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Phosphodiesterase in Medical News

FDA Approves TYVASO (Treprostinil) Inhalation Solution for the Treatment of Pulmonary Arterial Hypertension

...nd its wholly-owned subsidiary, Lung Rx, Inc. Nearly all clinical experience has been on a background of an endothelin receptor antagonist or a phosphodiesterase type 5 inhibitor. Important Safety Information for TYVASO TYVASO is a prostacyclin vasodilator indicated for the treatment of pulmon...

Nycomed Announces FDA Filing for Daxas(R) in COPD

... (See http://www.who.int/respiratory/copd/burden/en/index.html ) About Daxas Nycomed's Daxas is an orally administered phosphodiesterase 4 (PDE4) enzyme inhibitor targeting cells and mediators in the body believed to be important in the COPD disease process. Daxas is expected to act on ...

For Erectile Dysfunction, Physicians Indicate That Opportunity Exists for Emerging Therapies with Improved Efficacy in Difficult-to-Treat Patient Subpopulations

...armaceutical and healthcare issues, finds that although surveyed primary care physicians (PCPs) are generally satisfied with the efficacy of available phosphodiesterase type 5 (PDE5) inhibitors such as Pfizer's Viagra, Eli Lilly's Cialis and Bayer Healthcare/Schering-Plough/GlaxoSmithKline's Levitra, they are less sat...

Rapid Generic Erosion of Branded Agents, Including Market-Leading Viagra, Will Cause Sales of Erectile Dysfunction Drugs to Remain Flat Over the Next Decade

...The new Pharmacor report entitled Erectile Dysfunction finds that while therapeutic substitution of less-expensive, generic sildenafil for branded phosphodiesterase type 5 (PDE5) inhibitors will contribute to a significant loss of sales for Eli Lilly's Cialis and Bayer Healthcare/Schering-Plough/GlaxoSmithKline's ...

Warner Chilcott and Dong-A Sign U.S. License Agreement For Erectile Dysfunction Treatment

...ed that it has signed an agreement with Dong-A PharmTech Co. Ltd., based in Korea, to develop and market their orally-administered udenafil product, a phosphodiesterase type 5 (PDE5) inhibitor for the treatment of erectile dysfunction (ED) in the United States. Dong-A has successfully completed Phase 2 studies of the...

UCSD researchers identify potential new drug target for chronic leukemia

...llectively known as cyclic nucleotide phosphodiesterases, was 10 times higher in CLL patients than in normal individuals. The specific type of enzyme, phosphodiesterase 7B (PDE7B), controls the levels of cyclic AMP (cAMP), a molecule that can promote programmed cell death, a process that is defective in CLL. The team ...

Is sildenafil safe in cirrhosis patients?

...iver disease through inhibition of the type-5 phosphodiesterase. The type-5 phosphodiesterase is also present in human mesenteric arteries. The effect of sildenafil on s...anchnic blood flow, oxygen consumption and HVPG in patients with cirrhosis. phosphodiesterase type-5 inhibition is of no use as a therapeutic agent for alleviating porta...

Memory Pharmaceuticals Announces Six Abstracts Accepted for Presentation at Society for Neuroscience Meeting

...685 Tuesday, November 18, 2008 1:00 p.m. - 5:00 p.m. EST -- "Identification and characterization of a novel small molecule inhibitor for phosphodiesterase 10A as a potential PET-tracer using LC-MS/MS" Poster Session 885 Wednesday, November 19, 2008 1:00 p.m. - 5:00 p.m. EST -- "Camk2(alpha...

Cialis May Help Ease Pulmonary Hypertension

... that pulmonary hypertension is a progressive disease which results in substantial morbidity and mortality. "Prior studies have shown that the oral phosphodiesterase type 5 inhibitor, sildenafil (Viagra, Revatio) improves exercise capacity in patients with pulmonary arterial hypertension," Fonarow said. "This medic...

Abnormal 'editing' of gene messages may be a cause of lupus

...axminarayana years to uncover. The current studies demonstrate that, essentially, too much 150-kDa ADAR1 results in an increase in the gene message of phosphodiesterase 8A1 (PDE8A1), which is involved in the disruption of normal cell signaling and impairing cell function. 150-kDa ADAR1 is the culprit, Laxminaray...
Phosphodiesterase in Medical Technology

FDA Approves ADCIRCA(TM) (Tadalafil) Tablets for the Treatment of Pulmonary Arterial Hypertension

...g Administration (FDA) has approved ADCIRCA(TM) (tadalafil) tablets for oral administration, with a recommended dose of 40 mg, as the first once-daily phosphodiesterase type 5 (PDE5) inhibitor for the treatment of pulmonary arterial hypertension (PAH). ADCIRCA is indicated to improve exercise ability in WHO Group I P...

