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Phenylalanine in Medical News

BioMarin Announces Second Quarter 2009 Financial Results

...oped in partnership with Merck Serono, a division of Merck KGaA of Darmstadt, Germany. Other product candidates include PEG-PAL (PEGylated recombinant phenylalanine ammonia lyase), which is currently in development for the treatment of PKU and GALNS (N-acetylgalactosamine 6-sulfatase), which is currently in Phase ...

Patents Issued Covering Stable Tablet Formulation and Once Daily Dosing Regimen for Kuvan

...are indicated in the United States to reduce blood phenylalanine (Phe) levels in patients with hyperphenylalaninemi...ing enzyme cofactor that works in conjunction with phenylalanine hydroxylase (PAH) to metabolize Phe. Kuvan...ped world, is caused by a deficiency of the enzyme phenylalanine hydroxylase. PAH is required for the metabolism of...

Patient Enrollment Complete for Phase I/II Clinical Trial for GALNS for Morquio A Syndrome

...oped in partnership with Merck Serono, a division of Merck KGaA of Darmstadt, Germany. Other product candidates include PEG-PAL (PEGylated recombinant phenylalanine ammonia lyase), which is currently in Phase I clinical development for the treatment of PKU. For additional information, please visit www.BMRN.com. In...

Vegetable Amino Acid Lowers Blood Pressure

...ded. Similar but lesser effects on lowering blood pressure have been found for other amino acids more common in vegetable protein, such as proline, phenylalanine and serine, Brown said. "The solution to improving blood pressure is not based around a single nutrient," he said. "We are looking at a whole serie...

BioMarin to Host Second Quarter 2009 Financial Results Conference Call and Webcast on Thursday, July 30 at 5:00 p.m. ET (23:00 CET)

...oped in partnership with Merck Serono, a division of Merck KGaA of Darmstadt, Germany. Other product candidates include PEG-PAL (PEGylated recombinant phenylalanine ammonia lyase), which is in clinical development for the treatment of PKU and GALNS (N-acetylgalactosamine 6-sulfatase), which is currently in Phase 1...

Temporary Production Interruption at Allston Landing Manufacturing Facility Has No Impact on Aldurazyme

...oped in partnership with Merck Serono, a division of Merck KGaA of Darmstadt, Germany. Other product candidates include PEG-PAL (PEGylated recombinant phenylalanine ammonia lyase), which is in clinical development for the treatment of PKU and GALNS (N-acetylgalactosamine 6-sulfatase), which is currently in Phase 1...

Results From Phase 1 Clinical Study of PEG-PAL in PKU and Update on Phase 2 Clinical Study

...1 clinical study of PEG-PAL (PEGylated recombinant phenylalanine ammonia lyase) for the treatment of phenylketonuri...About PEG-PAL PEG-PAL (PEGylated recombinant phenylalanine ammonia lyase) is an investigational enzyme substi... candidates include PEG-PAL (PEGylated recombinant phenylalanine ammonia lyase), which is in clinical development f...

BioMarin to Present at the William Blair Growth Stock Conference

...oped in partnership with Merck Serono, a division of Merck KGaA of Darmstadt, Germany. Other product candidates include PEG-PAL (PEGylated recombinant phenylalanine ammonia lyase), which is currently in Phase I clinical development for the treatment of PKU and GALNS (N-acetylgalactosamine 6-sulfatase), which is cu...

BioMarin Receives 2009 Corporate Award for the Development of Kuvan

...cation for PKU. Kuvan is indicated to reduce blood phenylalanine (Phe) levels in patients with hyperphenylalaninemi... candidates include PEG-PAL (PEGylated recombinant phenylalanine ammonia lyase), which is currently in Phase I clin...ped world, is caused by a deficiency of the enzyme phenylalanine hydroxylase. PAH is required for the metabolism of...

ASHG hosts fourth annual DNA Day essay contest, supports genetics education efforts

...ity of phenylketonuria (or PKU), which is a rare, inherited single-gene disorder that affects a person's ability to properly metabolize the amino acid phenylalanine and, if left untreated, can cause problems with brain development that could lead to mental retardation. In her essay, Li gave a perceptive descriptio...
Phenylalanine in Medical Technology

BioMarin Initiates Phase 1/2 Clinical Trial for GALNS for Morquio A Syndrome

...oped in partnership with Merck Serono, a division of Merck KGaA of Darmstadt, Germany. Other product candidates include PEG-PAL (PEGylated recombinant phenylalanine ammonia lyase), which is currently in Phase 1 clinical development for the treatment of PKU. For additional information, please visit www.BMRN.com . ...

