in Allergic Rhinitis Patients

...atory drugs (MFAIDs). This class of drugs uniquely combines two promising approaches to preventing and reversing inflammation: first, they control the phospholipase A2 (PLA2) enzyme family, a known anti-inflammatory drug target. At the same time, they also enrich the cell surface glycosaminoglycans thereby protect...

Morria Biopharmaceuticals Plc Announces Results From its Pre-Clinical Screening of Novel Anti-Inflammatory Compounds

...atory drugs (MFAIDs). This class of drugs uniquely combines two promising approaches to preventing and reversing inflammation: first, they control the phospholipase A2 (PLA2) enzyme family, a known, but previously elusive anti-inflammatory drug target. At the same time, they also protect cells and tissues against ...

diaDexus, Inc. and Living Heart Foundation Offer the PLAC(R) Test to Detect Hidden Risk for Heart Attack and Stroke in Retired NFL Players

...d in assessing risk for both coronary heart disease and ischemic stroke associated with atherosclerosis. The PLAC Test measures lipoprotein-associated phospholipase A2 (Lp-PLA2), a vascular-specific inflammatory enzyme implicated in the formation of rupture-prone plaque. It is plaque rupture and thrombosis, not st...

Anthera Pharmaceuticals Completes $19 Million Financing; Appoints Christopher S. Henney as Chairman

... two previous clinical trials, Varespladib, a potent inhibitor of secretory phospholipase A2 (sPLA2), has demonstrated marked improvements in independent markers of ...re-clinical compounds that inhibit the enzymatic activity of members of the phospholipase (PLA2) family -- a group of enzymes responsible for the release of arachido...

Expert Consensus Panel Recommendation for Incorporating Lp-PLA2 Testing into Cardiovascular Disease Risk Assessment Guidelines

...tion to include testing for lipoprotein-associated phospholipase A2 (Lp-PLA2), a vascular-specific inflammatory mar...- Prone Plaque: The Role of Lipoprotein-Associated phospholipase A2 in Cardiovascular Risk Assessment" was authored...mendation for Incorporating Lipoprotein Associated phospholipase A2 Testing into Cardiovascular Disease Risk Assess...

Human Genome Sciences Announces First Quarter 2008 Financial Results and Key Developments

...nts with coronary heart disease (CHD). The study showed that darapladib produced sustained, dose-dependent inhibition of plasma lipoprotein-associated phospholipase A2 (Lp-PLA2) activity in patients receiving intensive atorvastatin (cholesterol-lowering) therapy. Lp-PLA2 is an enzyme associated with the formation ...

Anthera Presents Data on Varespladib at ATVB Meeting

...heart disease. Posters include: -- Effects of a Selective Secretory phospholipase A2 Inhibitor on Low-Density Lipoproteins in CHD Patients with Diabetes....re-clinical compounds that inhibit the enzymatic activity of members of the phospholipase (PLA2) family -- a group of enzymes responsible for the release of arachido...

diaDexus Selects Fisher HealthCare to Sell New Automated PLAC(R) Test

... atherosclerosis. Earlier detection and more aggressive treatment can prevent heart attacks and strokes. The PLAC Test measures lipoprotein-associated phospholipase A(2) (Lp-PLA(2)), a vascular-specific inflammatory enzyme implicated in the formation of rupture-prone plaque. It is plaque rupture and thrombosis, no...
Phospholipase in Biological Products

Rabbit Anti-Glutamate receptor 1, phospho (Ser845) Polyclonal Antibody, Unconjugated from GeneTex

Description:...ific receptors coupled to G-proteins. These receptors are called metabotropic glutamate receptors. In expression systems, Group-I receptors, stimulate phospholipase C as revealed by an increase in phosphoinositide turnover, and Ca2+ release from internal stores. Group-II and -III receptors are coupled to the inhib...
Company:GeneTex

Phosphate Colorimetric Assay Kit, 'EnzoLyte from AnaSpec

Description:... conveniently performed in 96- and 384-well plates for high-throughput screening of enzyme inhibitors. The kit has been used for assaying phosphatase, phospholipase or lipase, nucleoside triphosphatase (ATPase, GTPase etc) and phytase. The kit has the following components: Highly purified Malachite Green reagent ...
Company:AnaSpec
Phospholipase in Biological Definition

Enzyme

...f polyamines Peroxidase : the group of enzymes that can convert hydrogen peroxide or similar compounds Phenylalanine hydroxylase (PAH): phospholipase Polymerase : builds long chains of nucleic acid polymers from their constituents Protease (peptidase): those enzymes which cut peptide bo...

Lipase

...and C. Cambillau. 1996. A pancreatic lipase with a phospholipase A1 activity: crystal structure of a chimeric pancr...a 1376:417-32. Diaz, B. L., and J. P. Arm. 2003. phospholipase A(2). Prostaglandins Leukot Essent Fatty Acids 69:...ein of adeno-associated virus type 2 is carrying a phospholipase A2 domain required for virus infectivity. J Gen Vi...

Signal transduction

...s also called a Ca 2+ wave . The building of the wave is done by the feedback mechanism of the ryanodine receptor and the activation of phospholipase C by Ca 2+ , which leads to the production of inositol triphosphate , which in turn activates the InsP 3 receptor. Function of Ca 2+ ...
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