VIVUS Initiates Open Label Safety Study of Avanafil for Erectile Dysfunction

...n the study. Top-line results of REVIVE are expected in the fourth quarter of 2009. Avanafil, a next-generation, fast-acting, selective, oral, phosphodiesterase type 5 (PDE5) inhibitor, is VIVUS' investigational product for the treatment of ED. The phase 3 program for avanafil is funded through a $30 million c...

Omeros Receives $3.1 Million Milestone Payment from The Stanley Medical Research Institute for Schizophrenia Program

...estone payment to Omeros for having successfully met preclinical compound optimization criteria. Omeros' schizophrenia product candidates inhibit the phosphodiesterase 10 (PDE10) enzyme. "The award of this milestone payment reaffirms the strength of the preclinical data generated by our schizophrenia program," s...

Michael J. Fox Foundation Awards $2.7 Million to Four Industry Teams for Pre-Clinical Parkinson's Disease Research

...ession and Therapeutics Interventions in Parkinson's Disease Patrizia Fanara, Ph.D., KineMed, Inc. Selective Inhibition of Cyclic Nucleotide phosphodiesterase Type 7 (PDE7): A Novel and Efficacious Approach to Treating Parkinson's Disease Vincent Allen Florio, Ph.D., Omeros Corporation Development ...

deCODE Files IND for DG071, a Novel PDE4 Modulator Being Developed for Alzheimer's and Other Cognitive Disorders

...Nasdaq: DCGN ) today announced the filing of an investigational new drug (IND) application for DG071, the company's novel small-molecule modulator of phosphodiesterase 4 (PDE4), with the US Food and Drug Administration (FDA). The compound is being developed as a new and potentially safer means of targeting PDE4 to co...

Dong-A PharmTech Co., Ltd. Announces Portal Hypertension Clinical Trial With Udenafil

...of concept clinical study to investigate the use of udenafil, a long acting phosphodiesterase type 5 inhibitor, for portal hypertension, an unmet medical need. The multi...ing with Dr. Falk Pharma on evaluating the potential of our new long acting phosphodiesterase inhibitor, udenafil for treating portal hypertension. Dong-A PharmTech is c...

Furamidine Found to Inhibit a Key Enzyme Involved in Cancer Cell DNA Repair Mechanisms

...highlights a new high-throughput assay for evaluating potential tyrosyl-DNA phosphodiesterase (Tdp1) inhibitors and the activity of furamidine as a low micromolar inhibi...hput electrochemiluminescent assay for identification of human tyrosyl- DNA phosphodiesterase (Tdp1) inhibitors and characterization of furamidine (NSC305831) as an inhi...

Study: Identical Doses of BiDil Components Are Not Bioequivalent to the Fixed Dose Combination-BiDil-Used in A-HeFT

...ation BiDil is contraindicated in patients who are allergic to organic nitrates. Augmentation of the vasodilatory effects of isosorbide dinitrate by phosphodiesterase inhibitors (e.g., Viagra((R))/Revatio(TM), Levitra((R)), Cialis((R))) could result in severe hypotension. Treatment with hydralazine may produce a c...

Dong-A PharmTech Co., Ltd. Announces Positive Results for Udenafil, Its New Long Acting Drug For Erectile Dysfunction

... Ltd. announced today that it has completed a 340 patient phase 2b "at-home" clinical study for udenafil, its new long acting (12 hour half-life) oral phosphodiesterase type 5 (PDE5) inhibitor for erectile dysfunction (ED). The multi-center study conducted in the U.S. was a randomized, double-blind, placebo controlled...

Anacor Clinical Study of AN2728, a Novel Anti-Inflammatory Compound, Shows Efficacy in Psoriasis

...he target of the powerful monoclonal antibodies now marketed for the treatment of psoriasis. Company researchers have shown that AN2728 suppresses the phosphodiesterase 4 (PDE4) enzyme, leading to TNF-alpha inhibition. "This early-stage trial demonstrated definitive anti-inflammatory activity in humans. We are encou...
Phosphodiesterase in Biological News

Male impotence drugs may deserve a second look in women

...ond look at their potential in the 40 percent of women who report sexual dysfunction, researchers say. In one of the first studies of the effect of phosphodiesterase Type 5 inhibitors - Viagra, Levitra and Cialis - on the pudendal arteries that supply the penis, vagina and clitoris the blood needed to produce a sat...

Study may explain exercise-induced fatigue in muscular dystrophies

...ed cGMP that causes smooth muscle around blood vessels to relax thereby increasing blood flow. This nitric oxide signaling pathway is turned off by phosphodiesterase (PDE), an enzyme that breaks down cGMP. Viagra, a drug designed to increase blood flow, inhibits PDE and prolongs the existence of the cGMP molecules ...

Atomic-resolution views suggest function of enzyme that regulates light-detecting signals in eye

...only in the eye has given researchers at the University of Washington (UW) clues about how this enzyme, essential to vision, is activated. The enzyme, phosphodiesterase 6 (PDE6), is central to the way light entering the retina is converted into a cascade of signals to the brain. This particular form of the enzyme ...

