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Phenotypic in Medical News

Sex Hormone Protein May Predict Type 2 Diabetes

...etes, the researchers found. "To our knowledge, there are few biomarkers for type 2 diabetes prediction that have presented both genetic and plasma phenotypic evidence like ours," Liu said. The report was published in the Aug. 5 online edition of the New England Journal of Medicine . For the study, Li...

GeneGo Awarded NIH Grant to Develop Pharmacogenomics Software Suite

...s an integration and expert analysis of different kinds of experimental data (mRNA expression, proteomics , metabolomics, microRNA assays and other phenotypic data) and relevant bioactive chemistry (metabolites, drugs, other xenobiotics) within the framework of curated biological pathways and networks. GeneG...

New HIV Study Shows That Large Numbers of Women and People of Color Can Be Successfully Enrolled In U.S. HIV Clinical Studies

...e following points should be considered when initiating therapy with PREZISTA/rtv: Treatment history and, when available, genotypic or phenotypic testing should guide the use of PREZISTA/rtv. The use of other active agents with PREZISTA/rtv is associated with a greater likelihood of treat...

Eli Lilly and Company Announces New Drug Discovery Initiative

...ly and Company will be engaging researchers from around the world in a new and unique drug discovery initiative. The initiative, called the Lilly phenotypic Drug Discovery Initiative, or PD2 (pronounced PD-squared)*, uses Lilly-developed disease-state assays and a secure web portal to evaluate the therapeu...

AdvanDx Receives FDA 510(k) Clearance for GBS PNA FISH(R) for Rapid Detection of Group B Strep from Lim Broths

...tly taken for further culture workup and identification using conventional, phenotypic methods. This process can take anywhere from 3 to 4 days, and while Lim Br...highly sensitive and selective for Group B Strep, the subsequent workup and phenotypic identification can be time consuming and may miss some true positive sample...

GeneGo and OmicSoft Announce Integration

...an integration and expert analysis of different kinds of experimental data (mRNA expression, proteomics , metabolomics, microRNA assays and other phenotypic data) and relevant bioactive chemistry (metabolites, drugs, other xenobiotics) within the framework of curated biological pathways and networks. GeneG...

Advanced Analytical Reveals New Platform for Rapid Genotypic Identification of Microorganisms at ASM 2009

...leveland Clinic, added; "We evaluated the differentiation of various microorganisms on a prototype instrument and compared it with other genotypic and phenotypic methods. The instrument is capable of identifying organisms quickly and easily. The implementation of such technology in the clinical laboratory sho...

iZumi Bio and Kyoto University Form Collaboration to Advance Induced Pluripotent Stem Cell Technology

...cific aortic valve disease." iZumi and CiRA respectively offer the capability to take skin cells from a diseased patient with known genotypic and phenotypic information and reprogram the cells to behave similarly to human embryonic stem cells. These iPS cells can then be changed into various cell types in ...

PREZISTA(R) Now Available for Pediatric Patients Six Years of Age and Older as part of HIV Combination Therapy

...en initiating therapy with PREZISTA/r in treatment-experienced pediatric patients: Treatment history and, when available, genotypic or phenotypic testing should guide the use of PREZISTA/r. The use of other active agents with PREZISTA/r is associated with a greater likelihood of treatmen...

Washington University Becker Library Makes MetaCore Accessible Throughout the University

...ows an integration and expert analysis of different kinds of experimental data (mRNA expression, proteomics , metabolomics, microRNA assays and other phenotypic data) and relevant bioactive chemistry (metabolites, drugs, other xenobiotics) within the framework of curated biological pathways and networks. GeneG...
Phenotypic in Medical Technology

Cognition Therapeutics Closes Series A Financing to Advance Drug Candidates for Alzheimer's Disease

...imer's disease and other neurodegenerative diseases. These assays emphasize phenotypic or functional responses of mature primary neurons to the toxic proteins. Co...y platforms harken back to the origins of the pharmaceutical industry, when phenotypic responses were the sole screening method and natural product derivatives fo...