BioMarin Announces Positive Results From Phase 2A Clinical Study of 6R-BH4 in Sickle Cell Disease

...currently in Phase 2 clinical development for the treatment of peripheral arterial disease and sickle cell disease, and PEG-PAL (PEGylated recombinant phenylalanine ammonia lyase), which is currently in Phase 1 clinical development for the treatment of PKU. For additional information, please visit http://www.BMRN...

Peptimmune Announces Grant of United States Patent for PI-2301 Peptide Copolymer for Multiple Sclerosis

...ween the brain and other parts of the body is disrupted. The '790 patent claims "A linear random copolymer YFAK comprising amino acids tyrosine (Y), phenylalanine (F), alanine (A), and lysine (K)," )." which was licensed from Harvard University. The copolymer technology was developed in conjunction with Professo...

BioMarin Initiates Phase 1 Clinical Study of PEG-PAL in PKU

...1 clinical study of PEG-PAL (PEGylated recombinant phenylalanine ammonia lyase) for the treatment of phenylketonuri.... About PEG-PAL PEG-PAL (PEGylated recombinant phenylalanine ammonia lyase) is an investigational enzyme substi...e cell disease, and PEG-PAL (PEGylated recombinant phenylalanine ammonia lyase), which is currently in Phase 1 clin...

BioMarin Announces FDA Approval for Kuvan

...the disease." Kuvan is indicated to reduce blood phenylalanine (Phe) levels in patients with hyperphenylalaninemi...ydrochloride) Tablets is indicated to reduce blood phenylalanine (Phe) levels in patients with hyperphenylalaninemi...ing enzyme cofactor that works in conjunction with phenylalanine hydroxylase (PAH) to metabolize Phe. BioMarin and ...

Positive Kuvan(TM) Pivotal Phase 3 Trial Results Published in The Lancet

...Kuvan compared with placebo for reduction of blood phenylalanine in patients with PKU. The secondary objective was ...f patients in the placebo group had a blood phenylalanine concentration below the recommended 600 uM/L level (p=0.003). * Blood phenylalanine concentrations fell by about 200 uM/L after one ...
Phenylalanine in Medical Dictionary

Phenylalanine

Phenylalanine is an α-amino acid with the formula HO2CCH(NH2)CH2C6H5, which is found naturally in the breast milk of mammals and manufactured for food and drink products and are also sold as nutritional supplements for their... Phenylalanine is an essential amino acid (building bl...

Tryptophan

...tion on what it is used for. ... In humans, the L-isomer of tryptophan , which is the only form that is involved ... Tryptophan , tyrosine, and phenylalanine are the biggest of the standard ... Certified Vegetarian L-Tryptophan: 120 - 500 mg Capsules a super value so ... In the body, tryptophan serve...

Pku

...rized by a deficiency in the enzyme hepatic phenylalanine hydroxylase. :541 This enzyme is necessary to metabolize the amino acid phenylalanine to the... Online resource that offers Phenylk...y can't process a portion of the protein called phenylalanine ... The most effective treatment for PKU is a...

Phenylketonuria

...rized by a deficiency in the hepatic enzyme phenylalanine hydroxylase. :541 This enzyme is necessary to metabolize the amino acid phenylalanine to the... Phenylketonuria — Comprehensive o...baby lacks or has very low levels of the enzyme phenylalanine hydroxylase (PAH) Phenylketonuria (PKU) is ...

Alkaptonuria

... Alkaptonuria is a rare inherited genetic disorder of phenylalanine and tyrosine metabolism. This is an autosomal recessive condition that is due to a defect in the enzyme homogentisate 1,2-dioxygenase (EC 1.13.11...
Phenylalanine in Biological News

UW-Madison study reveals new options for people with PKU

...s we eat in everyday foods. While small amounts of phenylalanine are essential for PKU patients, excess amounts sta...plied most of his daily protein, but the amount of phenylalanine in his blood actually starting going down after he...n among individual subjects, but the overall blood phenylalanine levels measured after meals were comparable in the...

New drug holds out promise of normal diet for sufferers of devastating PKU genetic disease

...e genetic disease that is characterized by a deficiency in an enzyme called phenylalanine hydroxylase (PAH). Without PAH, the body cannot metabolize the amino ac...ks in humans," she said. "Certainly in the animal models we showed that the phenylalanine levels came down to normal. The treatment itself is enzyme therapy, so pati...

UF researchers develop improved gene therapy agent

...tion. To do that, the researchers replaced tyrosine with another amino acid, phenylalanine. The two amino acids are identical except for one thing phenylalanine lacks the part that attracts phosphate. We didnt change anything except the amino acid that does not allow phosphorylation to occur, he said. It w...