For some who have lost their sense of smell, a once popular asthma drug could help

...tients consumed 200, 400 or 600 mg of theophylline (correlated to blood levels) for a period of 2-6 months. The drug theophylline is a generalized phosphodiesterase inhibitor. Physicians have determined that the drug is a generalized inhibitor which means it causes certain chemicals like cAMP and cGMP to increase....

Texas A&M testing oral contraceptives for animals

...donations. The pill works by inhibiting the maturation of the egg, not the entire cycle, Kraemer says. The technical name for the drug is called a phosphodiesterase 3 inhibitor, and it is one member of a family of drugs being tested. Similar compounds have been tested in laboratories elsewhere in mice and monke...

Study finds Viagra increases release of key reproductive hormone

...one release by dampening neural excitation of the cells. This same enzyme, phosphodiesterase type 5, also limits blood flow by contracting the muscles around blood vess...rying to sort out the issues around whether there are additional effects of phosphodiesterase type 5 inhibitors," which include Viagra, Levitra and Cialis. The new repo...

Lack of key enzyme associated with development of rare tumor

...y to analyze samples of the patients' tumors. The researchers found four patients who had mutant copies of a gene that contains the information for phosphodiesterase 11A (PDE11A). Phosphodiesterases are a family of enzymes involved in "switching off" a cell's response to hormones, Dr. Stratakis explained. For a...

Scientists move forward understanding of schizophrenia

...burgh and Glasgow, together with scientists from the pharmaceutical company Merck, Sharp & Dohme Limited, report the discovery of the second gene, phosphodiesterase 4B (PDE4B) in the prestigious journal Science today (17 November). Their discoveries could lead to the eventual development of new drugs to treat ment...
Phosphodiesterase in Biological Technology

Amgen Exercises Option for Exclusive License to Cytokinetics' Cardiac Contractility Program That Includes CK-1827452

...most thoroughly characterized protein machines in human biology. Current inotropic agents, such as beta-adrenergic receptor agonists or inhibitors of phosphodiesterase activity, increase cardiac cell contractility by increasing the concentration of intracellular calcium, which further activates the cardiac sarcomere....

deCODE genetics Announces Third Quarter 2008 Financial Results

...s and cognition deficits. In October 2008 we filed an investigational new drug (IND) application for DG071, a novel small- molecule modulator of phosphodiesterase 4 (PDE4), being developed for Alzheimer's and other cognitive disorders. The compound is being developed as a new and potentially safer means of...

Nycomed's Daxas(R) Shows Encouraging Preliminary Results in Phase III COPD Studies

...lying risk factors, especially smoking. (see http://www.who.int/respiratory/copd/burden/en/index.html ) Nycomed's Daxas is an orally administered phosphodiesterase 4 (PDE4) enzyme inhibitor, targeting cells and mediators in the body believed to be important in the COPD disease process. Daxas is expected to act on...

AIM-Quoted Verona Pharma Progresses Anti-Asthma Drug Studies

...seases. The Company is currently developing RPL554, a long-acting bronchodilator/anti-inflammatory drug (belonging to a class of drugs known as mixed phosphodiesterase (PDE) 3/4 inhibitors) that could be rapidly brought to clinical proof-of-concept for the treatment of hay fever and asthma. As a PDE3/4 inhibitor, RPL...

cAMP DataFile: Homogenous Cyclic AMP detection using High Efficiency Fluorescence Polarization

...erion family. Applications Measurement of adenylyl cyclase activity 1 Monitoring phosphodiesterase activity 2 Assay Performance Calibration curve: A calibration curve was performed in 384-well microplates with a final v...

Use of Novel FlashPlate Technology to Measure cAMP Accumulation in Chinese Hamster Ovary Cells Expressing Human -2 Adrenoreceptors

... in Hams F-12 media containing 10% foetal bovine serum and 500 μg/ml Geneticin 418, harvested and resuspended in stimulation buffer, containing a phosphodiesterase inhibitor, provided with the FlashPlate kit. The cells were then spun at 200 g for 5 mins. at room temperature, the supernatant removed and the pellet...
Phosphodiesterase in Biological Products

Phosphodiesterase I from USB Corp.

Description:... Source: Crotalus adamanteus venom Description: phosphodiesterase I (venom exonuclease) is widely used in studying nucleic acid structure and...droxy-terminated ribo-oligonucleotides and deoxyribo-oligonucleotides (2) . phosphodiesterase I cleaves ADP-ribosylated proteins at the pyrophosphate linkages to yield p...
Company:USB Corp.
Phosphodiesterase in Biological Dictionary

Phosphodiester Bond

...osphate groups in the phosphodiester bond are negatively-charged. ... A phosphodiesterase is any enzyme that breaks a phosphodiester bond . ... What is phos...tionary. ... together via a phosphodiester bond and the the 1' ... A phosphodiesterase is any enzyme that breaks a phosphodiester bond . ... enzymes that d...
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