Long-Term Study Evaluates Boosted PREZISTA(R) Vs. Lopinavir/Ritonavir as Part of HIV Combination Therapy in Treatment-Naive Adults

...enced patients, the following points should be considered when initiating therapy with PREZISTA/r: treatment history and, when available, genotypic or phenotypic testing, should guide the use of PREZISTA/r. The use of other active agents with PREZISTA/r is associated with a greater likelihood of treatment respo...

Journal of Clinical Oncology Publishes Leukine(R) Study Demonstrating Positive Survival Outcomes in Patients with High-Risk Melanoma

...ve and safe medicines." About The Study In addition to clinical outcomes, patients underwent phenotype analysis of dendritic cells. Dendritic cell phenotypic analysis was performed at baseline and again at two, four, eight and 12 weeks. Control values for this analysis were established prior to the trial us...

IDX899 Demonstrates Rapid and Profound Inhibition of HIV Replication in a Phase I/II Clinical Trial in Treatment-Naive HIV-Infected Patients

... In a preclinical resistance study, IDX899 and other marketed and investigational NNRTIs were compared to evaluate in-vitro genotypic resistance and phenotypic cross-resistance profiles. IDX899 demonstrated potent antiviral activity against established NNRTI-resistant clinical isolates. Compared to efavirenz ...

DHHS Guidelines Support Use of Trofile(TM) Assay Prior to CCR5 Inhibitor Use

...ermine whether or not the patient's HIV experienced a shift in viral tropism while on the therapy. The DHHS guidelines recommend only high- throughput phenotypic assays be used for co-receptor testing for CCR5 therapeutics at this time and acknowledge that genotypic assays, while under investigation, are curren...

Supplemental New Drug Application for PREZISTA(TM) Submitted to U.S. Food and Drug Administration

...erapy. The following points should be considered when initiating therapy with PREZISTA/r: -- Treatment history and, when available, genotypic or phenotypic testing should guide the use of PREZISTA/r. -- The use of other active agents with PREZISTA/r is associated with a greater likelihood of tre...

The Pittsburgh Life Sciences Greenhouse Relocates Therapeutics Company to Pittsburgh

...f Alzheimer's disease. PLSG's investment will support the deployment of the phenotypic assay technology platform. "Our approach is to target the toxic proteins th...y loss," said Dr. Susan Catalano, Chief Science Officer and inventor of the phenotypic assay platform technology. "We are thrilled to welcome Cognition to south...

Aptivus(R) (tipranavir) Capsules Granted Full Approval by the U.S. FDA

...t recommended. -- The use of other active agents with APTIVUS/r is associated with a greater likelihood of treatment response. -- Genotypic or phenotypic testing and/or treatment history should guide the use of APTIVUS/r. The number of baseline primary protease inhibitor mutations affects the v...

Monogram Provides Update on Trofile(TM) Co-Receptor Tropism Assay

...men alone, and -- that patients receiving Selzentry experienced similar adverse events to those receiving an optimized regimen alone. Monogram's phenotypic resistance tests were used to optimize background therapy in Selzentry's clinical trials. Selzentry is designed to work differently from other availa...

New Phase 3 Study in Treatment-Naive Adults with HIV Evaluates Efficacy and Safety of Once-Daily PREZISTA(TM)/ritonavir vs. KALETRA(R) as Part of HIV Combination Therapy

...l therapy. The following points should be considered when initiating therapy with PREZISTA/r: -- Treatment history and, when available, genotypic or phenotypic testing should guide the use of PREZISTA/r. -- The use of other active agents with PREZISTA/r is associated with a greater likelihood of trea...
Phenotypic in Medical Dictionary

Sex-linked recessive

... Sex linkage is the phenotypic expression of an allele that is related to the chromosomal sex of the individual. This mode of inheritance is in contrast to the inheritance of trai...

Sex-linked dominant

... Sex linkage is the phenotypic expression of an allele that is related to the chromosomal sex of the individual. This mode of inheritance is in contrast to the inheritance of trai...

Genes

...ssary to construct the chemicals ... Genes and Disease Topic Room. Lead Editor: Alexandre Vieira, Ph.D. ... Epistatic interactions can alter the phenotypic effects of other genes in a variety of ways. ... ...