Gene's 'selective signature' aids detection of natural selection in microbial evolution

...e bacterium that has adapted to life near sulfurous hydrothermal vents in the ocean floor, the genes involved in metabolizing sugar and the amino acid phenylalanine underwent significant changes (over hundreds of millions of years) that may help the bacterium obtain carbon from amino acids rather than from sugars,...

Unique whey protein is promising supplement for strict PKU diet

...must avoid protein because, while small amounts of phenylalanine are required for life, excess amounts stay in thei... also looked at the brains of mice with PKU, where phenylalanine causes problems. Perhaps the most interesting obse...opeptide is that they had a 20 percent decrease in phenylalanine in their brains (compared to those fed the equival...

Biophysical Society announces winners of 2008 Student Travel Awards

...l Changes Associated with Antigen-Mediated IgE Receptor Signaling in Mast Cells. Isabelle C. Dragomir, Drexel University, Characterization of phenylalanine Based Short Peptides at Varying pHs, Temperatures, and Concentrations via Electronic Circular Dichroism and Absorption Spectroscopy. Kyle P. Ea...

Researchers discover natural herbicide released by grass

...which would normally provide negative feedback for phenylalanine biosynthesis" and, thereby, suppress plant growth....cumb to the toxin themselves. They found that when phenylalanine was added to plants dying from m-tyrosine exposure...uspect that these fescue varieties may overproduce phenylalanine to save themselves from their own toxin. People h...

Nationwide Children's Hospital involved in expanded access program for treatment of PKU

...cumstances. Individuals with PKU are born with a deficient enzyme called phenylalanine hydroxylase (PAH). With little or no PAH activity, they are unable to metabolize an essential amino acid, called phenylalanine (Phe), which is found in most foods including meat, eggs, dairy, nuts, past...

Paradigm shift in Alzheimers's research: new treatments

...oteolytic processing of APP, the precursor of A", and its proteases responsible for generating A". Ragged peptides with a major species beginning with phenylalanine at position 4 of Ab have been reported already in 1985 by Masters et al.1. In 1992, Mori et al. first described the presence of A"N3(pE) using mas...

The sound of proteins

... appear less often. Individual amino acids are expressed as chords, in which similar amino acids are paired. For example, the amino acids tyrosine and phenylalanine are both assigned a G major chord, but they can be distinguished because the notes in the chord are arranged differently. This means the resulting mus...
Phenylalanine in Biological Technology

Kuvan Receives Priority Review Status From Health Canada

...are indicated in the United States to reduce blood phenylalanine (Phe) levels in patients with hyperphenylalaninemi...ing enzyme cofactor that works in conjunction with phenylalanine hydroxylase (PAH) to metabolize Phe. Kuvan h...ped world, is caused by a deficiency of the enzyme phenylalanine hydroxylase. PAH is required for the metabolism of...

BioMarin to Present at the Jefferies Healthcare Conference

...oped in partnership with Merck Serono, a division of Merck KGaA of Darmstadt, Germany. Other product candidates include PEG-PAL (PEGylated recombinant phenylalanine ammonia lyase), which is currently in Phase I clinical development for the treatment of PKU and GALNS (N-acetylgalactosamine 6-sulfatase), which is cu...

BioMarin to Present at the Goldman Sachs Healthcare Conference

...oped in partnership with Merck Serono, a division of Merck KGaA of Darmstadt, Germany. Other product candidates include PEG-PAL (PEGylated recombinant phenylalanine ammonia lyase), which is currently in Phase I clinical development for the treatment of PKU and GALNS (N-acetylgalactosamine 6-sulfatase), which is cu...

BioMarin to Present at the Deutsche Bank Health Care Conference

...oped in partnership with Merck Serono, a division of Merck KGaA of Darmstadt, Germany. Other product candidates include PEG-PAL (PEGylated recombinant phenylalanine ammonia lyase), which is currently in Phase I clinical development for the treatment of PKU and GALNS (N-acetylgalactosamine 6-sulfatase), which is cu...

BioMarin to Present at the Baird Growth Stock Conference

...oped in partnership with Merck Serono, a division of Merck KGaA of Darmstadt, Germany. Other product candidates include PEG-PAL (PEGylated recombinant phenylalanine ammonia lyase), which is currently in Phase I clinical development for the treatment of PKU and GALNS (N-acetylgalactosamine 6-sulfatase), which is cu...

BioMarin Announces First Quarter 2009 Financial Results

...oped in partnership with Merck Serono, a division of Merck KGaA of Darmstadt, Germany. Other product candidates include PEG-PAL (PEGylated recombinant phenylalanine ammonia lyase), which is currently in Phase I clinical development for the treatment of PKU and GALNS (N-acetylgalactosamine 6-sulfatase), which is cu...