Eyes

...he brain. Complex optical systems with resolving power have come in ten fundamentally different forms, and 96% of... Eye color is a polygenic phenotypic character and is determined by the amount ... In human eyes , these variations in color are attributed to varying ratios of ... Your Eye Care...
Phenotypic in Biological News

A new kind of mutation could explain numerous phenotypic variations in various species

The authors describe the discovery of a novel class of mutations that disrupt the function of a gene and thereby cause a specific phenotype. The mutation created the appearance of an "illegitimate" microRNA (miRNA) recognition site in a gene that did not have it in its normal form. In this study, ...

Measuring intellectual disability

...al suggest that "[this] method should prove to be a powerful tool for further investigation of the relationships between FMRP and the diverse clinical phenotypic domains [of fragile X syndrome]." "Such domains include not only autism and autism spectrum disorders, but also developmental delay, behavioral diffic...

7th annual [BC]2 Basel Computational Biology Conference 'Molecular Evolution' June 18-19, 2009

... process. Richard E. Lenski, who will be speaking about the "Dynamics of phenotypic and Genomic Evolution During a 40,000-Generation Experiment with E. coli", ... findings in this project providing new insights on the dynamic coupling of phenotypic and genomic evolution and the role of complex mutations in the origin of ne...

Did the North Atlantic fisheries collapse due to fisheries-induced evolution?

...e, has, on average, decreased nearly one centimeter per year. The changes observed very likely are evolutionary genetic changes and not simply plastic phenotypic responses to the environment. They are comparable to changes that preceded the collapse of northern cod at Newfoundland. This finding further suppo...

The neurobiology of musicality related to the intrinsic attachment behavior?

...aying music together may add group cohesion. Thus, it is justified to hypothesize that music perception and creativity in music are linked to the same phenotypic spectrum of human cognitive social skills, like human bonding and altruism both associated with AVPR1A. We have shown for the first time in the molecu...

A genome may reduce your carbon footprint

...complete sequence assembly nor gene annotation is required to apply these techniques. In a species such as switchgrass there exists a great deal of phenotypic variation derived from latitudinal adaptation across its natural range and local adaptation to soil, temperature, and moisture conditions. It is still...

Color test enhances tomato analyzer software

...ed to analyze the morphology of tomato fruit. The researchers in this study developed a module for color measurement "to expand the array of objective phenotypic analyses implemented". TACT was applied to fruits and vegetables of various color and color uniformity. "TACT was designed to be user-friendly with...

Identifying mega-targets for high-yield plant breeding

...reeding programs. Results from this research are published in the January 2009 issue of the journal Crop Science . The researchers found that all phenotypic traits had significant genetic diversity, but only seven of the 20 traits evaluated showed differences in the amount of diversity among the breeding p...

BioScience tip sheet, February 2009

...viewed research articles: Biological Resource Centers and Systems Biology. Yufeng Wang and Timothy G. Lilburn. The authors propose leveraging phenotypic data from the few bacteria in resource collections that are well characterized with the larger numbers of bacteria for which there exist genetic seque...

Pigs and dogs can bridge gap between mice and humans in developing new therapies

...istics (phenotypes), so that results can be compared across Europe. "The workshop showed that there is excellent expertise in individual labs, but the phenotypic tests need to be harmonised and standardised to facilitate comparison of results obtained in different labs," said Angelika Schnieke, one of the works...
Phenotypic in Biological Technology

GeneGo Donates Proprietary Cytokine Pathway Maps to ISICR

...s an integration and expert analysis of different kinds of experimental data (mRNA expression, proteomics , metabolomics, microRNA assays and other phenotypic data) and relevant bioactive chemistry (metabolites, drugs, other xenobiotics) within the framework of curated biological pathways and networks. GeneG...

New Test from Quest Diagnostics Helps Physicians Choose HIV Antiretroviral Therapy in Patients with History of Drug Resistance

...at found that the Quest Diagnostics HIV-1 Coreceptor Tropism laboratory developed test demonstrated 74 percent agreement with Trofile(TM), the leading phenotypic tropism test available from Monogram Biosciences, and 74 percent agreement with SensiTrop(TM) II, a genotypic tropism test previously available from P...