BioMarin to Host First Quarter 2009 Financial Results Conference Call and Webcast on Thursday, April 30 at 5:00 p.m. ET (23:00 CET)

...ped in partnership with Merck Serono, a division of Merck KGaA of Darmstadt, Germany. Other product candidates include PEG-PAL (PEGylated recombinant phenylalanine ammonia lyase), which is currently in Phase 1 clinical development for the treatment of PKU. For additional information, please visit www.BMRN.com ....

BioMarin Receives Notice of Allowance for Once Daily Dosing Patent for Kuvan

...are indicated in the United States to reduce blood phenylalanine (Phe) levels in patients with hyperphenylalaninemi...ing enzyme cofactor that works in conjunction with phenylalanine hydroxylase (PAH) to metabolize Phe. Kuvan h...ped world, is caused by a deficiency of the enzyme phenylalanine hydroxylase. PAH is required for the metabolism of...

BioMarin to Present at the 4th Annual Citi Biotech Day

...ped in partnership with Merck Serono, a division of Merck KGaA of Darmstadt, Germany. Other product candidates include PEG-PAL (PEGylated recombinant phenylalanine ammonia lyase), which is currently in Phase 1 clinical development for the treatment of PKU. For additional information, please visit www.BMRN.com ....

BioMarin's Clinical Trial Application for GALNS for Morquio A Syndrome Accepted by the MHRA

...oped in partnership with Merck Serono, a division of Merck KGaA of Darmstadt, Germany. Other product candidates include PEG-PAL (PEGylated recombinant phenylalanine ammonia lyase), which is currently in Phase 1 clinical development for the treatment of PKU. For additional information, please visit www.BMRN.com . ...
Phenylalanine in Biological Products

Ribonucleic acid, transfer, phenylalanine specific from brewer's yeast from Sigma-Aldrich

Description: Preparation Note: Prepared by method of Wimmer, E., et al., Biochemistry, 7, 2623 (1968). Quality Clarifier: Acceptor Activity: approx. 1000 picomoles phenylalanine per A 260 unit (not determined by Sigma)...
Company:Sigma-Aldrich
Phenylalanine in Biological Definition

Amino acid

...essential amino acids are lysine , leucine , isoleucine , methionine , phenylalanine , threonine , tryptophan , valine , and (in children) histidine and a... acidic 147.13 3.15 2.10 9.47 4.07 F Phe phenylalanine hydrophobic 165.19 5.49 2.20 9.31 G Gly ...

Genetic code

... 2nd base U C A G 1st base U UUU (Phe/F) phenylalanine UUC (Phe/F) phenylalanine UUA (Leu/L) Leucine UUG (Leu/L) Leucine , Start UCU (Ser/S...

Enzyme

... in humans is phenylketonuria (PKU). The enzyme phenylalanine hydroxylase , which usually converts the essential amino acid phenylalanine into tyrosine does not work, resulting in a buildup of phenylalanine that leads to mental retardation. Enzymes in the h...

Genetic code

... 2nd base U C A G 1st base U UUU (Phe/F) phenylalanine UUC (Phe/F) phenylalanine UUA (Leu/L) Leucine UUG (Leu/L) Leucine , Start UCU (Ser/S...

Neurotransmitter

...itters Derived from amino acids : aspartate glutamate GABA glycine Monoamines (in the order of their synthesis): from phenylalanine and tyrosine : dopamine ( da ) norepinephrine ( ne /noradrenaline) epinephrine ( epi /adrenaline) from tryptophan : serot...

Protein

...ome in two forms: complete proteins contain all eight of the amino acids ( threonine , valine , tryptophan , isoleucine , leucine , lysine , phenylalanine , and methionine ) that humans cannot produce themselves, while incomplete proteins lack or contain only a very small proportion of one or more. Hu...
Phenylalanine in Biological Dictionary

Norepinephrine

...ted by the adrenal medulla and the nerve endings of the A compilation of neurotranmitter and amino acid information and how it affects you. ... phenylalanine and tyrosine are precursors to norepinephrine and epinephrine. ... Norepinephrine or noradrenaline is a hormone and a neurotransmitter; it is...

Anticodon

... the ... The codon (and, reciprocally, the anticodon ) codes for a specific amino acid. ... Anticodon : 3' CGA 5' Codon: 5' GCU 3' ... Example: phenylalanine tRNA with the anticodon 3' AAG 5' recognizes not only UUC ... Information about anticodon in the free online English dictionary and ... antico...
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