Prometheus Research Signs 3-Year Contract With Simons Foundation to Expand HTSQL Informatics System for Autism Research

...disorders. The SFARI database, known as SFARI Base, is a new resource for autism research that provides the scientific community access to genetic and phenotypic information on 2000 families. "Researchers need flexible, adaptive, and secure informatics systems that empower them to uncover critical data ea...

Amnis Launches New ImageStreamX Imaging Flow Cytometer

...ations Officer. "No other cell analysis platform gives you as much information in a single experiment or allows you to combine detailed functional and phenotypic studies," added Ortyn. "The modularity of the new ImageStreamX allows it to fit into a much wider range of budgets, while its performance charact...

Sigma-Aldrich Introduces MISSION(R) esiRNA for Low Cost, High Specificity Pooled RNAi Screening

... School , which has invested in a human genome-wide esiRNA library, is using esiRNA to help identify the human genes that enable HIV propagation. "The phenotypic results from the initial tests of MISSION esiRNA using our assay for finding HIV dependency factors demonstrated very effective knockdown over a wide ...

Cardiff University Becomes a GeneGo Center of Excellence

...an integration and expert analysis of different kinds of experimental data (mRNA expression, proteomics , metabolomics, microRNA assays and other phenotypic data) and relevant bioactive chemistry (metabolites, drugs, other xenobiotics) within the framework of curated biological pathways and networks. GeneG...

Children's Memorial Research Center, Chicago Becomes a Member of GeneGo's MetaMiner Stem Cell Partnership Program

...an integration and expert analysis of different kinds of experimental data (mRNA expression, proteomics , metabolomics, microRNA assays and other phenotypic data) and relevant bioactive chemistry (metabolites, drugs, other xenobiotics) within the framework of curated biological pathways and networks. GeneG...

VisualSonics to Sell Mauna Kea Technologies' Cellvizio(R) LAB on a Worldwide Basis to Animal Imaging Market

...es to conduct research in cardiovascular, cancer, and developmental biology areas. The technology supports applications that include genetic research, phenotypic studies and drug development. VisualSonics platforms combine high-resolution, real time in vivo imaging at reasonable cost with ease-of-use and quanti...

Van Andel Institute Joins the MetaMiner Oncology Partnership Program

...an integration and expert analysis of different kinds of experimental data (mRNA expression, proteomics , metabolomics, microRNA assays and other phenotypic data) and relevant bioactive chemistry (metabolites, drugs, other xenobiotics) within the framework of curated biological pathways and networks. GeneG...

GeneGo Announces Systems Tox Relationship With Entelos

...ows an integration and expert analysis of different kinds of experimental data (mRNA expression, proteomics , metabolomics, microRNA assays and other phenotypic data) and relevant bioactive chemistry (metabolites, drugs, other xenobiotics) within the framework of curated biological pathways and networks. GeneG...
Phenotypic in Biological Products

Guava EasyCyte from Guava Technologies

Description:...em is equipped with a blue laser (488 nm), three fluorescence detectors, forward scatter (FSC) and sides scatter (SSC) to identify cells with specific phenotypic markers or specific properties. The unique capability, not provided with other assay systems, of direct, absolute cell counts, is displayed as cells/m...
Company:Guava Technologies

Alkaline Phosphatase Detection Kit from CHEMICON

Description:... CHEMICONs Alkaline Phosphatase Detection Kit (Catalog number SCR004) is a specific and sensitive tool for the phenotypic assessment of ES cell differentiation by the determination of AP activity. Available separately from CHEMICON are the monoclonal antibodies TRA-2-49 ...
Company:CHEMICON

ES Cell Characterization Kit from CHEMICON

Description:...d TRA-1-81 [Andrews and Banting, 1984]. • CHEMICONs ES Cell Characterization Kit (Catalog number SCR001) is a specific and sensitive tool for the phenotypic assessment of the differentiation status of ES cells by measuring their AP activity, cell-surface stage-specific antigens (SSEA-1, SSEA-4) as well as ...
Company:CHEMICON
Phenotypic in Biological Definition

Experimental evolution

...fic journals . Further reading W. H. Dallinger (1887). The president's address. J. Roy. Microscop. Soc. , 185-199. R. E. Lenski (2004). phenotypic and genomic evolution during a 20,000-generation experiment with the bacterium Escherichia coli . Plant Breeding Reviews 24 , 225-265. S. F. El...

Homeobox

...d very early and that the basic mechanisms of morphogenesis are the same for many organisms. Mutations to homeobox genes can produce easily visible phenotypic changes. Two examples of homeobox mutations in the above-mentioned fruit fly are legs where the antennae should be, and a second pair of wings. Dup...

Phenotype

...ochemical, physiological and behavioral) determined by an interaction between its genotype and environment (see genotype-phenotype distinction and phenotypic plasticity for a further elaboration of this distinction). The idea of the phenotype has been generalized by Richard Dawkins to include effects o...
Phenotypic in Biological Dictionary

Transcapsidation

...ocess of transcapsidation is the encasing of genetic material ... ... ELISA to investigate heterologous encapsidation ( transcapsidation and phenotypic ... that among BYDV isolates transcapsidation is more common between distantly ... Transcapsidation , however, is not needed for umbravirus accu...

Trait

...rait class, a template class in the C++ programming language. Trait (abstract type), a model for ... A trait is a distinct variant of a phenotypic character of an organism that may be inherited, environmentally determined or somewhere in between. For example, eye color is a character or abstr...

Sex-linked

... Sex linkage is the phenotypic expression of an allele that is related to the chromosomal sex of the individual. This mode of inheritance is in contrast to the inheritance ...

Selection

... a ... The process of natural selection has played an important role in the production ... 2 Natural Selection as a Process. 3 Genetic Basis of phenotypic Variation ... Natural selection . Natural selection is one of the basic mechanisms of evolution, along with ... selection can develop complex ...

Quantitative trait loci

... Inheritance of quantitative traits or polygenic inheritance refers to the inheritance of a phenotypic characteristic that varies in degree and can be attributed to the interactions between two or more genes and their... quantitative trait locus...

Quantitative trait

...ic inheritance refers to the inheritance of a phenotypic characteristic that varies in degree and can be at...ying genes results in a continuous distribution of phenotypic values. ... Is A Quantitative Trait Locus? ... quantitative trait is one that has measurable phenotypic variation owing to ... Our study of quantita...

Punctuated equilibrium

...ria by Wesley Elsberry. Punctuated Equilibrium and Patterns from the Fossil Record ... According to the punctuated equilibrium hypothesis, phenotypic evolution ... Punctuated equilibrium originated as an extension of Ernst Mayr's concept of ... 4 Ernst Mayr's understanding of punctuated ...

Preformation

...nt of organs one or more growing ... Preformation proceeds below ground through the remainder of the growing season ... Does preformation limit phenotypic plasticity? ... Such extreme preformation may inhibit or delay developmental and morphological ... Near Matches. Ignore Exact. Full Text. Everyth...

Polygenic inheritance

...tative traits or polygenic inheritance refers to the inheritance of a phenotypic characteristic that varies in degree and can be attributed to the interacti..... Inheritance of quantitative traits refers to the inheritance of a phenotypic ... The paradigm of polygenic inheritance as being used to define multi...

Polygenic disorders

...rs are quite rare and affect one person in every... Inheritance of quantitative traits or polygenic inheritance refers to the inheritance of a phenotypic characteristic that varies in degree and can be attributed to the interactions between two or more genes and their... Genetic disorders may resul...
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(Date:4/23/2014)... SEATTLE, Washington, April 21, 2014 Five for-profit ... total of $1.25 million in Proof of Concept ... from ideas into commercial products, the Life Sciences ... a $300,000 Entrepreneur Mentoring Program grant to the ... a statewide advisory network to train the next ...
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(Date:4/23/2014)... shown that proliferation of endogenous neural precursor cells ... and axons. From the perspective of neural plasticity, ... University in China observed the effects of functional ... proliferation and expression of basic fibroblast growth factor ... on the infarct side. The researchers found that ...
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(Date:4/23/2014)... University of Exeter researcher has shed light on how ... in Australia,s remote outback have become reviled as pests ... of the Environment and Sustainability Institute at the University ... camel in Australia, from their historic role helping to ... as unwelcome "invader." , The deserts of the Australian ...
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